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Items: 1 to 50 of 79

1.

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.

Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott R, Wang Y, Shaffer SA, Kiebish MA, DiFiglia M, Aronin N, Khvorova A.

iScience. 2019 May 27;16:230-241. doi: 10.1016/j.isci.2019.05.029. [Epub ahead of print]

2.

Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.

Becerra-Artiles A, Cruz J, Leszyk JD, Sidney J, Sette A, Shaffer SA, Stern LJ.

Eur J Immunol. 2019 Apr 25. doi: 10.1002/eji.201948126. [Epub ahead of print]

PMID:
31020640
3.

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.

Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA.

Hum Mol Genet. 2019 Jul 1;28(13):2143-2160. doi: 10.1093/hmg/ddz048.

PMID:
30806671
4.

Selective profiling of ribosomes associated with yeast Upf proteins.

Ganesan R, Leszyk J, Jacobson A.

Methods. 2019 Feb 15;155:58-67. doi: 10.1016/j.ymeth.2018.12.008. Epub 2018 Dec 26.

PMID:
30593864
5.

HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.

Nanaware PP, Jurewicz MM, Leszyk JD, Shaffer SA, Stern LJ.

Mol Cell Proteomics. 2019 Mar;18(3):490-503. doi: 10.1074/mcp.RA118.000956. Epub 2018 Dec 20.

PMID:
30573663
6.

A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.

Rittershaus ESC, Baek SH, Krieger IV, Nelson SJ, Cheng YS, Nambi S, Baker RE, Leszyk JD, Shaffer SA, Sacchettini JC, Sassetti CM.

Cell Chem Biol. 2018 Dec 20;25(12):1495-1505.e3. doi: 10.1016/j.chembiol.2018.09.009. Epub 2018 Oct 11.

PMID:
30318462
7.

RNA binding proteins co-localize with small tau inclusions in tauopathy.

Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B.

Acta Neuropathol Commun. 2018 Aug 1;6(1):71. doi: 10.1186/s40478-018-0574-5.

8.

C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.

Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ.

Nat Methods. 2018 Jun;15(6):433-436. doi: 10.1038/s41592-018-0006-2. Epub 2018 May 7.

9.

Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria.

Sakatos A, Babunovic GH, Chase MR, Dills A, Leszyk J, Rosebrock T, Bryson B, Fortune SM.

Sci Adv. 2018 May 2;4(5):eaao1478. doi: 10.1126/sciadv.aao1478. eCollection 2018 May.

10.

Immunocontraceptive target repertoire defined by systematic identification of sperm membrane alloantigens in a single species.

Cormier N, McGlone JJ, Leszyk J, Hardy DM.

PLoS One. 2018 Jan 17;13(1):e0190891. doi: 10.1371/journal.pone.0190891. eCollection 2018.

11.

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.

Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B.

Nat Neurosci. 2018 Jan;21(1):72-80. doi: 10.1038/s41593-017-0022-z. Epub 2017 Nov 20.

12.

Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant.

Prokaeva T, Akar H, Spencer B, Havasi A, Cui H, O'Hara CJ, Gursky O, Leszyk J, Steffen M, Browning S, Rosenberg A, Connors LH.

Kidney Int Rep. 2017 Jul 29;2(6):1223-1232. doi: 10.1016/j.ekir.2017.07.009. eCollection 2017 Nov. No abstract available.

13.

Innate immune signaling in Drosophila is regulated by transforming growth factor β (TGFβ)-activated kinase (Tak1)-triggered ubiquitin editing.

Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, Shaffer SA, Silverman N.

J Biol Chem. 2017 May 26;292(21):8738-8749. doi: 10.1074/jbc.M117.788158. Epub 2017 Apr 4.

14.

Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.

Shin A, Shin B, Shin JW, Kim KH, Atwal RS, Hope JM, Gillis T, Leszyk JD, Shaffer SA, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS, Lee JM.

Hum Mol Genet. 2017 Apr 1;26(7):1258-1267. doi: 10.1093/hmg/ddx033.

15.

The nucleoside analog clitocine is a potent and efficacious readthrough agent.

Friesen WJ, Trotta CR, Tomizawa Y, Zhuo J, Johnson B, Sierra J, Roy B, Weetall M, Hedrick J, Sheedy J, Takasugi J, Moon YC, Babu S, Baiazitov R, Leszyk JD, Davis TW, Colacino JM, Peltz SW, Welch EM.

RNA. 2017 Apr;23(4):567-577. doi: 10.1261/rna.060236.116. Epub 2017 Jan 17.

16.

Identification of proximal sites for unwound DNA substrate in Escherichia coli topoisomerase I with oxidative crosslinking.

Cheng B, Zhou Q, Weng L, Leszyk JD, Greenberg MM, Tse-Dinh YC.

FEBS Lett. 2017 Jan;591(1):28-38. doi: 10.1002/1873-3468.12517. Epub 2016 Dec 20.

17.

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

Haraszti RA, Didiot MC, Sapp E, Leszyk J, Shaffer SA, Rockwell HE, Gao F, Narain NR, DiFiglia M, Kiebish MA, Aronin N, Khvorova A.

J Extracell Vesicles. 2016 Nov 17;5:32570. doi: 10.3402/jev.v5.32570. eCollection 2016.

18.

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.

Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12508-12513. Epub 2016 Oct 4.

19.

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B.

Cell Rep. 2016 May 17;15(7):1455-1466. doi: 10.1016/j.celrep.2016.04.045. Epub 2016 May 6.

20.

Spatially distinct and metabolically active membrane domain in mycobacteria.

Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5400-5. doi: 10.1073/pnas.1525165113. Epub 2016 Apr 25.

21.

Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts.

Specht CA, Lee CK, Huang H, Tipper DJ, Shen ZT, Lodge JK, Leszyk J, Ostroff GR, Levitz SM.

MBio. 2015 Dec 22;6(6):e01905-15. doi: 10.1128/mBio.01905-15.

22.

The 2012/2013 ABRF Proteomic Research Group Study: Assessing Longitudinal Intralaboratory Variability in Routine Peptide Liquid Chromatography Tandem Mass Spectrometry Analyses.

Bennett KL, Wang X, Bystrom CE, Chambers MC, Andacht TM, Dangott LJ, Elortza F, Leszyk J, Molina H, Moritz RL, Phinney BS, Thompson JW, Bunger MK, Tabb DL.

Mol Cell Proteomics. 2015 Dec;14(12):3299-309. doi: 10.1074/mcp.O115.051888. Epub 2015 Oct 4.

23.

Macrophage secretome from women with HIV-associated neurocognitive disorders.

Colon K, Perez-Laspiur J, Quiles R, Rodriguez Y, Wojna V, Shaffer SA, Leszyk J, Skolasky RL Jr, Melendez LM.

Proteomics Clin Appl. 2016 Feb;10(2):136-43. doi: 10.1002/prca.201400203. Epub 2015 Nov 18.

24.

Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis.

Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM.

AIDS. 2015 Oct 23;29(16):2081-92. doi: 10.1097/QAD.0000000000000823.

25.

Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.

Nasipak BT, Padilla-Benavides T, Green KM, Leszyk JD, Mao W, Konda S, Sif S, Shaffer SA, Ohkawa Y, Imbalzano AN.

Nat Commun. 2015 Jun 17;6:7441. doi: 10.1038/ncomms8441.

26.

Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3.

Roy B, Leszyk JD, Mangus DA, Jacobson A.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3038-43. doi: 10.1073/pnas.1424127112. Epub 2015 Mar 2.

27.

Supervillin binding to myosin II and synergism with anillin are required for cytokinesis.

Smith TC, Fridy PC, Li Y, Basil S, Arjun S, Friesen RM, Leszyk J, Chait BT, Rout MP, Luna EJ.

Mol Biol Cell. 2013 Dec;24(23):3603-19. doi: 10.1091/mbc.E12-10-0714. Epub 2013 Oct 2.

28.

Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers.

Jones KA, Kim PD, Patel BB, Kelsen SG, Braverman A, Swinton DJ, Gafken PR, Jones LA, Lane WS, Neveu JM, Leung HE, Shaffer SA, Leszyk JD, Stanley BA, Fox TE, Stanley A, Hall MJ, Hampel H, South CD, de la Chapelle A, Burt RW, Jones DA, Kopelovich L, Yeung AT.

J Proteome Res. 2013 Oct 4;12(10):4351-65. doi: 10.1021/pr400307u. Epub 2013 Sep 19.

29.

Lactotransferrin in Asian elephant (Elephas maximus) seminal plasma correlates with semen quality.

Kiso WK, Selvaraj V, Nagashima J, Asano A, Brown JL, Schmitt DL, Leszyk J, Travis AJ, Pukazhenthi BS.

PLoS One. 2013 Aug 16;8(8):e71033. doi: 10.1371/journal.pone.0071033. eCollection 2013.

30.

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus.

Singh G, Kucukural A, Cenik C, Leszyk JD, Shaffer SA, Weng Z, Moore MJ.

Cell. 2012 Nov 9;151(4):915-916. doi: 10.1016/j.cell.2012.10.032. Epub 2012 Nov 8. No abstract available.

31.

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

Singh G, Kucukural A, Cenik C, Leszyk JD, Shaffer SA, Weng Z, Moore MJ.

Cell. 2012 Nov 9;151(4):750-764. doi: 10.1016/j.cell.2012.10.007. Epub 2012 Oct 18. Erratum in: Cell. 2012 Nov 9;151(4):915-6. Cell. 2012 Nov 9;151(4):915-916.

32.

LPS remodeling is an evolved survival strategy for bacteria.

Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8716-21. doi: 10.1073/pnas.1202908109. Epub 2012 May 14. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13877.

33.

Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons.

Koles K, Nunnari J, Korkut C, Barria R, Brewer C, Li Y, Leszyk J, Zhang B, Budnik V.

J Biol Chem. 2012 May 11;287(20):16820-34. doi: 10.1074/jbc.M112.342667. Epub 2012 Mar 21.

34.

Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.

Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Yang K, Guberski DL, Mordes JP, Greiner DL, Rossini AA, Bortell R.

Exp Biol Med (Maywood). 2010 Nov;235(11):1328-37. doi: 10.1258/ebm.2010.010150.

35.
36.

Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation.

Romero R, Kusanovic JP, Gotsch F, Erez O, Vaisbuch E, Mazaki-Tovi S, Moser A, Tam S, Leszyk J, Master SR, Juhasz P, Pacora P, Ogge G, Gomez R, Yoon BH, Yeo L, Hassan SS, Rogers WT.

J Matern Fetal Neonatal Med. 2010 Apr;23(4):261-80. doi: 10.3109/14767050903067386.

PMID:
19670042
37.

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.

Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP.

Biochem J. 2008 May 1;411(3):647-55. doi: 10.1042/BJ20071084.

38.

Proteomic analysis of rat liver phosphoproteins after treatment with protein kinase inhibitor H89 (N-(2-[p-bromocinnamylamino-]ethyl)-5-isoquinolinesulfonamide).

Davis MA, Hinerfeld D, Joseph S, Hui YH, Huang NH, Leszyk J, Rutherford-Bethard J, Tam SW.

J Pharmacol Exp Ther. 2006 Aug;318(2):589-95. Epub 2006 May 10.

PMID:
16687476
39.

Characterization of an alternate form of Newcastle disease virus fusion protein.

Pantua H, McGinnes LW, Leszyk J, Morrison TG.

J Virol. 2005 Sep;79(18):11660-70.

40.

Proteomic analysis of a eukaryotic cilium.

Pazour GJ, Agrin N, Leszyk J, Witman GB.

J Cell Biol. 2005 Jul 4;170(1):103-13.

41.

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP.

J Biol Chem. 2005 Jun 3;280(22):21622-8. Epub 2005 Mar 30.

42.

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch L, Nicoloro S, Chouinard M, Lazar MA, Chui PC, Leszyk J, Straubhaar J, Czech MP, Corvera S.

J Clin Invest. 2004 Nov;114(9):1281-9.

43.

Role of insulin action and cell size on protein expression patterns in adipocytes.

Blüher M, Wilson-Fritch L, Leszyk J, Laustsen PG, Corvera S, Kahn CR.

J Biol Chem. 2004 Jul 23;279(30):31902-9. Epub 2004 May 6.

44.

EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.

Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP.

J Biol Chem. 2004 Mar 12;279(11):10593-605. Epub 2003 Dec 15.

45.

Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.

Semiz S, Park JG, Nicoloro SM, Furcinitti P, Zhang C, Chawla A, Leszyk J, Czech MP.

EMBO J. 2003 May 15;22(10):2387-99.

46.

Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, Czech M, Corvera S.

Mol Cell Biol. 2003 Feb;23(3):1085-94.

47.

Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.

Nebl T, Pestonjamasp KN, Leszyk JD, Crowley JL, Oh SW, Luna EJ.

J Biol Chem. 2002 Nov 8;277(45):43399-409. Epub 2002 Aug 28.

48.
49.

PYK2 as a mediator of endothelin-1/G alpha 11 signaling to GLUT4 glucose transporters.

Park JG, Bose A, Leszyk J, Czech MP.

J Biol Chem. 2001 Dec 21;276(51):47751-4. Epub 2001 Oct 15.

50.

Cytoplasmic dynein intermediate chain phosphorylation regulates binding to dynactin.

Vaughan PS, Leszyk JD, Vaughan KT.

J Biol Chem. 2001 Jul 13;276(28):26171-9. Epub 2001 May 4.

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