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Inter-manufacturer comparison of automated immunoassays for the measurement of soluble FMS-like tyrosine kinase-1 and placental growth factor.

Cheng YKY, Poon LCY, Shennan A, Leung TY, Sahota DS.

Pregnancy Hypertens. 2019 Jul;17:165-171. doi: 10.1016/j.preghy.2019.06.004. Epub 2019 Jun 20.


Prenatal Diagnosis of Fetuses With Increased Nuchal Translucency by Genome Sequencing Analysis.

Choy KW, Wang H, Shi M, Chen J, Yang Z, Zhang R, Yan H, Wang Y, Chen S, Chau MHK, Cao Y, Chan OYM, Kwok YK, Zhu Y, Chen M, Leung TY, Dong Z.

Front Genet. 2019 Aug 16;10:761. doi: 10.3389/fgene.2019.00761. eCollection 2019.


Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis.

Wang H, Dong Z, Zhang R, Chau MHK, Yang Z, Tsang KYC, Wong HK, Gui B, Meng Z, Xiao K, Zhu X, Wang Y, Chen S, Leung TY, Cheung SW, Kwok YK, Morton CC, Zhu Y, Choy KW.

Genet Med. 2019 Aug 26. doi: 10.1038/s41436-019-0634-7. [Epub ahead of print]


Prenatal diagnosis of pathogenic genomic imbalance in fetuses with increased nuchal translucency but normal karyotyping using chromosomal microarray.

Leung TY, Au Yeung KC, Leung WC, Leung KY, Lo TK, To WWK, Lau WL, Chan LW, Sahota DS, Choy RKW.

Hong Kong Med J. 2019 Aug;25 Suppl 5(4):30-32. No abstract available.


Topologic Analysis of Plasma Mitochondrial DNA Reveals the Coexistence of Both Linear and Circular Molecules.

Ma ML, Zhang H, Jiang P, Sin STK, Lam WKJ, Cheng SH, Lee WS, Gai W, Tse OYO, Peng W, Wong J, Raghupathy R, Wong RSM, Sahota D, Leung TY, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2019 Sep;65(9):1161-1170. doi: 10.1373/clinchem.2019.308122. Epub 2019 Jul 1.


Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis.

Chau MHK, Cao Y, Yvonne Kwok KY, Chan S, Chan YM, Wang H, Yang Z, Wong HK, Leung TY, Choy KW.

Am J Obstet Gynecol. 2019 Jun 14. pii: S0002-9378(19)30771-9. doi: 10.1016/j.ajog.2019.06.007. [Epub ahead of print]


Parental consanguinity in Hong Kong.

Siong KH, Au Yeung SKC, Leung TY.

Hong Kong Med J. 2019 Jun;25(3):192-200. doi: 10.12809/hkmj187783. Epub 2019 Jun 10.


Genetic association of retroesophageal left brachiocephalic vein.

Chan YM, Law KM, Poon LCY, Luk HM, Cheng YKY, Leung TY.

Ultrasound Obstet Gynecol. 2019 Apr 1. doi: 10.1002/uog.20275. [Epub ahead of print]


Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD.

Genome Res. 2019 Mar;29(3):418-427. doi: 10.1101/gr.242719.118.


Prenatal visualization of paraumbilical veins in fetus with intra-abdominal umbilical vein stricture and intrauterine growth restriction.

Chan YM, Law KM, Poon LCY, Leung TY.

Ultrasound Obstet Gynecol. 2019 Feb 24. doi: 10.1002/uog.20248. [Epub ahead of print]


Factors that affect ultrasound-determined labor progress in women undergoing induction of labor.

Chaemsaithong P, Kwan AHW, Tse WT, Lim WT, Chan WWY, Chong KC, Leung TY, Poon LC.

Am J Obstet Gynecol. 2019 Jun;220(6):592.e1-592.e15. doi: 10.1016/j.ajog.2019.01.236. Epub 2019 Feb 5.


Prevalence of chromosomal abnormalities and 22q11.2 deletion in conotruncal and non-conotruncal antenatally diagnosed congenital heart diseases in a Chinese population.

Kong CW, Cheng YKY, To WWK, Leung TY.

Hong Kong Med J. 2019 Feb;25(1):6-12. doi: 10.12809/hkmj187552. Epub 2019 Jan 18.


Enrichment of fetal and maternal long cell-free DNA fragments from maternal plasma following DNA repair.

Vong JSL, Jiang P, Cheng SH, Lee WS, Tsang JCH, Leung TY, Chan KCA, Chiu RWK, Lo YMD.

Prenat Diagn. 2019 Jan;39(2):88-99. doi: 10.1002/pd.5406. Epub 2019 Jan 10.


Comparative analysis of single-cell parallel sequencing approaches in oocyte application.

Qian Y, Liao J, Suen AHC, Lee AWT, Chung HS, Tang NLS, Chow KL, Cao Q, Yip YL, Leung TY, Chan WY, Chan DYL, Li TC, Lee TL.

Int J Biochem Cell Biol. 2019 Feb;107:1-5. doi: 10.1016/j.biocel.2018.12.003. Epub 2018 Dec 6.


Transvaginal three-dimensional ultrasound assessment of Sylvian fissures at 18-30 weeks' gestation.

Poon LC, Sahota DS, Chaemsaithong P, Nakamura T, Machida M, Naruse K, Wah YM, Leung TY, Pooh RK.

Ultrasound Obstet Gynecol. 2019 Aug;54(2):190-198. doi: 10.1002/uog.20172. Epub 2019 Jul 8.


Objective assessment of the fetal facial profile at second and third trimester of pregnancy.

Lu J, Sahota DS, Poon LC, Ting YH, Cheng YKY, Wang Y, Leung TY.

Prenat Diagn. 2019 Jan;39(2):107-115. doi: 10.1002/pd.5371. Epub 2018 Oct 30.


Molecular and clinical characterization of citrin deficiency in a cohort of Chinese patients in Hong Kong.

Chong SC, Lo P, Chow CW, Yuen L, Chu WCW, Leung TY, Hui J, Scaglia F.

Mol Genet Metab Rep. 2018 Sep 1;17:3-8. doi: 10.1016/j.ymgmr.2018.08.002. eCollection 2018 Dec.


Pre-Induction Transperineal Ultrasound Assessment for the Prediction of Labor Outcome.

Chan WWY, Chaemsaithong P, Lim WT, Tse AWT, Kwan AHW, Leung TY, Sahota DS, Poon LC.

Fetal Diagn Ther. 2019;45(4):256-267. doi: 10.1159/000489122. Epub 2018 Aug 17.


Pelvic floor disorders related to pregnancy: a prospective observational study.

Chan SS, Choy KW, Yiu KW, Cheung RY, Leung TY.

Hong Kong Med J. 2017 Jun;23 Suppl 2(3):42-46. No abstract available.


Soluble fms-like tyrosine kinase-1 and placental growth factor in Chinese pregnant women during second and third trimesters.

Cheng YK, Law LW, Leung TY, Chan OK, Sahota DS.

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):45-47. No abstract available.


Target-enriched massively parallel sequencing for genetic diagnosis of hereditary hearing loss in patients with normal array CGH result.

Choy KW, Cao Y, Lam ST, Lo FM, Morton CC, Leung TY.

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):11-14. No abstract available.


Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing.

Sun K, Jiang P, Wong AIC, Cheng YKY, Cheng SH, Zhang H, Chan KCA, Leung TY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5106-E5114. doi: 10.1073/pnas.1804134115. Epub 2018 May 14.


Hypoechoic liver in fetuses with trisomy 21.

Omar PM, Lim WT, Ting YH, Lao TT, Law KM, Cheung AHK, Ng JKM, Leung TY.

J Matern Fetal Neonatal Med. 2019 Oct;32(19):3315-3317. doi: 10.1080/14767058.2018.1459556. Epub 2018 Apr 9.


Odon device for instrumental vaginal deliveries: results of a medical device pilot clinical study.

Schvartzman JA, Krupitzki H, Merialdi M, Betrán AP, Requejo J, Nguyen MH, Vayena E, Fiorillo AE, Gadow EC, Vizcaino FM, von Petery F, Marroquin V, Cafferata ML, Mazzoni A, Vannevel V, Pattinson RC, Gülmezoglu AM, Althabe F, Bonet M; World Health Organization Odon Device Research Group.

Reprod Health. 2018 Mar 12;15(1):45. doi: 10.1186/s12978-018-0485-8.


Soluble fms-like tyrosine kinase-1, placental growth factor and their ratio as a predictor for pre-eclampsia in East Asians.

Cheng YKY, Law LW, Leung TY, Chan OK, Sahota DS.

Pregnancy Hypertens. 2018 Jan;11:61-65. doi: 10.1016/j.preghy.2017.12.002. Epub 2017 Dec 21.


Pitfalls in assessing chorioamnionicity: novel observations and literature review.

Lu J, Cheng YKY, Ting YH, Law KM, Leung TY.

Am J Obstet Gynecol. 2018 Sep;219(3):242-254. doi: 10.1016/j.ajog.2018.02.010. Epub 2018 Feb 17. Review. Erratum in: Am J Obstet Gynecol. 2019 May;220(5):499.


Is it time to move towards non-invasive prenatal screening for Down syndrome and screening for pre-eclampsia?

Wang R, Chien P, Leung TY.

BJOG. 2018 Mar;125(4):397-398. doi: 10.1111/1471-0528.15126. No abstract available.


Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring.

Sun K, Lun FMF, Leung TY, Chiu RWK, Lo YMD, Sun H.

Prenat Diagn. 2018 Feb;38(3):196-203. doi: 10.1002/pd.5214. Epub 2018 Jan 31.


Body mass index at 11-13 weeks' gestation and pregnancy complications in a Southern Chinese population: a retrospective cohort study.

Chaemsaithong P, Leung TY, Sahota D, Cheng YKY, Leung WC, Lo TK, Poon LCY.

J Matern Fetal Neonatal Med. 2019 Jun;32(12):2056-2068. doi: 10.1080/14767058.2018.1424824. Epub 2018 Jan 21.


Uses of FloSeal© in obstetric hemorrhage: Case series and literature review.

Chung JP, Leung TY.

Taiwan J Obstet Gynecol. 2017 Dec;56(6):827-830. doi: 10.1016/j.tjog.2017.10.022. Review.


Maternal height and risk of hypertensive disorders in pregnancy.

Lao TT, Hui ASY, Sahota DS, Leung TY.

J Matern Fetal Neonatal Med. 2019 May;32(9):1420-1425. doi: 10.1080/14767058.2017.1410786. Epub 2017 Dec 17.


Women's preference for non-invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study.

Cheng Y, Leung WC, Leung TY, Choy KW, Chiu R, Lo TK, Kwok KY, Sahota DS.

BJOG. 2018 Mar;125(4):451-459. doi: 10.1111/1471-0528.15022. Epub 2018 Jan 14.


Identification of balanced chromosomal rearrangements previously unknown among participants in the 1000 Genomes Project: implications for interpretation of structural variation in genomes and the future of clinical cytogenetics.

Dong Z, Wang H, Chen H, Jiang H, Yuan J, Yang Z, Wang WJ, Xu F, Guo X, Cao Y, Zhu Z, Geng C, Cheung WC, Kwok YK, Yang H, Leung TY, Morton CC, Cheung SW, Choy KW.

Genet Med. 2018 Jul;20(7):697-707. doi: 10.1038/gim.2017.170. Epub 2017 Nov 2.


Acceptance towards giving birth to a child with beta-thalassemia major - A prospective study.

Chan YM, Chan OK, Cheng YKY, Leung TY, Lao TTH, Sahota DS.

Taiwan J Obstet Gynecol. 2017 Oct;56(5):618-621. doi: 10.1016/j.tjog.2017.08.007.


First trimester screening for pre-eclampsia in Chinese pregnancies: case-control study.

Cheng Y, Leung TY, Law LW, Ting YH, Law KM, Sahota DS.

BJOG. 2018 Mar;125(4):442-449. doi: 10.1111/1471-0528.14970. Epub 2018 Jan 11.


Transverse technique: complementary approach to measurement of first-trimester uterine artery Doppler.

Drouin O, Johnson JA, Chaemsaithong P, Metcalfe A, Huber J, Schwarzenberger J, Winters E, Stavness L, Tse AWT, Lu J, Lim WT, Leung TY, Bujold E, Sahota D, Poon LC.

Ultrasound Obstet Gynecol. 2018 Nov;52(5):639-647. doi: 10.1002/uog.18917.


First Report of a Novel Deletion Due to εγδβ-Thalassemia in a Chinese Family.

Hui ASY, Au PKC, Ting YH, Kan ASY, Cheng YKY, Leung AWK, Chan KYK, Li CK, Tang MHY, Leung TY.

Hemoglobin. 2017 May;41(3):175-179. doi: 10.1080/03630269.2017.1366918.


Expanded newborn metabolic screening programme in Hong Kong: a three-year journey.

Chong SC, Law LK, Hui J, Lai CY, Leung TY, Yuen YP.

Hong Kong Med J. 2017 Oct;23(5):489-96. doi: 10.12809/hkmj176274. Epub 2017 Sep 1.


Prediction of labor outcome using serial transperineal ultrasound in the first stage of labor.

Chor CM, Poon LCY, Leung TY.

J Matern Fetal Neonatal Med. 2019 Jan;32(1):31-37. doi: 10.1080/14767058.2017.1369946. Epub 2017 Oct 3.


Systematic Selection of Reference Genes for the Normalization of Circulating RNA Transcripts in Pregnant Women Based on RNA-Seq Data.

Chim SSC, Wong KKW, Chung CYL, Lam SKW, Kwok JSL, Lai CY, Cheng YKY, Hui ASY, Meng M, Chan OK, Tsui SKW, Lee KY, Chan TF, Leung TY.

Int J Mol Sci. 2017 Aug 4;18(8). pii: E1709. doi: 10.3390/ijms18081709.


Triplet pregnancy with fetal reduction: experience in Hong Kong.

Tse WT, Law LW, Sahota DS, Leung TY, Cheng YK.

Hong Kong Med J. 2017 Aug;23(4):326-32. doi: 10.12809/hkmj176267. Epub 2017 Jun 23.


Uterine artery pulsatility index in the first trimester: assessment of intersonographer and intersampling site measurement differences.

Chaemsaithong P, Ting YH, Cheng KYY, Poon CYL, Leung TY, Sahota DS.

J Matern Fetal Neonatal Med. 2018 Sep;31(17):2276-2283. doi: 10.1080/14767058.2017.1341481. Epub 2017 Jul 11.


Antenatal diagnosis and management of foetal intestinal volvulus.

Yip KW, Cheng YKY, Leung TY.

Med J Malaysia. 2017 Apr;72(2):126-127.


Prospective assessment of INTERGROWTH-21st and World Health Organization estimated fetal weight reference curves.

Cheng YKY, Lu J, Leung TY, Chan YM, Sahota DS.

Ultrasound Obstet Gynecol. 2018 Jun;51(6):792-798. doi: 10.1002/uog.17514.


Maternal rubella immunity status and pre-eclampsia.

Lao TT, Sahota DS, Law LW, Leung TY.

Am J Reprod Immunol. 2017 Jul;78(1). doi: 10.1111/aji.12677. Epub 2017 Mar 30.


Single-Stranded DNA Library Preparation Preferentially Enriches Short Maternal DNA in Maternal Plasma.

Vong JSL, Tsang JCH, Jiang P, Lee WS, Leung TY, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2017 May;63(5):1031-1037. doi: 10.1373/clinchem.2016.268656. Epub 2017 Mar 9.


Prenatal Diagnosis of a Retroesophageal Left Brachiocephalic Vein: Two Case Reports.

Cheng YKY, Law KM, Chak PK, To KF, Chan YM, Leung TY.

J Ultrasound Med. 2017 May;36(5):1065-1069. doi: 10.7863/ultra.16.05003. Epub 2017 Mar 4.


Identification of fragile X pre-mutation carriers in the Chinese obstetric population using a robust FMR1 polymerase chain reaction assay: implications for screening and prenatal diagnosis.

Cheng YK, Lin CS, Kwok YK, Chan YM, Lau TK, Leung TY, Choy KW.

Hong Kong Med J. 2017 Apr;23(2):110-6. doi: 10.12809/hkmj164936. Epub 2017 Mar 3.


Establishing Prenatal Surgery for Myelomeningocele in Asia: The Singapore Consensus.

Wataganara T, Seshadri S, Leung TY, Matter C, Ngerncham M, Triyasunant N, Mali PV, Biswas A, Nawapun K, Phithakwatchara N, Flake AW, Johnson MP, Biswas A, Choolani M.

Fetal Diagn Ther. 2017;41(3):161-178. doi: 10.1159/000452218. Epub 2017 Feb 21. Review.

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