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Items: 1 to 50 of 104

1.

Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat.

Feng Y, Chen Y, Yang B, Lan Q, Wang T, Cui G, Ren Z, Choi IC, Leung GP, Yan F, Chen D, Yu HH, Lee SMY.

Biomed Res Int. 2019 Jul 1;2019:7465272. doi: 10.1155/2019/7465272. eCollection 2019.

2.

Oridonin synergistically enhances the anti-tumor efficacy of doxorubicin against aggressive breast cancer via pro-apoptotic and anti-angiogenic effects.

Li J, Wu Y, Wang D, Zou L, Fu C, Zhang J, Leung GP.

Pharmacol Res. 2019 Aug;146:104313. doi: 10.1016/j.phrs.2019.104313. Epub 2019 Jun 13.

PMID:
31202781
3.

Application of UPLC-MS/MS to simultaneously detect four bioactive compounds in the tumour-shrinking decoction (FM1523) for uterine fibroids treatment.

Cheng IC, Li RK, Leung GP, Li SL, Kong M, Lao LX, Zhang ZJ, Lin WL, Ng EH, Rong JH, Chen JP, Su J, Zhang KY, Meng W.

Phytochem Anal. 2019 Jul;30(4):447-455. doi: 10.1002/pca.2827. Epub 2019 Mar 27.

PMID:
30916852
4.

A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis-causing mutation.

Chen X, Zhu S, Zhenin M, Xu W, Bose SJ, Wong MP, Leung GPH, Senderowitz H, Chen JH.

FASEB J. 2019 Apr;33(4):5126-5142. doi: 10.1096/fj.201801218RR. Epub 2019 Jan 22.

PMID:
30668920
5.

Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer's Disease Models In vitro and In vivo.

Liu JY, Chen XX, Chen HY, Shi J, Leung GP, Tang SC, Lao LX, Yip HK, Lee KF, Sze SC, Zhang ZJ, Zhang KY.

Neuroscience. 2018 Dec 1;394:72-82. doi: 10.1016/j.neuroscience.2018.09.016. Epub 2018 Sep 26.

PMID:
30266683
6.

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.

Leung GP, Feng T, Sigoillot FD, Geyer FC, Shirley MD, Ruddy DA, Rakiec DP, Freeman AK, Engelman JA, Jaskelioff M, Stuart DD.

Mol Cancer Res. 2019 Jan;17(1):199-211. doi: 10.1158/1541-7786.MCR-18-0327. Epub 2018 Sep 10.

PMID:
30201825
7.

Survey highlights the need to expand offerings of introductory pharmacy practice experiences in psychiatry and neurology: Benefits and example experiences.

Bostwick JR, Leung GP, Smith TL, Ahmed U, Bainbridge JL, Peyronnet JX.

Ment Health Clin. 2018 Mar 26;8(1):7-13. doi: 10.9740/mhc.2018.01.007. eCollection 2018 Jan.

8.

Ellagitannins from Pomegranate Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats while Enhancing Its Chemotoxicity against HT-29 Colorectal Cancer Cells through Intrinsic Apoptosis Induction.

Chen XX, Lam KK, Feng YB, Xu K, Sze SC, Tang SC, Leung GP, Lee CK, Shi J, Yang ZJ, Li ST, Zhang ZJ, Zhang KY.

J Agric Food Chem. 2018 Jul 11;66(27):7054-7064. doi: 10.1021/acs.jafc.8b02458. Epub 2018 Jul 2.

PMID:
29920075
9.

Pro-angiogenic effects of Ilexsaponin A1 on human umbilical vein endothelial cells in vitro and zebrafish in vivo.

Li J, Zhang J, Zou L, Lee SM, Yang C, Seto SW, Leung GP.

Phytomedicine. 2017 Dec 1;36:229-237. doi: 10.1016/j.phymed.2017.10.006. Epub 2017 Oct 7.

PMID:
29157819
10.

Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats.

Chen XX, Lam KH, Chen QX, Leung GP, Tang SCW, Sze SC, Xiao JB, Feng F, Wang Y, Zhang KY, Zhang ZJ.

Food Chem Toxicol. 2017 Dec;110:49-61. doi: 10.1016/j.fct.2017.10.017. Epub 2017 Oct 10.

PMID:
29030256
11.

Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin.

Li S, Ai N, Shen M, Dang Y, Chong CM, Pan P, Kwan YW, Chan SW, Leung GPH, Hoi MPM, Hou T, Lee SM.

Cell Death Discov. 2017 Aug 21;3:17051. doi: 10.1038/cddiscovery.2017.51. eCollection 2017.

12.

Proanthocyanidins from Uncaria rhynchophylla induced apoptosis in MDA-MB-231 breast cancer cells while enhancing cytotoxic effects of 5-fluorouracil.

Chen XX, Leung GP, Zhang ZJ, Xiao JB, Lao LX, Feng F, Mak JC, Wang Y, Sze SC, Zhang KY.

Food Chem Toxicol. 2017 Sep;107(Pt A):248-260. doi: 10.1016/j.fct.2017.07.012. Epub 2017 Jul 5.

PMID:
28689063
13.

MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT.

Li Z, Li S, Hu L, Li F, Cheung AC, Shao W, Que Y, Leung GP, Yang C.

Afr J Tradit Complement Altern Med. 2017 Jan 13;14(2):241-252. doi: 10.21010/ajtcam.v14i2.26. eCollection 2017.

14.

An andrographolide derivative AGP-26b exhibiting anti-angiogenic activity in HUVECs and zebrafish via blocking the VEGFA/VEGFR2 signaling pathway.

Huang B, Peng Y, Li J, Li S, Sun Y, Wang D, Yang B, Chan JY, Yu H, Leung GP, Hoi MP, Zhou GC, Lee SM.

Mol Biosyst. 2017 Feb 28;13(3):525-536. doi: 10.1039/c6mb00641h.

PMID:
28098292
15.

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine.

Zhou X, Cui G, Tseng HH, Lee SM, Leung GP, Chan SW, Kwan YW, Hoi MP.

Evid Based Complement Alternat Med. 2016;2016:9627258. doi: 10.1155/2016/9627258. Epub 2016 Nov 23. Review.

16.

Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+ Channels (BKCa).

Tseng HH, Vong CT, Leung GP, Seto SW, Kwan YW, Lee SM, Hoi MP.

Evid Based Complement Alternat Med. 2016;2016:5272531. Epub 2016 Nov 23.

17.

Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine.

Tang PCT, Yang C, Li RW, Lee SM, Hoi MP, Chan SW, Kwan YW, Tse CM, Leung GP.

Eur J Pharmacol. 2016 Nov 15;791:544-551. doi: 10.1016/j.ejphar.2016.07.002. Epub 2016 Jul 5.

PMID:
27388143
18.

Role of the nicotinic acetylcholine receptor α3 subtype in vascular inflammation.

Yang C, Li Z, Yan S, He Y, Dai R, Leung GP, Pan S, Yang J, Yan R, Du G.

Br J Pharmacol. 2016 Nov;173(22):3235-3247. doi: 10.1111/bph.13609. Epub 2016 Sep 29.

19.

Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods.

Zhou X, Choi PS, Yang JM, Or PMY, Hoi PM, Lee SMY, Leung GPH, Ngai SM, Kong SK, Ho HP, Wong MYM, Chan SW, Yeung JHK, Kwan YW.

Springerplus. 2016 Aug 30;5(1):1438. doi: 10.1186/s40064-016-3115-3. eCollection 2016.

20.

Rtt107 BRCT domains act as a targeting module in the DNA damage response.

Leung GP, Brown JA, Glover JN, Kobor MS.

DNA Repair (Amst). 2016 Jan;37:22-32. doi: 10.1016/j.dnarep.2015.10.007. Epub 2015 Nov 10.

PMID:
26641499
21.

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway.

Li S, Dang Y, Zhou X, Huang B, Huang X, Zhang Z, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Sci Rep. 2015 Nov 16;5:16815. doi: 10.1038/srep16815.

22.

In vitro vitamin K(2) and 1α,25-dihydroxyvitamin D(3) combination enhances osteoblasts anabolism of diabetic mice.

Poon CC, Li RW, Seto SW, Kong SK, Ho HP, Hoi MP, Lee SM, Ngai SM, Chan SW, Leung GP, Kwan YW.

Eur J Pharmacol. 2015 Nov 15;767:30-40. doi: 10.1016/j.ejphar.2015.09.048. Epub 2015 Oct 8.

PMID:
26452518
23.

Equilibrative Nucleoside Transporters 1 and 4: Which One Is a Better Target for Cardioprotection Against Ischemia-Reperfusion Injury?

Yang C, Leung GP.

J Cardiovasc Pharmacol. 2015 Jun;65(6):517-21. doi: 10.1097/FJC.0000000000000194. Review.

24.

Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries.

Li RW, Yang C, Shan L, Zhang Z, Wang Y, Kwan YW, Lee SM, Hoi MP, Chan SW, Cheung AC, Cheung KH, Leung GP.

Eur J Pharmacol. 2015 Aug 15;761:153-60. doi: 10.1016/j.ejphar.2015.04.041. Epub 2015 May 4.

PMID:
25952729
25.

Oleanolic Acid Loaded PEGylated PLA and PLGA Nanoparticles with Enhanced Cytotoxic Activity against Cancer Cells.

Man DK, Casettari L, Cespi M, Bonacucina G, Palmieri GF, Sze SC, Leung GP, Lam JK, Kwok PC.

Mol Pharm. 2015 Jun 1;12(6):2112-25. doi: 10.1021/acs.molpharmaceut.5b00085. Epub 2015 Apr 28.

PMID:
25881668
26.

Relaxation effect of abacavir on rat basilar arteries.

Li RW, Yang C, Chan SW, Hoi MP, Lee SM, Kwan YW, Leung GP.

PLoS One. 2015 Apr 8;10(4):e0123043. doi: 10.1371/journal.pone.0123043. eCollection 2015.

27.

Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels.

Xu YC, Leung SW, Leung GP, Man RY.

Br J Pharmacol. 2015 Jun;172(12):3003-14. doi: 10.1111/bph.13108. Epub 2015 Mar 27.

28.

Inhalable dry powder formulations of siRNA and pH-responsive peptides with antiviral activity against H1N1 influenza virus.

Liang W, Chow MY, Lau PN, Zhou QT, Kwok PC, Leung GP, Mason AJ, Chan HK, Poon LL, Lam JK.

Mol Pharm. 2015 Mar 2;12(3):910-21. doi: 10.1021/mp500745v. Epub 2015 Jan 30.

PMID:
25599953
29.

Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries.

Cai Y, Manio MM, Leung GP, Xu A, Tang EH, Vanhoutte PM.

Eur J Pharmacol. 2015 Jan 15;747:18-28. doi: 10.1016/j.ejphar.2014.11.036. Epub 2014 Dec 6.

PMID:
25489922
30.

Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis.

Li S, Zhou XL, Dang YY, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Biochim Biophys Acta. 2015 Feb;1850(2):373-84. doi: 10.1016/j.bbagen.2014.10.023. Epub 2014 Oct 29.

PMID:
25450186
31.

Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway.

Cui G, Luk SC, Li RA, Chan KK, Lei SW, Wang L, Shen H, Leung GP, Lee SM.

J Cardiovasc Pharmacol. 2015 Jan;65(1):39-46. doi: 10.1097/FJC.0000000000000161.

PMID:
25343567
32.

VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation.

Li S, Dang YY, Oi Lam Che G, Kwan YW, Chan SW, Leung GP, Lee SM, Hoi MP.

Toxicol Appl Pharmacol. 2014 Nov 1;280(3):408-20. doi: 10.1016/j.taap.2014.09.005. Epub 2014 Sep 16.

PMID:
25234792
33.

Endothelium-dependent and -independent relaxation of rat aorta induced by extract of Schizophyllum commune.

Chen H, Li S, Wang P, Yan S, Hu L, Pan X, Yang C, Leung GP.

Phytomedicine. 2014 Sep 25;21(11):1230-6. doi: 10.1016/j.phymed.2014.06.008. Epub 2014 Jul 25.

PMID:
25172784
34.

Uptake and protective effects of ergothioneine in human endothelial cells.

Li RW, Yang C, Sit AS, Kwan YW, Lee SM, Hoi MP, Chan SW, Hausman M, Vanhoutte PM, Leung GP.

J Pharmacol Exp Ther. 2014 Sep;350(3):691-700. doi: 10.1124/jpet.114.214049. Epub 2014 Jul 14.

PMID:
25022513
35.

Vasodilatory effect of 14,15-epoxyeicosatrienoic acid on mesenteric arteries in hypertensive and aged rats.

Yang C, Yang J, Xu X, Yan S, Pan S, Pan X, Zhang C, Leung GP.

Prostaglandins Other Lipid Mediat. 2014 Aug;112:1-8. doi: 10.1016/j.prostaglandins.2014.05.001. Epub 2014 May 28.

PMID:
24880050
36.

Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.

Leung GP, Aristizabal MJ, Krogan NJ, Kobor MS.

G3 (Bethesda). 2014 Apr 2;4(6):1059-69. doi: 10.1534/g3.114.011205.

37.

Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis.

Li WY, Ng YF, Zhang H, Guo ZD, Guo DJ, Kwan YW, Leung GP, Lee SM, Yu PH, Chan SW.

Inflammopharmacology. 2014 Apr;22(2):127-34. doi: 10.1007/s10787-013-0186-4. Epub 2013 Aug 22.

PMID:
23975033
38.

Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.

Seto SW, Au AL, Poon CC, Zhang Q, Li RW, Yeung JH, Kong SK, Ngai SM, Wan S, Ho HP, Lee SM, Hoi MP, Chan SW, Leung GP, Kwan YW.

PLoS One. 2013 Jun 17;8(6):e66404. doi: 10.1371/journal.pone.0066404. Print 2013.

39.

Differential ligand binding affinities of human estrogen receptor-α isoforms.

Lin AH, Li RW, Ho EY, Leung GP, Leung SW, Vanhoutte PM, Man RY.

PLoS One. 2013 Apr 30;8(4):e63199. doi: 10.1371/journal.pone.0063199. Print 2013.

40.

DNA-loaded chitosan oligosaccharide nanoparticles with enhanced permeability across Calu-3 cells.

Ye Y, Xu Y, Liang W, Leung GP, Cheung KH, Zheng C, Chen F, Lam JK.

J Drug Target. 2013 May;21(5):474-86. doi: 10.3109/1061186X.2013.766885. Epub 2013 Mar 12.

PMID:
23480724
41.

Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells.

Li RW, Yang C, Kwan YW, Chan SW, Lee SM, Leung GP.

Front Pharmacol. 2013 Feb 12;4:14. doi: 10.3389/fphar.2013.00014. eCollection 2013.

42.

Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions.

Zhou X, Chan SW, Tseng HL, Deng Y, Hoi PM, Choi PS, Or PM, Yang JM, Lam FF, Lee SM, Leung GP, Kong SK, Ho HP, Kwan YW, Yeung JH.

Phytomedicine. 2012 Nov 15;19(14):1263-9. doi: 10.1016/j.phymed.2012.08.011. Epub 2012 Sep 29.

PMID:
23026310
43.

Serum nitric oxide synthase activity is a novel predictor of impaired vasorelaxation in rats.

Chan E, Chan JY, Wu JH, Wan CW, Leung GP, Lee SM, Kwan YW, Chan SW.

Clin Exp Pharmacol Physiol. 2012 Oct;39(10):894-6. doi: 10.1111/j.1440-1681.2012.05748.x.

PMID:
22823573
44.

Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors.

Leung GP.

Adv Exp Med Biol. 2012;942:347-69. doi: 10.1007/978-94-007-2869-1_16. Review.

PMID:
22399431
45.

Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models?

Song JX, Sze SC, Ng TB, Lee CK, Leung GP, Shaw PC, Tong Y, Zhang YB.

J Ethnopharmacol. 2012 Feb 15;139(3):698-711. doi: 10.1016/j.jep.2011.12.030. Epub 2011 Dec 29. Review.

PMID:
22212501
46.

Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo.

Zhang Y, Hu G, Li S, Li ZH, Lam CO, Hong SJ, Kwan YW, Chan SW, Leung GP, Lee SM.

Mol Med Rep. 2012 Mar;5(3):805-11. doi: 10.3892/mmr.2011.716. Epub 2011 Dec 15.

PMID:
22179585
47.

Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae.

Hu G, Siu SO, Li S, Chu IK, Kwan YW, Chan SW, Leung GP, Yan R, Lee SM.

Xenobiotica. 2012 Mar;42(3):294-303. doi: 10.3109/00498254.2011.617015. Epub 2011 Oct 2.

PMID:
21961561
48.

Transcriptional profiling of angiogenesis activities of calycosin in zebrafish.

Li S, Lou S, Lei BU, Chan TF, Kwan YW, Chan SW, Leung GP, Tsui SK, Lee SM.

Mol Biosyst. 2011 Nov;7(11):3112-21. doi: 10.1039/c1mb05206c. Epub 2011 Sep 12.

PMID:
21909574
49.

Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats.

Chan E, Liu XX, Guo DJ, Kwan YW, Leung GP, Lee SM, Chan SW.

Am J Chin Med. 2011;39(4):693-704.

PMID:
21721150
50.

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.

Leung GP, Lee L, Schmidt TI, Shirahige K, Kobor MS.

J Biol Chem. 2011 Jul 22;286(29):26250-7. doi: 10.1074/jbc.M111.235200. Epub 2011 Jun 3.

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