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Bioanalytical challenges and unique considerations to support pharmacokinetic characterization of bispecific biotherapeutics.

Ma M, Colletti K, Yang TY, Leung S, Pederson S, Hottenstein CS, Xu X, Warrino D, Wakshull E.

Bioanalysis. 2019 Mar 19. doi: 10.4155/bio-2018-0146. [Epub ahead of print]


Safety profile of iron polymaltose infusions.

Lee AYS, Leung SHP.

Hosp Pract (1995). 2019 Mar 18:1-3. doi: 10.1080/21548331.2019.1593006. [Epub ahead of print]


Intra-operative high inspired oxygen fraction does not increase the risk of postoperative respiratory complications: Alternating intervention clinical trial.

Cohen B, Ruetzler K, Kurz A, Leung S, Rivas E, Ezell J, Mao G, Sessler DI, Turan A.

Eur J Anaesthesiol. 2019 Mar 8. doi: 10.1097/EJA.0000000000000980. [Epub ahead of print]


In Vivo Analysis of Embryo Development and Behavioral Response of Medaka Fish under Static Magnetic Field Exposures.

Sun W, He Y, Leung SW, Kong YC.

Int J Environ Res Public Health. 2019 Mar 8;16(5). pii: E844. doi: 10.3390/ijerph16050844.


Continuous-Flow Left Ventricular Assist Device Survival Improves with Multidisciplinary Approach.

Jorde UP, Shah AM, Sims DB, Madan S, Siddiqi N, Luke A, Saeed O, Patel SR, Murthy S, Shin J, Oviedo J, Watts S, Jakobleff W, Forest S, Vukelic S, Belov D, Puius Y, Minamoto G, Muggia V, Carlese A, Leung S, Rahmanian M, Leff J, Goldstein D.

Ann Thorac Surg. 2019 Mar 7. pii: S0003-4975(19)30260-7. doi: 10.1016/j.athoracsur.2019.01.063. [Epub ahead of print]


Traditional risk factors may not explain increased incidence of myocardial infarction in MS.

Marrie RA, Garland A, Schaffer SA, Fransoo R, Leung S, Yogendran M, Kingwell E, Tremlett H.

Neurology. 2019 Mar 6. pii: 10.1212/WNL.0000000000007251. doi: 10.1212/WNL.0000000000007251. [Epub ahead of print]


Increased threshold in nonselective His-bundle pacing suspected to be caused by amiodarone.

Kim J, Goldbarg S, Leung S, Yang H, Slotwiner D.

HeartRhythm Case Rep. 2018 Nov 23;5(2):112-114. doi: 10.1016/j.hrcr.2018.11.007. eCollection 2019 Feb. No abstract available.


Regurgitation and pulmonary aspiration during cardio-pulmonary resuscitation (CPR) with a laryngeal tube: A pilot crossover human cadaver study.

Ruetzler K, Leung S, Chmiela M, Rivas E, Szarpak L, Khanna S, Mao G, Drake RL, Sessler DI, Turan A.

PLoS One. 2019 Feb 27;14(2):e0212704. doi: 10.1371/journal.pone.0212704. eCollection 2019.


The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype.

Leung DYM, Calatroni A, Zaramela LS, LeBeau PK, Dyjack N, Brar K, David G, Johnson K, Leung S, Ramirez-Gama M, Liang B, Rios C, Montgomery MT, Richers BN, Hall CF, Norquest KA, Jung J, Bronova I, Kreimer S, Conover Talbot C Jr, Crumrine D, Cole RN, Elias P, Zengler K, Seibold MA, Berdyshev E, Goleva E.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaav2685. doi: 10.1126/scitranslmed.aav2685.


Validation of an algorithm for identifying MS cases in administrative health claims datasets.

Culpepper WJ, Marrie RA, Langer-Gould A, Wallin MT, Campbell JD, Nelson LM, Kaye WE, Wagner L, Tremlett H, Chen LH, Leung S, Evans C, Yao S, LaRocca NG; United States Multiple Sclerosis Prevalence Workgroup (MSPWG).

Neurology. 2019 Mar 5;92(10):e1016-e1028. doi: 10.1212/WNL.0000000000007043. Epub 2019 Feb 15.


Efficient metal halide perovskite light-emitting diodes with significantly improved light extraction on nanophotonic substrates.

Zhang Q, Tavakoli MM, Gu L, Zhang D, Tang L, Gao Y, Guo J, Lin Y, Leung SF, Poddar S, Fu Y, Fan Z.

Nat Commun. 2019 Feb 13;10(1):727. doi: 10.1038/s41467-019-08561-y.


Association of Systemic Antibiotic Treatment of Acne With Skin Microbiota Characteristics.

Chien AL, Tsai J, Leung S, Mongodin EF, Nelson AM, Kang S, Garza LA.

JAMA Dermatol. 2019 Feb 13. doi: 10.1001/jamadermatol.2018.5221. [Epub ahead of print]


Academic Advancement in the Current Era: Integrating and Empowering Clinician Educators.

Shafer KM, Hira RS, Sinha SS, Pfeiffer M, Abudayyeh I, Feldman DN, Leung S, Damp J, Gopinathannair R, Valente AM, Sivaram CA, Freeman AM.

J Am Coll Cardiol. 2019 Feb 12;73(5):620-623. doi: 10.1016/j.jacc.2018.11.032. No abstract available.


Feasibility of a group-based laughter yoga intervention as an adjunctive treatment for residual symptoms of depression, anxiety and stress in people with depression.

Bressington D, Mui J, Yu C, Leung SF, Cheung K, Wu CST, Bollard M, Chien WT.

J Affect Disord. 2019 Apr 1;248:42-51. doi: 10.1016/j.jad.2019.01.030. Epub 2019 Jan 28.


A Multi-institutional Case Series With Review of Point-of-Care Ultrasound to Diagnose Malrotation and Midgut Volvulus in the Pediatric Emergency Department.

Garcia AM, Asad I, Tessaro MO, Sivitz A, Osborn K, Shaahinfar A, Leung SK, Rowe E, Riera A.

Pediatr Emerg Care. 2019 Jan 29. doi: 10.1097/PEC.0000000000001737. [Epub ahead of print]


Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery.

Wang Q, Zuo Z, Cheung CKC, Leung SSY.

Int J Pharm. 2019 Mar 25;559:86-101. doi: 10.1016/j.ijpharm.2019.01.030. Epub 2019 Jan 21.


Acceptance and Commitment Therapy for Parental Management of Childhood Asthma: An RCT.

Chong YY, Mak YW, Leung SP, Lam SY, Loke AY.

Pediatrics. 2019 Feb;143(2). pii: e20181723. doi: 10.1542/peds.2018-1723. Epub 2019 Jan 18.


Consensus statements on the management of clinically localized prostate cancer from the Hong Kong Urological Association and the Hong Kong Society of Uro-Oncology.

Ma WK, Poon DM, Chan CK, Chan TW, Cheung FY, Ho LY, Lee EK, Leung AK, Leung SY, So HS, Tam PC, Kwong PW.

BJU Int. 2019 Jan 17. doi: 10.1111/bju.14681. [Epub ahead of print] Review.


AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi: 10.1073/pnas.1816585116. Epub 2019 Jan 7.


Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.

David Hong W, Leung SC, Amporndanai K, Davies J, Priestley RS, Nixon GL, Berry NG, Samar Hasnain S, Antonyuk S, Ward SA, Biagini GA, O'Neill PM.

ACS Med Chem Lett. 2018 Oct 19;9(12):1205-1210. doi: 10.1021/acsmedchemlett.8b00371. eCollection 2018 Dec 13.


Prevalence and Factors Associated with Psychiatric Medication Use in Bariatric Surgery Candidates.

Hawkins M, Lee A, Leung S, Hawa R, Wnuk S, Yanofsky R, Sockalingam S.

Psychosomatics. 2018 Nov 27. pii: S0033-3182(18)30494-8. doi: 10.1016/j.psym.2018.11.007. [Epub ahead of print]


Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma.

Talhouk A, Derocher H, Schmidt P, Leung S, Milne K, Gilks CB, Anglesio MS, Nelson BH, McAlpine JN.

Clin Cancer Res. 2018 Dec 6. doi: 10.1158/1078-0432.CCR-18-3241. [Epub ahead of print]


Absence of genetic selection in a pathogenic Escherichia coli strain exposed to the manure-amended soil environment.

Truhlar AM, Denes TG, Cantilina KK, Leung SK, Walter MT, Hay AG.

PLoS One. 2018 Dec 7;13(12):e0208346. doi: 10.1371/journal.pone.0208346. eCollection 2018.


Initiating Advance Care Planning in Primary Care: A Model for Success.

Rose BL, Leung S, Gustin J, Childers J.

J Palliat Med. 2018 Nov 27. doi: 10.1089/jpm.2018.0380. [Epub ahead of print]


The stabilization of primitive bicontinuous cubic phases with tunable swelling over a wide composition range.

Leung SSW, Leal C.

Soft Matter. 2019 Feb 6;15(6):1269-1277. doi: 10.1039/c8sm02059k.


The Use of Post-ablation Stimulated Thyroglobulin in Predicting Clinical Outcomes in Differentiated Thyroid Carcinoma - What Cut-off Values Should We Use?

Wong KCW, Ng TY, Yu KS, Kwok JSS, Chan KCA, Suen JJS, Leung SF, Chan ATC.

Clin Oncol (R Coll Radiol). 2019 Feb;31(2):e11-e20. doi: 10.1016/j.clon.2018.10.009. Epub 2018 Nov 17.


Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline.

Stromp TA, Spear TJ, Holtkamp RM, Andres KN, Kaine JC, Alghuraibawi WH, Leung SW, Fornwalt BK, Vandsburger MH.

Sci Rep. 2018 Nov 19;8(1):16972. doi: 10.1038/s41598-018-35394-4.


Upfront Combination Therapy, Compared with Monotherapy, for Patients Not Previously Treated with a Biologic Agent Associates With Reduced Risk of Inflammatory Bowel Disease-related Complications in a Population-based Cohort Study.

Targownik LE, Benchimol EI, Bernstein CN, Singh H, Lix L, Tennakoon A, Leung S, Aviña A, Coward S, Jones J, Kaplan G, Murthy SK, Nguyen GC, Peña-Sánchez JN.

Clin Gastroenterol Hepatol. 2018 Nov 15. pii: S1542-3565(18)31246-1. doi: 10.1016/j.cgh.2018.11.003. [Epub ahead of print]


Jet nebulization of bacteriophages with different tail morphologies - Structural effects.

Leung SSY, Carrigy NB, Vehring R, Finlay WH, Morales S, Carter EA, Britton WJ, Kutter E, Chan HK.

Int J Pharm. 2019 Jan 10;554:322-326. doi: 10.1016/j.ijpharm.2018.11.026. Epub 2018 Nov 13.


Author Correction: The prognostic effects of somatic mutations in ER-positive breast cancer.

Griffith OL, Spies NC, Anurag M, Griffith M, Luo J, Tu D, Yeo B, Kunisaki J, Miller CA, Krysiak K, Hundal J, Ainscough BJ, Skidmore ZL, Campbell K, Kumar R, Fronick C, Cook L, Snider JE, Davies S, Kavuri SM, Chang EC, Magrini V, Larson DE, Fulton RS, Liu S, Leung S, Voduc D, Bose R, Dowsett M, Wilson RK, Nielsen TO, Mardis ER, Ellis MJ.

Nat Commun. 2018 Nov 14;9(1):4850. doi: 10.1038/s41467-018-07407-3.


TIM-3 expression in breast cancer.

Burugu S, Gao D, Leung S, Chia SK, Nielsen TO.

Oncoimmunology. 2018 Aug 23;7(11):e1502128. doi: 10.1080/2162402X.2018.1502128. eCollection 2018.


Development of flow cytometric opsonophagocytosis and antibody-mediated complement deposition assays for non-typeable Haemophilus influenzae.

Thomas SR, Leung S, Knox K, Wilkinson TMA, Staples KJ, Lestrate P, Wauters D, Gorringe A, Taylor SC.

BMC Microbiol. 2018 Oct 29;18(1):167. doi: 10.1186/s12866-018-1314-5.


A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex.

Marzi SJ, Leung SK, Ribarska T, Hannon E, Smith AR, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, Lunnon K, Schalkwyk LC, Mill J.

Nat Neurosci. 2018 Nov;21(11):1618-1627. doi: 10.1038/s41593-018-0253-7. Epub 2018 Oct 22.


A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY.

Cell Stem Cell. 2018 Dec 6;23(6):882-897.e11. doi: 10.1016/j.stem.2018.09.016. Epub 2018 Oct 18.


PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.

Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MSY, Ma S.

Cell Rep. 2018 Oct 16;25(3):690-701.e8. doi: 10.1016/j.celrep.2018.09.053.


Nuclear β-catenin and CDX2 expression in ovarian endometrioid carcinoma identify patients with favourable outcome.

Wang L, Rambau PF, Kelemen LE, Anglesio MS, Leung S, Talhouk A, Köbel M.

Histopathology. 2019 Feb;74(3):452-462. doi: 10.1111/his.13772.


Use of eHealth and mHealth technology by persons with multiple sclerosis.

Marrie RA, Leung S, Tyry T, Cutter GR, Fox R, Salter A.

Mult Scler Relat Disord. 2019 Jan;27:13-19. doi: 10.1016/j.msard.2018.09.036. Epub 2018 Oct 2.


Surface Effect on 2D Hybrid Perovskite Crystals: Perovskites Using an Ethanolamine Organic Layer as an Example.

Ho KT, Leung SF, Li TY, Maity P, Cheng B, Fu HC, Mohammed OF, He JH.

Adv Mater. 2018 Nov;30(46):e1804372. doi: 10.1002/adma.201804372. Epub 2018 Oct 1.


Genome-Informed Targeted Therapy for Osteosarcoma.

Sayles LC, Breese MR, Koehne AL, Leung SG, Lee AG, Liu HY, Spillinger A, Shah AT, Tanasa B, Straessler K, Hazard FK, Spunt SL, Marina N, Kim GE, Cho SJ, Avedian RS, Mohler DG, Kim MO, DuBois SG, Hawkins DS, Sweet-Cordero EA.

Cancer Discov. 2019 Jan;9(1):46-63. doi: 10.1158/2159-8290.CD-17-1152. Epub 2018 Sep 28.


Food Avoidance Beliefs and Behaviors Among Chinese Cancer Patients: Validation of a New Measurement Tool.

Yung TKC, Kim JH, Leung SF, Yeung RMW, Poon ANY, Au EWC, Lau JTF.

J Nutr Educ Behav. 2019 Feb;51(2):162-172. doi: 10.1016/j.jneb.2018.07.009. Epub 2018 Sep 18.


Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker's Guide.

Chong YK, Ho CC, Leung SY, Lau SKP, Woo PCY.

Comput Struct Biotechnol J. 2018 Aug 28;16:316-334. doi: 10.1016/j.csbj.2018.08.003. eCollection 2018. Review.


Thermoelectric Nanocomposite Foams Using Non-Conducting Polymers with Hybrid 1D and 2D Nanofillers.

Aghelinejad M, Leung SN.

Materials (Basel). 2018 Sep 18;11(9). pii: E1757. doi: 10.3390/ma11091757.


Is metformin still the most efficacious first-line oral hypoglycaemic drug in treating type 2 diabetes? A network meta-analysis of randomized controlled trials.

Jia Y, Lao Y, Zhu H, Li N, Leung SW.

Obes Rev. 2019 Jan;20(1):1-12. doi: 10.1111/obr.12753. Epub 2018 Sep 17. Review.


Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans.

Gupta VA, Leung SW, Winkler MA, Sorrell VL.

J Vis Exp. 2018 Aug 28;(138). doi: 10.3791/57918.


Directional Self-Assembly and Photoinduced Polymerization of Diacetylene-Containing Platinum(II) Terpyridine Complexes.

Fang S, Leung SY, Li Y, Yam VW.

Chemistry. 2018 Oct 17;24(58):15596-15602. doi: 10.1002/chem.201802592. Epub 2018 Sep 16.


The prognostic effects of somatic mutations in ER-positive breast cancer.

Griffith OL, Spies NC, Anurag M, Griffith M, Luo J, Tu D, Yeo B, Kunisaki J, Miller CA, Krysiak K, Hundal J, Ainscough BJ, Skidmore ZL, Campbell K, Kumar R, Fronick C, Cook L, Snider JE, Davies S, Kavuri SM, Chang EC, Magrini V, Larson DE, Fulton RS, Liu S, Leung S, Voduc D, Bose R, Dowsett M, Wilson RK, Nielsen TO, Mardis ER, Ellis MJ.

Nat Commun. 2018 Sep 4;9(1):3476. doi: 10.1038/s41467-018-05914-x. Erratum in: Nat Commun. 2018 Nov 14;9(1):4850.


Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study.

Acs B, Pelekanou V, Bai Y, Martinez-Morilla S, Toki M, Leung SCY, Nielsen TO, Rimm DL.

Lab Invest. 2019 Jan;99(1):107-117. doi: 10.1038/s41374-018-0123-7. Epub 2018 Sep 4.


Spine-GAN: Semantic segmentation of multiple spinal structures.

Han Z, Wei B, Mercado A, Leung S, Li S.

Med Image Anal. 2018 Dec;50:23-35. doi: 10.1016/ Epub 2018 Aug 25.


Maternal car driving capacity after birth: a pilot prospective study randomizing postnatal women to early verses late driving in a driving simulator.

Harpham ME, Nassar N, Leung S, Lainchbury A, Shand AW.

J Matern Fetal Neonatal Med. 2018 Sep 25:1-8. doi: 10.1080/14767058.2018.1519537. [Epub ahead of print]


An international multicenter study to evaluate reproducibility of automated scoring for assessment of Ki67 in breast cancer.

Rimm DL, Leung SCY, McShane LM, Bai Y, Bane AL, Bartlett JMS, Bayani J, Chang MC, Dean M, Denkert C, Enwere EK, Galderisi C, Gholap A, Hugh JC, Jadhav A, Kornaga EN, Laurinavicius A, Levenson R, Lima J, Miller K, Pantanowitz L, Piper T, Ruan J, Srinivasan M, Virk S, Wu Y, Yang H, Hayes DF, Nielsen TO, Dowsett M.

Mod Pathol. 2019 Jan;32(1):59-69. doi: 10.1038/s41379-018-0109-4. Epub 2018 Aug 24.


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