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CD9 blockade suppresses disease progression of high-risk pediatric B-cell precursor acute lymphoblastic leukemia and enhances chemosensitivity.

Leung KT, Zhang C, Chan KYY, Li K, Cheung JTK, Ng MHL, Zhang XB, Sit T, Lee WYW, Kang W, To KF, Yu JWS, Man TKF, Wang H, Tsang KS, Cheng FWT, Lam GKS, Chow TW, Leung AWK, Leung TF, Yuen PMP, Ng PC, Li CK.

Leukemia. 2019 Oct 17. doi: 10.1038/s41375-019-0593-7. [Epub ahead of print]


Sexual function, self-esteem, and general well-being in Chinese adult survivors of childhood cancers: a cross-sectional survey.

Ng CF, Hong CYL, Lau BSY, Teoh JYC, Yee SCH, Leung AWK, Yuen JWM.

Hong Kong Med J. 2019 Oct;25(5):372-381. doi: 10.12809/hkmj197913. Epub 2019 Oct 9.


Identifying psychological predictors of adherence to a community-based lifestyle modification program for weight loss among Chinese overweight and obese adults.

Leung AWY, Chan RSM, Sea MMM, Woo J.

Nutr Res Pract. 2019 Oct;13(5):415-424. doi: 10.4162/nrp.2019.13.5.415. Epub 2019 Aug 30.


Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use.

Chen KTJ, Anantha M, Leung AWY, Kulkarni JA, Militao GGC, Wehbe M, Sutherland B, Cullis PR, Bally MB.

Drug Deliv Transl Res. 2019 Sep 3. doi: 10.1007/s13346-019-00674-7. [Epub ahead of print]


WNT/β-catenin modulates the axial identity of embryonic stem cell-derived human neural crest.

Gomez GA, Prasad MS, Wong M, Charney RM, Shelar PB, Sandhu N, Hackland JOS, Hernandez JC, Leung AW, García-Castro MI.

Development. 2019 Aug 29;146(16). pii: dev175604. doi: 10.1242/dev.175604.


Recent Treatment Advances and the Role of Nanotechnology, Combination Products, and Immunotherapy in Changing the Therapeutic Landscape of Acute Myeloid Leukemia.

Chen KTJ, Gilabert-Oriol R, Bally MB, Leung AWY.

Pharm Res. 2019 Jun 24;36(9):125. doi: 10.1007/s11095-019-2654-z. Review.


Understanding the effect of repeated administration of meloxicam on feline renal cortex and medulla: A lipidomics and metabolomics approach.

Rivera-Velez SM, Broughton-Neiswanger LE, Suarez MA, Slovak JE, Hwang JK, Navas J, Leung AWS, Piñeyro PE, Villarino NF.

J Vet Pharmacol Ther. 2019 Jul;42(4):476-486. doi: 10.1111/jvp.12788. Epub 2019 Jun 12.


An adherent-cell depletion technique to generate human neural progenitors and neurons.

Leung AW, Li JYH.

J Cell Physiol. 2019 Nov;234(11):19933-19941. doi: 10.1002/jcp.28591. Epub 2019 Apr 10.


Curcumin-mediated photodynamic inactivation (PDI) against DH5α contaminated in oysters and cellular toxicological evaluation of PDI-treated oysters.

Gao Y, Wu J, Li Z, Zhang X, Lu N, Xue C, Leung AW, Xu C, Tang Q.

Photodiagnosis Photodyn Ther. 2019 Jun;26:244-251. doi: 10.1016/j.pdpdt.2019.04.002. Epub 2019 Apr 3.


What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Leung AWY, Amador C, Wang LC, Mody UV, Bally MB.

Pharmaceutics. 2019 Mar 16;11(3). pii: E124. doi: 10.3390/pharmaceutics11030124. Review.


Corrigendum to "Next generation organoids for biomedical research and applications" [Biotechnology Advances 36 (2018) 132-149].

Lou YR, Leung AW.

Biotechnol Adv. 2019 May - Jun;37(3):505. doi: 10.1016/j.biotechadv.2019.03.001. Epub 2019 Mar 8. No abstract available.


Human neural crest induction by temporal modulation of WNT activation.

Gomez GA, Prasad MS, Sandhu N, Shelar PB, Leung AW, García-Castro MI.

Dev Biol. 2019 May 15;449(2):99-106. doi: 10.1016/j.ydbio.2019.02.015. Epub 2019 Mar 1.


A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy.

Xiao Q, Zhu W, Feng W, Lee SS, Leung AW, Shen J, Gao L, Xu C.

Front Pharmacol. 2019 Jan 9;9:1534. doi: 10.3389/fphar.2018.01534. eCollection 2018. Review.


Relationship between body image and health-related quality of life in Chinese cancer survivors during the transitional cancer survivorship.

Chow KM, Chan CWH, Leung AWY, Wong MMH, Choi KC.

Psychooncology. 2019 Feb;28(2):324-328. doi: 10.1002/pon.4943. Epub 2018 Dec 3.


Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong.

Liu APY, Ip JJK, Leung AWK, Luk CW, Li CH, Ho KKH, Lo R, Chan EKW, Chan ACY, Chung PHY, Chiang AKS.

Pediatr Blood Cancer. 2019 Jan;66(1):e27482. doi: 10.1002/pbc.27482. Epub 2018 Sep 30.


Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response.

Gilabert-Oriol R, Ryan GM, Leung AWY, Firmino NS, Bennewith KL, Bally MB.

Int J Mol Sci. 2018 Sep 26;19(10). pii: E2922. doi: 10.3390/ijms19102922. Review.


Sonodynamic bactericidal activity of curcumin against foodborne bacteria.

Xu CS, Ip M, Leung AW, Wang XN, Yang ZR, Zhang BT, Ip SP.

Hong Kong Med J. 2018 Oct;24 Suppl 6(5):43-44. No abstract available.


Design of an Amphiphilic iRGD Peptide and Self-Assembling Nanovesicles for Improving Tumor Accumulation and Penetration and the Photodynamic Efficacy of the Photosensitizer.

Jiang Y, Pang X, Liu R, Xiao Q, Wang P, Leung AW, Luan Y, Xu C.

ACS Appl Mater Interfaces. 2018 Sep 19;10(37):31674-31685. doi: 10.1021/acsami.8b11699. Epub 2018 Sep 5.


Copper-CX-5461: A novel liposomal formulation for a small molecule rRNA synthesis inhibitor.

Leung AWY, Anantha M, Dragowska WH, Wehbe M, Bally MB.

J Control Release. 2018 Sep 28;286:1-9. doi: 10.1016/j.jconrel.2018.07.025. Epub 2018 Jul 18.


Proteomic analysis reveals that pheophorbide a-mediated photodynamic treatment inhibits prostate cancer growth by hampering GDP-GTP exchange of ras-family proteins.

Xu DD, Xu CB, Lam HM, Wong FL, Leung AWN, Leong MML, Cho WCS, Hoeven R, Lv Q, Rong R.

Photodiagnosis Photodyn Ther. 2018 Sep;23:35-39. doi: 10.1016/j.pdpdt.2018.05.014. Epub 2018 May 22.


Different neural activities support auditory working memory in musicians and bilinguals.

Alain C, Khatamian Y, He Y, Lee Y, Moreno S, Leung AWS, Bialystok E.

Ann N Y Acad Sci. 2018 May 17. doi: 10.1111/nyas.13717. [Epub ahead of print]


Outcomes and morbidities of patients who survive haemoglobin Bart's hydrops fetalis syndrome: 20-year retrospective review.

Chan WY, Leung AW, Luk CW, Li RC, Ling AS, Ha SY.

Hong Kong Med J. 2018 Apr;24(2):107-118. doi: 10.12809/hkmj176336. Epub 2018 Apr 6.


Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461.

Prosser KE, Leung AWY, Harrypersad S, Lewis AR, Bally MB, Walsby CJ.

Chemistry. 2018 Apr 25;24(24):6334-6338. doi: 10.1002/chem.201800289. Epub 2018 Apr 6.


Mutations in Hnrnpa1 cause congenital heart defects.

Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ.

JCI Insight. 2018 Jan 25;3(2). pii: 98555. doi: 10.1172/jci.insight.98555. eCollection 2018 Jan 25.


Gemtuzumab Ozogamicin Containing Chemotherapy for Relapsed or Refractory Acute Myeloid Leukemia (AML) in Children.

Liu AP, Leung AW, Cheuk DK, Lee V, Ha SY.

J Pediatr Hematol Oncol. 2018 Mar;40(2):163-168. doi: 10.1097/MPH.0000000000001010. No abstract available.


The Molecular Pathway Regulating Bergmann Glia and Folia Generation in the Cerebellum.

Leung AW, Li JYH.

Cerebellum. 2018 Feb;17(1):42-48. doi: 10.1007/s12311-017-0904-3. Review.


Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies.

Lu Z, Lai ZQ, Leung AWN, Leung PS, Li ZS, Lin ZX.

Oncotarget. 2017 May 10;8(49):84974-84985. doi: 10.18632/oncotarget.17761. eCollection 2017 Oct 17.


Next generation organoids for biomedical research and applications.

Lou YR, Leung AW.

Biotechnol Adv. 2018 Jan - Feb;36(1):132-149. doi: 10.1016/j.biotechadv.2017.10.005. Epub 2017 Oct 19. Review. Erratum in: Biotechnol Adv. 2019 May - Jun;37(3):505.


Differences in definitive endoderm induction approaches using growth factors and small molecules.

Bogacheva MS, Khan S, Kanninen LK, Yliperttula M, Leung AW, Lou YR.

J Cell Physiol. 2018 Apr;233(4):3578-3589. doi: 10.1002/jcp.26214. Epub 2017 Nov 23.


Number Line Estimation Predicts Mathematical Skills: Difference in Grades 2 and 4.

Zhu M, Cai D, Leung AWS.

Front Psychol. 2017 Sep 12;8:1576. doi: 10.3389/fpsyg.2017.01576. eCollection 2017.


First Report of a Novel Deletion Due to εγδβ-Thalassemia in a Chinese Family.

Hui ASY, Au PKC, Ting YH, Kan ASY, Cheng YKY, Leung AWK, Chan KYK, Li CK, Tang MHY, Leung TY.

Hemoglobin. 2017 May;41(3):175-179. doi: 10.1080/03630269.2017.1366918.


Sonodynamic bactericidal efficacy of hypocrellin A and B against methicillin-resistant Staphylococcus aureus.

Leung AW, Ip M, Xu CS, Wang XN, Yung PT, Hua HY.

Hong Kong Med J. 2017 Aug;23 Suppl 5(4):36-37. No abstract available.


Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy.

Xiao Q, Wu J, Pang X, Jiang Y, Wang P, Leung AW, Gao L, Jiang S, Xu C.

Curr Med Chem. 2018;25(7):839-860. doi: 10.2174/0929867324666170823143137. Review.


An Overview of Factors Associated with Adherence to Lifestyle Modification Programs for Weight Management in Adults.

Leung AWY, Chan RSM, Sea MMM, Woo J.

Int J Environ Res Public Health. 2017 Aug 16;14(8). pii: E922. doi: 10.3390/ijerph14080922. Review.


In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.

Leung AWY, Veinotte CJ, Melong N, Oh MH, Chen K, Enfield KSS, Backstrom I, Warburton C, Yapp D, Berman JN, Bally MB, Lockwood WW.

Clin Cancer Res. 2017 Nov 1;23(21):6555-6566. doi: 10.1158/1078-0432.CCR-17-0700. Epub 2017 Aug 8.


Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status.

Wehbe M, Lo C, Leung AWY, Dragowska WH, Ryan GM, Bally MB.

Invest New Drugs. 2017 Dec;35(6):682-690. doi: 10.1007/s10637-017-0488-2. Epub 2017 Jul 21.


Efficacy of abdominal acupuncture for neck pain: A randomized controlled trial.

Ho LF, Lin ZX, Leung AWN, Chen L, Zhang H, Ng BFL, Ziea ETC, Guo Y.

PLoS One. 2017 Jul 17;12(7):e0181360. doi: 10.1371/journal.pone.0181360. eCollection 2017.


A Perspective - can copper complexes be developed as a novel class of therapeutics?

Wehbe M, Leung AWY, Abrams MJ, Orvig C, Bally MB.

Dalton Trans. 2017 Aug 22;46(33):10758-10773. doi: 10.1039/c7dt01955f. Review.


Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent.

Wehbe M, Anantha M, Shi M, Leung AW, Dragowska WH, Sanche L, Bally MB.

Int J Nanomedicine. 2017 May 31;12:4129-4146. doi: 10.2147/IJN.S137347. eCollection 2017.


Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia.

Heng X, Guo Q, Leung AW, Li JY.

Elife. 2017 May 10;6. pii: e23253. doi: 10.7554/eLife.23253.


Hepatitis B infection acquired after haematopioetic stem cell transplant through horizontal mode.

Chan MCW, Cheng FWT, Sze KH, Wong AH, Leung AWK, Chan PKS, Li CK.

J Med Virol. 2017 Oct;89(10):1882-1884. doi: 10.1002/jmv.24835. Epub 2017 May 23.


A simple passive equilibration method for loading carboplatin into pre-formed liposomes incubated with ethanol as a temperature dependent permeability enhancer.

Wehbe M, Malhotra A, Anantha M, Roosendaal J, Leung AWY, Plackett D, Edwards K, Gilabert-Oriol R, Bally MB.

J Control Release. 2017 Apr 28;252:50-61. doi: 10.1016/j.jconrel.2017.03.010. Epub 2017 Mar 10.


Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathway.

Jia Y, Wang X, Liu Q, Leung AW, Wang P, Xu C.

Ultrasonics. 2017 Jan;73:154-161. doi: 10.1016/j.ultras.2016.09.013. Epub 2016 Sep 13.


The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia.

Li X, Li Z, Li K, Zeng YW, Shi HS, Xie WL, Yang ZY, Lui SS, Cheung EF, Leung AW, Chan RC.

Sci Rep. 2016 Oct 18;6:35481. doi: 10.1038/srep35481.


Synthetic lethality in lung cancer and translation to clinical therapies.

Leung AW, de Silva T, Bally MB, Lockwood WW.

Mol Cancer. 2016 Sep 29;15(1):61. Review.


Neural Plastic Effects of Working Memory Training Influenced by Self-perceived Stress in Stroke: A Case Illustration.

Leung AW, Barrett LM, Butterworth D, Werther K, Dawson DR, Brintnell ES.

Front Psychol. 2016 Aug 30;7:1266. doi: 10.3389/fpsyg.2016.01266. eCollection 2016.


Palmatine hydrochloride mediated photodynamic inactivation of breast cancer MCF-7 cells: Effectiveness and mechanism of action.

Wu J, Xiao Q, Zhang N, Xue C, Leung AW, Zhang H, Tang QJ, Xu C.

Photodiagnosis Photodyn Ther. 2016 Sep;15:133-8. doi: 10.1016/j.pdpdt.2016.07.006. Epub 2016 Jul 18.


Acupuncture for Detoxification in Treatment of Opioid Addiction.

Wu SL, Leung AW, Yew DT.

East Asian Arch Psychiatry. 2016 Jun;26(2):70-6. Review.


Sulfonation, an underexploited area: from skeletal development to infectious diseases and cancer.

Leung AW, Backstrom I, Bally MB.

Oncotarget. 2016 Aug 23;7(34):55811-55827. doi: 10.18632/oncotarget.10046. Review.


Electroacupuncture and splinting versus splinting alone to treat carpal tunnel syndrome: a randomized controlled trial.

Chung VCH, Ho RST, Liu S, Chong MKC, Leung AWN, Yip BHK, Griffiths SM, Zee BCY, Wu JCY, Sit RWS, Lau AYL, Wong SYS.

CMAJ. 2016 Sep 6;188(12):867-875. doi: 10.1503/cmaj.151003. Epub 2016 Jun 6.

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