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Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD.

Jin M, Lee EC, Ra SW, Fishbane N, Tam S, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Aaron SD, Reed RM, Man SFP, Leung JM, Sin DD.

Chest. 2018 Jul 3. pii: S0012-3692(18)30803-1. doi: 10.1016/j.chest.2018.05.022. [Epub ahead of print]


Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis.

MacKenzie KK, Britt-Spells AM, Sands LP, Leung JM.

Anesthesiology. 2018 Jun 15. doi: 10.1097/ALN.0000000000002323. [Epub ahead of print]


Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV).

Xu S, Vucic EA, Shaipanich T, Lam S, Lam W, Montaner JS, Sin DD, Paul Man SF, Leung JM.

Respir Res. 2018 Jun 13;19(1):117. doi: 10.1186/s12931-018-0821-0.


Parasite-Microbiota Interactions With the Vertebrate Gut: Synthesis Through an Ecological Lens.

Leung JM, Graham AL, Knowles SCL.

Front Microbiol. 2018 May 14;9:843. doi: 10.3389/fmicb.2018.00843. eCollection 2018. Review.


Rapid environmental effects on gut nematode susceptibility in rewilded mice.

Leung JM, Budischak SA, Chung The H, Hansen C, Bowcutt R, Neill R, Shellman M, Loke P, Graham AL.

PLoS Biol. 2018 Mar 8;16(3):e2004108. doi: 10.1371/journal.pbio.2004108. eCollection 2018 Mar.


Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD.

Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Paul Man SF, Aaron SD, Reed RM, Sin DD; Canadian Respiratory Research Network (CRRN).

Respir Res. 2018 Feb 14;19(1):30. doi: 10.1186/s12931-018-0733-z.


Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets.

Leung JM, Sin DD.

BMJ. 2017 Sep 25;358:j3772. doi: 10.1136/bmj.j3772. Review.


Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells.

Tang MS, Bowcutt R, Leung JM, Wolff MJ, Gundra UM, Hudesman D, Malter LB, Poles MA, Chen LA, Pei Z, Neto AG, Abidi WM, Ullman T, Mayer L, Bonneau RA, Cho I, Loke P.

Inflamm Bowel Dis. 2017 Sep;23(9):1544-1554. doi: 10.1097/MIB.0000000000001208.


Concern of underdiagnosing asthma-COPD overlap syndrome if age limit of 40 years for asthma is used.

Sin DD, Leung JM, Wechsler ME.

Eur Respir J. 2017 Aug 3;50(2). pii: 1701120. doi: 10.1183/13993003.01120-2017. Print 2017 Aug. No abstract available.


Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.

Leung JM, Sands LP, Chen N, Ames C, Berven S, Bozic K, Burch S, Chou D, Covinsky K, Deviren V, Kinjo S, Kramer JH, Ries M, Tay B, Vail T, Weinstein P, Chang S, Meckler G, Newman S, Tsai T, Voss V, Youngblom E; Perioperative Medicine Research Group.

Anesthesiology. 2017 Oct;127(4):633-644. doi: 10.1097/ALN.0000000000001804.


Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo.

Gras S, Jackson A, Woods S, Pall G, Whitelaw J, Leung JM, Ward GE, Roberts CW, Meissner M.

Wellcome Open Res. 2017 Jul 24;2:32. doi: 10.12688/wellcomeopenres.11594.2. eCollection 2017.


Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram.

Muhlhofer WG, Zak R, Kamal T, Rizvi B, Sands LP, Yuan M, Zhang X, Leung JM.

Br J Anaesth. 2017 May 1;118(5):755-761. doi: 10.1093/bja/aex054.


Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease.

Li X, Obeidat M, Zhou G, Leung JM, Tashkin D, Wise R, Connett J, Joubert P, Bossé Y, van den Berge M, Brandsma CA, Nickle DC, Hao K, Paré PD, Sin DD.

EBioMedicine. 2017 May;19:139-145. doi: 10.1016/j.ebiom.2017.04.020. Epub 2017 Apr 12.


Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease.

Leitao Filho FS, Won Ra S, Mattman A, Schellenberg RS, Fishbane N, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, Martinez FJ, Leung JM, Man SFP, Aaron SD, Reed RM, Sin DD.

J Allergy Clin Immunol. 2017 Oct;140(4):1164-1167.e6. doi: 10.1016/j.jaci.2017.01.046. Epub 2017 Apr 27. No abstract available.


The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD.

Leung JM, Tiew PY, Mac Aogáin M, Budden KF, Yong VF, Thomas SS, Pethe K, Hansbro PM, Chotirmall SH.

Respirology. 2017 May;22(4):634-650. doi: 10.1111/resp.13032. Epub 2017 Mar 25. Review.


Stability and function of a putative microtubule-organizing center in the human parasite Toxoplasma gondii.

Leung JM, He Y, Zhang F, Hwang YC, Nagayasu E, Liu J, Murray JM, Hu K.

Mol Biol Cell. 2017 May 15;28(10):1361-1378. doi: 10.1091/mbc.E17-01-0045. Epub 2017 Mar 22.


Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion.

Leung JM, Fishbane N, Jones M, Morin A, Xu S, Liu JC, MacIsaac J, Milloy MJ, Hayashi K, Montaner J, Horvath S, Kobor M, Sin DD, Harrigan PR, Man SF.

Aging (Albany NY). 2017 Feb 23;9(3):687-705. doi: 10.18632/aging.101184.


Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion.

Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung JM, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M.

BMC Biol. 2017 Jan 18;15(1):1. doi: 10.1186/s12915-016-0343-5.


Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection.

Leung JM, Malagoli A, Santoro A, Besutti G, Ligabue G, Scaglioni R, Dai D, Hague C, Leipsic J, Sin DD, Man SP, Guaraldi G.

PLoS One. 2016 Nov 30;11(11):e0167247. doi: 10.1371/journal.pone.0167247. eCollection 2016.


The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus.

Sze MA, Xu S, Leung JM, Vucic EA, Shaipanich T, Moghadam A, Harris M, Guillemi S, Sinha S, Nislow C, Murphy D, Hague C, Leipsic J, Lam S, Lam W, Montaner JS, Sin DD, Man SF.

BMC Pulm Med. 2016 Nov 9;16(1):142.


Simultaneous multiview capture and fusion improves spatial resolution in wide-field and light-sheet microscopy.

Wu Y, Chandris P, Winter PW, Kim EY, Jaumouillé V, Kumar A, Guo M, Leung JM, Smith C, Rey-Suarez I, Liu H, Waterman CM, Ramamurthi KS, La Riviere PJ, Shroff H.

Optica. 2016 Aug 20;3(8):897-910. Epub 2016 Aug 11.


Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery.

Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM.

J Neuroinflammation. 2016 Aug 30;13(1):211. doi: 10.1186/s12974-016-0681-9.


COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry.

Leung JM, Chen V, Hollander Z, Dai D, Tebbutt SJ, Aaron SD, Vandemheen KL, Rennard SI, FitzGerald JM, Woodruff PG, Lazarus SC, Connett JE, Coxson HO, Miller B, Borchers C, McManus BM, Ng RT, Sin DD.

PLoS One. 2016 Aug 15;11(8):e0161129. doi: 10.1371/journal.pone.0161129. eCollection 2016.


Reply: heterogeneous population.

Hirsch J, Leung JM.

Br J Anaesth. 2016 Aug;117(2):262. doi: 10.1093/bja/aew198. No abstract available.


A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation.

Chen YW, Leung JM, Sin DD.

PLoS One. 2016 Jul 19;11(7):e0158843. doi: 10.1371/journal.pone.0158843. eCollection 2016. Review.


Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?

Tkacova R, Dai DLY, Vonk JM, Leung JM, Hiemstra PS, van den Berge M, Kunz L, Hollander Z, Tashkin D, Wise R, Connett J, Ng R, McManus B, Paul Man SF, Postma DS, Sin DD.

J Allergy Clin Immunol. 2016 Dec;138(6):1571-1579.e10. doi: 10.1016/j.jaci.2016.04.022. Epub 2016 May 24.


What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion.

Sin DD, Miravitlles M, Mannino DM, Soriano JB, Price D, Celli BR, Leung JM, Nakano Y, Park HY, Wark PA, Wechsler ME.

Eur Respir J. 2016 Sep;48(3):664-73. doi: 10.1183/13993003.00436-2016. Epub 2016 Jun 23.


Protocol for the Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) study: a pragmatic, randomised clinical trial.

Wildes TS, Winter AC, Maybrier HR, Mickle AM, Lenze EJ, Stark S, Lin N, Inouye SK, Schmitt EM, McKinnon SL, Muench MR, Murphy MR, Upadhyayula RT, Fritz BA, Escallier KE, Apakama GP, Emmert DA, Graetz TJ, Stevens TW, Palanca BJ, Hueneke R, Melby S, Torres B, Leung JM, Jacobsohn E, Avidan MS.

BMJ Open. 2016 Jun 15;6(6):e011505. doi: 10.1136/bmjopen-2016-011505. Erratum in: BMJ Open. 2016 Jun 27;6(6):e011505corr1.


The impact of albendazole treatment on the incidence of viral- and bacterial-induced diarrhea in school children in southern Vietnam: study protocol for a randomized controlled trial.

Leung JM, Hong CT, Trung NH, Thi HN, Minh CN, Thi TV, Hong DT, Man DN, Knowles SC, Wolbers M, Hoang Nle T, Thwaites G, Graham AL, Baker S.

Trials. 2016 Jun 6;17(1):279. doi: 10.1186/s13063-016-1406-1.


The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor.

Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM.

Anesth Analg. 2016 Jul;123(1):206-12. doi: 10.1213/ANE.0000000000001330.


Chronic Obstructive Pulmonary Disease and Stroke. Strange Bedfellows.

Leung JM, Sin DD.

Am J Respir Crit Care Med. 2016 Feb 1;193(3):227-8. doi: 10.1164/rccm.201510-1977ED. No abstract available.


Beyond Marfan: the clinical impact of bronchiectasis and non-tuberculous mycobacteria in connective tissue diseases.

Leung JM, Olivier KN, Prevots DR, McDonnell NB.

Int J Tuberc Lung Dis. 2015 Nov;19(11):1409. doi: 10.5588/ijtld.15.0597. No abstract available.


Prognostic Significance of Postoperative Subsyndromal Delirium.

Shim J, DePalma G, Sands LP, Leung JM.

Psychosomatics. 2015 Nov-Dec;56(6):644-51. doi: 10.1016/j.psym.2015.05.002. Epub 2015 May 15.


Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease.

Szymanski EP, Leung JM, Fowler CJ, Haney C, Hsu AP, Chen F, Duggal P, Oler AJ, McCormack R, Podack E, Drummond RA, Lionakis MS, Browne SK, Prevots DR, Knowles M, Cutting G, Liu X, Devine SE, Fraser CM, Tettelin H, Olivier KN, Holland SM.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):618-28. doi: 10.1164/rccm.201502-0387OC.


Preoperative Sleep Disruption and Postoperative Delirium.

Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K.

J Clin Sleep Med. 2015 Aug 15;11(8):907-13. doi: 10.5664/jcsm.4944.


Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease.

Liu JC, Leung JM, Ngan DA, Nashta NF, Guillemi S, Harris M, Lima VD, Um SJ, Li Y, Tam S, Shaipanich T, Raju R, Hague C, Leipsic JA, Bourbeau J, Tan WC, Harrigan PR, Sin DD, Montaner J, Man SF.

PLoS One. 2015 Apr 17;10(4):e0124426. doi: 10.1371/journal.pone.0124426. eCollection 2015.


Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery.

Hirsch J, DePalma G, Tsai TT, Sands LP, Leung JM.

Br J Anaesth. 2015 Sep;115(3):418-26. doi: 10.1093/bja/aeu458. Epub 2015 Jan 23.


Plasma pro-surfactant protein B and lung function decline in smokers.

Leung JM, Mayo J, Tan W, Tammemagi CM, Liu G, Peacock S, Shepherd FA, Goffin J, Goss G, Nicholas G, Tremblay A, Johnston M, Martel S, Laberge F, Bhatia R, Roberts H, Burrowes P, Manos D, Stewart L, Seely JM, Gingras M, Pasian S, Tsao MS, Lam S, Sin DD; Pan-Canadian Early Lung Cancer Study Group.

Eur Respir J. 2015 Apr;45(4):1037-45. doi: 10.1183/09031936.00184214. Epub 2015 Jan 22. Erratum in: Eur Respir J. 2016 Sep;48(3):962.


Inferred metagenomic comparison of mucosal and fecal microbiota from individuals undergoing routine screening colonoscopy reveals similar differences observed during active inflammation.

Tang MS, Poles J, Leung JM, Wolff MJ, Davenport M, Lee SC, Lim YA, Chua KH, Loke P, Cho I.

Gut Microbes. 2015;6(1):48-56. doi: 10.1080/19490976.2014.1000080. Epub 2015 Jan 20.


Sensitivity and specificity of the animal fluency test for predicting postoperative delirium.

Long LS, Wolpaw JT, Leung JM.

Can J Anaesth. 2015 Jun;62(6):603-8. doi: 10.1007/s12630-014-0306-7. Epub 2014 Dec 24.


COPD exacerbations: reducing the burden by predicting the future?

Leung JM, Sin DD.

Int J Tuberc Lung Dis. 2014 Dec;18(12):1387. doi: 10.5588/ijtld.14.0762. No abstract available.


A sum greater than its parts.

Leung JM, Man SF.

Eur Respir J. 2014 Dec;44(6):1394-6. doi: 10.1183/09031936.00126514. No abstract available.


Smoke and mirrors: the perils of water-pipe smoking and implications for Western countries.

Leung JM, Sin DD.

Chest. 2014 Oct;146(4):875-876. doi: 10.1378/chest.14-0603. No abstract available.


A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility.

Bookwalter CS, Kelsen A, Leung JM, Ward GE, Trybus KM.

J Biol Chem. 2014 Oct 31;289(44):30832-41. doi: 10.1074/jbc.M114.572453. Epub 2014 Sep 17.


Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.

Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, Kim SG, Li H, Gao Z, Mahana D, Zárate Rodriguez JG, Rogers AB, Robine N, Loke P, Blaser MJ.

Cell. 2014 Aug 14;158(4):705-721. doi: 10.1016/j.cell.2014.05.052.


Tidal volume and plateau pressure use for acute lung injury from 2000 to present: a systematic literature review.

Jaswal DS, Leung JM, Sun J, Cui X, Li Y, Kern S, Welsh J, Natanson C, Eichacker PQ.

Crit Care Med. 2014 Oct;42(10):2278-89. doi: 10.1097/CCM.0000000000000504. Review.


Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion.

Leung JM, Tran F, Pathak RB, Poupart S, Heaslip AT, Ballif BA, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 3;9(6):e98056. doi: 10.1371/journal.pone.0098056. eCollection 2014.


The determinants of poor respiratory health status in adults living with human immunodeficiency virus infection.

Leung JM, Liu JC, Mtambo A, Ngan D, Nashta N, Guillemi S, Harris M, Lima VD, Mattman A, Shaipanich T, Raju R, Hague C, Leipsic JA, Sin DD, Montaner JS, Man SF.

AIDS Patient Care STDS. 2014 May;28(5):240-7. doi: 10.1089/apc.2013.0373. Epub 2014 Apr 17.


Surface modification of polydimethylsiloxane with a covalent antithrombin-heparin complex to prevent thrombosis.

Leung JM, Berry LR, Chan AK, Brash JL.

J Biomater Sci Polym Ed. 2014;25(8):786-801. doi: 10.1080/09205063.2014.907669. Epub 2014 Apr 15.


Metabolic alterations to the mucosal microbiota in inflammatory bowel disease.

Davenport M, Poles J, Leung JM, Wolff MJ, Abidi WM, Ullman T, Mayer L, Cho I, Loke P.

Inflamm Bowel Dis. 2014 Apr;20(4):723-31. doi: 10.1097/MIB.0000000000000011.

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