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Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation.

Chen PJ, Ko IL, Lee CL, Hu HC, Chang FR, Wu YC, Leu YL, Wu CC, Lin CY, Pan CY, Tsai YF, Hwang TL.

EBioMedicine. 2019 Jan 29. pii: S2352-3964(19)30050-7. doi: 10.1016/j.ebiom.2019.01.043. [Epub ahead of print]


Melatonin Inhibits in Vitro Smooth Muscle Cell Inflammation and Proliferation and Atherosclerosis in Apolipoprotein E-Deficient Mice.

Li HY, Leu YL, Wu YC, Wang SH.

J Agric Food Chem. 2019 Feb 5. doi: 10.1021/acs.jafc.8b06217. [Epub ahead of print]


Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.

Cheng KW, Tseng CH, Tzeng CC, Leu YL, Cheng TC, Wang JY, Chang JM, Lu YC, Cheng CM, Chen IJ, Cheng YA, Chen YL, Cheng TL.

Pharmacol Res. 2019 Jan;139:41-49. doi: 10.1016/j.phrs.2018.10.029. Epub 2018 Nov 1.


Designing Novel Poly(oxyalkylene)-segmented Ester based Polymeric Dispersants for Efficient TiO2 Photoanodes of Dye-sensitized Solar Cells.

Leu YA, Lu YA, Yeh MH, Shih PT, Shen SY, Ho KC, Lin JJ.

ACS Appl Mater Interfaces. 2018 Oct 12. doi: 10.1021/acsami.8b09852. [Epub ahead of print]


Prevalence of different carbapenemase genes among carbapenem-resistant Acinetobacter baumannii blood isolates in Taiwan.

Wang TH, Leu YS, Wang NY, Liu CP, Yan TR.

Antimicrob Resist Infect Control. 2018 Oct 11;7:123. doi: 10.1186/s13756-018-0410-5. eCollection 2018.


HIC1 and RassF1A Methylation Attenuates Tubulin Expression and Cell Stiffness in Cancer.

Chen CC, He BC, Chen YL, Lee KD, Tung CH, Hsu CC, Lin PY, Chu PY, Leu YW, Fu WE, Hsiao SH.

Int J Mol Sci. 2018 Sep 22;19(10). pii: E2884. doi: 10.3390/ijms19102884.


The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption.

Alalaiwe A, Hung CF, Leu YL, Tahara K, Chen HH, Hu KY, Fang JY.

Eur J Pharm Sci. 2018 Nov 1;124:114-126. doi: 10.1016/j.ejps.2018.08.031. Epub 2018 Aug 25.


Inflammatory myofibroblastic tumor of the larynx.

Wang YH, Leu YS, Chang WC.

Ear Nose Throat J. 2018 Jul;97(7):190-197. No abstract available.


Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome-A Taiwan Cancer Registry national database analysis.

Cheng YJ, Tsai MH, Chiang CJ, Tsai ST, Liu TW, Lou PJ, Liao CT, Lin JC, Chang JT, Tsai MH, Chu PY, Leu YS, Tsai KY, Terng SD, Chien CY, Yang MH, Hao SP, Wang CC, Tsai MH, Chen HHW, Kuo C, Wu YH.

Cancer Med. 2018 Jun 14. doi: 10.1002/cam4.1611. [Epub ahead of print]


Reversible glycosidic switch for secure delivery of molecular nanocargos.

Burnouf PA, Leu YL, Su YC, Wu K, Lin WC, Roffler SR.

Nat Commun. 2018 May 10;9(1):1843. doi: 10.1038/s41467-018-04225-5.


Quantitative competitive allele-specific TaqMan duplex PCR (qCAST-Duplex PCR) assay: a refined method for highly sensitive and specific detection of JAK2V617F mutant allele burdens.

Hsu CC, Huang CE, Wu YY, Chen YY, Lung J, Leu YW, Li CP, Tsou HY, Chuang WH, Lu CH, Chen CC.

Haematologica. 2018 Oct;103(10):e450-e454. doi: 10.3324/haematol.2018.187989. Epub 2018 May 10. No abstract available.


Propolin C Inhibited Migration and Invasion via Suppression of EGFR-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Cancer Cells.

Pai JT, Lee YC, Chen SY, Leu YL, Weng MS.

Evid Based Complement Alternat Med. 2018 Feb 25;2018:7202548. doi: 10.1155/2018/7202548. eCollection 2018.


Inverse Correlation between Methylation and Expression of the Delta-like Ligand 1 Gene in Gastric Cancer.

Shen CH, Tung SY, Tseng MJ, Leu YW.

Chin J Physiol. 2018 Apr 30;61(2):65-74. doi: 10.4077/CJP.2018.BAG513.


Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5.

Chen CY, Chen CC, Shieh TM, Hsueh C, Wang SH, Leu YL, Lian JH, Wang TH.

Int J Mol Sci. 2018 Jan 27;19(2). pii: E380. doi: 10.3390/ijms19020380.


Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52.

Chen CC, Huang JS, Wang TH, Kuo CH, Wang CJ, Wang SH, Leu YL.

Int J Mol Sci. 2017 Dec 7;18(12). pii: E2655. doi: 10.3390/ijms18122655.


Modulation of HIF-1α and STAT3 signaling contributes to anti-angiogenic effect of YC-1 in mice with liver fibrosis.

Lee TY, Leu YL, Wen CK.

Oncotarget. 2017 Sep 16;8(49):86206-86216. doi: 10.18632/oncotarget.21039. eCollection 2017 Oct 17.


The effects of artocarpin on wound healing: in vitro and in vivo studies.

Yeh CJ, Chen CC, Leu YL, Lin MW, Chiu MM, Wang SH.

Sci Rep. 2017 Nov 15;7(1):15599. doi: 10.1038/s41598-017-15876-7.


Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity.

Cheng KW, Tseng CH, Yang CN, Tzeng CC, Cheng TC, Leu YL, Chuang YC, Wang JY, Lu YC, Chen YL, Cheng TL.

J Med Chem. 2017 Nov 22;60(22):9222-9238. doi: 10.1021/acs.jmedchem.7b00963. Epub 2017 Nov 9.


JAK2V617F influences epigenomic changes in myeloproliferative neoplasms.

Chen CC, Chiu CC, Lee KD, Hsu CC, Chen HC, Huang TH, Hsiao SH, Leu YW.

Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):470-476. doi: 10.1016/j.bbrc.2017.10.108. Epub 2017 Oct 21.


Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid.

Chen SG, Leu YL, Cheng ML, Ting SC, Liu CC, Wang SD, Yang CH, Hung CY, Sakurai H, Chen KH, Ho HY.

Sci Rep. 2017 Sep 25;7(1):12264. doi: 10.1038/s41598-017-12388-2.


Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71 in vitro and in vivo.

Chen SG, Cheng ML, Chen KH, Horng JT, Liu CC, Wang SM, Sakurai H, Leu YL, Wang SD, Ho HY.

Sci Rep. 2017 Apr 20;7(1):935. doi: 10.1038/s41598-017-01110-x.


Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas.

Liao CT, Wen YW, Yang LY, Lee SR, Ng SH, Liu TW, Tsai ST, Tsai MH, Lin JC, Chen PR, Lou PJ, Wang CP, Chu PY, Hwang TZ, Leu YS, Tsai KY, Terng SD, Chen TM, Wang CH, Chien CY, Chen WC, Lee LY, Lin CY, Wang HM, Hsieh CH, Tsao CK, Fang TJ, Huang SF, Kang CJ, Chang KP, Yen TC.

Oral Oncol. 2017 Apr;67:95-102. doi: 10.1016/j.oraloncology.2017.02.011. Epub 2017 Feb 20.


Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells.

Wu TR, Huang TT, Martel J, Liau JC, Chiu CY, Leu YL, Jian WT, Chang IT, Lu CC, Ojcius DM, Ko YF, Lai HC, Young JD.

J Ethnopharmacol. 2017 Apr 6;201:117-122. doi: 10.1016/j.jep.2017.02.008. Epub 2017 Feb 4.


Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms.

Chen CC, You JY, Lung J, Huang CE, Chen YY, Leu YW, Ho HY, Li CP, Lu CH, Lee KD, Hsu CC, Gau JP.

Haematologica. 2017 Mar;102(3):509-518. doi: 10.3324/haematol.2016.154385. Epub 2017 Jan 5.


Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma.

Liao CT, Chen HN, Wen YW, Lee SR, Ng SH, Liu TW, Tsai ST, Tsai MH, Lin JC, Lou PJ, Wang CP, Chu PY, Leu YS, Tsai KY, Terng SD, Chen TM, Wang CH, Chien CY, Chen WC, Lee LY, Lin CY, Wang HM, Lin CH, Fang TJ, Huang SF, Kang CJ, Chang KP, Yang LY, Yen TC.

Eur J Cancer. 2017 Feb;72:226-234. doi: 10.1016/j.ejca.2016.11.010. Epub 2017 Jan 2.


Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo.

Chen CC, Liang CJ, Leu YL, Chen YL, Wang SH.

PLoS One. 2016 Dec 15;11(12):e0168092. doi: 10.1371/journal.pone.0168092. eCollection 2016.


Clinical Outcomes of Taiwanese Patients with cT4 Oral Cavity Squamous Cell Carcinoma: Toward the Identification of the Optimal Initial Treatment Approach for cT4b Patients.

Liao CT, Wen YW, Lee SR, Liu TW, Tsai ST, Tsai MH, Lin JC, Lou PJ, Chu PY, Leu YS, Tsai KY, Terng SD, Chen TM, Wang CH, Chien CY, Chen WC, Lee LY, Lin CY, Wang HM, Ng SH, Lin CH, Fang TJ, Huang SF, Kang CJ, Chang KP, Yang LY, Yen TC; Taiwan Oral Cancer Advisory Group.

Ann Surg Oncol. 2017 Mar;24(3):785-793. doi: 10.1245/s10434-016-5629-x. Epub 2016 Nov 28.


Anticancer activity of Kalanchoe tubiflora extract against human lung cancer cells in vitro and in vivo.

Hsieh YJ, Huang HS, Leu YL, Peng KC, Chang CJ, Chang MY.

Environ Toxicol. 2016 Nov;31(11):1663-1673. doi: 10.1002/tox.22170. Epub 2015 Jul 15.


Three-dimensional reconstruction of trachea using computed tomography imaging as therapy for tracheal stenosis in infants.

Kuo CF, Leu YS, Kuo R, Su CH, Yuan TC, Ke BH, Wu NY.

Comput Methods Programs Biomed. 2016 Aug;132:177-87. doi: 10.1016/j.cmpb.2016.04.027. Epub 2016 Apr 29.


Multifunctional Iodide-Free Polymeric Ionic Liquid for Quasi-Solid-State Dye-Sensitized Solar Cells with a High Open-Circuit Voltage.

Lin YF, Li CT, Lee CP, Leu YA, Ezhumalai Y, Vittal R, Chen MC, Lin JJ, Ho KC.

ACS Appl Mater Interfaces. 2016 Jun 22;8(24):15267-78. doi: 10.1021/acsami.6b02767. Epub 2016 Jun 14.


Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation.

Prijovich ZM, Burnouf PA, Chou HC, Huang PT, Chen KC, Cheng TL, Leu YL, Roffler SR.

Mol Pharm. 2016 Apr 4;13(4):1242-50. doi: 10.1021/acs.molpharmaceut.5b00771. Epub 2016 Mar 8.


Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.

Tzeng HH, Hsu CH, Chung TH, Lee WC, Lin CH, Wang WC, Hsiao CY, Leu YW, Wang TH.

PLoS One. 2015 Dec 29;10(12):e0145542. doi: 10.1371/journal.pone.0145542. eCollection 2015.


Multiple analyses of factors related to complications in endoscopic sinus surgery.

Chou TW, Chen PS, Lin HC, Lee KS, Tsai HT, Lee JC, Leu YS, Wang YP.

J Chin Med Assoc. 2016 Feb;79(2):88-92. doi: 10.1016/j.jcma.2015.11.001. Epub 2015 Dec 17.


Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer.

Chen HC, Huang HY, Chen YL, Lee KD, Chu YR, Lin PY, Hsu CC, Chu PY, Huang TH, Hsiao SH, Leu YW.

Ann Surg Oncol. 2017 Feb;24(2):578-585. doi: 10.1245/s10434-015-5024-z. Epub 2015 Dec 15.


Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium.

Chen CY, Leu YL, Fang Y, Lin CF, Kuo LM, Sung WC, Tsai YF, Chung PJ, Lee MC, Kuo YT, Yang HW, Hwang TL.

Sci Rep. 2015 Dec 14;5:18204. doi: 10.1038/srep18204.


Two stages weighted sampling strategy for detecting the relation between gene expression and disease.

Yang CC, Lin WS, Lee CP, Leu Y.

Int J Data Min Bioinform. 2015;12(2):207-23.


Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells.

Chen CC, Lee KD, Pai MY, Chu PY, Hsu CC, Chiu CC, Chen LT, Chang JY, Hsiao SH, Leu YW.

Cancer Cell Int. 2015 Oct 13;15:98. doi: 10.1186/s12935-015-0248-3. eCollection 2015.


Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4.

Tsai YF, Yu HP, Chung PJ, Leu YL, Kuo LM, Chen CY, Hwang TL.

Free Radic Biol Med. 2015 Dec;89:387-400. doi: 10.1016/j.freeradbiomed.2015.08.008. Epub 2015 Nov 4.


Antihypertensive Effect of a Combination of Uracil and Glycerol Derived from Lactobacillus plantarum Strain TWK10-Fermented Soy Milk.

Liu YY, Zeng SY, Leu YL, Tsai TY.

J Agric Food Chem. 2015 Aug 26;63(33):7333-42. doi: 10.1021/acs.jafc.5b01649. Epub 2015 Aug 12.


Inventory of Engineered Nanoparticle-Containing Consumer Products Available in the Singapore Retail Market and Likelihood of Release into the Aquatic Environment.

Zhang Y, Leu YR, Aitken RJ, Riediker M.

Int J Environ Res Public Health. 2015 Jul 24;12(8):8717-43. doi: 10.3390/ijerph120808717.


Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model.

Pan TL, Wang PW, Huang CH, Leu YL, Wu TH, Wu YR, You JS.

Sci Rep. 2015 Jul 2;5:11734. doi: 10.1038/srep11734.


Discovery of specific inhibitors for intestinal E. coli  β-glucuronidase through in silico virtual screening.

Cheng TC, Chuang KH, Roffler SR, Cheng KW, Leu YL, Chuang CH, Huang CC, Kao CH, Hsieh YC, Chang LS, Cheng TL, Chen CS.

ScientificWorldJournal. 2015;2015:740815. doi: 10.1155/2015/740815. Epub 2015 Mar 9.


Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade.

Liu YK, Chen KH, Leu YL, Way TD, Wang LW, Chen YJ, Liu YM.

Onco Targets Ther. 2014 Dec 31;8:99-109. doi: 10.2147/OTT.S68765. eCollection 2015.


Discovery of Akt kinase inhibitors through structure-based virtual screening and their evaluation as potential anticancer agents.

Chuang CH, Cheng TC, Leu YL, Chuang KH, Tzou SC, Chen CS.

Int J Mol Sci. 2015 Feb 2;16(2):3202-12. doi: 10.3390/ijms16023202.


EGF and EGFR genetic polymorphisms predict prognosis in locally advanced pharyngolaryngeal squamous cell carcinoma patients receiving postoperative concurrent chemoradiotherapy.

Su NW, Leu YS, Lee JC, Liu CJ, Cheng CY, Lin JS, Chen YJ, Chen CK, Fang IC, Hsieh RK, Chang YF.

Onco Targets Ther. 2014 Nov 28;7:2197-204. doi: 10.2147/OTT.S70188. eCollection 2014.


Automatic recognizing of vocal fold disorders from glottis images.

Huang CC, Leu YS, Kuo CF, Chu WL, Chu YH, Wu HC.

Proc Inst Mech Eng H. 2014 Sep;228(9):952-61. doi: 10.1177/0954411914551851.


PET imaging of β-glucuronidase activity by an activity-based 124I-trapping probe for the personalized glucuronide prodrug targeted therapy.

Su YC, Cheng TC, Leu YL, Roffler SR, Wang JY, Chuang CH, Kao CH, Chen KC, Wang HE, Cheng TL.

Mol Cancer Ther. 2014 Dec;13(12):2852-63. doi: 10.1158/1535-7163.MCT-14-0212. Epub 2014 Oct 2.


Early life ethanol exposure causes long-lasting disturbances in rat mesenchymal stem cells via epigenetic modifications.

Leu YW, Chu PY, Chen CM, Yeh KT, Liu YM, Lee YH, Kuo ST, Hsiao SH.

Biochem Biophys Res Commun. 2014 Oct 24;453(3):338-44. doi: 10.1016/j.bbrc.2014.09.083. Epub 2014 Sep 26.


Augmented cellular uptake of nanoparticles using tea catechins: effect of surface modification on nanoparticle-cell interaction.

Lu YC, Luo PC, Huang CW, Leu YL, Wang TH, Wei KC, Wang HE, Ma YH.

Nanoscale. 2014 Sep 7;6(17):10297-306. doi: 10.1039/c4nr00617h.


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