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Items: 1 to 50 of 113


Expanding instrumented gait testing in the community setting: A portable, depth-sensing camera captures joint motion in older adults.

Dawe RJ, Yu L, Leurgans SE, Truty T, Curran T, Hausdorff JM, Wimmer MA, Block JA, Bennett DA, Buchman AS.

PLoS One. 2019 May 15;14(5):e0215995. doi: 10.1371/journal.pone.0215995. eCollection 2019.


Incident Mobility Disability, Mild Cognitive Impairment, and Mortality in Community-Dwelling Older Adults.

Yu L, Boyle PA, Leurgans SE, Wilson RS, Bennett DA, Buchman AS.

Neuroepidemiology. 2019 Apr 15:1-8. doi: 10.1159/000499334. [Epub ahead of print]


Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies.

Buchman AS, Yu L, Wilson RS, Leurgans SE, Nag S, Shulman JM, Barnes LL, Schneider JA, Bennett DA.

Neurology. 2019 Apr 16;92(16):e1821-e1830. doi: 10.1212/WNL.0000000000007315. Epub 2019 Mar 20.


Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons.

Capuano AW, Wilson RS, Honer WG, Petyuk VA, Leurgans SE, Yu L, Gatchel JR, Arnold S, Bennett DA, Arvanitakis Z.

J Affect Disord. 2019 May 1;250:313-318. doi: 10.1016/j.jad.2019.03.051. Epub 2019 Mar 8.


Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults.

Makkinejad N, Schneider JA, Yu J, Leurgans SE, Kotrotsou A, Evia AM, Bennett DA, Arfanakis K.

Neurobiol Aging. 2019 May;77:104-111. doi: 10.1016/j.neurobiolaging.2019.01.022. Epub 2019 Jan 31.


Postmortem neurodegenerative markers and trajectories of decline in cognitive systems.

Wilson RS, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Bennett DA, Boyle PA.

Neurology. 2019 Feb 19;92(8):e831-e840. doi: 10.1212/WNL.0000000000006949. Epub 2019 Jan 23.


Physical activity, common brain pathologies, and cognition in community-dwelling older adults.

Buchman AS, Yu L, Wilson RS, Lim A, Dawe RJ, Gaiteri C, Leurgans SE, Schneider JA, Bennett DA.

Neurology. 2019 Feb 19;92(8):e811-e822. doi: 10.1212/WNL.0000000000006954. Epub 2019 Jan 16.


Spinal motor neurons and motor function in older adults.

Buchman AS, Leurgans SE, VanderHorst VGJM, Nag S, Schneider JA, Bennett DA.

J Neurol. 2019 Jan;266(1):174-182. doi: 10.1007/s00415-018-9118-y. Epub 2018 Nov 16.


Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.

Boyle PA, Yu L, Leurgans SE, Wilson RS, Brookmeyer R, Schneider JA, Bennett DA.

Ann Neurol. 2019 Jan;85(1):114-124. doi: 10.1002/ana.25380. Epub 2018 Dec 19.


Watershed microinfarct pathology and cognition in older persons.

Kapasi A, Leurgans SE, James BD, Boyle PA, Arvanitakis Z, Nag S, Bennett DA, Buchman AS, Schneider JA.

Neurobiol Aging. 2018 Oct;70:10-17. doi: 10.1016/j.neurobiolaging.2018.05.027. Epub 2018 May 30.


TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer's disease.

Nag S, Yu L, Boyle PA, Leurgans SE, Bennett DA, Schneider JA.

Acta Neuropathol Commun. 2018 May 1;6(1):33. doi: 10.1186/s40478-018-0531-3.


Neurodegenerative disease and cognitive retest learning.

Wilson RS, Capuano AW, Yu L, Yang J, Kim N, Leurgans SE, Lamar M, Schneider JA, Bennett DA, Boyle PA.

Neurobiol Aging. 2018 Jun;66:122-130. doi: 10.1016/j.neurobiolaging.2018.02.016. Epub 2018 Mar 29.


Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age.

Ramos-Miguel A, Jones AA, Sawada K, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG.

Neurobiol Dis. 2018 Jun;114:31-44. doi: 10.1016/j.nbd.2018.02.006. Epub 2018 Feb 26.


Memory complaints, dementia, and neuropathology in older blacks and whites.

Arvanitakis Z, Leurgans SE, Fleischman DA, Schneider JA, Rajan KB, Pruzin JJ, Shah RC, Evans DA, Barnes LL, Bennett DA.

Ann Neurol. 2018 Apr;83(4):718-729. doi: 10.1002/ana.25189. Epub 2018 Mar 30.


Ex-vivo quantitative susceptibility mapping of human brain hemispheres.

Evia AM, Kotrotsou A, Tamhane AA, Dawe RJ, Kapasi A, Leurgans SE, Schneider JA, Bennett DA, Arfanakis K.

PLoS One. 2017 Dec 20;12(12):e0188395. doi: 10.1371/journal.pone.0188395. eCollection 2017.


Person-specific contribution of neuropathologies to cognitive loss in old age.

Boyle PA, Yu L, Wilson RS, Leurgans SE, Schneider JA, Bennett DA.

Ann Neurol. 2018 Jan;83(1):74-83. doi: 10.1002/ana.25123. Epub 2018 Jan 14.


Age and the association of dementia-related pathology with trajectories of cognitive decline.

Jansen WJ, Wilson RS, Visser PJ, Nag S, Schneider JA, James BD, Leurgans SE, Capuano AW, Bennett DA, Boyle PA.

Neurobiol Aging. 2018 Jan;61:138-145. doi: 10.1016/j.neurobiolaging.2017.08.029. Epub 2017 Sep 5.


Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease.

Buchman AS, Nag S, Leurgans SE, Miller J, VanderHorst VGJM, Bennett DA, Schneider JA.

Brain Pathol. 2018 Jul;28(4):560-568. doi: 10.1111/bpa.12560. Epub 2017 Oct 27.


Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults.

Dawe RJ, Leurgans SE, Yang J, Bennett JM, Hausdorff JM, Lim AS, Gaiteri C, Bennett DA, Buchman AS.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):636-642. doi: 10.1093/gerona/glx167.


Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism.

Buchman AS, Leurgans SE, Nag S, VanderHorst VGJM, Kapasi A, Schneider JA, Bennett DA.

Stroke. 2017 Oct;48(10):2792-2798. doi: 10.1161/STROKEAHA.117.017643. Epub 2017 Sep 20.


Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample.

Ramos-Miguel A, García-Sevilla JA, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG, García-Fuster MJ.

Mol Neurodegener. 2017 Mar 20;12(1):26. doi: 10.1186/s13024-017-0168-x.


Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology.

Thaker AA, Weinberg BD, Dillon WP, Hess CP, Cabral HJ, Fleischman DA, Leurgans SE, Bennett DA, Hyman BT, Albert MS, Killiany RJ, Fischl B, Dale AM, Desikan RS.

AJNR Am J Neuroradiol. 2017 May;38(5):961-965. doi: 10.3174/ajnr.A5133. Epub 2017 Mar 9.


Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline.

Boyle PA, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Wilson RS, Bennett DA.

Brain. 2017 Mar 1;140(3):804-812. doi: 10.1093/brain/aww341.


Urinary Incontinence, Incident Parkinsonism, and Parkinson's Disease Pathology in Older Adults.

Buchman NM, Leurgans SE, Shah RJ, VanderHorst V, Wilson RS, Bachner YG, Tanne D, Schneider JA, Bennett DA, Buchman AS.

J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1295-1301. doi: 10.1093/gerona/glw235.


Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.

Ramos-Miguel A, Sawada K, Jones AA, Thornton AE, Barr AM, Leurgans SE, Schneider JA, Bennett DA, Honer WG.

Acta Neuropathol. 2017 Mar;133(3):395-407. doi: 10.1007/s00401-016-1647-9. Epub 2016 Nov 19.


Self-Reported Sleep in Older African Americans and White Americans.

Turner AD, Lim AS, Leurgans SE, Bennett DA, Buchman AS, Barnes LL.

Ethn Dis. 2016 Oct 20;26(4):521-528.


Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology.

Pruzin JJ, Schneider JA, Capuano AW, Leurgans SE, Barnes LL, Ahima RS, Arnold SE, Bennett DA, Arvanitakis Z.

Alzheimer Dis Assoc Disord. 2017 Jan-Mar;31(1):41-47. doi: 10.1097/WAD.0000000000000172.


Incident parkinsonism in older adults without Parkinson disease.

Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, Shulman JM, Bennett DA.

Neurology. 2016 Sep 6;87(10):1036-44. doi: 10.1212/WNL.0000000000003059. Epub 2016 Aug 3.


Postmortem MRI: a novel window into the neurobiology of late life cognitive decline.

Dawe RJ, Yu L, Leurgans SE, Schneider JA, Buchman AS, Arfanakis K, Bennett DA, Boyle PA.

Neurobiol Aging. 2016 Sep;45:169-177. doi: 10.1016/j.neurobiolaging.2016.05.023. Epub 2016 Jun 6.


Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study.

Arvanitakis Z, Capuano AW, Leurgans SE, Bennett DA, Schneider JA.

Lancet Neurol. 2016 Aug;15(9):934-943. doi: 10.1016/S1474-4422(16)30029-1. Epub 2016 Jun 14.


Sigmoidal mixed models for longitudinal data.

Capuano AW, Wilson RS, Leurgans SE, Dawson JD, Bennett DA, Hedeker D.

Stat Methods Med Res. 2018 Mar;27(3):863-875. doi: 10.1177/0962280216645632. Epub 2016 Apr 28.


The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts.

Arvanitakis Z, Capuano AW, Leurgans SE, Buchman AS, Bennett DA, Schneider JA.

Brain Pathol. 2017 Jan;27(1):77-85. doi: 10.1111/bpa.12365. Epub 2016 Apr 14.


Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample.

Ramos-Miguel A, Hercher C, Beasley CL, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG.

Mol Neurodegener. 2015 Dec 2;10:65. doi: 10.1186/s13024-015-0061-4.


Parkinsonism in Older Adults and Its Association With Adverse Health Outcomes and Neuropathology.

Buchman AS, Wilson RS, Shulman JM, Leurgans SE, Schneider JA, Bennett DA.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):549-56. doi: 10.1093/gerona/glv153. Epub 2015 Sep 10.


Change in motor function and adverse health outcomes in older African-Americans.

Buchman AS, Wilson RS, Leurgans SE, Bennett DA, Barnes LL.

Exp Gerontol. 2015 Oct;70:71-7. doi: 10.1016/j.exger.2015.07.009. Epub 2015 Jul 21.


Neuropathologic correlates of regional brain volumes in a community cohort of older adults.

Kotrotsou A, Schneider JA, Bennett DA, Leurgans SE, Dawe RJ, Boyle PA, Golak T, Arfanakis K.

Neurobiol Aging. 2015 Oct;36(10):2798-805. doi: 10.1016/j.neurobiolaging.2015.06.025. Epub 2015 Jun 30.


Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial.

David FJ, Robichaud JA, Leurgans SE, Poon C, Kohrt WM, Goldman JG, Comella CL, Vaillancourt DE, Corcos DM.

Mov Disord. 2015 Oct;30(12):1657-63. doi: 10.1002/mds.26291. Epub 2015 Jul 6.


Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies.

Yang J, Yu L, Gaiteri C, Srivastava GP, Chibnik LB, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA.

Int J Biochem Cell Biol. 2015 Oct;67:58-64. doi: 10.1016/j.biocel.2015.05.009. Epub 2015 May 21.


Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment.

Arvanitakis Z, Fleischman DA, Arfanakis K, Leurgans SE, Barnes LL, Bennett DA.

Brain Struct Funct. 2016 May;221(4):2135-46. doi: 10.1007/s00429-015-1034-7. Epub 2015 Apr 2.


Physical activity, motor function, and white matter hyperintensity burden in healthy older adults.

Fleischman DA, Yang J, Arfanakis K, Arvanitakis Z, Leurgans SE, Turner AD, Barnes LL, Bennett DA, Buchman AS.

Neurology. 2015 Mar 31;84(13):1294-300. doi: 10.1212/WNL.0000000000001417. Epub 2015 Mar 11.


Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease.

Nag S, Yu L, Capuano AW, Wilson RS, Leurgans SE, Bennett DA, Schneider JA.

Ann Neurol. 2015 Jun;77(6):942-52. doi: 10.1002/ana.24388. Epub 2015 Apr 22.


Negative social interactions and risk of mild cognitive impairment in old age.

Wilson RS, Boyle PA, James BD, Leurgans SE, Buchman AS, Bennett DA.

Neuropsychology. 2015 Jul;29(4):561-70. doi: 10.1037/neu0000154. Epub 2014 Dec 15.


Is intralesional treatment of giant cell tumor of the distal radius comparable to resection with respect to local control and functional outcome?

Wysocki RW, Soni E, Virkus WW, Scarborough MT, Leurgans SE, Gitelis S.

Clin Orthop Relat Res. 2015 Feb;473(2):706-15. doi: 10.1007/s11999-014-4054-3. Epub 2014 Dec 4.


Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.

Yu L, Chibnik LB, Srivastava GP, Pochet N, Yang J, Xu J, Kozubek J, Obholzer N, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA.

JAMA Neurol. 2015 Jan;72(1):15-24. doi: 10.1001/jamaneurol.2014.3049.


Relation of antiphospholipid antibodies to postmortem brain infarcts in older people.

Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Capuano AW, Yu L, Leurgans SE, Bennett DA, Levine SR.

Circulation. 2015 Jan 13;131(2):182-9. doi: 10.1161/CIRCULATIONAHA.114.012479. Epub 2014 Oct 9.


Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease.

Pivtoraiko VN, Abrahamson EE, Leurgans SE, DeKosky ST, Mufson EJ, Ikonomovic MD.

Neurobiol Aging. 2015 Jan;36(1):12-9. doi: 10.1016/j.neurobiolaging.2014.06.021. Epub 2014 Jun 24.


Two-year exercise program improves physical function in Parkinson's disease: the PRET-PD randomized clinical trial.

Prodoehl J, Rafferty MR, David FJ, Poon C, Vaillancourt DE, Comella CL, Leurgans SE, Kohrt WM, Corcos DM, Robichaud JA.

Neurorehabil Neural Repair. 2015 Feb;29(2):112-22. doi: 10.1177/1545968314539732. Epub 2014 Jun 24.


Contribution of Alzheimer disease to mortality in the United States.

James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K, Bennett DA.

Neurology. 2014 Mar 25;82(12):1045-50. doi: 10.1212/WNL.0000000000000240. Epub 2014 Mar 5.


Ex vivo T2 relaxation: associations with age-related neuropathology and cognition.

Dawe RJ, Bennett DA, Schneider JA, Leurgans SE, Kotrotsou A, Boyle PA, Arfanakis K.

Neurobiol Aging. 2014 Jul;35(7):1549-61. doi: 10.1016/j.neurobiolaging.2014.01.144. Epub 2014 Feb 6.


Associations between quantitative mobility measures derived from components of conventional mobility testing and Parkinsonian gait in older adults.

Buchman AS, Leurgans SE, Weiss A, Vanderhorst V, Mirelman A, Dawe R, Barnes LL, Wilson RS, Hausdorff JM, Bennett DA.

PLoS One. 2014 Jan 22;9(1):e86262. doi: 10.1371/journal.pone.0086262. eCollection 2014.

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