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Items: 37

1.

Truth Behind the Appearances: Translating New Drug Therapies to Humans.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2019 Oct 14. doi: 10.1097/TA.0000000000002507. [Epub ahead of print] No abstract available.

PMID:
31626027
2.

Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA.

Morris JL, Letson HL, Grant A, Wilkinson M, Hazratwala K, McEwen P.

Biol Open. 2019 Sep 18;8(9). pii: bio045203. doi: 10.1242/bio.045203.

3.

Conventional and Specific-Pathogen Free Rats Respond Differently to Anesthesia and Surgical Trauma.

Letson HL, Morris J, Biros E, Dobson GP.

Sci Rep. 2019 Jun 28;9(1):9399. doi: 10.1038/s41598-019-45871-z.

4.

Adenosine, lidocaine, and Mg2+ fluid therapy leads to 72-hour survival after hemorrhagic shock: A model for studying differential gene expression and extending biological time.

Letson HL, Morris JL, Biros E, Dobson GP.

J Trauma Acute Care Surg. 2019 Sep;87(3):606-613. doi: 10.1097/TA.0000000000002397.

PMID:
31162330
5.

The role of invasive monitoring in the resuscitation of major burns: a systematic review and meta-analysis.

Davenport LM, Dobson GP, Letson HL.

Int J Burns Trauma. 2019 Apr 15;9(2):28-40. eCollection 2019.

6.

Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution.

McCutchan A, Dobson GP, Stewart N, Letson HL, Grant AL, Jovanovic IA, Hazratwala K, Wilkinson M, McEwen P, Morris J.

J Exp Orthop. 2019 Apr 15;6(1):16. doi: 10.1186/s40634-019-0185-5.

7.

The CNS theory of osteoarthritis: Opportunities beyond the joint.

Morris JL, Letson HL, Gillman R, Hazratwala K, Wilkinson M, McEwen P, Dobson GP.

Semin Arthritis Rheum. 2019 Mar 16. pii: S0049-0172(19)30012-5. doi: 10.1016/j.semarthrit.2019.03.008. [Epub ahead of print] Review.

PMID:
30982553
8.

Specific pathogen-free (SPF) animal status as a variable in biomedical research: Have we come full circle?

Dobson GP, Letson HL, Biros E, Morris J.

EBioMedicine. 2019 Mar;41:42-43. doi: 10.1016/j.ebiom.2019.02.038. Epub 2019 Feb 23. No abstract available.

9.

Response to letter to the editor.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2019 Feb;86(2):376. doi: 10.1097/TA.0000000000002107. No abstract available.

PMID:
30376545
10.

Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study.

Grant AL, Letson HL, Morris JL, McEwen P, Hazratwala K, Wilkinson M, Dobson GP.

J Orthop Surg Res. 2018 Jun 18;13(1):149. doi: 10.1186/s13018-018-0855-5.

11.

Defining the osteoarthritis patient: back to the future.

Dobson GP, Letson HL, Grant A, McEwen P, Hazratwala K, Wilkinson M, Morris JL.

Osteoarthritis Cartilage. 2018 Aug;26(8):1003-1007. doi: 10.1016/j.joca.2018.04.018. Epub 2018 May 25. Review.

12.
13.

Adenosine, lidocaine, and Mg2+ (ALM) resuscitation fluid protects against experimental traumatic brain injury.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2018 Jun;84(6):908-916. doi: 10.1097/TA.0000000000001874.

PMID:
29554045
14.

Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage?

Dobson GP, Doma K, Letson HL.

J Trauma Acute Care Surg. 2018 Mar;84(3):532-536. doi: 10.1097/TA.0000000000001779. Review. No abstract available.

PMID:
29462114
15.

Clinical relevance of a p-value: Does TXA save lives after trauma or post-partum hemorrhage?

Dobson GP, Doma K, Letson HL.

J Trauma Acute Care Surg. 2017 Dec 28. doi: 10.1097/TA.0000000000001779. [Epub ahead of print] No abstract available.

PMID:
29283963
16.

The Adenosine Hypothesis Revisited: Modulation of Coupling between Myocardial Perfusion and Arterial Compliance.

Dobson GP, Arsyad A, Letson HL.

Front Physiol. 2017 Oct 20;8:824. doi: 10.3389/fphys.2017.00824. eCollection 2017.

17.

Tranexamic acid for post-partum haemorrhage in the WOMAN trial.

Letson HL, Dobson GP.

Lancet. 2017 Sep 30;390(10102):1581-1582. doi: 10.1016/S0140-6736(17)31947-5. Epub 2017 Sep 28. No abstract available.

PMID:
28980953
18.

Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg2+ infusion to dampen the stress response.

Davenport L, Letson HL, Dobson GP.

Innate Immun. 2017 Jul;23(5):482-494. doi: 10.1177/1753425917718921.

PMID:
28691873
19.

Tranexamic acid leads to paradoxical coagulation changes during cardiac surgery: a pilot rotational thromboelastometry study.

Sharma R, Letson HL, Smith S, Dobson GP.

J Surg Res. 2017 Sep;217:100-112. doi: 10.1016/j.jss.2017.05.006. Epub 2017 May 8.

PMID:
28602219
20.

3% NaCl adenosine, lidocaine, Mg2+ (ALM) bolus and 4 hours "drip" infusion reduces noncompressible hemorrhage by 60% in a rat model.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2017 Jun;82(6):1063-1072. doi: 10.1097/TA.0000000000001454.

PMID:
28520687
21.

Buprenorphine Analgesia Leads to Coagulopathy and Increased Plasma Fibrinogen in Healthy Rats: Implications For Small Animal Research.

Griffin MJ, Letson HL, Dobson GP.

Shock. 2017 Jul;48(1):78-84. doi: 10.1097/SHK.0000000000000821.

PMID:
27984521
22.
23.

Differential contributions of platelets and fibrinogen to early coagulopathy in a rat model of hemorrhagic shock.

Letson HL, Dobson GP.

Thromb Res. 2016 May;141:58-65. doi: 10.1016/j.thromres.2016.03.007. Epub 2016 Mar 7.

PMID:
26970714
24.

Adenosine, lidocaine, and Mg2+ (ALM): From cardiac surgery to combat casualty care--Teaching old drugs new tricks.

Dobson GP, Letson HL.

J Trauma Acute Care Surg. 2016 Jan;80(1):135-45. doi: 10.1097/TA.0000000000000881. Review.

PMID:
26683400
25.

Mechanisms of early trauma-induced coagulopathy: The clot thickens or not?

Dobson GP, Letson HL, Sharma R, Sheppard FR, Cap AP.

J Trauma Acute Care Surg. 2015 Aug;79(2):301-9. doi: 10.1097/TA.0000000000000729.

PMID:
26218701
26.

Correction of acute traumatic coagulopathy with small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ occurs within 5 minutes: a ROTEM analysis.

Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2015 Apr;78(4):773-83. doi: 10.1097/TA.0000000000000587.

PMID:
25807406
27.

Adenosine, lidocaine and Mg2+ improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model.

Granfeldt A, Letson HL, Dobson GP, Shi W, Vinten-Johansen J, Tønnesen E.

Crit Care. 2014 Dec 11;18(6):682. doi: 10.1186/s13054-014-0682-y.

28.

Adenosine, lidocaine and Mg2+ (ALM) induces a reversible hypotensive state, reduces lung edema and prevents coagulopathy in the rat model of polymicrobial sepsis.

Griffin MJ, Letson HL, Dobson GP.

J Trauma Acute Care Surg. 2014 Sep;77(3):471-8. doi: 10.1097/TA.0000000000000361.

PMID:
25159253
29.

Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation.

Granfeldt A, Letson HL, Hyldebrandt JA, Wang ER, Salcedo PA, Nielsen TK, Tønnesen E, Vinten-Johansen J, Dobson GP.

Crit Care Med. 2014 May;42(5):e329-44. doi: 10.1097/CCM.0000000000000225.

PMID:
24557427
30.

Optimization of the rodent model of polymicrobial sepsis.

Griffin M, Letson HL, Dobson GP.

Int Immunopharmacol. 2014 Apr;19(2):405. doi: 10.1016/j.intimp.2014.01.016. Epub 2014 Jan 29. No abstract available.

PMID:
24485942
31.

The Bellamy challenge: it's about time.

Dobson GP, Letson HL, Tadaki D.

J R Army Med Corps. 2014 Mar;160(1):9-15. doi: 10.1136/jramc-2013-000145. Epub 2013 Oct 18. Review.

PMID:
24142962
32.

Adenosine, lidocaine, and Mg2+ (ALM™) increases survival and corrects coagulopathy after eight-minute asphyxial cardiac arrest in the rat.

Djabir Y, Letson HL, Dobson GP.

Shock. 2013 Sep;40(3):222-32. doi: 10.1097/SHK.0b013e3182a03566.

PMID:
23846412
33.

Acute coagulopathy of trauma in the rat. Shock 39: 440-446, 2013.

Letson HL, Dobson GP.

Shock. 2013 Jul;40(1):74. doi: 10.1097/SHK.0b013e318296e18e. No abstract available.

PMID:
23770764
34.

Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock.

Letson HL, Pecheniuk NM, Mhango LP, Dobson GP.

Crit Care Med. 2012 Aug;40(8):2417-22. doi: 10.1097/CCM.0b013e31825334c3.

PMID:
22809911
35.
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