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Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes.

Ma DL, Wu C, Liu H, Wu KJ, Leung CH.

J Mater Chem B. 2019 Oct 24. doi: 10.1039/c9tb01889a. [Epub ahead of print] Review.


Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors.

Leung CH, Zhang JT, Yang GJ, Liu H, Han QB, Ma DL.

Int J Mol Sci. 2019 Sep 10;20(18). pii: E4445. doi: 10.3390/ijms20184445. Review.


A simple iridium(III) dimer as a switch-on luminescent chemosensor for carbon disulfide detection in water samples.

Liu JB, Wu C, Chen F, Leung CH, Ma DL.

Anal Chim Acta. 2019 Nov 20;1083:166-171. doi: 10.1016/j.aca.2019.07.070. Epub 2019 Aug 2.


Rebalancing metal dyshomeostasis for Alzheimer's disease therapy.

Yang GJ, Liu H, Ma DL, Leung CH.

J Biol Inorg Chem. 2019 Sep 5. doi: 10.1007/s00775-019-01712-y. [Epub ahead of print] Review.


Understanding the Composition of a Successful Tweet in Urology.

Teoh JY, Mackenzie G, Smith M, Yuen SK, Gudaru K, Leow JJ, Leung CH, Ng CF, Loeb S.

Eur Urol Focus. 2019 Aug 28. pii: S2405-4569(19)30226-3. doi: 10.1016/j.euf.2019.08.008. [Epub ahead of print]


Synthesis and Evaluation of Dibenzothiophene Analogues as Pin1 Inhibitors for Cervical Cancer Therapy.

Wu KJ, Liu X, Wong SY, Zhou Y, Ma DL, Leung CH.

ACS Omega. 2019 May 24;4(5):9228-9234. doi: 10.1021/acsomega.9b00281. eCollection 2019 May 31.


Diabetic status and the relationship of blood glucose to mortality in adults with carbapenem-resistant Acinetobacter baumannii complex bacteremia.

Leung CH, Liu CP.

J Microbiol Immunol Infect. 2019 Aug;52(4):654-662. doi: 10.1016/j.jmii.2018.06.005. Epub 2018 Jul 2.


Is papillary thyroid microcarcinoma a biologically different disease? A propensity score-matched analysis.

Hsu YC, Lee JJ, Chien MN, Chen MJ, Leung CH, Cheng SP.

J Surg Oncol. 2019 Nov;120(6):1023-1030. doi: 10.1002/jso.25670. Epub 2019 Aug 12.


Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells.

Ma DL, Wu C, Wu KJ, Leung CH.

Molecules. 2019 Jul 28;24(15). pii: E2739. doi: 10.3390/molecules24152739. Review.


Oligosaccharide-marker approach for qualitative and quantitative analysis of specific polysaccharide in herb formula by ultra-high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry: Dendrobium officinale, a case study.

Wong TL, Li LF, Zhang JX, Bai SP, Zhou LS, Fung HY, Zhang QW, Ma DL, Leung CH, Zhao ZZ, Han QB.

J Chromatogr A. 2019 Dec 6;1607:460388. doi: 10.1016/j.chroma.2019.460388. Epub 2019 Jul 21.


An iridium(III) complex/G-quadruplex ensemble for detection of ochratoxin A based on long-lifetime luminescent.

Zhang JT, Kang TS, Wong SY, Pei RJ, Ma DL, Leung CH.

Anal Biochem. 2019 Sep 1;580:49-55. doi: 10.1016/j.ab.2019.06.005. Epub 2019 Jun 11.


Aurone derivatives as Vps34 inhibitors that modulate autophagy.

Li G, Boyle JW, Ko CN, Zeng W, Wong VKW, Wan JB, Chan PWH, Ma DL, Leung CH.

Acta Pharm Sin B. 2019 May;9(3):537-544. doi: 10.1016/j.apsb.2019.01.016. Epub 2019 Jan 30.


Outcomes of transperineal and transrectal ultrasound-guided prostate biopsy.

Lo KL, Chui KL, Leung CH, Ma SF, Lim K, Ng T, Wong J, Li JKM, Mak SK, Ng CF.

Hong Kong Med J. 2019 Jun;25(3):209-215. doi: 10.12809/hkmj187599. Epub 2019 May 29.


Streptococcus bovis Endocarditis after Colonic Polypectomy.

Chongprasertpon N, Cusack R, Coughlan JJ, Chung WT, Leung CH, Kiernan TJ.

Eur J Case Rep Intern Med. 2019 May 8;6(5):001110. doi: 10.12890/2019_001110. eCollection 2019.


A portable oligonucleotide-based microfluidic device for the detection of VEGF165 in a three-step suspended-droplet mode.

Ko CN, Sun H, Wu KJ, Leung CH, Ren K, Ma DL.

Dalton Trans. 2019 Jul 2;48(26):9824-9830. doi: 10.1039/c9dt00427k.


A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(iii) complexes.

Wu C, Wu KJ, Liu JB, Zhou XM, Leung CH, Ma DL.

Chem Commun (Camb). 2019 May 30;55(45):6353-6356. doi: 10.1039/c9cc02189b.


Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis.

Bao WR, Li ZP, Zhang QW, Li LF, Liu HB, Ma DL, Leung CH, Lu AP, Bian ZX, Han QB.

Front Pharmacol. 2019 Feb 11;9:1580. doi: 10.3389/fphar.2018.01580. eCollection 2018.


Iridium(III)-based chemosensors for the detection of metal ions.

Ma DL, Wong SY, Kang TS, Ng HP, Han QB, Leung CH.

Methods. 2019 Sep 15;168:3-17. doi: 10.1016/j.ymeth.2019.02.013. Epub 2019 Feb 20. Review.


Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies.

Ma DL, Wu C, Cheng SS, Lee FW, Han QB, Leung CH.

Int J Mol Sci. 2019 Jan 15;20(2). pii: E341. doi: 10.3390/ijms20020341. Review.


Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines.

Yang GJ, Ko CN, Zhong HJ, Leung CH, Ma DL.

Cancers (Basel). 2019 Jan 15;11(1). pii: E92. doi: 10.3390/cancers11010092.


Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men.

Teoh JY, Chan CK, Wang MH, Leung CH, Chan ES, Chiu PK, Yee CH, Wong HM, Hou SS, Ng CF.

Asian J Androl. 2019 Sep-Oct;21(5):468-472. doi: 10.4103/aja.aja_101_18.


An Increased Neutrophil-to-Lymphocyte Ratio Predicts Incomplete Response to Therapy in Differentiated Thyroid Cancer.

Lee F, Yang PS, Chien MN, Lee JJ, Leung CH, Cheng SP.

Int J Med Sci. 2018 Nov 23;15(14):1757-1763. doi: 10.7150/ijms.28498. eCollection 2018.


A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2.

Vellaisamy K, Li G, Wang W, Leung CH, Ma DL.

Chem Sci. 2018 Oct 1;9(43):8171-8177. doi: 10.1039/c8sc02733a. eCollection 2018 Nov 21.


Silver nanoclusters functionalized with Ce(III) ions are a viable "turn-on-off" fluorescent probe for sulfide.

Liu J, Bao H, Ma DL, Leung CH.

Mikrochim Acta. 2018 Dec 12;186(1):16. doi: 10.1007/s00604-018-3149-z.


Pharmacological Inhibition of LSD1 for Cancer Treatment.

Yang GJ, Lei PM, Wong SY, Ma DL, Leung CH.

Molecules. 2018 Dec 4;23(12). pii: E3194. doi: 10.3390/molecules23123194. Review.


A Territory-wide, Multicenter, Age- and Prostate-specific Antigen-matched Study Comparing Chemohormonal Therapy and Hormonal Therapy Alone in Chinese Men With Metastatic Hormone-sensitive Prostate Cancer.

Teoh JYC, Poon DMC, Lam D, Chan T, Chan MFT, Lee EKC, Law S, Chan K, Cheng NM, Lai KM, Leung CH, Ng CF.

Clin Genitourin Cancer. 2019 Feb;17(1):e203-e208. doi: 10.1016/j.clgc.2018.10.010. Epub 2018 Oct 27.


Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock.

Leung CH, Caldarone CA, Guan R, Wen XY, Ailenberg M, Kapus A, Szaszi K, Rotstein OD.

Antioxid Redox Signal. 2019 May 10;30(14):1760-1773. doi: 10.1089/ars.2018.7541. Epub 2018 Dec 20.


A Multicentre Evaluation of the Role of the Prostate Health Index (PHI) in Regions with Differing Prevalence of Prostate Cancer: Adjustment of PHI Reference Ranges is Needed for European and Asian Settings.

Chiu PK, Ng CF, Semjonow A, Zhu Y, Vincendeau S, Houlgatte A, Lazzeri M, Guazzoni G, Stephan C, Haese A, Bruijne I, Teoh JY, Leung CH, Casale P, Chiang CH, Tan LG, Chiong E, Huang CY, Wu HC, Nieboer D, Ye DW, Bangma CH, Roobol MJ.

Eur Urol. 2019 Apr;75(4):558-561. doi: 10.1016/j.eururo.2018.10.047. Epub 2018 Nov 2.


Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response.

Kang TS, Ko CN, Zhang JT, Wu C, Wong CY, Ma DL, Leung CH.

Inorg Chem. 2018 Nov 19;57(22):14023-14026. doi: 10.1021/acs.inorgchem.8b02256. Epub 2018 Oct 30.


Iridium(iii) complexes as reaction based chemosensors for medical diagnostics.

Ma DL, Ng HP, Wong SY, Vellaisamy K, Wu KJ, Leung CH.

Dalton Trans. 2018 Nov 21;47(43):15278-15282. doi: 10.1039/c8dt03492c. Epub 2018 Oct 1. Review.


Recent progress and developments of iridium-based compounds as probes for environmental analytes.

Kang TS, Zhang JT, Vellaisamy K, Ma DL, Leung CH.

Dalton Trans. 2018 Oct 2;47(38):13314-13317. doi: 10.1039/c8dt01167b.


Iridium-based probe for luminescent nitric oxide monitoring in live cells.

Wu C, Wu KJ, Kang TS, Wang HD, Leung CH, Liu JB, Ma DL.

Sci Rep. 2018 Aug 20;8(1):12467. doi: 10.1038/s41598-018-30991-9.


UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids.

He J, Chen K, Hu ZM, Li K, Song W, Yu LY, Leung CH, Ma DL, Qiao X, Ye M.

Chem Commun (Camb). 2018 Aug 11;54(62):8594-8597. doi: 10.1039/c8cc04215b. Epub 2018 Jul 16.


Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy.

Yang GJ, Wang W, Mok SWF, Wu C, Law BYK, Miao XM, Wu KJ, Zhong HJ, Wong CY, Wong VKW, Ma DL, Leung CH.

Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13091-13095. doi: 10.1002/anie.201807305. Epub 2018 Jul 19.


Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation.

Li ZP, Liu HB, Zhang QW, Li LF, Bao WR, Ma DL, Leung CH, Bian ZX, Lu AP, Han QB.

Molecules. 2018 Jun 28;23(7). pii: E1563. doi: 10.3390/molecules23071563.


The concurrent validity of the Internet Addiction Test (IAT) and the Mobile Phone Dependence Questionnaire (MPDQ).

Chin F, Leung CH.

PLoS One. 2018 Jun 26;13(6):e0197562. doi: 10.1371/journal.pone.0197562. eCollection 2018.


Trial Protocol: The use of mindfulness-based intervention for improving bracing compliance for adolescent idiopathic scoliosis patients: protocol for a randomised, controlled trial.

Yip BHK, Li X, Leung CHY, Gao T, Chung VCH, Yu FWP, Lam TP, Cheng JCY, Wong SYS.

J Physiother. 2018 Jul;64(3):193. doi: 10.1016/j.jphys.2018.02.019. Epub 2018 Jun 12.


Silencing Stem Cell Factor Gene in Fibroblasts to Regulate Paracrine Factor Productions and Enhance c-Kit Expression in Melanocytes on Melanogenesis.

Li PH, Liu LH, Chang CC, Gao R, Leung CH, Ma DL, David Wang HM.

Int J Mol Sci. 2018 May 16;19(5). pii: E1475. doi: 10.3390/ijms19051475.


Cell imaging of dopamine receptor using agonist labeling iridium(iii) complex.

Vellaisamy K, Li G, Ko CN, Zhong HJ, Fatima S, Kwan HY, Wong CY, Kwong WJ, Tan W, Leung CH, Ma DL.

Chem Sci. 2017 Dec 19;9(5):1119-1125. doi: 10.1039/c7sc04798c. eCollection 2018 Feb 7.


Fracture risk prediction using FRAX in patients following hematopoietic stem cell transplantation.

Pundole X, Murphy WA, Ebede CC, Karim E, Manocha S, Don-Pedro D, Rondon G, Leung CH, Liu S, Du XL, Champlin RE, Lu H.

Arch Osteoporos. 2018 Apr 4;13(1):38. doi: 10.1007/s11657-018-0453-5.


Analysis of HSP27 and the Autophagy Marker LC3B+ Puncta Following Preoperative Chemotherapy Identifies High-Risk Osteosarcoma Patients.

Livingston JA, Wang WL, Tsai JW, Lazar AJ, Leung CH, Lin H, Advani S, Daw N, Santiago-O'Farrill J, Hollomon M, Gordon NB, Kleinerman ES.

Mol Cancer Ther. 2018 Jun;17(6):1315-1323. doi: 10.1158/1535-7163.MCT-17-0901. Epub 2018 Mar 28.


Hemorrhagic Shock/Resuscitation Reduces the M2 Phenotype of Alveolar Macrophages: A Potential Mechanism Contributing to Increased LPS-Induced Lung Injury.

Safavian D, Leung CH, Kapus A, Ailenberg M, Szaszi K, Shani R, Di Ciano-Oliveira C, Ghazarian M, Rotstein O.

Shock. 2019 Feb;51(2):213-220. doi: 10.1097/SHK.0000000000001135.


Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells.

Yang GJ, Zhong HJ, Ko CN, Wong SY, Vellaisamy K, Ye M, Ma DL, Leung CH.

Chem Commun (Camb). 2018 Mar 6;54(20):2463-2466. doi: 10.1039/c7cc09384e.


Small Molecule Pin1 Inhibitor Blocking NF-κB Signaling in Prostate Cancer Cells.

Wu KJ, Zhong HJ, Yang G, Wu C, Huang JM, Li G, Ma DL, Leung CH.

Chem Asian J. 2018 Feb 2;13(3):275-279. doi: 10.1002/asia.201701216. Epub 2018 Jan 15.


Luminescent Iridium(III) Chemosensor for Tandem Detection of F- and Al3.

Liu JB, Wang W, Li G, Wang RX, Leung CH, Ma DL.

ACS Omega. 2017 Dec 21;2(12):9150-9155. doi: 10.1021/acsomega.7b01646. eCollection 2017 Dec 31.


Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing.

Wu KJ, Zhong HJ, Li G, Liu C, Wang HD, Ma DL, Leung CH.

Eur J Med Chem. 2018 Jan 1;143:1021-1027. doi: 10.1016/j.ejmech.2017.11.101. Epub 2017 Dec 6.


Clinical Activity of Pazopanib in Patients with Advanced Desmoplastic Small Round Cell Tumor.

Menegaz BA, Cuglievan B, Benson J, Camacho P, Lamhamedi-Cherradi SE, Leung CH, Warneke CL, Huh W, Subbiah V, Benjamin RS, Patel S, Daw N, Hayes-Jordan A, Ludwig JA.

Oncologist. 2018 Mar;23(3):360-366. doi: 10.1634/theoncologist.2017-0408. Epub 2017 Dec 6.


Real-time detection of oxalyl chloride based on a long-lived iridium(iii) probe.

Wu C, Li G, Han QB, Pei RJ, Liu JB, Ma DL, Leung CH.

Dalton Trans. 2017 Dec 12;46(48):17074-17079. doi: 10.1039/c7dt04054g.


Metalated Chromene and Chromone Complexes: pH Switchable Metal-Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity.

Ng SW, Chung LH, Yeung CF, Lo HS, Shek HL, Kang TS, Leung CH, Ma DL, Wong CY.

Chemistry. 2018 Feb 6;24(8):1779-1783. doi: 10.1002/chem.201705450. Epub 2017 Dec 7.


Ruling out dark matter interpretation of the galactic GeV excess by gamma-ray data of galaxy clusters.

Chan MH, Leung CH.

Sci Rep. 2017 Nov 2;7(1):14895. doi: 10.1038/s41598-017-14950-4.

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