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Items: 1 to 50 of 88

1.

Chronic Cognitive Deficits and Associated Histopathology Following Closed-Head Concussive Injury in Rats.

Deng-Bryant Y, Leung LY, Madathil S, Flerlage J, Yang F, Yang W, Gilsdorf J, Shear D.

Front Neurol. 2019 Jul 2;10:699. doi: 10.3389/fneur.2019.00699. eCollection 2019.

2.

Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI.

Pandya JD, Leung LY, Yang X, Flerlage WJ, Gilsdorf JS, Deng-Bryant Y, Shear DA.

Front Neurol. 2019 Jun 11;10:605. doi: 10.3389/fneur.2019.00605. eCollection 2019.

3.

Natural Language Processing for the Identification of Silent Brain Infarcts From Neuroimaging Reports.

Fu S, Leung LY, Wang Y, Raulli AO, Kallmes DF, Kinsman KA, Nelson KB, Clark MS, Luetmer PH, Kingsbury PR, Kent DM, Liu H.

JMIR Med Inform. 2019 Apr 21;7(2):e12109. doi: 10.2196/12109.

4.

Does an assessment aid improve Glasgow Coma Scale scoring by helicopter rescuers in Hong Kong: A randomised controlled trial.

Chan SY, Tsang CH, Woo WWK, Yeung CY, Leung LY, Lo RSL, Hung KKC, Graham CA.

Australas Emerg Care. 2018 Aug;21(3):105-110. doi: 10.1016/j.auec.2018.06.001. Epub 2018 Jun 25.

PMID:
30998881
5.

Patients' responses to incidentally discovered silent brain infarcts - a qualitative study.

Leung LY, Han PKJ, Lundquist C, Weinstein G, Thaler DE, Kent DM.

J Patient Rep Outcomes. 2019 Apr 15;3(1):23. doi: 10.1186/s41687-019-0112-7.

6.

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL.

Cell. 2019 Apr 4;177(2):492-493. doi: 10.1016/j.cell.2019.03.037. No abstract available.

PMID:
30951673
7.

Agreement between capillary and venous lactate in emergency department patients: prospective observational study.

Graham CA, Leung LY, Lo RS, Lee KH, Yeung CY, Chan SY, Cattermole GN, Hung KK.

BMJ Open. 2019 Apr 3;9(4):e026109. doi: 10.1136/bmjopen-2018-026109.

8.

Trajectory of functional outcome and health status after moderate-to-major trauma in Hong Kong: A prospective 5 year cohort study.

Rainer TH, Hung KKC, Yeung JHH, Cheung SKC, Leung YK, Leung LY, Goggins WB, Ho HF, Kam CW, Cheung NK, Graham CA.

Injury. 2019 May;50(5):1111-1117. doi: 10.1016/j.injury.2019.02.017. Epub 2019 Feb 22.

PMID:
30827704
9.

Enduring Neuroprotective Effect of Subacute Neural Stem Cell Transplantation After Penetrating TBI.

Kassi AAY, Mahavadi AK, Clavijo A, Caliz D, Lee SW, Ahmed AI, Yokobori S, Hu Z, Spurlock MS, Wasserman JM, Rivera KN, Nodal S, Powell HR, Di L, Torres R, Leung LY, Rubiano AM, Bullock RM, Gajavelli S.

Front Neurol. 2019 Jan 17;9:1097. doi: 10.3389/fneur.2018.01097. eCollection 2018. Review.

10.

qSOFA is a Poor Predictor of Short-Term Mortality in All Patients: A Systematic Review of 410,000 Patients.

Lo RSL, Leung LY, Brabrand M, Yeung CY, Chan SY, Lam CCY, Hung KKC, Graham CA.

J Clin Med. 2019 Jan 8;8(1). pii: E61. doi: 10.3390/jcm8010061. Review.

11.

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL.

Cell. 2019 Jan 24;176(3):610-624.e18. doi: 10.1016/j.cell.2018.11.035. Epub 2019 Jan 3. Erratum in: Cell. 2019 Apr 4;177(2):492-493.

PMID:
30612739
12.

Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type.

Madathil SK, Wilfred BS, Urankar SE, Yang W, Leung LY, Gilsdorf JS, Shear DA.

Front Neurol. 2018 Nov 15;9:964. doi: 10.3389/fneur.2018.00964. eCollection 2018.

13.

A tyrosine sulfation-dependent HLA-I modification identifies memory B cells and plasma cells.

Chan JTH, Liu Y, Khan S, St-Germain JR, Zou C, Leung LYT, Yang J, Shi M, Grunebaum E, Campisi P, Propst EJ, Holler T, Bar-Or A, Wither JE, Cairo CW, Moran MF, Palazzo AF, Cooper MD, Ehrhardt GRA.

Sci Adv. 2018 Nov 7;4(11):eaar7653. doi: 10.1126/sciadv.aar7653. eCollection 2018 Nov.

14.

A Proposed Complete Methodology to Predict Gravity Flow Obstruction of Pharmaceutical Powders in Drug Product Manufacturing.

Leung LY, Mao C, Pieters SR, Yang CY.

J Pharm Sci. 2019 Jan;108(1):464-475. doi: 10.1016/j.xphs.2018.09.014. Epub 2018 Sep 21.

PMID:
30248334
15.

Selective Brain Cooling Reduces Motor Deficits Induced by Combined Traumatic Brain Injury, Hypoxemia and Hemorrhagic Shock.

Leung LY, Cardiff K, Yang X, Srambical Wilfred B, Gilsdorf J, Shear D.

Front Neurol. 2018 Aug 3;9:612. doi: 10.3389/fneur.2018.00612. eCollection 2018.

16.

Trauma team activation criteria and outcomes of geriatric trauma: 10 year single centre cohort study.

Hung KK, Yeung JHH, Cheung CSK, Leung LY, Cheng RCH, Cheung NK, Graham CA.

Am J Emerg Med. 2019 Mar;37(3):450-456. doi: 10.1016/j.ajem.2018.06.011. Epub 2018 Jun 5.

PMID:
30041911
17.

Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.

Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf JS, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Wang KKW.

J Neurotrauma. 2019 Jan 15;36(2):348-359. doi: 10.1089/neu.2017.5586. Epub 2018 Aug 30.

PMID:
29987972
18.

Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in Aicda-/- and Ung-/- Mice.

Galicia G, Lee DSW, Ramaglia V, Ward LA, Yam JY, Leung LYT, Li R, Handy M, Zhang J, Drohomyrecky PC, Lancaster E, Bar-Or A, Martin A, Gommerman JL.

J Immunol. 2018 Aug 15;201(4):1119-1130. doi: 10.4049/jimmunol.1700729. Epub 2018 Jul 6.

19.

Correction: Clinicians' perspectives on incidentally discovered silent brain infarcts - A qualitative study.

Leung LY, Han PKJ, Lundquist C, Weinstein G, Thaler DE, Kent DM.

PLoS One. 2018 May 16;13(5):e0197706. doi: 10.1371/journal.pone.0197706. eCollection 2018.

20.

A mechanistic study on tablet ejection force and its sensitivity to lubrication for pharmaceutical powders.

Uzondu B, Leung LY, Mao C, Yang CY.

Int J Pharm. 2018 May 30;543(1-2):234-244. doi: 10.1016/j.ijpharm.2018.03.064. Epub 2018 Apr 3.

PMID:
29621552
21.

Clinicians' perspectives on incidentally discovered silent brain infarcts - A qualitative study.

Leung LY, Han PKJ, Lundquist C, Weinstein G, Thaler DE, Kent DM.

PLoS One. 2018 Mar 29;13(3):e0194971. doi: 10.1371/journal.pone.0194971. eCollection 2018. Erratum in: PLoS One. 2018 May 16;13(5):e0197706.

22.

Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial.

Hung KKC, Graham CA, Lo RSL, Leung YK, Leung LY, Man SY, Woo WK, Cattermole GN, Rainer TH.

PLoS One. 2018 Feb 6;13(2):e0192043. doi: 10.1371/journal.pone.0192043. eCollection 2018.

23.

Accuracy of Prediction Instruments for Diagnosing Large Vessel Occlusion in Individuals With Suspected Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke.

Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, Towfighi A, Whiteley WN, Zahuranec DB; American Heart Association Stroke Council.

Stroke. 2018 Mar;49(3):e111-e122. doi: 10.1161/STR.0000000000000160. Epub 2018 Jan 24. Review. Erratum in: Stroke. 2018 Mar;49(3):e139.

PMID:
29367333
24.

Effect of Dysphagia Screening Strategies on Clinical Outcomes After Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke.

Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, Towfighi A, Whiteley WN, Zahuranec DB; American Heart Association Stroke Council.

Stroke. 2018 Mar;49(3):e123-e128. doi: 10.1161/STR.0000000000000159. Epub 2018 Jan 24. Review. Erratum in: Stroke. 2018 Mar;49(3):e140.

PMID:
29367332
25.

Improvement of blood loss volume estimation by paramedics using a pictorial nomogram: A developmental study.

Yeung CY, Yim WW, Chan SY, Lo RSL, Leung LY, Hung KKC, Graham CA.

Injury. 2017 Dec;48(12):2693-2698. doi: 10.1016/j.injury.2017.10.045. Epub 2017 Oct 31.

PMID:
29108791
26.

Longitudinal Care for Young Adults With Stroke.

Leung LY, Melkumova E, Thaler DE.

JAMA Neurol. 2017 Oct 1;74(10):1163-1164. doi: 10.1001/jamaneurol.2017.1874. Review. No abstract available.

PMID:
28828467
27.

Blood Pressure and Heart Rate Measures Associated With Increased Risk of Covert Brain Infarction and Worsening Leukoaraiosis in Older Adults.

Leung LY, Bartz TM, Rice K, Floyd J, Psaty B, Gutierrez J, Longstreth WT Jr, Mukamal KJ.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1579-1586. doi: 10.1161/ATVBAHA.117.309298. Epub 2017 Jun 29.

28.

Alterations in brain-derived neurotrophic factor and insulin-like growth factor-1 protein levels after penetrating ballistic-like brain injury in rats.

Madathil SK, Deng-Bryant Y, Wilfred BS, Leung LY, Gilsdorf JS, Shear DA.

J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S16-S24. doi: 10.1097/TA.0000000000001471.

PMID:
28628600
29.

Factors Influencing Oral Anticoagulant Prescribing Practices for Atrial Fibrillation.

Leung LY, McAllister M, Selim M, Fisher M.

J Stroke. 2017 May;19(2):232-235. doi: 10.5853/jos.2016.01102. Epub 2017 May 2. No abstract available.

30.

Flow Function of Pharmaceutical Powders Is Predominantly Governed by Cohesion, Not by Friction Coefficients.

Leung LY, Mao C, Srivastava I, Du P, Yang CY.

J Pharm Sci. 2017 Jul;106(7):1865-1873. doi: 10.1016/j.xphs.2017.04.012. Epub 2017 Apr 14.

PMID:
28416416
31.

Functional and Molecular Correlates after Single and Repeated Rat Closed-Head Concussion: Indices of Vulnerability after Brain Injury.

Mountney A, Boutté AM, Cartagena CM, Flerlage WF, Johnson WD, Rho C, Lu XC, Yarnell A, Marcsisin S, Sousa J, Vuong C, Zottig V, Leung LY, Deng-Bryant Y, Gilsdorf J, Tortella FC, Shear DA.

J Neurotrauma. 2017 Oct 1;34(19):2768-2789. doi: 10.1089/neu.2016.4679. Epub 2017 May 24.

PMID:
28326890
32.

More to Atherosclerosis Than Stenosis: Symptomatic Carotid Artery With Intraplaque Hemorrhage.

Rai S, Thaler DE, Salehi P, Madan N, Leung LY.

Stroke. 2017 Apr;48(4):e104-e107. doi: 10.1161/STROKEAHA.117.016923. Epub 2017 Mar 14. Review. No abstract available.

PMID:
28292865
33.

Circulating human leucine-rich α-2-glycoprotein 1 mRNA and protein levels to detect acute appendicitis in patients with acute abdominal pain.

Rainer TH, Leung LY, Chan C, Leung YK, Cheng NM, Lai P, Cheung YS, Graham CA.

Clin Biochem. 2017 Jun;50(9):485-490. doi: 10.1016/j.clinbiochem.2017.02.010. Epub 2017 Feb 12.

PMID:
28202345
34.

Air-puff induced vocalizations: A novel approach to detecting negative affective state following concussion in rats.

Browning JR, Whiteman AC, Leung LY, Lu XM, Shear DA.

J Neurosci Methods. 2017 Jan 1;275:45-49. doi: 10.1016/j.jneumeth.2016.10.017. Epub 2016 Oct 29.

PMID:
27984100
35.

Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.

Leung LY, Deng-Bryant Y, Cardiff K, Winter M, Tortella F, Shear D.

J Trauma Acute Care Surg. 2016 Nov;81(5):860-867.

PMID:
27769083
36.

Therapeutic drug monitoring of mexiletine at a large academic medical center.

Nei SD, Danelich IM, Lose JM, Leung LY, Asirvatham SJ, McLeod CJ.

SAGE Open Med. 2016 Sep 21;4:2050312116670659. eCollection 2016.

37.

Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma.

Pandya JD, Sullivan PG, Leung LY, Tortella FC, Shear DA, Deng-Bryant Y.

Methods Mol Biol. 2016;1462:597-610. doi: 10.1007/978-1-4939-3816-2_32.

PMID:
27604740
38.

Cognitive Evaluation Using Morris Water Maze in Neurotrauma.

Deng-Bryant Y, Leung LY, Caudle K, Tortella F, Shear D.

Methods Mol Biol. 2016;1462:539-51. doi: 10.1007/978-1-4939-3816-2_29.

PMID:
27604737
39.

Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia.

Leung LY, Deng-Bryant Y, Shear D, Tortella F.

Methods Mol Biol. 2016;1462:445-58. doi: 10.1007/978-1-4939-3816-2_25.

PMID:
27604733
40.

Methods of Drug Delivery in Neurotrauma.

Deng-Bryant Y, Readnower R, Leung LY, Tortella F, Shear D.

Methods Mol Biol. 2016;1462:89-100. doi: 10.1007/978-1-4939-3816-2_6.

PMID:
27604714
41.

Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke.

Rainer TH, Leung LY, Chan CPY, Leung YK, Abrigo JM, Wang D, Graham CA.

Clin Biochem. 2016 Jun;49(9):663-668. doi: 10.1016/j.clinbiochem.2016.02.016. Epub 2016 Mar 9.

PMID:
26968104
42.

Factors Associated with Delay in Presentation to the Hospital for Young Adults with Ischemic Stroke.

Leung LY, Caplan LR.

Cerebrovasc Dis. 2016;42(1-2):10-4. doi: 10.1159/000443242. Epub 2016 Mar 9.

PMID:
26953591
43.

Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury.

Lu XC, Shear DA, Deng-Bryant Y, Leung LY, Wei G, Chen Z, Tortella FC.

Ther Hypothermia Temp Manag. 2016 Mar;6(1):30-9. doi: 10.1089/ther.2015.0017. Epub 2015 Dec 18.

44.

Combined hypoxemic and hypotensive insults altered physiological responses and neurofunction in a severity-dependent manner following penetrating ballistic-like brain injury in rats.

Leung LY, Deng-Bryant Y, Shear D, Tortella F.

J Trauma Acute Care Surg. 2015 Oct;79(4 Suppl 2):S130-8. doi: 10.1097/TA.0000000000000785.

PMID:
26406425
45.

Traumatic Brain Injury and Polytrauma in Theaters of Combat: The Case for Neurotrauma Resuscitation?

Tortella FC, Leung LY.

Shock. 2015 Aug;44 Suppl 1:17-26. doi: 10.1097/SHK.0000000000000380. Review.

PMID:
25895144
46.

Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.

Lu XC, Shear DA, Graham PB, Bridson GW, Uttamsingh V, Chen Z, Leung LY, Tortella FC.

J Neurotrauma. 2015 Oct 15;32(20):1621-32. doi: 10.1089/neu.2014.3766. Epub 2015 Jun 11.

47.

Glucose and oxygen metabolism after penetrating ballistic-like brain injury.

Gajavelli S, Kentaro S, Diaz J, Yokobori S, Spurlock M, Diaz D, Jackson C, Wick A, Zhao W, Leung LY, Shear D, Tortella F, Bullock MR.

J Cereb Blood Flow Metab. 2015 May;35(5):773-80. doi: 10.1038/jcbfm.2014.243. Epub 2015 Feb 11.

48.

Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury.

Deng-Bryant Y, Readnower RD, Leung LY, Cunningham TL, Shear DA, Tortella FC.

Restor Neurol Neurosci. 2015;33(2):189-203. doi: 10.3233/RNN-140455.

PMID:
25588460
49.

Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP).

Rosen DB, Leung LY, Louie B, Cordeiro JA, Conroy A, Shapira I, Fields SZ, Cesano A, Hawtin RE.

J Transl Med. 2014 Jun 25;12:184. doi: 10.1186/1479-5876-12-184.

50.

The WRAIR projectile concussive impact model of mild traumatic brain injury: re-design, testing and preclinical validation.

Leung LY, Larimore Z, Holmes L, Cartagena C, Mountney A, Deng-Bryant Y, Schmid K, Shear D, Tortella F.

Ann Biomed Eng. 2014 Aug;42(8):1618-30. doi: 10.1007/s10439-014-1014-8. Epub 2014 Apr 23.

PMID:
24756867

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