Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 131

1.

Mechanisms of non-segmented negative sense RNA viral antagonism of host RIG-I-like receptors.

Leung DW.

J Mol Biol. 2019 Jun 13. pii: S0022-2836(19)30364-X. doi: 10.1016/j.jmb.2019.06.002. [Epub ahead of print] Review.

PMID:
31202887
2.

Ebola Virus Replication Stands Out.

Wang W, Wu C, Amarasinghe GK, Leung DW.

Trends Microbiol. 2019 Jul;27(7):565-566. doi: 10.1016/j.tim.2019.05.004. Epub 2019 May 30.

PMID:
31155428
3.

Marburg virus RNA synthesis is inhibited by a synthetic anti-VP35 antibody.

Amatya P, Wagner N, Chen G, Luthra P, Shi L, Borek D, Pavlenco A, Rohrs HW, Basler CF, Sidhu SS, Gross ML, Leung DW.

ACS Infect Dis. 2019 May 23. doi: 10.1021/acsinfecdis.9b00091. [Epub ahead of print]

PMID:
31120240
4.

Potent Neutralization of Staphylococcal Enterotoxin B In Vivo by Antibodies that Block Binding to the T-Cell Receptor.

Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, Sidhu SS.

J Mol Biol. 2019 Mar 27. pii: S0022-2836(19)30148-2. doi: 10.1016/j.jmb.2019.03.017. [Epub ahead of print]

PMID:
30928493
5.

Overexpression of OsIAAGLU reveals a role for IAA-glucose conjugation in modulating rice plant architecture.

Yu XL, Wang HY, Leung DWM, He ZD, Zhang JJ, Peng XX, Liu EE.

Plant Cell Rep. 2019 Jun;38(6):731-739. doi: 10.1007/s00299-019-02402-4. Epub 2019 Mar 22.

PMID:
30903268
6.

The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer.

Chanthamontri CK, Jordan DS, Wang W, Wu C, Lin Y, Brett TJ, Gross ML, Leung DW.

Biochemistry. 2019 Feb 12;58(6):657-664. doi: 10.1021/acs.biochem.8b01154. Epub 2019 Jan 10.

PMID:
30592210
7.

Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets.

Basler CF, Krogan NJ, Leung DW, Amarasinghe GK.

Antiviral Res. 2019 Feb;162:90-100. doi: 10.1016/j.antiviral.2018.12.006. Epub 2018 Dec 11. Review.

PMID:
30550800
8.

Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.

Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ.

Cell. 2018 Dec 13;175(7):1917-1930.e13. doi: 10.1016/j.cell.2018.08.044.

PMID:
30550789
9.

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes.

Edwards MR, Liu H, Shabman RS, Ginell GM, Luthra P, Ramanan P, Keefe LJ, Köllner B, Amarasinghe GK, Taylor DJ, Leung DW, Basler CF.

Cell Rep. 2018 Jul 24;24(4):861-872.e6. doi: 10.1016/j.celrep.2018.06.045.

10.

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms.

Warfield KL, Howell KA, Vu H, Geisbert J, Wong G, Shulenin S, Sproule S, Holtsberg FW, Leung DW, Amarasinghe GK, Swenson DL, Bavari S, Kobinger GP, Geisbert TW, Aman MJ.

J Infect Dis. 2018 Nov 22;218(suppl_5):S553-S564. doi: 10.1093/infdis/jiy316.

PMID:
29939318
11.

Phytotoxicity testing of diesel-contaminated water using Petunia grandiflora Juss. Mix F1 and Marigold-Nemo Mix (Tagetes patula L.).

Wante SP, Leung DWM.

Environ Monit Assess. 2018 Jun 17;190(7):408. doi: 10.1007/s10661-018-6790-4.

PMID:
29911298
12.

Race/ethnicity, psychological resilience, and social support among OEF/OIF combat veterans.

Herbert MS, Leung DW, Pittman JOE, Floto E, Afari N.

Psychiatry Res. 2018 Jul;265:265-270. doi: 10.1016/j.psychres.2018.04.052. Epub 2018 May 6.

PMID:
29763847
13.

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.

Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK.

Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8.

14.

LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.

Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW.

J Biol Chem. 2018 Apr 20;293(16):6022-6038. doi: 10.1074/jbc.RA117.001246. Epub 2018 Mar 1.

15.

Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.

Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W, Amarasinghe GK.

Cell. 2018 Feb 22;172(5):966-978.e12. doi: 10.1016/j.cell.2018.02.009.

16.

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A.

Nat Immunol. 2018 Feb;19(2):130-140. doi: 10.1038/s41590-017-0013-y. Epub 2017 Dec 18.

17.

Novel potato plants with enhanced cadmium resistance and antioxidative defence generated after in vitro cell line selection.

Ashrafzadeh S, Leung DWM.

PLoS One. 2017 Oct 2;12(10):e0185621. doi: 10.1371/journal.pone.0185621. eCollection 2017.

18.

Insights into Resistance to Fe Deficiency Stress from a Comparative Study of In Vitro-Selected Novel Fe-Efficient and Fe-Inefficient Potato Plants.

Boamponsem GA, Leung DWM, Lister C.

Front Plant Sci. 2017 Sep 13;8:1581. doi: 10.3389/fpls.2017.01581. eCollection 2017.

19.

Filovirus Strategies to Escape Antiviral Responses.

Olejnik J, Hume AJ, Leung DW, Amarasinghe GK, Basler CF, Mühlberger E.

Curr Top Microbiol Immunol. 2017;411:293-322. doi: 10.1007/82_2017_13. Review.

20.

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW.

Nat Microbiol. 2017 Jun 30;2:17101. doi: 10.1038/nmicrobiol.2017.101.

21.

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.

Xu W, Luthra P, Wu C, Batra J, Leung DW, Basler CF, Amarasinghe GK.

Nat Commun. 2017 Jun 8;8:15576. doi: 10.1038/ncomms15576.

22.

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.

Luthra P, Aguirre S, Yen BC, Pietzsch CA, Sanchez-Aparicio MT, Tigabu B, Morlock LK, García-Sastre A, Leung DW, Williams NS, Fernandez-Sesma A, Bukreyev A, Basler CF.

MBio. 2017 Apr 4;8(2). pii: e00368-17. doi: 10.1128/mBio.00368-17.

23.

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.

Liu G, Nash PJ, Johnson B, Pietzsch C, Ilagan MX, Bukreyev A, Basler CF, Bowlin TL, Moir DT, Leung DW, Amarasinghe GK.

ACS Infect Dis. 2017 Mar 10;3(3):190-198. doi: 10.1021/acsinfecdis.6b00209. Epub 2017 Feb 9.

24.

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2017 Jan 31;91(4). pii: e01715-16. doi: 10.1128/JVI.01715-16. Print 2017 Feb 15.

25.

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses.

Johnson B, Li J, Adhikari J, Edwards MR, Zhang H, Schwarz T, Leung DW, Basler CF, Gross ML, Amarasinghe GK.

J Mol Biol. 2016 Aug 28;428(17):3483-94. doi: 10.1016/j.jmb.2016.07.020. Epub 2016 Aug 4.

26.

Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.

Chatterjee S, Basler CF, Amarasinghe GK, Leung DW.

J Mol Biol. 2016 Aug 28;428(17):3467-82. doi: 10.1016/j.jmb.2016.07.017. Epub 2016 Jul 31. Review.

27.

When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.

Leung DW, Amarasinghe GK.

Curr Opin Struct Biol. 2016 Feb;36:133-41. doi: 10.1016/j.sbi.2016.02.001. Epub 2016 Feb 23. Review.

28.

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.

Edwards MR, Liu G, Mire CE, Sureshchandra S, Luthra P, Yen B, Shabman RS, Leung DW, Messaoudi I, Geisbert TW, Amarasinghe GK, Basler CF.

Cell Rep. 2016 Feb 23;14(7):1632-1640. doi: 10.1016/j.celrep.2016.01.049. Epub 2016 Feb 11.

29.

Divergent biochemical and enzymatic properties of oxalate oxidase isoforms encoded by four similar genes in rice.

Li XC, Liao YY, Leung DW, Wang HY, Chen BL, Peng XX, Liu EE.

Phytochemistry. 2015 Oct;118:216-23. doi: 10.1016/j.phytochem.2015.08.019. Epub 2015 Sep 4.

PMID:
26347131
30.

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.

Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK.

Cell Rep. 2015 Apr 21;11(3):376-89. doi: 10.1016/j.celrep.2015.03.034. Epub 2015 Apr 9.

31.

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

Luthra P, Jordan DS, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2015 May;89(9):5148-53. doi: 10.1128/JVI.03652-14. Epub 2015 Mar 4.

32.

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK.

Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008.

33.

The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway.

Edwards MR, Johnson B, Mire CE, Xu W, Shabman RS, Speller LN, Leung DW, Geisbert TW, Amarasinghe GK, Basler CF.

Cell Rep. 2014 Mar 27;6(6):1017-1025. doi: 10.1016/j.celrep.2014.01.043. Epub 2014 Mar 13.

34.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK.

J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1.

35.

Relationship between disease resistance and rice oxalate oxidases in transgenic rice.

Zhang XY, Nie ZH, Wang WJ, Leung DW, Xu DG, Chen BL, Chen Z, Zeng LX, Liu EE.

PLoS One. 2013 Oct 24;8(10):e78348. doi: 10.1371/journal.pone.0078348. eCollection 2013.

36.

Development of RNA aptamers targeting Ebola virus VP35.

Binning JM, Wang T, Luthra P, Shabman RS, Borek DM, Liu G, Xu W, Leung DW, Basler CF, Amarasinghe GK.

Biochemistry. 2013 Nov 26;52(47):8406-19. doi: 10.1021/bi400704d. Epub 2013 Nov 14.

37.

Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.

Luthra P, Ramanan P, Mire CE, Weisend C, Tsuda Y, Yen B, Liu G, Leung DW, Geisbert TW, Ebihara H, Amarasinghe GK, Basler CF.

Cell Host Microbe. 2013 Jul 17;14(1):74-84. doi: 10.1016/j.chom.2013.06.010.

38.

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.

Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20661-6. doi: 10.1073/pnas.1213559109. Epub 2012 Nov 26.

39.

Structural insights into RNA recognition and activation of RIG-I-like receptors.

Leung DW, Amarasinghe GK.

Curr Opin Struct Biol. 2012 Jun;22(3):297-303. doi: 10.1016/j.sbi.2012.03.011. Epub 2012 May 2. Review.

40.

Aptamers in virology: recent advances and challenges.

Binning JM, Leung DW, Amarasinghe GK.

Front Microbiol. 2012 Feb 8;3:29. doi: 10.3389/fmicb.2012.00029. eCollection 2012.

41.

Molecular mechanisms of viral inhibitors of RIG-I-like receptors.

Leung DW, Basler CF, Amarasinghe GK.

Trends Microbiol. 2012 Mar;20(3):139-46. doi: 10.1016/j.tim.2011.12.005. Epub 2012 Feb 8. Review.

42.

DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function.

Shabman RS, Leung DW, Johnson J, Glennon N, Gulcicek EE, Stone KL, Leung L, Hensley L, Amarasinghe GK, Basler CF.

J Infect Dis. 2011 Nov;204 Suppl 3:S911-8. doi: 10.1093/infdis/jir343.

43.

Filoviral immune evasion mechanisms.

Ramanan P, Shabman RS, Brown CS, Amarasinghe GK, Basler CF, Leung DW.

Viruses. 2011 Sep;3(9):1634-49. doi: 10.3390/v3091634. Epub 2011 Sep 7. Review.

44.

The protective effect of sodium nitroprusside (SNP) treatment on Arabidopsis thaliana seedlings exposed to toxic level of Pb is not linked to avoidance of Pb uptake.

Phang IC, Leung DW, Taylor HH, Burritt DJ.

Ecotoxicol Environ Saf. 2011 Jul;74(5):1310-5. doi: 10.1016/j.ecoenv.2011.02.006. Epub 2011 Mar 3.

PMID:
21376397
45.

Improved rapid detection of trypsin isoinhibitors using non-denaturing polyacrylamide gels with immobilised azoalbumin.

Alizadeh H, Leung DW.

Phytochem Anal. 2011 Jul-Aug;22(4):374-7. doi: 10.1002/pca.1290. Epub 2010 Dec 30.

PMID:
21204154
46.

Ebolavirus VP35 is a multifunctional virulence factor.

Leung DW, Prins KC, Basler CF, Amarasinghe GK.

Virulence. 2010 Nov-Dec;1(6):526-31. Epub 2010 Nov 1.

47.

Conidiogenic effects of mannose-binding lectins isolated from cotyledons of red kidney bean (Phaseolus vulgaris) on Alternaria alternata.

Alizadeh H, Leung DW, Cole AL.

Phytochemistry. 2011 Jan;72(1):94-9. doi: 10.1016/j.phytochem.2010.11.002. Epub 2010 Nov 25.

PMID:
21112064
48.

Characterization of activity of a potential food-grade leucine aminopeptidase from kiwifruit.

Premarathne AA, Leung DW.

Enzyme Res. 2010 Nov 4;2010:517283. doi: 10.4061/2010/517283.

49.

Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function.

Prins KC, Binning JM, Shabman RS, Leung DW, Amarasinghe GK, Basler CF.

J Virol. 2010 Oct;84(20):10581-91. doi: 10.1128/JVI.00925-10. Epub 2010 Aug 4.

50.

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):689-92. doi: 10.1107/S1744309110013266. Epub 2010 May 27.

Supplemental Content

Loading ...
Support Center