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Items: 30


Developmentally regulated Shh expression is robust to TAD perturbations.

Williamson I, Kane L, Devenney PS, Flyamer IM, Anderson E, Kilanowski F, Hill RE, Bickmore WA, Lettice LA.

Development. 2019 Sep 30;146(19). pii: dev179523. doi: 10.1242/dev.179523.


The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression.

Lettice LA, Devenney P, De Angelis C, Hill RE.

Cell Rep. 2017 Aug 8;20(6):1396-1408. doi: 10.1016/j.celrep.2017.07.037.


SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells.

Benabdallah NS, Gautier P, Hekimoglu-Balkan B, Lettice LA, Bhatia S, Bickmore WA.

Open Biol. 2016 Nov;6(11). pii: 160197.


Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity.

Williamson I, Lettice LA, Hill RE, Bickmore WA.

Development. 2016 Aug 15;143(16):2994-3001. doi: 10.1242/dev.139188. Epub 2016 Jul 11.


Mapping the Shh long-range regulatory domain.

Anderson E, Devenney PS, Hill RE, Lettice LA.

Development. 2014 Oct;141(20):3934-43. doi: 10.1242/dev.108480. Epub 2014 Sep 24.


Development of five digits is controlled by a bipartite long-range cis-regulator.

Lettice LA, Williamson I, Devenney PS, Kilanowski F, Dorin J, Hill RE.

Development. 2014 Apr;141(8):1715-25. doi: 10.1242/dev.095430.


WT1 regulates the expression of inhibitory chemokines during heart development.

Velecela V, Lettice LA, Chau YY, Slight J, Berry RL, Thornburn A, Gunst QD, van den Hoff M, Reina M, Martínez FO, Hastie ND, Martínez-Estrada OM.

Hum Mol Genet. 2013 Dec 20;22(25):5083-95. doi: 10.1093/hmg/ddt358. Epub 2013 Jul 29.


Alterations to the remote control of Shh gene expression cause congenital abnormalities.

Hill RE, Lettice LA.

Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120357. doi: 10.1098/rstb.2012.0357. Print 2013.


Anterior-posterior differences in HoxD chromatin topology in limb development.

Williamson I, Eskeland R, Lettice LA, Hill AE, Boyle S, Grimes GR, Hill RE, Bickmore WA.

Development. 2012 Sep;139(17):3157-67. doi: 10.1242/dev.081174.


Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, Taylor MS, Lawson KA, Dorin JR, Jackson AP.

Cell. 2012 May 25;149(5):1008-22. doi: 10.1016/j.cell.2012.04.011. Epub 2012 May 10.


Human limb abnormalities caused by disruption of hedgehog signaling.

Anderson E, Peluso S, Lettice LA, Hill RE.

Trends Genet. 2012 Aug;28(8):364-73. doi: 10.1016/j.tig.2012.03.012. Epub 2012 Apr 24. Review.


Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly.

Lettice LA, Williamson I, Wiltshire JH, Peluso S, Devenney PS, Hill AE, Essafi A, Hagman J, Mort R, Grimes G, DeAngelis CL, Hill RE.

Dev Cell. 2012 Feb 14;22(2):459-67. doi: 10.1016/j.devcel.2011.12.010.


Enhancer-adoption as a mechanism of human developmental disease.

Lettice LA, Daniels S, Sweeney E, Venkataraman S, Devenney PS, Gautier P, Morrison H, Fantes J, Hill RE, FitzPatrick DR.

Hum Mutat. 2011 Dec;32(12):1492-9. doi: 10.1002/humu.21615. Epub 2011 Oct 20.


Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.

Martínez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, Hall E, Reichmann J, Devenney PS, Hohenstein P, Hosen N, Hill RE, Muñoz-Chapuli R, Hastie ND.

Nat Genet. 2010 Jan;42(1):89-93. doi: 10.1038/ng.494. Epub 2009 Dec 20.


A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb.

Furniss D, Lettice LA, Taylor IB, Critchley PS, Giele H, Hill RE, Wilkie AO.

Hum Mol Genet. 2008 Aug 15;17(16):2417-23. doi: 10.1093/hmg/ddn141. Epub 2008 May 7.


Long-range gene control and genetic disease.

Kleinjan DA, Lettice LA.

Adv Genet. 2008;61:339-88. doi: 10.1016/S0065-2660(07)00013-2. Review.


Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly.

Lettice LA, Hill AE, Devenney PS, Hill RE.

Hum Mol Genet. 2008 Apr 1;17(7):978-85. Epub 2007 Dec 21.


Preaxial polydactyly: a model for defective long-range regulation in congenital abnormalities.

Lettice LA, Hill RE.

Curr Opin Genet Dev. 2005 Jun;15(3):294-300. Review.


Digital dialogues in Dundee: 8th International Conference on Limb Development.

Lettice LA, Kapoor T, Hill RE.

Dev Dyn. 2005 Jun;233(2):252-5. No abstract available.


The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.

Hecksher-Sørensen J, Watson RP, Lettice LA, Serup P, Eley L, De Angelis C, Ahlgren U, Hill RE.

Development. 2004 Oct;131(19):4665-75. Epub 2004 Aug 25.


Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution.

Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE.

Development. 2004 Mar;131(6):1235-45. Epub 2004 Feb 18.


A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly.

Lettice LA, Heaney SJ, Purdie LA, Li L, de Beer P, Oostra BA, Goode D, Elgar G, Hill RE, de Graaff E.

Hum Mol Genet. 2003 Jul 15;12(14):1725-35.


Sonic hedgehog: restricted expression and limb dysmorphologies.

Hill RE, Heaney SJ, Lettice LA.

J Anat. 2003 Jan;202(1):13-20. Review.


Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.

Lettice LA, Horikoshi T, Heaney SJ, van Baren MJ, van der Linde HC, Breedveld GJ, Joosse M, Akarsu N, Oostra BA, Endo N, Shibata M, Suzuki M, Takahashi E, Shinka T, Nakahori Y, Ayusawa D, Nakabayashi K, Scherer SW, Heutink P, Hill RE, Noji S.

Proc Natl Acad Sci U S A. 2002 May 28;99(11):7548-53.


The mouse bagpipe gene controls development of axial skeleton, skull, and spleen.

Lettice LA, Purdie LA, Carlson GJ, Kilanowski F, Dorin J, Hill RE.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9695-700.


Human (DACH) and mouse (Dach) homologues of Drosophila dachshund map to chromosomes 13q22 and 14E3, respectively.

Hammond KL, Lettice LA, Hill RE, Lee M, Boyle S, Hanson IM.

Genomics. 1999 Jan 15;55(2):252-3. No abstract available.


Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb.

Hammond KL, Hanson IM, Brown AG, Lettice LA, Hill RE.

Mech Dev. 1998 Jun;74(1-2):121-31.


Properties of the dorsalizing signal in gastrulae of Xenopus laevis.

Lettice LA, Slack JM.

Development. 1993 Jan;117(1):263-71.


Specification of the body plan during Xenopus gastrulation: dorsoventral and anteroposterior patterning of the mesoderm.

Slack JM, Isaacs HV, Johnson GE, Lettice LA, Tannahill D, Thompson J.

Dev Suppl. 1992:143-9.


Comparison between two peptide epitopes presented to cytotoxic T lymphocytes by HLA-A2. Evidence for discrete locations within HLA-A2.

Robbins PA, Lettice LA, Rota P, Santos-Aguado J, Rothbard J, McMichael AJ, Strominger JL.

J Immunol. 1989 Dec 15;143(12):4098-103.


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