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Items: 1 to 50 of 90

1.

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells.

Wei HJ, Letterio JJ, Pareek TK.

J Vis Exp. 2018 May 18;(135). doi: 10.3791/57637.

PMID:
29863666
2.

Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation.

Barker EC, Kim BG, Yoon JH, Tochtrop GP, Letterio JJ, Choi SH.

Carcinogenesis. 2018 Jan 12;39(1):36-46. doi: 10.1093/carcin/bgx115.

PMID:
29069290
3.

A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE.

Wei HJ, Pareek TK, Liu Q, Letterio JJ.

Sci Rep. 2017 Aug 29;7(1):9886. doi: 10.1038/s41598-017-06907-4.

4.

Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice.

Askew D, Pareek TK, Eid S, Ganguly S, Tyler M, Huang AY, Letterio JJ, Cooke KR.

Blood. 2017 Jan 12;129(2):246-256. doi: 10.1182/blood-2016-05-702738. Epub 2016 Nov 14.

5.

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity.

Dorand RD, Nthale J, Myers JT, Barkauskas DS, Avril S, Chirieleison SM, Pareek TK, Abbott DW, Stearns DS, Letterio JJ, Huang AY, Petrosiute A.

Science. 2016 Jul 22;353(6297):399-403. doi: 10.1126/science.aae0477. Epub 2016 Jul 21.

6.

Myeloid-derived suppressor cells: The green light for myeloma immune escape.

Malek E, de Lima M, Letterio JJ, Kim BG, Finke JH, Driscoll JJ, Giralt SA.

Blood Rev. 2016 Sep;30(5):341-8. doi: 10.1016/j.blre.2016.04.002. Epub 2016 Apr 12. Review.

PMID:
27132116
7.

The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region.

Jeon WK, Choi J, Park SJ, Jo EJ, Lee YK, Lim S, Kim JH, Letterio JJ, Liu F, Kim SJ, Kim BC.

Oncotarget. 2015 Dec 8;6(39):41650-66. doi: 10.18632/oncotarget.6146.

8.

Hepatic Stellate Cells Inhibit T Cells through Active TGF-β1 from a Cell Surface-Bound Latent TGF-β1/GARP Complex.

Li Y, Kim BG, Qian S, Letterio JJ, Fung JJ, Lu L, Lin F.

J Immunol. 2015 Sep 15;195(6):2648-56. doi: 10.4049/jimmunol.1500139. Epub 2015 Aug 5.

9.

Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727.

Lam E, Choi SH, Pareek TK, Kim BG, Letterio JJ.

Mol Immunol. 2015 Oct;67(2 Pt B):317-24. doi: 10.1016/j.molimm.2015.06.015. Epub 2015 Jul 19.

10.

Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex.

Lam E, Pareek TK, Letterio JJ.

Cell Cycle. 2015;14(8):1327-36. doi: 10.4161/15384101.2014.987621.

11.

Alex's Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011.

Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS.

Neuro Oncol. 2015 Jan;16 Suppl 10:x1-x36. doi: 10.1093/neuonc/nou327.

12.

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review.

Owusu-Ansah A, Choi SH, Petrosiute A, Letterio JJ, Huang AY.

Front Med. 2015 Mar;9(1):46-56. doi: 10.1007/s11684-015-0375-1. Epub 2014 Dec 15. Review.

PMID:
25511620
13.

Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.

Gatbonton-Schwager TN, Sadhukhan S, Zhang GF, Letterio JJ, Tochtrop GP.

Redox Biol. 2014 Apr 24;2:755-63. doi: 10.1016/j.redox.2014.04.009. eCollection 2014.

14.

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.

Choi SH, Kim BG, Robinson J, Fink S, Yan M, Sporn MB, Markowitz SD, Letterio JJ.

J Clin Invest. 2014 Jun;124(6):2472-82. doi: 10.1172/JCI69672. Epub 2014 May 16.

15.

Disruption of Smad4 expression in T cells leads to IgA nephropathy-like manifestations.

Inoshita H, Kim BG, Yamashita M, Choi SH, Tomino Y, Letterio JJ, Emancipator SN.

PLoS One. 2013 Nov 4;8(11):e78736. doi: 10.1371/journal.pone.0078736. eCollection 2013.

16.

Cdk5: An Emerging Kinase in Pain Signaling.

Pareek TK, Zipp L, Letterio JJ.

Brain Disord Ther. 2013 Jul;2013(Suppl 1). pii: 003. doi: 10.4172/2168-975X.S1-003. Epub 2012 Oct 3.

17.

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.

Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, Sporn MB, Letterio JJ.

Sci Rep. 2011;1:201. doi: 10.1038/srep00201. Epub 2011 Dec 19.

18.

Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

Gatbonton-Schwager TN, Letterio JJ, Tochtrop GP.

J Nat Prod. 2012 Apr 27;75(4):591-8. doi: 10.1021/np200823p. Epub 2012 Feb 16.

19.

Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis.

Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ.

J Exp Med. 2010 Oct 25;207(11):2507-19. doi: 10.1084/jem.20100876. Epub 2010 Oct 11.

20.

The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.

Auletta JJ, Alabran JL, Kim BG, Meyer CJ, Letterio JJ.

J Interferon Cytokine Res. 2010 Jul;30(7):497-508. doi: 10.1089/jir.2009.0100.

21.

Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages.

Barker EC, Gatbonton-Schwager TN, Han Y, Clay JE, Letterio JJ, Tochtrop GP.

J Nat Prod. 2010 Jun 25;73(6):1064-8. doi: 10.1021/np1000076.

22.

Targeting improves MSC treatment of inflammatory bowel disease.

Ko IK, Kim BG, Awadallah A, Mikulan J, Lin P, Letterio JJ, Dennis JE.

Mol Ther. 2010 Jul;18(7):1365-72. doi: 10.1038/mt.2010.54. Epub 2010 Apr 13.

23.

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.

Do JS, Fink PJ, Li L, Spolski R, Robinson J, Leonard WJ, Letterio JJ, Min B.

J Immunol. 2010 Feb 15;184(4):1675-9. doi: 10.4049/jimmunol.0903539. Epub 2010 Jan 8.

24.

Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines.

Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H.

J Exp Med. 2009 Sep 28;206(10):2131-9. doi: 10.1084/jem.20090639. Epub 2009 Sep 8.

25.
26.
27.

The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.

Liby K, Voong N, Williams CR, Risingsong R, Royce DB, Honda T, Gribble GW, Sporn MB, Letterio JJ.

Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4288-93.

28.

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Anver M, Wolfraim L, Hong S, Mushinski E, Potter M, Kim SJ, Fu XY, Deng C, Letterio JJ.

Nature. 2006 Jun 22;441(7096):1015-9. Erratum in: Nature. 2006 Dec 7;444(7120):780. Kasperczak, Barbara [corrected to Kasprzak, Barbara].

PMID:
16791201
29.

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.

Lin YW, Nichols RA, Letterio JJ, Aplan PD.

Blood. 2006 Mar 15;107(6):2540-3. Epub 2005 Nov 10.

31.

TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

Kullberg MC, Hay V, Cheever AW, Mamura M, Sher A, Letterio JJ, Shevach EM, Piccirillo CA.

Eur J Immunol. 2005 Oct;35(10):2886-95.

32.

TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.

Letterio JJ.

Oncogene. 2005 Aug 29;24(37):5701-12. Review.

PMID:
16123803
33.

Disruption of the TGF-beta pathway and modeling human cancer in mice.

Letterio JJ.

Mutat Res. 2005 Aug 25;576(1-2):120-31. Review.

PMID:
15935406
34.

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.

Marie JC, Letterio JJ, Gavin M, Rudensky AY.

J Exp Med. 2005 Apr 4;201(7):1061-7.

36.

IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent.

Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA.

J Immunol. 2004 Sep 15;173(6):4020-9.

37.
38.

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, Letterio JJ.

N Engl J Med. 2004 Aug 5;351(6):552-9.

39.

CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

Mamura M, Lee W, Sullivan TJ, Felici A, Sowers AL, Allison JP, Letterio JJ.

Blood. 2004 Jun 15;103(12):4594-601. Epub 2004 Mar 11.

40.

Depressed adrenomedullin in the embryonic transforming growth factor-beta1 null mouse becomes elevated postnatally.

Bodegas E, Martínez A, Ozbun LL, Garayoa M, Letterio JJ, Montuenga LM, Jakowlew SB.

Int J Dev Biol. 2004 Feb;48(1):67-70.

41.

Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta.

Sosne G, Xu L, Prach L, Mrock LK, Kleinman HK, Letterio JJ, Hazlett LD, Kurpakus-Wheater M.

Exp Cell Res. 2004 Feb 1;293(1):175-83.

PMID:
14729067
42.

Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.

Terabe M, Matsui S, Park JM, Mamura M, Noben-Trauth N, Donaldson DD, Chen W, Wahl SM, Ledbetter S, Pratt B, Letterio JJ, Paul WE, Berzofsky JA.

J Exp Med. 2003 Dec 1;198(11):1741-52.

43.

Concentration-dependent bifunctional effect of TGF-beta 1 on immunoglobulin production: a role for Smad3 in IgA production in vitro.

McKarns SC, Letterio JJ, Kaminski NE.

Int Immunopharmacol. 2003 Dec;3(13-14):1761-74.

PMID:
14636827
44.

Differential regulation of mouse B cell development by transforming growth factor beta1.

Kaminski DA, Letterio JJ, Burrows PD.

Dev Immunol. 2002 Jun;9(2):85-95.

45.

Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells.

Cao Z, Flanders KC, Bertolette D, Lyakh LA, Wurthner JU, Parks WT, Letterio JJ, Ruscetti FW, Roberts AB.

Blood. 2003 Jan 15;101(2):498-507. Epub 2002 Sep 12.

46.

Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis.

Kullberg MC, Jankovic D, Gorelick PL, Caspar P, Letterio JJ, Cheever AW, Sher A.

J Exp Med. 2002 Aug 19;196(4):505-15.

47.

Development and application of fully functional epitope-tagged forms of transforming growth factor-beta.

Wolfraim LA, Alkemade GM, Alex B, Sharpe S, Parks WT, Letterio JJ.

J Immunol Methods. 2002 Aug 1;266(1-2):7-18.

PMID:
12133618
48.

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.

Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, Mizuhara H, Shevach EM.

J Exp Med. 2002 Jul 15;196(2):237-46.

49.

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects.

Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, Patel SC, Khozin S, Liu ZY, Green J, Anver MR, Merlino G, Wakefield LM.

J Clin Invest. 2002 Jun;109(12):1607-15.

50.

Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice.

Kulkarni AB, Thyagarajan T, Letterio JJ.

Curr Mol Med. 2002 May;2(3):303-27. Review.

PMID:
12041733

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