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Items: 1 to 50 of 115

1.

Model Systems to Investigate NOX-Dependent Cell Migration and Invasiveness.

Boudreau HE, Leto TL.

Methods Mol Biol. 2019;1982:473-485. doi: 10.1007/978-1-4939-9424-3_28.

PMID:
31172490
2.

Functional Characterization of DUOX Enzymes in Reconstituted Cell Models.

Korzeniowska A, Donkó ÁP, Morand S, Leto TL.

Methods Mol Biol. 2019;1982:173-190. doi: 10.1007/978-1-4939-9424-3_11.

PMID:
31172473
3.

Heterozygous activating mutation in RAC2 causes infantile-onset combined immunodeficiency with susceptibility to viral infections.

Sharapova SO, Haapaniemi E, Sakovich IS, Kostyuchenko LV, Donkó A, Dulau-Florea A, Malko O, Bondarenko AV, Stegantseva MV, Leto TL, Uygun V, Karasu GT, Holland SM, Hsu AP, Aleinikova OV.

Clin Immunol. 2019 May 7;205:1-5. doi: 10.1016/j.clim.2019.05.003. [Epub ahead of print]

PMID:
31071452
4.

Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.

Hsu AP, Donkó A, Arrington ME, Swamydas M, Fink D, Das A, Escobedo O, Bonagura V, Szabolcs P, Steinberg HN, Bergerson J, Skoskiewicz A, Makhija M, Davis J, Foruraghi L, Palmer C, Fuleihan RL, Church JA, Bhandoola A, Lionakis MS, Campbell S, Leto TL, Kuhns DB, Holland SM.

Blood. 2019 May 2;133(18):1977-1988. doi: 10.1182/blood-2018-11-886028. Epub 2019 Feb 5.

PMID:
30723080
5.

Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.

Sugamata R, Donko A, Murakami Y, Boudreau HE, Qi CF, Kwon J, Leto TL.

J Immunol. 2019 Jan 15;202(2):428-440. doi: 10.4049/jimmunol.1601395. Epub 2018 Dec 17.

PMID:
30559322
6.

PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.

Moody TW, Lee L, Iordanskaia T, Ramos-Alvarez I, Moreno P, Boudreau HE, Leto TL, Jensen RT.

Peptides. 2018 Sep 28. pii: S0196-9781(18)30174-8. doi: 10.1016/j.peptides.2018.09.005. [Epub ahead of print]

PMID:
30273693
7.

Interaction between p22phox and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation.

Zana M, Péterfi Z, Kovács HA, Tóth ZE, Enyedi B, Morel F, Paclet MH, Donkó Á, Morand S, Leto TL, Geiszt M.

Free Radic Biol Med. 2018 Feb 20;116:41-49. doi: 10.1016/j.freeradbiomed.2017.12.031. Epub 2017 Dec 24.

PMID:
29278739
8.

Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.

Boudreau HE, Ma WF, Korzeniowska A, Park JJ, Bhagwat MA, Leto TL.

Oncotarget. 2017 Jul 4;8(27):44379-44397. doi: 10.18632/oncotarget.17892.

9.

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.

Chu FF, Esworthy RS, Doroshow JH, Grasberger H, Donko A, Leto TL, Gao Q, Shen B.

Redox Biol. 2017 Apr;11:144-156. doi: 10.1016/j.redox.2016.11.001. Epub 2016 Nov 22.

10.

Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration.

Kwon J, Wang A, Burke DJ, Boudreau HE, Lekstrom KJ, Korzeniowska A, Sugamata R, Kim YS, Yi L, Ersoy I, Jaeger S, Palaniappan K, Ambruso DR, Jackson SH, Leto TL.

Free Radic Biol Med. 2016 Jul;96:99-115. doi: 10.1016/j.freeradbiomed.2016.04.009. Epub 2016 Apr 14.

11.

When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.

Carré A, Louzada RA, Fortunato RS, Ameziane-El-Hassani R, Morand S, Ogryzko V, de Carvalho DP, Grasberger H, Leto TL, Dupuy C.

Antioxid Redox Signal. 2015 Sep 20;23(9):724-33. doi: 10.1089/ars.2015.6265. Epub 2015 Apr 20.

12.

The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.

Ueyama T, Sakuma M, Ninoyu Y, Hamada T, Dupuy C, Geiszt M, Leto TL, Saito N.

J Biol Chem. 2015 Mar 6;290(10):6495-506. doi: 10.1074/jbc.M114.592717. Epub 2015 Jan 13.

13.

NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases.

Rada B, Park JJ, Sil P, Geiszt M, Leto TL.

Inflamm Res. 2014 Oct;63(10):821-30. doi: 10.1007/s00011-014-0756-y. Epub 2014 Jul 22.

14.

Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2.

Donkó Á, Morand S, Korzeniowska A, Boudreau HE, Zana M, Hunyady L, Geiszt M, Leto TL.

Free Radic Biol Med. 2014 Aug;73:190-200. doi: 10.1016/j.freeradbiomed.2014.05.006. Epub 2014 May 20.

15.

Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation.

Yoo DG, Winn M, Pang L, Moskowitz SM, Malech HL, Leto TL, Rada B.

J Immunol. 2014 May 15;192(10):4728-38. doi: 10.4049/jimmunol.1301589. Epub 2014 Apr 16.

16.

Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells.

Boudreau HE, Casterline BW, Burke DJ, Leto TL.

Br J Cancer. 2014 May 13;110(10):2569-82. doi: 10.1038/bjc.2014.165. Epub 2014 Apr 8.

17.

The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.

Steven Esworthy R, Kim BW, Wang Y, Gao Q, Doroshow JH, Leto TL, Chu FF.

Free Radic Biol Med. 2013 Dec;65:1273-1283. doi: 10.1016/j.freeradbiomed.2013.09.013. Epub 2013 Oct 1.

18.

Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase.

Rada B, Boudreau HE, Park JJ, Leto TL.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):125-34. doi: 10.1165/rcmb.2013-0254OC.

19.

Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase.

Rada B, Jendrysik MA, Pang L, Hayes CP, Yoo DG, Park JJ, Moskowitz SM, Malech HL, Leto TL.

PLoS One. 2013;8(1):e54205. doi: 10.1371/journal.pone.0054205. Epub 2013 Jan 14.

20.

Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.

Rada B, Leto TL.

Trends Microbiol. 2013 Feb;21(2):73-81. doi: 10.1016/j.tim.2012.10.004. Epub 2012 Nov 7. Review.

21.

Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.

Esworthy RS, Kim BW, Rivas GE, Leto TL, Doroshow JH, Chu FF.

PLoS One. 2012;7(9):e44262. doi: 10.1371/journal.pone.0044262. Epub 2012 Sep 6.

22.

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.

Boudreau HE, Casterline BW, Rada B, Korzeniowska A, Leto TL.

Free Radic Biol Med. 2012 Oct 1;53(7):1489-99. doi: 10.1016/j.freeradbiomed.2012.06.016. Epub 2012 Jun 19.

23.

Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P.

Waisberg M, Cerqueira GC, Yager SB, Francischetti IM, Lu J, Gera N, Srinivasan P, Miura K, Rada B, Lukszo J, Barbian KD, Leto TL, Porcella SF, Narum DL, El-Sayed N, Miller LH, Pierce SK.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5429-34. doi: 10.1073/pnas.1202689109. Epub 2012 Mar 19.

24.

Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity.

Ambruso DR, Ellison MA, Thurman GW, Leto TL.

Biochim Biophys Acta. 2012 Feb;1823(2):306-15. doi: 10.1016/j.bbamcr.2011.11.014. Epub 2011 Dec 8.

25.

Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.

Ueyama T, Nakakita J, Nakamura T, Kobayashi T, Kobayashi T, Son J, Sakuma M, Sakaguchi H, Leto TL, Saito N.

J Biol Chem. 2011 Nov 25;286(47):40693-705. doi: 10.1074/jbc.M111.237289. Epub 2011 Sep 28.

26.
27.

Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin.

Rada B, Gardina P, Myers TG, Leto TL.

Mucosal Immunol. 2011 Mar;4(2):158-71. doi: 10.1038/mi.2010.62. Epub 2010 Oct 20.

28.

The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling.

Kwon J, Shatynski KE, Chen H, Morand S, de Deken X, Miot F, Leto TL, Williams MS.

Sci Signal. 2010 Aug 3;3(133):ra59. doi: 10.1126/scisignal.2000976.

29.

Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa.

Rada B, Leto TL.

FEBS Lett. 2010 Mar 5;584(5):917-22. doi: 10.1016/j.febslet.2010.01.025. Epub 2010 Jan 19.

30.

Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress.

Boudreau HE, Emerson SU, Korzeniowska A, Jendrysik MA, Leto TL.

J Virol. 2009 Dec;83(24):12934-46. doi: 10.1128/JVI.01059-09. Epub 2009 Oct 7.

31.

Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.

Leto TL, Morand S, Hurt D, Ueyama T.

Antioxid Redox Signal. 2009 Oct;11(10):2607-19. doi: 10.1089/ARS.2009.2637. Review.

32.

Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation.

Morand S, Ueyama T, Tsujibe S, Saito N, Korzeniowska A, Leto TL.

FASEB J. 2009 Apr;23(4):1205-18. doi: 10.1096/fj.08-120006. Epub 2008 Dec 12.

33.

Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin.

Rada B, Leto TL.

Immunol Res. 2009;43(1-3):198-209. doi: 10.1007/s12026-008-8071-8.

34.
35.

Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain.

Shmelzer Z, Karter M, Eisenstein M, Leto TL, Hadad N, Ben-Menahem D, Gitler D, Banani S, Wolach B, Rotem M, Levy R.

J Biol Chem. 2008 Nov 14;283(46):31898-908. doi: 10.1074/jbc.M804674200. Epub 2008 Sep 2.

36.

Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis.

Ueyama T, Kusakabe T, Karasawa S, Kawasaki T, Shimizu A, Son J, Leto TL, Miyawaki A, Saito N.

J Immunol. 2008 Jul 1;181(1):629-40.

37.

Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.

Rada B, Leto TL.

Contrib Microbiol. 2008;15:164-87. doi: 10.1159/000136357. Review.

38.

The K-562 cell model for analysis of neutrophil NADPH oxidase function.

Leto TL, Lavigne MC, Homoyounpour N, Lekstrom K, Linton G, Malech HL, de Mendez I.

Methods Mol Biol. 2007;412:365-83. doi: 10.1007/978-1-59745-467-4_24.

PMID:
18453124
39.

Radical generation and alterations of erythrocyte integrity as bioindicators of diagnostic or prognostic value in COPD?

Minetti M, Leto TL, Malorni W.

Antioxid Redox Signal. 2008 Apr;10(4):829-36. doi: 10.1089/ars.2007.1864. Review.

PMID:
18179360
40.

Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b.

Taylor RM, Lord CI, Riesselman MH, Gripentrog JM, Leto TL, McPhail LC, Berdichevsky Y, Pick E, Jesaitis AJ.

Biochemistry. 2007 Dec 11;46(49):14291-304. Epub 2007 Nov 16.

PMID:
18004884
41.

Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.

Choi H, Leto TL, Hunyady L, Catt KJ, Bae YS, Rhee SG.

J Biol Chem. 2008 Jan 4;283(1):255-67. Epub 2007 Nov 2.

42.

Novel sources of reactive oxygen species in the human body.

Orient A, Donkó A, Szabó A, Leto TL, Geiszt M.

Nephrol Dial Transplant. 2007 May;22(5):1281-8. Epub 2007 Mar 8. Review. No abstract available.

PMID:
17347280
43.

Two different pathways are involved in peroxynitrite-induced senescence and apoptosis of human erythrocytes.

Pietraforte D, Matarrese P, Straface E, Gambardella L, Metere A, Scorza G, Leto TL, Malorni W, Minetti M.

Free Radic Biol Med. 2007 Jan 15;42(2):202-14. Epub 2006 Oct 12.

PMID:
17189826
44.

Subcellular localization and function of alternatively spliced Noxo1 isoforms.

Ueyama T, Lekstrom K, Tsujibe S, Saito N, Leto TL.

Free Radic Biol Med. 2007 Jan 15;42(2):180-90. Epub 2006 Sep 12.

45.

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.

Ueyama T, Tatsuno T, Kawasaki T, Tsujibe S, Shirai Y, Sumimoto H, Leto TL, Saito N.

Mol Biol Cell. 2007 Feb;18(2):441-54. Epub 2006 Nov 22.

46.

Role of Nox family NADPH oxidases in host defense.

Leto TL, Geiszt M.

Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1549-61. Review.

PMID:
16987010
48.

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases.

Ueyama T, Geiszt M, Leto TL.

Mol Cell Biol. 2006 Mar;26(6):2160-74.

49.
50.

The Nox family of NAD(P)H oxidases: host defense and beyond.

Geiszt M, Leto TL.

J Biol Chem. 2004 Dec 10;279(50):51715-8. Epub 2004 Sep 13. Review. No abstract available.

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