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Route of Infection Strongly Impacts the Host-Pathogen Relationship.

Demars A, Lison A, Machelart A, Van Vyve M, Potemberg G, Vanderwinden JM, De Bolle X, Letesson JJ, Muraille E.

Front Immunol. 2019 Jul 11;10:1589. doi: 10.3389/fimmu.2019.01589. eCollection 2019.


Allergic Asthma Favors Brucella Growth in the Lungs of Infected Mice.

Machelart A, Potemberg G, Van Maele L, Demars A, Lagneaux M, De Trez C, Sabatel C, Bureau F, De Prins S, Percier P, Denis O, Jurion F, Romano M, Vanderwinden JM, Letesson JJ, Muraille E.

Front Immunol. 2018 Aug 10;9:1856. doi: 10.3389/fimmu.2018.01856. eCollection 2018.


Transposon Sequencing of Brucella abortus Uncovers Essential Genes for Growth In Vitro and Inside Macrophages.

Sternon JF, Godessart P, Gonçalves de Freitas R, Van der Henst M, Poncin K, Francis N, Willemart K, Christen M, Christen B, Letesson JJ, De Bolle X.

Infect Immun. 2018 Jul 23;86(8). pii: e00312-18. doi: 10.1128/IAI.00312-18. Print 2018 Aug.


The Fast-Growing Brucella suis Biovar 5 Depends on Phosphoenolpyruvate Carboxykinase and Pyruvate Phosphate Dikinase but Not on Fbp and GlpX Fructose-1,6-Bisphosphatases or Isocitrate Lyase for Full Virulence in Laboratory Models.

Zúñiga-Ripa A, Barbier T, Lázaro-Antón L, de Miguel MJ, Conde-Álvarez R, Muñoz PM, Letesson JJ, Iriarte M, Moriyón I.

Front Microbiol. 2018 Apr 5;9:641. doi: 10.3389/fmicb.2018.00641. eCollection 2018.


Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria.

Lobet E, Willemart K, Ninane N, Demazy C, Sedzicki J, Lelubre C, De Bolle X, Renard P, Raes M, Dehio C, Letesson JJ, Arnould T.

Sci Rep. 2018 Mar 26;8(1):5173. doi: 10.1038/s41598-018-23483-3.


3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum.

Sedzicki J, Tschon T, Low SH, Willemart K, Goldie KN, Letesson JJ, Stahlberg H, Dehio C.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210799. doi: 10.1242/jcs.210799.


Documenting the absence of brucellosis in cattle, goats and dogs in a "One Health" interface in the Mnisi community, Limpopo, South Africa.

Simpson G, Marcotty T, Rouille E, Matekwe N, Letesson JJ, Godfroid J.

Trop Anim Health Prod. 2018 Apr;50(4):903-906. doi: 10.1007/s11250-017-1495-1. Epub 2017 Dec 23.


Trypanosoma Infection Favors Brucella Elimination via IL-12/IFNγ-Dependent Pathways.

Machelart A, Van Vyve M, Potemberg G, Demars A, De Trez C, Tima HG, Vanwalleghem G, Romano M, Truyens C, Letesson JJ, Muraille E.

Front Immunol. 2017 Jul 31;8:903. doi: 10.3389/fimmu.2017.00903. eCollection 2017.


Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen.

Machelart A, Khadrawi A, Demars A, Willemart K, De Trez C, Letesson JJ, Muraille E.

Infect Immun. 2017 Oct 18;85(11). pii: e00115-17. doi: 10.1128/IAI.00115-17. Print 2017 Nov.


Field performance of six Mycobacterium avium subsp. paratuberculosis antigens in a 20h interferon gamma release assay in Belgium.

Dernivoix K, Roupie V, Welby S, Roelandt S, Viart S, Letesson JJ, Wattiez R, Huygen K, Govaerts M.

Vet Immunol Immunopathol. 2017 Jul;189:17-27. doi: 10.1016/j.vetimm.2017.05.008. Epub 2017 May 30.


Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection.

Barbier T, Machelart A, Zúñiga-Ripa A, Plovier H, Hougardy C, Lobet E, Willemart K, Muraille E, De Bolle X, Van Schaftingen E, Moriyón I, Letesson JJ.

Front Microbiol. 2017 Jun 13;8:1088. doi: 10.3389/fmicb.2017.01088. eCollection 2017.


Brucella central carbon metabolism: an update.

Barbier T, Zúñiga-Ripa A, Moussa S, Plovier H, Sternon JF, Lázaro-Antón L, Conde-Álvarez R, De Bolle X, Iriarte M, Moriyón I, Letesson JJ.

Crit Rev Microbiol. 2018 Mar;44(2):182-211. doi: 10.1080/1040841X.2017.1332002. Epub 2017 Jun 12. Review.


Brucella Genital Tropism: What's on the Menu.

Letesson JJ, Barbier T, Zúñiga-Ripa A, Godfroid J, De Bolle X, Moriyón I.

Front Microbiol. 2017 Mar 28;8:506. doi: 10.3389/fmicb.2017.00506. eCollection 2017. No abstract available.


Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection.

Bruffaerts N, Vluggen C, Roupie V, Duytschaever L, Van den Poel C, Denoël J, Wattiez R, Letesson JJ, Fretin D, Rigouts L, Chapeira O, Mathys V, Saegerman C, Huygen K.

PLoS One. 2017 Feb 9;12(2):e0171895. doi: 10.1371/journal.pone.0171895. eCollection 2017.


CtrA controls cell division and outer membrane composition of the pathogen Brucella abortus.

Francis N, Poncin K, Fioravanti A, Vassen V, Willemart K, Ong TA, Rappez L, Letesson JJ, Biondi EG, De Bolle X.

Mol Microbiol. 2017 Mar;103(5):780-797. doi: 10.1111/mmi.13589. Epub 2017 Jan 10.


Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains.

Suárez-Esquivel M, Ruiz-Villalobos N, Castillo-Zeledón A, Jiménez-Rojas C, Roop Ii RM, Comerci DJ, Barquero-Calvo E, Chacón-Díaz C, Caswell CC, Baker KS, Chaves-Olarte E, Thomson NR, Moreno E, Letesson JJ, De Bolle X, Guzmán-Verri C.

Front Microbiol. 2016 Sep 29;7:1557. eCollection 2016.


Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with Brucella melitensis in Mice.

Hanot Mambres D, Machelart A, Potemberg G, De Trez C, Ryffel B, Letesson JJ, Muraille E.

J Immunol. 2016 May 1;196(9):3780-93. doi: 10.4049/jimmunol.1502265. Epub 2016 Apr 1.


Brucella abortus Cell Cycle and Infection Are Coordinated.

De Bolle X, Crosson S, Matroule JY, Letesson JJ.

Trends Microbiol. 2015 Dec;23(12):812-821. doi: 10.1016/j.tim.2015.09.007. Epub 2015 Oct 20. Review.


In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.

Hanot Mambres D, Machelart A, Vanderwinden JM, De Trez C, Ryffel B, Letesson JJ, Muraille E.

PLoS One. 2015 Sep 16;10(9):e0137835. doi: 10.1371/journal.pone.0137835. eCollection 2015.


Mitochondria: a target for bacteria.

Lobet E, Letesson JJ, Arnould T.

Biochem Pharmacol. 2015 Apr 1;94(3):173-85. doi: 10.1016/j.bcp.2015.02.007. Epub 2015 Feb 20.


The quest for a true One Health perspective of brucellosis.

Godfroid J, DeBolle X, Roop RM, O'Callaghan D, Tsolis RM, Baldwin C, Santos RL, McGiven J, Olsen S, Nymo IH, Larsen A, Al Dahouk S, Letesson JJ.

Rev Sci Tech. 2014 Aug;33(2):521-38. Review.


Brucella, nitrogen and virulence.

Ronneau S, Moussa S, Barbier T, Conde-Álvarez R, Zuniga-Ripa A, Moriyon I, Letesson JJ.

Crit Rev Microbiol. 2016 Aug;42(4):507-25. doi: 10.3109/1040841X.2014.962480. Epub 2014 Dec 4. Review.


Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella.

Barbier T, Collard F, Zúñiga-Ripa A, Moriyón I, Godard T, Becker J, Wittmann C, Van Schaftingen E, Letesson JJ.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17815-20. doi: 10.1073/pnas.1414622111. Epub 2014 Dec 1.


On the link between cell cycle and infection of the Alphaproteobacterium Brucella abortus.

Deghelt M, Letesson JJ, De Bolle X.

Microb Cell. 2014 Sep 29;1(10):346-348. doi: 10.15698/mic2014.10.171.


Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy.

Hamer I, Goffin E, De Bolle X, Letesson JJ, Jadot M.

BMC Microbiol. 2014 Sep 2;14:223. doi: 10.1186/s12866-014-0223-5.


G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus.

Deghelt M, Mullier C, Sternon JF, Francis N, Laloux G, Dotreppe D, Van der Henst C, Jacobs-Wagner C, Letesson JJ, De Bolle X.

Nat Commun. 2014 Jul 9;5:4366. doi: 10.1038/ncomms5366.


Brucella melitensis invades murine erythrocytes during infection.

Vitry MA, Hanot Mambres D, Deghelt M, Hack K, Machelart A, Lhomme F, Vanderwinden JM, Vermeersch M, De Trez C, Pérez-Morga D, Letesson JJ, Muraille E.

Infect Immun. 2014 Sep;82(9):3927-38. doi: 10.1128/IAI.01779-14. Epub 2014 Jul 7.


Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models.

Zúñiga-Ripa A, Barbier T, Conde-Álvarez R, Martínez-Gómez E, Palacios-Chaves L, Gil-Ramírez Y, Grilló MJ, Letesson JJ, Iriarte M, Moriyón I.

J Bacteriol. 2014 Aug 15;196(16):3045-57. doi: 10.1128/JB.01663-14. Epub 2014 Jun 16.


Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis.

Vitry MA, Hanot Mambres D, De Trez C, Akira S, Ryffel B, Letesson JJ, Muraille E.

J Immunol. 2014 Apr 15;192(8):3740-52. doi: 10.4049/jimmunol.1302561. Epub 2014 Mar 19.


Quorum sensing and self-quorum quenching in the intracellular pathogen Brucellamelitensis.

Terwagne M, Mirabella A, Lemaire J, Deschamps C, De Bolle X, Letesson JJ.

PLoS One. 2013 Dec 11;8(12):e82514. doi: 10.1371/journal.pone.0082514. eCollection 2013.


The Brucella pathogens are polarized bacteria.

Van der Henst C, de Barsy M, Zorreguieta A, Letesson JJ, De Bolle X.

Microbes Infect. 2013 Dec;15(14-15):998-1004. doi: 10.1016/j.micinf.2013.10.008. Epub 2013 Oct 18. Review.


BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.

Salcedo SP, Marchesini MI, Degos C, Terwagne M, Von Bargen K, Lepidi H, Herrmann CK, Santos Lacerda TL, Imbert PR, Pierre P, Alexopoulou L, Letesson JJ, Comerci DJ, Gorvel JP.

Front Cell Infect Microbiol. 2013 Jul 8;3:28. doi: 10.3389/fcimb.2013.00028. eCollection 2013.


Innate immune recognition of flagellin limits systemic persistence of Brucella.

Terwagne M, Ferooz J, Rolán HG, Sun YH, Atluri V, Xavier MN, Franchi L, Núñez G, Legrand T, Flavell RA, De Bolle X, Letesson JJ, Tsolis RM.

Cell Microbiol. 2013 Jun;15(6):942-960. doi: 10.1111/cmi.12088. Epub 2013 Jan 7.


Small GTPases and Brucella entry into the endoplasmic reticulum.

de Bolle X, Letesson JJ, Gorvel JP.

Biochem Soc Trans. 2012 Dec 1;40(6):1348-52. doi: 10.1042/BST20120156.


Brucella melitensis MucR, an orthologue of Sinorhizobium meliloti MucR, is involved in resistance to oxidative, detergent, and saline stresses and cell envelope modifications.

Mirabella A, Terwagne M, Zygmunt MS, Cloeckaert A, De Bolle X, Letesson JJ.

J Bacteriol. 2013 Feb;195(3):453-65. doi: 10.1128/JB.01336-12. Epub 2012 Nov 16.


Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice.

Vitry MA, De Trez C, Goriely S, Dumoutier L, Akira S, Ryffel B, Carlier Y, Letesson JJ, Muraille E.

Infect Immun. 2012 Dec;80(12):4271-80. doi: 10.1128/IAI.00761-12. Epub 2012 Sep 24.


Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPase.

Nkengfac B, Pouyez J, Bauwens E, Vandenhaute J, Letesson JJ, Wouters J, De Bolle X.

BMC Biochem. 2012 Aug 14;13:16. doi: 10.1186/1471-2091-13-16.


The two-component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength.

Mirabella A, Yañez Villanueva RM, Delrue RM, Uzureau S, Zygmunt MS, Cloeckaert A, De Bolle X, Letesson JJ.

Microbiology. 2012 Oct;158(Pt 10):2642-2651. doi: 10.1099/mic.0.060863-0. Epub 2012 Aug 2.


The histidine kinase PdhS controls cell cycle progression of the pathogenic alphaproteobacterium Brucella abortus.

Van der Henst C, Beaufay F, Mignolet J, Didembourg C, Colinet J, Hallet B, Letesson JJ, De Bolle X.

J Bacteriol. 2012 Oct;194(19):5305-14. doi: 10.1128/JB.00699-12. Epub 2012 Jul 27.


A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells.

de Barsy M, Mirabella A, Letesson JJ, De Bolle X.

Microbiology. 2012 Oct;158(Pt 10):2610-2618. doi: 10.1099/mic.0.060509-0. Epub 2012 Jul 19.


In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice.

Copin R, Vitry MA, Hanot Mambres D, Machelart A, De Trez C, Vanderwinden JM, Magez S, Akira S, Ryffel B, Carlier Y, Letesson JJ, Muraille E.

PLoS Pathog. 2012;8(3):e1002575. doi: 10.1371/journal.ppat.1002575. Epub 2012 Mar 29.


The alkylation response protein AidB is localized at the new poles and constriction sites in Brucella abortus.

Dotreppe D, Mullier C, Letesson JJ, De Bolle X.

BMC Microbiol. 2011 Nov 23;11:257. doi: 10.1186/1471-2180-11-257.


Immunogenicity of eight Mycobacterium avium subsp. paratuberculosis specific antigens in DNA vaccinated and Map infected mice.

Roupie V, Viart S, Leroy B, Romano M, Trinchero N, Govaerts M, Letesson JJ, Wattiez R, Huygen K.

Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):74-85. doi: 10.1016/j.vetimm.2011.10.012. Epub 2011 Oct 28.


Brucella adaptation and survival at the crossroad of metabolism and virulence.

Barbier T, Nicolas C, Letesson JJ.

FEBS Lett. 2011 Oct 3;585(19):2929-34. doi: 10.1016/j.febslet.2011.08.011. Epub 2011 Aug 19. Review.


Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century.

Godfroid J, Scholz HC, Barbier T, Nicolas C, Wattiau P, Fretin D, Whatmore AM, Cloeckaert A, Blasco JM, Moriyon I, Saegerman C, Muma JB, Al Dahouk S, Neubauer H, Letesson JJ.

Prev Vet Med. 2011 Nov 1;102(2):118-31. doi: 10.1016/j.prevetmed.2011.04.007. Epub 2011 May 14. Review.


Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.

de Barsy M, Jamet A, Filopon D, Nicolas C, Laloux G, Rual JF, Muller A, Twizere JC, Nkengfac B, Vandenhaute J, Hill DE, Salcedo SP, Gorvel JP, Letesson JJ, De Bolle X.

Cell Microbiol. 2011 Jul;13(7):1044-58. doi: 10.1111/j.1462-5822.2011.01601.x. Epub 2011 May 30.


Role of FlbT in flagellin production in Brucella melitensis.

Ferooz J, Lemaire J, Letesson JJ.

Microbiology. 2011 May;157(Pt 5):1253-1262. doi: 10.1099/mic.0.044867-0. Epub 2011 Jan 27.


RpoE1, an extracytoplasmic function sigma factor, is a repressor of the flagellar system in Brucella melitensis.

Ferooz J, Lemaire J, Delory M, De Bolle X, Letesson JJ.

Microbiology. 2011 May;157(Pt 5):1263-1268. doi: 10.1099/mic.0.044875-0. Epub 2011 Jan 27.


Morphological analysis of the sheathed flagellum of Brucella melitensis.

Ferooz J, Letesson JJ.

BMC Res Notes. 2010 Dec 9;3:333. doi: 10.1186/1756-0500-3-333.


Identification of the essential Brucella melitensis porin Omp2b as a suppressor of Bax-induced cell death in yeast in a genome-wide screening.

Laloux G, Deghelt M, de Barsy M, Letesson JJ, De Bolle X.

PLoS One. 2010 Oct 11;5(10):e13274. doi: 10.1371/journal.pone.0013274.

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