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Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection.

Bobat S, Flores-Langarica A, Hitchcock J, Marshall JL, Kingsley RA, Goodall M, Gil-Cruz C, Serre K, Leyton DL, Letran SE, Gaspal F, Chester R, Chamberlain JL, Dougan G, López-Macías C, Henderson IR, Alexander J, MacLennan IC, Cunningham AF.

Eur J Immunol. 2011 Jun;41(6):1606-18. doi: 10.1002/eji.201041089. Epub 2011 May 10.


TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen.

Letran SE, Lee SJ, Atif SM, Flores-Langarica A, Uematsu S, Akira S, Cunningham AF, McSorley SJ.

J Immunol. 2011 May 1;186(9):5406-12. doi: 10.4049/jimmunol.1003576. Epub 2011 Mar 30.


TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.

Letran SE, Lee SJ, Atif SM, Uematsu S, Akira S, McSorley SJ.

Eur J Immunol. 2011 Jan;41(1):29-38. doi: 10.1002/eji.201040717. Epub 2010 Dec 3.

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