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Items: 32


Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome.

Ehmsen S, Pedersen MH, Wang G, Terp MG, Arslanagic A, Hood BL, Conrads TP, Leth-Larsen R, Ditzel HJ.

Cell Rep. 2019 Jun 25;27(13):3927-3938.e6. doi: 10.1016/j.celrep.2019.05.104.


CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients.

Pedersen MH, Hood BL, Ehmsen S, Beck HC, Conrads TP, Bak M, Ditzel HJ, Leth-Larsen R.

Int J Cancer. 2019 Feb 1;144(3):631-640. doi: 10.1002/ijc.31798. Epub 2018 Nov 7.


Research integrity among PhD students within clinical research at the University of Southern Denmark.

Jensen LB, Kyvik KO, Leth-Larsen R, Eriksen MB.

Dan Med J. 2018 Apr;65(4). pii: A5469.


Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors.

Pedersen MH, Hood BL, Beck HC, Conrads TP, Ditzel HJ, Leth-Larsen R.

Oncoimmunology. 2017 Mar 16;6(5):e1305531. doi: 10.1080/2162402X.2017.1305531. eCollection 2017.


Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening.

Christensen AG, Ehmsen S, Terp MG, Batra R, Alcaraz N, Baumbach J, Noer JB, Moreira J, Leth-Larsen R, Larsen MR, Ditzel HJ.

Stem Cells. 2017 Aug;35(8):1898-1912. doi: 10.1002/stem.2654. Epub 2017 Jun 23.


NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.

Lund RR, Leth-Larsen R, Caterino TD, Terp MG, Nissen J, Lænkholm AV, Jensen ON, Ditzel HJ.

Mol Cell Proteomics. 2015 Nov;14(11):2988-99. doi: 10.1074/mcp.M115.050385. Epub 2015 Sep 8.


Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition.

Edwards SL, Poongavanam V, Kanwar JR, Roy K, Hillman KM, Prasad N, Leth-Larsen R, Petersen M, Marušič M, Plavec J, Wengel J, Veedu RN.

Chem Commun (Camb). 2015 Jun 11;51(46):9499-502. doi: 10.1039/c5cc02756j. Epub 2015 May 13.


S100A14 is a novel independent prognostic biomarker in the triple-negative breast cancer subtype.

Ehmsen S, Hansen LT, Bak M, Brasch-Andersen C, Ditzel HJ, Leth-Larsen R.

Int J Cancer. 2015 Nov 1;137(9):2093-103. doi: 10.1002/ijc.29582. Epub 2015 May 21.


Elucidation of epithelial-mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis.

Pauling JK, Christensen AG, Batra R, Alcaraz N, Barbosa E, Larsen MR, Beck HC, Leth-Larsen R, Azevedo V, Ditzel HJ, Baumbach J.

Integr Biol (Camb). 2014 Nov;6(11):1058-68. doi: 10.1039/c4ib00137k.


Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells.

Terp MG, Olesen KA, Arnspang EC, Lund RR, Lagerholm BC, Ditzel HJ, Leth-Larsen R.

J Immunol. 2013 Oct 15;191(8):4165-73. doi: 10.4049/jimmunol.1301274. Epub 2013 Sep 16.


Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family.

Vitashenkova N, Moeller JB, Leth-Larsen R, Schlosser A, Lund KP, Tornøe I, Vitved L, Hansen S, Willis A, Kharazova AD, Skjødt K, Sorensen GL, Holmskov U.

J Biol Chem. 2012 Dec 14;287(51):42846-55. doi: 10.1074/jbc.M112.420976. Epub 2012 Oct 31.


Identification of markers associated with highly aggressive metastatic phenotypes using quantitative comparative proteomics.

Terp MG, Lund RR, Jensen ON, Leth-Larsen R, Ditzel HJ.

Cancer Genomics Proteomics. 2012 Sep-Oct;9(5):265-73.


Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis.

Leth-Larsen R, Terp MG, Christensen AG, Elias D, Kühlwein T, Jensen ON, Petersen OW, Ditzel HJ.

Mol Med. 2012 Sep 25;18:1109-21. doi: 10.2119/molmed.2012.00091.


Quantitative proteomics of primary tumors with varying metastatic capabilities using stable isotope-labeled proteins of multiple histogenic origins.

Lund RR, Terp MG, Laenkholm AV, Jensen ON, Leth-Larsen R, Ditzel HJ.

Proteomics. 2012 Jul;12(13):2139-48. doi: 10.1002/pmic.201100490. Epub 2012 Jun 18.


Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry.

Palmisano G, Lendal SE, Engholm-Keller K, Leth-Larsen R, Parker BL, Larsen MR.

Nat Protoc. 2010 Dec;5(12):1974-82. doi: 10.1038/nprot.2010.167. Epub 2010 Nov 18.


Plasma membrane proteomics and its application in clinical cancer biomarker discovery.

Leth-Larsen R, Lund RR, Ditzel HJ.

Mol Cell Proteomics. 2010 Jul;9(7):1369-82. doi: 10.1074/mcp.R900006-MCP200. Epub 2010 Apr 8. Review.


Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction.

Sorensen GL, Hoegh SV, Leth-Larsen R, Thomsen TH, Floridon C, Smith K, Kejling K, Tornoe I, Crouch EC, Holmskov U.

Mol Immunol. 2009 Sep;46(15):3060-9. doi: 10.1016/j.molimm.2009.06.005. Epub 2009 Jul 3.


Efficient isolation and quantitative proteomic analysis of cancer cell plasma membrane proteins for identification of metastasis-associated cell surface markers.

Lund R, Leth-Larsen R, Jensen ON, Ditzel HJ.

J Proteome Res. 2009 Jun;8(6):3078-90. doi: 10.1021/pr801091k.


Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry.

Leth-Larsen R, Lund R, Hansen HV, Laenkholm AV, Tarin D, Jensen ON, Ditzel HJ.

Mol Cell Proteomics. 2009 Jun;8(6):1436-49. doi: 10.1074/mcp.M800061-MCP200. Epub 2009 Mar 24.


The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages.

Leth-Larsen R, Zhong F, Chow VT, Holmskov U, Lu J.

Immunobiology. 2007;212(3):201-11. Epub 2007 Jan 26.


Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice.

Sorensen GL, Hjelmborg JV, Leth-Larsen R, Schmidt V, Fenger M, Poulain F, Hawgood S, Sørensen TI, Kyvik KO, Holmskov U.

Scand J Immunol. 2006 Dec;64(6):633-8.


Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication.

Meschi J, Crouch EC, Skolnik P, Yahya K, Holmskov U, Leth-Larsen R, Tornoe I, Tecle T, White MR, Hartshorn KL.

J Gen Virol. 2005 Nov;86(Pt 11):3097-107.


Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus.

White MR, Crouch E, Vesona J, Tacken PJ, Batenburg JJ, Leth-Larsen R, Holmskov U, Hartshorn KL.

Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L606-16. Epub 2005 Jun 10.


A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.

Leth-Larsen R, Garred P, Jensenius H, Meschi J, Hartshorn K, Madsen J, Tornoe I, Madsen HO, Sørensen G, Crouch E, Holmskov U.

J Immunol. 2005 Feb 1;174(3):1532-8.


The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome.

Gravholt CH, Leth-Larsen R, Lauridsen AL, Thiel S, Hansen TK, Holmskov U, Naeraa RW, Christiansen JS.

Eur J Endocrinol. 2004 Mar;150(3):355-62.


Surfactant protein D in the female genital tract.

Leth-Larsen R, Floridon C, Nielsen O, Holmskov U.

Mol Hum Reprod. 2004 Mar;10(3):149-54. Epub 2004 Jan 29.


Surfactant protein D (SP-D) serum levels in patients with community-acquired pneumonia.

Leth-Larsen R, Nordenbaek C, Tornoe I, Moeller V, Schlosser A, Koch C, Teisner B, Junker P, Holmskov U.

Clin Immunol. 2003 Jul;108(1):29-37.


Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340.

Ligtenberg TJ, Bikker FJ, Groenink J, Tornoe I, Leth-Larsen R, Veerman EC, Nieuw Amerongen AV, Holmskov U.

Biochem J. 2001 Oct 1;359(Pt 1):243-8.


Structural characterisation of human proteinosis surfactant protein A.

Berg T, Leth-Larsen R, Holmskov U, Højrup P.

Biochim Biophys Acta. 2000 Nov 30;1543(1):159-73.


Structural characterization of human and bovine lung surfactant protein D.

Leth-Larsen R, Holmskov U, Højrup P.

Biochem J. 1999 Nov 1;343 Pt 3:645-52.


The third serine proteinase with chymotrypsin specificity isolated from Atlantic cod (Gadus morhua) is a type-II elastase.

Asgeirsson B, Leth-Larsen R, Thórólfsson M, Nedertoft MM, Højrup P.

Eur J Biochem. 1998 Aug 1;255(3):638-46.


Structure of chymotrypsin variant B from Atlantic cod, Gadus morhua.

Leth-Larsen R, Asgeirsson B, Thórólfsson M, Nørregaard-Madsen M, Højrup P.

Biochim Biophys Acta. 1996 Sep 13;1297(1):49-56.


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