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Items: 1 to 50 of 161

1.

Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells.

Zhu Z, Zhang P, Li N, Kiang KMY, Cheng SY, Wong VK, Leung GK.

Biomed Res Int. 2019 Sep 23;2019:2710693. doi: 10.1155/2019/2710693. eCollection 2019.

2.

The Impact of Time of Day on Energy Expenditure: Implications for Long-Term Energy Balance.

Shaw E, Leung GKW, Jong J, Coates AM, Davis R, Blair M, Huggins CE, Dorrian J, Banks S, Kellow NJ, Bonham MP.

Nutrients. 2019 Oct 6;11(10). pii: E2383. doi: 10.3390/nu11102383. Review.

3.

Temporal pattern of eating in night shift workers.

Shaw E, Dorrian J, Coates AM, Leung GKW, Davis R, Rosbotham E, Warnock R, Huggins CE, Bonham MP.

Chronobiol Int. 2019 Dec;36(12):1613-1625. doi: 10.1080/07420528.2019.1660358. Epub 2019 Sep 9.

PMID:
31495232
4.

Safety of candour: how protected are apologies in open disclosure?

Leung GKK, Porter G.

BMJ. 2019 Jun 13;365:l4047. doi: 10.1136/bmj.l4047. No abstract available.

PMID:
31196893
5.

Response to letter regarding "Combined aspiration thrombectomy and continuous intrasinus thrombolysis for cerebral venous sinus thrombosis: technical note and case series".

Tsang ACO, Tsang FCP, Lee R, Leung GKK, Lui WM.

Neuroradiology. 2019 Aug;61(8):847-848. doi: 10.1007/s00234-019-02239-4. Epub 2019 Jun 5. No abstract available.

PMID:
31165916
6.

Successful Emergency Rescue Open Embolectomy for Failed Endovascular Thrombectomy in Acute Ischemic Stroke: 2-Dimensional Operative Video.

Chan DYC, Tsang ACO, Tsang FCP, Li LF, Ho WS, Lui WM, Leung GKK.

Oper Neurosurg (Hagerstown). 2019 Jun 4. pii: opz140. doi: 10.1093/ons/opz140. [Epub ahead of print]

PMID:
31162591
7.

Repair of Anterior Skull Base Defect by Dual-Layer/Split-Frontal Pericranial Flap.

Li LF, Pu JK, Chung JC, Lui WM, Leung GK.

World Neurosurg. 2019 Feb;122:59-62. doi: 10.1016/j.wneu.2018.10.112. Epub 2018 Oct 26.

PMID:
31108066
8.

Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis.

Low ZX, Yeo KA, Sharma VK, Leung GK, McIntyre RS, Guerrero A, Lu B, Sin Fai Lam CC, Tran BX, Nguyen LH, Ho CS, Tam WW, Ho RC.

Int J Environ Res Public Health. 2019 Apr 26;16(9). pii: E1479. doi: 10.3390/ijerph16091479.

9.

Genetic landscape of RASopathies in Chinese: Three decades' experience in Hong Kong.

Yu KPT, Luk HM, Leung GKC, Mak CCY, Cheng SSW, Hau EWL, Chan DKH, Lam STS, Tong TMF, Chung BHY, Lo IFM.

Am J Med Genet C Semin Med Genet. 2019 Jun;181(2):208-217. doi: 10.1002/ajmg.c.31692. Epub 2019 Mar 21.

PMID:
30896080
10.

Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy.

Tsang MH, Leung GK, Ho AC, Yeung KS, Mak CC, Pei SL, Yu MH, Kan AS, Chan KY, Kwong KL, Lee SL, Yung AW, Fung CW, Chung BH.

Epilepsia Open. 2018 Dec 6;4(1):63-72. doi: 10.1002/epi4.12282. eCollection 2019 Mar.

11.

Effects of macronutrient manipulation on postprandial metabolic responses in overweight males with high fasting lipids during simulated shift work: A randomized crossover trial.

Bonham MP, Kaias E, Huggins CE, Davis R, Leung GK, Eikelis N, Shaw E, Murgia C.

Clin Nutr. 2019 Feb 15. pii: S0261-5614(19)30072-X. doi: 10.1016/j.clnu.2019.02.018. [Epub ahead of print]

PMID:
30853262
12.

Burden of large vessel occlusion stroke and the service gap of thrombectomy: A population-based study using a territory-wide public hospital system registry.

Tsang ACO, You J, Li LF, Tsang FCP, Woo PPS, Tsui ELH, Yu P, Leung GKK.

Int J Stroke. 2019 Feb 11:1747493019830585. doi: 10.1177/1747493019830585. [Epub ahead of print]

PMID:
30741611
13.

Improving Survival with Tranexamic Acid in Cerebral Contusions or Traumatic Subarachnoid Hemorrhage: Univariate and Multivariate Analysis of Independent Factors Associated with Lower Mortality.

Chan DYC, Tsang ACO, Li LF, Cheng KKF, Tsang FCP, Taw BBT, Pu JKS, Ho WWS, Lui WM, Leung GKK.

World Neurosurg. 2019 May;125:e665-e670. doi: 10.1016/j.wneu.2019.01.145. Epub 2019 Feb 2.

PMID:
30721773
14.

Progesterone Is More Effective Than Dexamethasone in Prolonging Overall Survival and Preserving Neurologic Function in Experimental Animals with Orthotopic Glioblastoma Allografts.

Cheng Y, Yeung WL, Zhang P, Li N, Kiang MY, Leung GKK.

World Neurosurg. 2019 May;125:e497-e507. doi: 10.1016/j.wneu.2019.01.113. Epub 2019 Jan 31.

PMID:
30710720
15.

Effect of Night Time Eating on Postprandial Triglyceride Metabolism in Healthy Adults: A Systematic Literature Review.

Bonham MP, Kaias E, Zimberg I, Leung GKW, Davis R, Sletten TL, Windsor-Aubrey H, Huggins CE.

J Biol Rhythms. 2019 Apr;34(2):119-130. doi: 10.1177/0748730418824214. Epub 2019 Jan 25.

PMID:
30681036
16.

A significant inflation in TGM6 genetic risk casts doubt in its causation in spinocerebellar ataxia type 35.

Fung JLF, Tsang MHY, Leung GKC, Yeung KS, Mak CCY, Fung CW, Chan SHS, Yu MHC, Chung BHY.

Parkinsonism Relat Disord. 2019 Jun;63:42-45. doi: 10.1016/j.parkreldis.2019.01.013. Epub 2019 Jan 17.

PMID:
30670339
17.

Emergency endoscopic third ventriculostomy for blocked shunts? Univariate and multivariate analysis of independent predictors for failure.

Chan DYC, Tsang ACO, Ho WWS, Cheng KKF, Li LF, Tsang FCP, Taw BBT, Pu JKS, Leung GKK, Lui MWM.

J Neurosurg. 2018 Nov 1:1-7. doi: 10.3171/2018.6.JNS1865. [Epub ahead of print]

PMID:
30497141
18.

Targeting proteoglycan receptor PTPσ restores sensory function after spinal cord dorsal root injury by activation of Erks/CREB signaling pathway.

Yao M, Sun H, Yuan Q, Li N, Li H, Tang Y, Leung GK, Wu W.

Neuropharmacology. 2019 Jan;144:208-218. doi: 10.1016/j.neuropharm.2018.10.035. Epub 2018 Oct 28.

PMID:
30393073
19.

Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES).

Leung GKC, Mak CCY, Fung JLF, Wong WHS, Tsang MHY, Yu MHC, Pei SLC, Yeung KS, Mok GTK, Lee CP, Hui APW, Tang MHY, Chan KYK, Liu APY, Yang W, Sham PC, Kan ASY, Chung BHY.

BMC Med Genomics. 2018 Oct 25;11(1):93. doi: 10.1186/s12920-018-0409-z.

20.

Mosaic KRAS mutation in a patient with encephalocraniocutaneous lipomatosis and renovascular hypertension.

McDonell LM, Leung GK, Daoud H, Ip J, Chim S, Luk HM, Lan L; Care4Rare Canada Consortium, Boycott KM, Chung BH.

Am J Med Genet A. 2018 Nov;176(11):2523-2527. doi: 10.1002/ajmg.a.40349. Epub 2018 Oct 5. No abstract available.

PMID:
30289595
21.

Clinical significance of CRNDE transcript variants in glioblastoma multiforme.

Kiang KMY, Leung GKK.

Noncoding RNA Res. 2017 Jul 26;2(2):119-121. doi: 10.1016/j.ncrna.2017.07.001. eCollection 2017 Jun.

22.

Forward and reverse mutations in stages of cancer development.

Hu T, Kumar Y, Shazia I, Duan SJ, Li Y, Chen L, Chen JF, Yin R, Kwong A, Leung GK, Mat WK, Wu Z, Long X, Chan CH, Chen S, Lee P, Ng SK, Ho TYC, Yang J, Ding X, Tsang SY, Zhou X, Zhang DH; International Cancer Genome Consortium, Zhou EX, Xu L, Poon WS, Wang HY, Xue H.

Hum Genomics. 2018 Aug 22;12(1):40. doi: 10.1186/s40246-018-0170-6.

23.

Combined aspiration thrombectomy and continuous intrasinus thrombolysis for cerebral venous sinus thrombosis: technical note and case series.

Tsang ACO, Hwang AC, Chiu RHY, Chan DYC, Tsang FCP, Ho WS, Lee R, Leung GKK, Lui WM.

Neuroradiology. 2018 Oct;60(10):1093-1096. doi: 10.1007/s00234-018-2084-3. Epub 2018 Aug 21.

PMID:
30132019
24.

Exome sequencing for paediatric-onset diseases: impact of the extensive involvement of medical geneticists in the diagnostic odyssey.

Mak CC, Leung GK, Mok GT, Yeung KS, Yang W, Fung CW, Chan SH, Lee SL, Lee NC, Pfundt R, Lau YL, Chung BH.

NPJ Genom Med. 2018 Aug 6;3:19. doi: 10.1038/s41525-018-0056-5. eCollection 2018.

25.

Medical manslaughter in Hong Kong-how, why, and why not.

Leung GK.

Hong Kong Med J. 2018 Aug;24(4):384-390. doi: 10.12809/hkmj187346. Epub 2018 Jul 27. Review.

26.

Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest.

Li N, Zhang P, Kiang KMY, Cheng YS, Leung GKK.

Biomed Res Int. 2018 Jun 28;2018:5364973. doi: 10.1155/2018/5364973. eCollection 2018.

27.

The application of point-of-care platelet function assay in guiding platelet transfusion in aspirin-users with intracranial haemorrhages.

Cheng KY, Tsang CP, Leung GKK, Lui WM.

J Clin Neurosci. 2018 Sep;55:52-56. doi: 10.1016/j.jocn.2018.06.037. Epub 2018 Jul 2.

PMID:
30042067
28.

Long-Term Risk of In-Stent Restenosis and Stent Fracture for Extracranial Vertebral Artery Stenting.

Li MKA, Tsang ACO, Tsang FCP, Ho WS, Lee R, Leung GKK, Lui WM.

Clin Neuroradiol. 2018 Jul 23. doi: 10.1007/s00062-018-0708-y. [Epub ahead of print]

PMID:
30039353
29.

Paternal uniparental disomy of chromosome 19 in a pair of monochorionic diamniotic twins with dysmorphic features and developmental delay.

Yeung KS, Ho MSP, Lee SL, Kan ASY, Chan KYK, Tang MHY, Mak CCY, Leung GKC, So PL, Pfundt R, Marshall CR, Scherer SW, Choufani S, Weksberg R, Hon-Yin Chung B.

J Med Genet. 2018 Dec;55(12):847-852. doi: 10.1136/jmedgenet-2018-105328. Epub 2018 Jul 14.

PMID:
30007940
30.

A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer.

Kiang KM, Leung GK.

Biomed Res Int. 2018 May 16;2018:3465929. doi: 10.1155/2018/3465929. eCollection 2018. Review.

31.

New Hong Kong statute protects factual statements in medical apologies from use in litigation.

Leung GK, Porter G.

Med Leg J. 2018 Jan 1:25817218771803. doi: 10.1177/0025817218771803. [Epub ahead of print]

PMID:
29676657
32.

Does modifying the timing of meal intake improve cardiovascular risk factors? Protocol of an Australian pilot intervention in night shift workers with abdominal obesity.

Bonham MP, Leung GKW, Davis R, Sletten TL, Murgia C, Young MJ, Eikelis N, Lambert EA, Huggins CE.

BMJ Open. 2018 Mar 14;8(3):e020396. doi: 10.1136/bmjopen-2017-020396.

33.

Three-in-one protocol reduces mortality of patients with haemodynamically unstable pelvic fractures-a five year multi-centred review in Hong Kong.

Cheng M, Lee KY, Chang AL, Ho HF, Chan LS, Lee KB, Kwok PH, Lee AW, Wong KK, Kam CW, Leung GK, Wong JS, Cheung NK, Yeung JH, Tang N, Choi SH, Lau TW, Wong HT, Leung M.

Int Orthop. 2018 Oct;42(10):2459-2466. doi: 10.1007/s00264-018-3842-x. Epub 2018 Feb 27.

PMID:
29487990
34.

We need a stroke system.

Leung GK.

Hong Kong Med J. 2018 Feb;24(1):9-10. doi: 10.12809/hkmj175075. No abstract available.

35.

Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies.

Leung GKC, Luk HM, Tang VHM, Gao WW, Mak CCY, Yu MHC, Wong WL, Chu YWY, Yang WL, Wong WHS, Ma ACH, Leung AYH, Jin DY, Chan KYK, Allanson J, Lo IFM, Chung BHY.

Sci Rep. 2018 Feb 5;8(1):2421. doi: 10.1038/s41598-018-20894-0.

36.

Malpractice litigation in acute stroke care - where are we now?

Leung GK, Porter G.

Med Leg J. 2018 Sep;86(3):134-139. doi: 10.1177/0025817217750494. Epub 2018 Jan 10.

PMID:
29319407
37.

Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism.

Yeung KS, Tso WWY, Ip JJK, Mak CCY, Leung GKC, Tsang MHY, Ying D, Pei SLC, Lee SL, Yang W, Chung BH.

Mol Autism. 2017 Dec 20;8:66. doi: 10.1186/s13229-017-0182-4. eCollection 2017.

38.

Effect of meal timing on postprandial glucose responses to a low glycemic index meal: A crossover trial in healthy volunteers.

Leung GKW, Huggins CE, Bonham MP.

Clin Nutr. 2019 Feb;38(1):465-471. doi: 10.1016/j.clnu.2017.11.010. Epub 2017 Nov 22.

PMID:
29248250
39.

Okur-Chung neurodevelopmental syndrome: Eight additional cases with implications on phenotype and genotype expansion.

Chiu ATG, Pei SLC, Mak CCY, Leung GKC, Yu MHC, Lee SL, Vreeburg M, Pfundt R, van der Burgt I, Kleefstra T, Frederic TM, Nambot S, Faivre L, Bruel AL, Rossi M, Isidor B, Küry S, Cogne B, Besnard T, Willems M, Reijnders MRF, Chung BHY.

Clin Genet. 2018 Apr;93(4):880-890. doi: 10.1111/cge.13196. Epub 2018 Feb 13.

PMID:
29240241
40.

Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling.

Sun S, Kiang KMY, Ho ASW, Lee D, Poon MW, Xu FF, Pu JKS, Kan ANC, Lee NPY, Liu XB, Man K, Day PJR, Lui WM, Fung CF, Leung GKK.

Oncotarget. 2017 May 19;8(42):71911-71923. doi: 10.18632/oncotarget.18026. eCollection 2017 Sep 22.

41.

Noonan syndrome in diverse populations.

Kruszka P, Porras AR, Addissie YA, Moresco A, Medrano S, Mok GTK, Leung GKC, Tekendo-Ngongang C, Uwineza A, Thong MK, Muthukumarasamy P, Honey E, Ekure EN, Sokunbi OJ, Kalu N, Jones KL, Kaplan JD, Abdul-Rahman OA, Vincent LM, Love A, Belhassan K, Ouldim K, El Bouchikhi I, Shukla A, Girisha KM, Patil SJ, Sirisena ND, Dissanayake VHW, Paththinige CS, Mishra R, Klein-Zighelboim E, Gallardo Jugo BE, Chávez Pastor M, Abarca-Barriga HH, Skinner SA, Prijoles EJ, Badoe E, Gill AD, Shotelersuk V, Smpokou P, Kisling MS, Ferreira CR, Mutesa L, Megarbane A, Kline AD, Kimball A, Okello E, Lwabi P, Aliku T, Tenywa E, Boonchooduang N, Tanpaiboon P, Richieri-Costa A, Wonkam A, Chung BHY, Stevenson RE, Summar M, Mandal K, Phadke SR, Obregon MG, Linguraru MG, Muenke M.

Am J Med Genet A. 2017 Sep;173(9):2323-2334. doi: 10.1002/ajmg.a.38362. Epub 2017 Jul 27.

42.

Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder-implications of a copy number variation involving DPP10.

Mak ASL, Chiu ATG, Leung GKC, Mak CCY, Chu YWY, Mok GTK, Tang WF, Chan KYK, Tang MHY, Lau Yim ET, So KW, Tao VQ, Fung CW, Wong VCN, Uddin M, Lee SL, Marshall CR, Scherer SW, Kan ASY, Chung BHY.

Mol Autism. 2017 Jun 26;8:31. doi: 10.1186/s13229-017-0136-x. eCollection 2017.

43.

Antiplatelet Resumption after Antiplatelet-Related Intracerebral Hemorrhage: A Retrospective Hospital-Based Study.

Teo KC, Lau GKK, Mak RHY, Leung HY, Chang RSK, Tse MY, Lee R, Leung GKK, Ho SL, Cheung RTF, Siu DCW, Chan KH.

World Neurosurg. 2017 Oct;106:85-91. doi: 10.1016/j.wneu.2017.06.015. Epub 2017 Jun 10.

PMID:
28606579
44.

In Reply to "Moyamoya Disease: Impact of Evolving Different Management Approaches to Improve Overall Neurologic Outcome".

Cheung AH, Leung GKK.

World Neurosurg. 2017 Jun;102:687. doi: 10.1016/j.wneu.2017.03.127. No abstract available.

PMID:
28582832
45.

Iatrogenic Sigmoid Sinus Occlusion Rescued by Graft Repair and Endovascular Thrombolysis.

Li LF, Pu JK, Tsang CP, Tsang AC, Lui WM, Leung GK.

World Neurosurg. 2017 Aug;104:1047.e13-1047.e17. doi: 10.1016/j.wneu.2017.05.041. Epub 2017 May 16.

PMID:
28526646
46.

An Exploratory Analysis of the Geographical Distribution of Trauma Incidents in Shenzhen, China.

Zhang GX, Fan JKM, Chan FSY, Leung GKK, Lo CM, Yu YM, Zhang H, Brundage SI, Jansen JO.

World J Surg. 2017 Sep;41(9):2207-2214. doi: 10.1007/s00268-017-4002-y.

PMID:
28508236
47.

CRNDE Expression Positively Correlates with EGFR Activation and Modulates Glioma Cell Growth.

Kiang KM, Zhang XQ, Zhang GP, Li N, Cheng SY, Poon MW, Pu JK, Lui WM, Leung GK.

Target Oncol. 2017 Jun;12(3):353-363. doi: 10.1007/s11523-017-0488-3.

PMID:
28493025
48.

Outcome after operative intervention for traumatic brain injuries in the elderly.

Li LF, Lui WM, Wong HH, Yuen WK, Leung GK.

Asian J Neurosurg. 2017 Jan-Mar;12(1):37-43. doi: 10.4103/1793-5482.148787.

49.

A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update.

Chiu AT, Leung GK, Chu YW, Gripp KW, Chung BH.

Am J Med Genet A. 2017 Apr;173(4):1109-1114. doi: 10.1002/ajmg.a.38118.

PMID:
28328122
50.

Rutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition.

Zhang P, Sun S, Li N, Ho ASW, Kiang KMY, Zhang X, Cheng YS, Poon MW, Lee D, Pu JKS, Leung GKK.

J Neurooncol. 2017 May;132(3):393-400. doi: 10.1007/s11060-017-2387-y. Epub 2017 Mar 14.

PMID:
28293765

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