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Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles.

Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, Law WL, Lo OSH, Yuen ST, Clevers H, Leung SY.

Gut. 2020 Mar 26. pii: gutjnl-2019-320019. doi: 10.1136/gutjnl-2019-320019. [Epub ahead of print]


Supramolecular assembly of bent dinuclear amphiphilic alkynylplatinum(ii) terpyridine complexes: diverse nanostructures through subtle tuning of the mode of molecular stacking.

Leung SK, Chan AK, Leung SY, Leung MY, Yam VW.

Chem Sci. 2019 Nov 27;11(2):499-507. doi: 10.1039/c9sc04475b. eCollection 2020 Jan 14.


Discovering Cancer-Related miRNAs from miRNA-Target Interactions by Support Vector Machines.

Pian C, Mao S, Zhang G, Du J, Li F, Leung SY, Fan X.

Mol Ther Nucleic Acids. 2020 Mar 6;19:1423-1433. doi: 10.1016/j.omtn.2020.01.019. Epub 2020 Jan 25.


Platinum(II) Probes for Sensing Polyelectrolyte Lengths and Architectures.

Zhang K, Yeung MC, Leung SY, Yam VW.

ACS Appl Mater Interfaces. 2020 Feb 19;12(7):8503-8512. doi: 10.1021/acsami.9b17611. Epub 2020 Feb 6.


Multiresponsive Luminescent Cationic Cyclometalated Gold(III) Amphiphiles and Their Supramolecular Assembly.

Leung MY, Leung SY, Yim KC, Chan AK, Ng M, Yam VW.

J Am Chem Soc. 2019 Dec 11;141(49):19466-19478. doi: 10.1021/jacs.9b10607. Epub 2019 Dec 2.


Management of advanced prostate cancer in Hong Kong: Insights from an APCCC-Derived survey.

Poon DM, Ma WK, Chan TW, Ho FK, Ho LY, Leung AK, Leung SY, Sze HC, Kwong PW, Chan ES.

Asia Pac J Clin Oncol. 2019 Oct;15 Suppl 6:8-13. doi: 10.1111/ajco.13247. Epub 2019 Oct 23.


Characterization of Corneal Biomechanical Properties and Determination of Natural Intraocular Pressure Using CID-GAT.

Lu SH, Chong IT, Leung SYY, Lam DCC.

Transl Vis Sci Technol. 2019 Sep 11;8(5):10. doi: 10.1167/tvst.8.5.10. eCollection 2019 Sep.


Association between long-term orthokeratology responses and corneal biomechanics.

Lam AKC, Hon Y, Leung SYY, Shu-Ho L, Chong J, Lam DCC.

Sci Rep. 2019 Aug 29;9(1):12566. doi: 10.1038/s41598-019-49041-z.


Breakthrough Moments: Organoid Models of Cancer.

Chan AS, Yan HHN, Leung SY.

Cell Stem Cell. 2019 Jun 6;24(6):839-840. doi: 10.1016/j.stem.2019.05.006.


Establishing Pure Cancer Organoid Cultures: Identification, Selection and Verification of Cancer Phenotypes and Genotypes.

Wallaschek N, Niklas C, Pompaiah M, Wiegering A, Germer CT, Kircher S, Brändlein S, Maurus K, Rosenwald A, Yan HHN, Leung SY, Bartfeld S.

J Mol Biol. 2019 Jul 12;431(15):2884-2893. doi: 10.1016/j.jmb.2019.05.031. Epub 2019 May 29.


DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.

Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, Bogatyrova O, Kaucher S, Bermejo JL, Leung SY, Chan TL, Lasitschka F, Bohrer MH, Marx A, Haußen RH, Herold-Mende C, Dyckhoff G, Boukamp P, Delank KW, Hörmann K, Lippert BM, Baier G, Dietz A, Oakes CC, Plass C, Becher H, Schmezer P, Ramroth H, Popanda O.

Clin Epigenetics. 2019 May 3;11(1):67. doi: 10.1186/s13148-019-0666-5.


Consensus statements on the management of clinically localized prostate cancer from the Hong Kong Urological Association and the Hong Kong Society of Uro-Oncology.

Ma WK, Poon DM, Chan CK, Chan TW, Cheung FY, Ho LY, Lee EK, Leung AK, Leung SY, So HS, Tam PC, Kwong PW.

BJU Int. 2019 Aug;124(2):221-241. doi: 10.1111/bju.14681. Epub 2019 Feb 5. Review.


A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY.

Cell Stem Cell. 2018 Dec 6;23(6):882-897.e11. doi: 10.1016/j.stem.2018.09.016. Epub 2018 Oct 18.


PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.

Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MSY, Ma S.

Cell Rep. 2018 Oct 16;25(3):690-701.e8. doi: 10.1016/j.celrep.2018.09.053.


Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker's Guide.

Chong YK, Ho CC, Leung SY, Lau SKP, Woo PCY.

Comput Struct Biotechnol J. 2018 Aug 28;16:316-334. doi: 10.1016/j.csbj.2018.08.003. eCollection 2018. Review.


Directional Self-Assembly and Photoinduced Polymerization of Diacetylene-Containing Platinum(II) Terpyridine Complexes.

Fang S, Leung SY, Li Y, Yam VW.

Chemistry. 2018 Oct 17;24(58):15596-15602. doi: 10.1002/chem.201802592. Epub 2018 Sep 16.


Energy Landscape in Supramolecular Coassembly of Platinum(II) Complexes and Polymers: Morphological Diversity, Transformation, and Dilution Stability of Nanostructures.

Zhang K, Yeung MC, Leung SY, Yam VW.

J Am Chem Soc. 2018 Aug 1;140(30):9594-9605. doi: 10.1021/jacs.8b04779. Epub 2018 Jul 24.


Chronic disease self-management and cognitive training programme to improve diabetic control in older outpatients with memory complaints: a randomised trial.

Kwok TC, Ma CW, Leung SY, Lee J, So WY, Hui E.

Hong Kong Med J. 2018 Feb;24 Suppl 2(1):16-20. No abstract available.


MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis.

Tong Y, Sun J, Wong CF, Kang Q, Ru B, Wong CN, Chan AS, Leung SY, Zhang J.

Genome Biol. 2018 Jun 5;19(1):73. doi: 10.1186/s13059-018-1442-0.


A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor.

Wong TH, Lee CL, Su HH, Lee CL, Wu CC, Wang CC, Sheu CC, Lai RS, Leung SY, Lin CC, Wei YF, Wang CJ, Lin YC, Chen HL, Huang MS, Yen JH, Huang SK, Suen JL.

Sci Rep. 2018 Mar 26;8(1):5198. doi: 10.1038/s41598-018-23542-9.


Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma.

Hung CH, Wang CC, Suen JL, Sheu CC, Kuo CH, Liao WT, Yang YH, Wu CC, Leung SY, Lai RS, Lin CC, Wei YF, Lee CY, Huang MS, Huang SK.

Sci Rep. 2018 Jan 17;8(1):919. doi: 10.1038/s41598-017-19105-z.


Management of Recurrent Preschool, Doctor-Diagnosed Wheeze.

Siu KK, Leung SY, Kong SY, Ng DK.

Indian J Pediatr. 2018 Aug;85(8):658-666. doi: 10.1007/s12098-017-2537-4. Epub 2018 Jan 8. Review.


Formation of 1D Infinite Chains Directed by Metal-Metal and/or π-π Stacking Interactions of Water-Soluble Platinum(II) 2,6-Bis(benzimidazol-2'-yl)pyridine Double Complex Salts.

Wong VC, Po C, Leung SY, Chan AK, Yang S, Zhu B, Cui X, Yam VW.

J Am Chem Soc. 2018 Jan 17;140(2):657-666. doi: 10.1021/jacs.7b09770. Epub 2018 Jan 5.


Influence of Short-Term Orthokeratology to Corneal Tangent Modulus: A Randomized Study.

Lam AK, Leung SY, Hon Y, Shu-Ho L, Wong KY, Tiu PK, Lam DC.

Curr Eye Res. 2018 Apr;43(4):474-481. doi: 10.1080/02713683.2017.1418895. Epub 2017 Dec 28.


Consensus statements on the management of metastatic prostate cancer from the Hong Kong Urological Association and Hong Kong Society of Uro-Oncology.

Poon DM, Chan CK, Chan TW, Cheung FY, Kwong PW, Lee EK, Leung AK, Leung SY, Ma WK, So HS, Tam PC, Ho LY.

BJU Int. 2018 May;121(5):703-715. doi: 10.1111/bju.14091. Epub 2018 Jan 8.


Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY.

Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.


Living supramolecular polymerization achieved by collaborative assembly of platinum(II) complexes and block copolymers.

Zhang K, Yeung MC, Leung SY, Yam VW.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11844-11849. doi: 10.1073/pnas.1712827114. Epub 2017 Oct 23.


A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis.

Tse H, Gu Q, Sze KH, Chu IK, Kao RY, Lee KC, Lam CW, Yang D, Tai SS, Ke Y, Chan E, Chan WM, Dai J, Leung SP, Leung SY, Yuen KY.

J Biol Chem. 2017 Nov 24;292(47):19503-19520. doi: 10.1074/jbc.M117.791558. Epub 2017 Sep 26.


Whole genome gene expression changes and hematological effects of rikkunshito in patients with advanced non-small cell lung cancer receiving first line chemotherapy.

Chen YC, Lin AS, Hung YC, Chen KD, Wu CY, Lie CH, Hsiao CC, Chen CJ, Liu SF, Fang WF, Chang JC, Wang TY, Wang YH, Chung YH, Chao TY, Leung SY, Su MC, Lin MC.

Exp Ther Med. 2017 Sep;14(3):2040-2052. doi: 10.3892/etm.2017.4773. Epub 2017 Jul 11.


Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.

Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD.

N Engl J Med. 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717. Erratum in: N Engl J Med. 2018 Mar 8;378(10 ):973.


Synthesis of Luminescent Platinum(II) 2,6-Bis(N-dodecylbenzimidazol-2'-yl)pyridine Foldamers and Their Supramolecular Assembly and Metallogel Formation.

Chan MH, Ng M, Leung SY, Lam WH, Yam VW.

J Am Chem Soc. 2017 Jun 28;139(25):8639-8645. doi: 10.1021/jacs.7b03635. Epub 2017 Jun 16.


Histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation are associated with active pulmonary tuberculosis disease.

Chen YC, Chao TY, Leung SY, Chen CJ, Wu CC, Fang WF, Wang YH, Chang HC, Wang TY, Lin YY, Zheng YX, Lin MC, Hsiao CC.

Am J Transl Res. 2017 Apr 15;9(4):1943-1955. eCollection 2017.


Development of ocular viscosity characterization method.

Shu-Hao Lu, Guo-Zhen Chen, Leung SY, Lam DC.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:5200-5203. doi: 10.1109/EMBC.2016.7591899.


Self-Assembled Architectures of Alkynylplatinum(II) Amphiphiles and Their Structural Optimization: A Balance of the Interplay Among Pt···Pt, π-π Stacking, and Hydrophobic-Hydrophobic Interactions.

Fu HL, Po C, Leung SY, Yam VW.

ACS Appl Mater Interfaces. 2017 Jan 25;9(3):2786-2795. doi: 10.1021/acsami.6b12584. Epub 2017 Jan 12.


A randomized placebo-controlled trial of traditional Chinese medicine as an add-on therapy to oral montelukast in the treatment of mild persistent asthma in children.

Chan PH, To CY, Chan EY, Li H, Zhang X, Chow PY, Liu PL, Leung SY, Chan CH, Chan KY, Chan JY, Ng JP, Ng DK.

Complement Ther Med. 2016 Dec;29:219-228. doi: 10.1016/j.ctim.2016.10.010. Epub 2016 Oct 11.


Genomics Study of Gastric Cancer and Its Molecular Subtypes.

Yuen ST, Leung SY.

Adv Exp Med Biol. 2016;908:419-39. doi: 10.1007/978-3-319-41388-4_21. Review.


Synthesis, Electrochemistry, and Photophysical Studies of Ruthenium(II) Polypyridine Complexes with D-π-A-π-D Type Ligands and Their Application Studies as Organic Memories.

Leung MY, Leung SY, Wu D, Yu T, Yam VW.

Chemistry. 2016 Sep 19;22(39):14013-14021. doi: 10.1002/chem.201602228. Epub 2016 Aug 9.


Tuning of Supramolecular Architectures of l-Valine-Containing Dicyanoplatinum(II) 2,2'-Bipyridine Complexes by Metal-Metal, π-π Stacking, and Hydrogen-Bonding Interactions.

Fu HL, Po C, He H, Leung SY, Wong KS, Yam VW.

Chemistry. 2016 Aug 8;22(33):11826-36. doi: 10.1002/chem.201601983. Epub 2016 Jul 14.


RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation.

Yan HHN, Lai JCW, Ho SL, Leung WK, Law WL, Lee JFY, Chan AKW, Tsui WY, Chan ASY, Lee BCH, Yue SSK, Man AHY, Clevers H, Yuen ST, Leung SY.

Gut. 2017 Sep;66(9):1645-1656. doi: 10.1136/gutjnl-2016-311849. Epub 2016 Jun 21.


Preimplantation genetic diagnosis for hereditary cancer syndrome: local experience.

Lee VC, Chow JF, Lau EY, Kwong A, Leung SY, Yeung WS, Ho PC, Ng EH.

Hong Kong Med J. 2016 Jun;22(3):289-91. doi: 10.12809/hkmj144499. No abstract available.


Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

Swanton C, Soria JC, Bardelli A, Biankin A, Caldas C, Chandarlapaty S, de Koning L, Dive C, Feunteun J, Leung SY, Marais R, Mardis ER, McGranahan N, Middleton G, Quezada SA, Rodón J, Rosenfeld N, Sotiriou C, André F.

Ann Oncol. 2016 Aug;27(8):1443-8. doi: 10.1093/annonc/mdw192. Epub 2016 May 3.


A new grid-scale model simulating the spatiotemporal distribution of PM2.5-PAHs for exposure assessment.

Lee CL, Huang HC, Wang CC, Sheu CC, Wu CC, Leung SY, Lai RS, Lin CC, Wei YF, Lai IC, Jiang H, Chou WL, Chung WY, Huang MS, Huang SK.

J Hazard Mater. 2016 Aug 15;314:286-294. doi: 10.1016/j.jhazmat.2016.04.047. Epub 2016 Apr 22.


Self-assembly of alkynylplatinum(II) terpyridine amphiphiles into nanostructures via steric control and metal-metal interactions.

Leung SY, Wong KM, Yam VW.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2845-50. doi: 10.1073/pnas.1601673113. Epub 2016 Mar 1.


Metal-Metal and π-π Interactions Directed End-to-End Assembly of Gold Nanorods.

Leung FC, Leung SY, Chung CY, Yam VW.

J Am Chem Soc. 2016 Mar 9;138(9):2989-92. doi: 10.1021/jacs.6b01382. Epub 2016 Feb 25.


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