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Research Note: Evaluation of a heat stress model to induce gastrointestinal leakage in broiler chickens.

Ruff J, Barros TL, Tellez G Jr, Blankenship J, Lester H, Graham BD, Selby CAM, Vuong CN, Dridi S, Greene ES, Hernandez-Velasco X, Hargis BM, Tellez-Isaias G.

Poult Sci. 2020 Mar;99(3):1687-1692. doi: 10.1016/j.psj.2019.10.075. Epub 2019 Dec 27.


Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum.

Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA.

Front Cell Neurosci. 2019 Nov 12;13:499. doi: 10.3389/fncel.2019.00499. eCollection 2019.


Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem.

Lester HA, Dougherty DA.

Neuron. 2019 Nov 6;104(3):431-432. doi: 10.1016/j.neuron.2019.10.029.


Brain Region-Specific nAChR and Associated Protein Abundance Alterations Following Chronic Nicotine and/or Menthol Exposure.

Mulcahy MJ, Huard SM, Paulo JA, Wang JH, McKinney S, Henderson BJ, Lester HA.

J Proteome Res. 2020 Jan 3;19(1):36-48. doi: 10.1021/acs.jproteome.9b00286. Epub 2019 Oct 28.


Data Products, Quality and Validation of the DLR Earth Sensing Imaging Spectrometer (DESIS).

Alonso K, Bachmann M, Burch K, Carmona E, Cerra D, de Los Reyes R, Dietrich D, Heiden U, Hölderlin A, Ickes J, Knodt U, Krutz D, Lester H, Müller R, Pagnutti M, Reinartz P, Richter R, Ryan R, Sebastian I, Tegler M.

Sensors (Basel). 2019 Oct 15;19(20). pii: E4471. doi: 10.3390/s19204471.


Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor.

Blom AEM, Campello HR, Lester HA, Gallagher T, Dougherty DA.

J Am Chem Soc. 2019 Oct 9;141(40):15840-15849. doi: 10.1021/jacs.9b06580. Epub 2019 Sep 24.


Impact of team configuration and team stability on primary care quality.

Hysong SJ, Amspoker AB, Hughes AM, Woodard L, Oswald FL, Petersen LA, Lester HF.

Implement Sci. 2019 Mar 6;14(1):22. doi: 10.1186/s13012-019-0864-8.


Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors.

Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA.

J Gen Physiol. 2019 Jun 3;151(6):738-757. doi: 10.1085/jgp.201812201. Epub 2019 Feb 4.


Chronic Menthol Does Not Change Stoichiometry or Functional Plasma Membrane Levels of Mouse α3β4-Containing Nicotinic Acetylcholine Receptors.

Bavan S, Kim CH, Henderson BJ, Lester HA.

Mol Pharmacol. 2019 Apr;95(4):398-407. doi: 10.1124/mol.118.114769. Epub 2019 Jan 22.


Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs.

Zhou C, Gu W, Wu H, Yan X, Deshpande P, Xiao C, Lester HA.

Neuropharmacology. 2019 Apr;148:220-228. doi: 10.1016/j.neuropharm.2019.01.015. Epub 2019 Jan 17.


Menthol Stereoisomers Exhibit Different Effects on α4β2 nAChR Upregulation and Dopamine Neuron Spontaneous Firing.

Henderson BJ, Grant S, Chu BW, Shahoei R, Huard SM, Saladi SSM, Tajkhorshid E, Dougherty DA, Lester HA.

eNeuro. 2019 Jan 4;5(6). pii: ENEURO.0465-18.2018. doi: 10.1523/ENEURO.0465-18.2018. eCollection 2018 Nov-Dec.


Dietary supplementation with ferric tyrosine improves zootechnical performance and reduces caecal Campylobacter spp. load in broilers.

Currie D, Green M, Dufailu OA, Matthaios P, Soultanas P, McCartney E, Lester H, Van Den Eede L, Apajalahti J, Mahdavi J.

Br Poult Sci. 2018 Dec;59(6):646-653. doi: 10.1080/00071668.2018.1507015. Epub 2018 Sep 7.


α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor.

Nichols AL, Noridomi K, Hughes CR, Jalali-Yazdi F, Eaton JB, Lai LH, Advani G, Lukas RJ, Lester HA, Chen L, Roberts RW.

ACS Chem Biol. 2018 Sep 21;13(9):2568-2576. doi: 10.1021/acschembio.8b00513. Epub 2018 Aug 13.


Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein.

Subramaniam SR, Magen I, Bove N, Zhu C, Lemesre V, Dutta G, Elias CJ, Lester HA, Chesselet MF.

Neurobiol Dis. 2018 Sep;117:170-180. doi: 10.1016/j.nbd.2018.05.018. Epub 2018 Jun 1.


Photoactivatable drugs for nicotinic optopharmacology.

Banala S, Arvin MC, Bannon NM, Jin XT, Macklin JJ, Wang Y, Peng C, Zhao G, Marshall JJ, Gee KR, Wokosin DL, Kim VJ, McIntosh JM, Contractor A, Lester HA, Kozorovitskiy Y, Drenan RM, Lavis LD.

Nat Methods. 2018 May;15(5):347-350. doi: 10.1038/nmeth.4637. Epub 2018 Mar 26.


Deletion of lynx1 reduces the function of α6* nicotinic receptors.

Parker RL, O'Neill HC, Henley BM, Wageman CR, Drenan RM, Marks MJ, Miwa JM, Grady SR, Lester HA.

PLoS One. 2017 Dec 5;12(12):e0188715. doi: 10.1371/journal.pone.0188715. eCollection 2017.


Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala.

Tarren JR, Lester HA, Belmer A, Bartlett SE.

Front Mol Neurosci. 2017 Oct 24;10:338. doi: 10.3389/fnmol.2017.00338. eCollection 2017.


TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors.

Wall TR, Henderson BJ, Voren G, Wageman CR, Deshpande P, Cohen BN, Grady SR, Marks MJ, Yohannes D, Kenny PJ, Bencherif M, Lester HA.

Front Pharmacol. 2017 Sep 26;8:641. doi: 10.3389/fphar.2017.00641. eCollection 2017.


Effects of bacitracin methylene disalicylate and diet change on gastrointestinal integrity and endotoxin permeability in the duodenum of broiler chicken.

Koltes DA, Lester HD, Frost M, Aldridge D, Christensen KD, Scanes CG.

BMC Res Notes. 2017 Sep 8;10(1):470. doi: 10.1186/s13104-017-2781-8.


Granulocytes as models for human protein marker identification following nicotine exposure.

Mulcahy MJ, Lester HA.

J Neurochem. 2017 Aug;142 Suppl 2:151-161. doi: 10.1111/jnc.14010. Review.


TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus.

Hurtado-Zavala JI, Ramachandran B, Ahmed S, Halder R, Bolleyer C, Awasthi A, Stahlberg MA, Wagener RJ, Anderson K, Drenan RM, Lester HA, Miwa JM, Staiger JF, Fischer A, Dean C.

Nat Commun. 2017 Jul 19;8:15878. doi: 10.1038/ncomms15878.


Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors.

Post MR, Tender GS, Lester HA, Dougherty DA.

eNeuro. 2017 Mar 30;4(2). pii: ENEURO.0032-17.2017. doi: 10.1523/ENEURO.0032-17.2017. eCollection 2017 Mar-Apr.


Menthol Enhances Nicotine Reward-Related Behavior by Potentiating Nicotine-Induced Changes in nAChR Function, nAChR Upregulation, and DA Neuron Excitability.

Henderson BJ, Wall TR, Henley BM, Kim CH, McKinney S, Lester HA.

Neuropsychopharmacology. 2017 Nov;42(12):2285-2291. doi: 10.1038/npp.2017.72. Epub 2017 Apr 2.


Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP Expression.

Henley BM, Cohen BN, Kim CH, Gold HD, Srinivasan R, McKinney S, Deshpande P, Lester HA.

J Vis Exp. 2017 Feb 10;(120). doi: 10.3791/54981.


Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors.

Post MR, Lester HA, Dougherty DA.

Biochemistry. 2017 Apr 4;56(13):1836-1840. doi: 10.1021/acs.biochem.7b00213. Epub 2017 Mar 21.


Investigating anthelmintic efficacy against gastrointestinal nematodes in cattle by considering appropriate probability distributions for faecal egg count data.

Love JW, Kelly LA, Lester HE, Nanjiani I, Taylor MA, Robertson C.

Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):71-82. doi: 10.1016/j.ijpddr.2017.01.002. Epub 2017 Jan 16.


D2R2: an evidence-based decision support tool to aid prioritisation of animal health issues for government funding.

Gibbens JC, Frost AJ, Houston CW, Lester H, Gauntlett FA.

Vet Rec. 2016 Nov 26;179(21):547. doi: 10.1136/vr.103684. Epub 2016 Oct 5. Review.


Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy.

Kim J, Henley BM, Kim CH, Lester HA, Yang C.

Biomed Opt Express. 2016 Jul 22;7(8):3097-110. doi: 10.1364/BOE.7.003097. eCollection 2016 Aug 1.


Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression.

Nichols WA, Henderson BJ, Marotta CB, Yu CY, Richards C, Dougherty DA, Lester HA, Cohen BN.

PLoS One. 2016 Jun 23;11(6):e0158032. doi: 10.1371/journal.pone.0158032. eCollection 2016.


The course of negative symptom in first episode psychosis and the relationship with social recovery.

Gee B, Hodgekins J, Fowler D, Marshall M, Everard L, Lester H, Jones PB, Amos T, P Singh S, Sharma V, Freemantle N, Birchwood M.

Schizophr Res. 2016 Jul;174(1-3):165-171. doi: 10.1016/j.schres.2016.04.017. Epub 2016 Apr 28.


Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.

Henderson BJ, Wall TR, Henley BM, Kim CH, Nichols WA, Moaddel R, Xiao C, Lester HA.

J Neurosci. 2016 Mar 9;36(10):2957-74. doi: 10.1523/JNEUROSCI.4194-15.2016.


Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons.

Srinivasan R, Henley BM, Henderson BJ, Indersmitten T, Cohen BN, Kim CH, McKinney S, Deshpande P, Xiao C, Lester HA.

J Neurosci. 2016 Jan 6;36(1):65-79. doi: 10.1523/JNEUROSCI.2126-15.2016.


A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial.

Littlewood E, Duarte A, Hewitt C, Knowles S, Palmer S, Walker S, Andersen P, Araya R, Barkham M, Bower P, Brabyn S, Brierley G, Cooper C, Gask L, Kessler D, Lester H, Lovell K, Muhammad U, Parry G, Richards DA, Richardson R, Tallon D, Tharmanathan P, White D, Gilbody S; REEACT Team.

Health Technol Assess. 2015 Dec;19(101):viii, xxi-171. doi: 10.3310/hta191010.


Patient experience of computerised therapy for depression in primary care.

Knowles SE, Lovell K, Bower P, Gilbody S, Littlewood E, Lester H.

BMJ Open. 2015 Nov 30;5(11):e008581. doi: 10.1136/bmjopen-2015-008581.


Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial.

Gilbody S, Littlewood E, Hewitt C, Brierley G, Tharmanathan P, Araya R, Barkham M, Bower P, Cooper C, Gask L, Kessler D, Lester H, Lovell K, Parry G, Richards DA, Andersen P, Brabyn S, Knowles S, Shepherd C, Tallon D, White D; REEACT Team.

BMJ. 2015 Nov 11;351:h5627. doi: 10.1136/bmj.h5627. Erratum in: BMJ. 2016;352:i195.


Investigating trajectories of social recovery in individuals with first-episode psychosis: a latent class growth analysis.

Hodgekins J, Birchwood M, Christopher R, Marshall M, Coker S, Everard L, Lester H, Jones P, Amos T, Singh S, Sharma V, Freemantle N, Fowler D.

Br J Psychiatry. 2015 Dec;207(6):536-43. doi: 10.1192/bjp.bp.114.153486. Epub 2015 Aug 20.


Effect of Structured Touch and Guided Imagery for Pain and Anxiety in Elective Joint Replacement Patients--A Randomized Controlled Trial: M-TIJRP.

Forward JB, Greuter NE, Crisall SJ, Lester HF.

Perm J. 2015 Fall;19(4):18-28. doi: 10.7812/TPP/14-236. Epub 2015 Jul 24.


An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.

Marotta CB, Lester HA, Dougherty DA.

Chem Biol. 2015 Aug 20;22(8):1063-73. doi: 10.1016/j.chembiol.2015.06.018. Epub 2015 Jul 23.


Ketamine inside neurons?

Lester HA, Lavis LD, Dougherty DA.

Am J Psychiatry. 2015 Nov 1;172(11):1064-6. doi: 10.1176/appi.ajp.2015.14121537. Epub 2015 Jul 17. No abstract available.


Layers of listening: qualitative analysis of the impact of early intervention services for first-episode psychosis on carers' experiences.

Lavis A, Lester H, Everard L, Freemantle N, Amos T, Fowler D, Hodgekins J, Jones P, Marshall M, Sharma V, Larsen J, McCrone P, Singh S, Smith J, Birchwood M.

Br J Psychiatry. 2015 Aug;207(2):135-42. doi: 10.1192/bjp.bp.114.146415. Epub 2015 May 21.


The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.

Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux JP, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SC, Imad Damaj M, Lester HA, Patapoutian A, Mogil JS.

Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986.


Barriers to shared decision making in mental health care: qualitative study of the Joint Crisis Plan for psychosis.

Farrelly S, Lester H, Rose D, Birchwood M, Marshall M, Waheed W, Henderson RC, Szmukler G, Thornicroft G.

Health Expect. 2016 Apr;19(2):448-58. doi: 10.1111/hex.12368. Epub 2015 Apr 27.


Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.

Post MR, Limapichat W, Lester HA, Dougherty DA.

Neuropharmacology. 2015 Oct;97:376-82. doi: 10.1016/j.neuropharm.2015.04.009. Epub 2015 Apr 20.


Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus.

Xiao C, Miwa JM, Henderson BJ, Wang Y, Deshpande P, McKinney SL, Lester HA.

J Neurosci. 2015 Mar 4;35(9):3734-46. doi: 10.1523/JNEUROSCI.3528-14.2015.


The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.

Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S.

Neuropharmacology. 2015 Sep;96(Pt B):274-88. doi: 10.1016/j.neuropharm.2015.02.006. Epub 2015 Feb 19. Review.


Inside-out neuropharmacology of nicotinic drugs.

Henderson BJ, Lester HA.

Neuropharmacology. 2015 Sep;96(Pt B):178-93. doi: 10.1016/j.neuropharm.2015.01.022. Epub 2015 Feb 4. Review.


Improving Therapeutic Relationships: Joint Crisis Planning for Individuals With Psychotic Disorders.

Farrelly S, Lester H, Rose D, Birchwood M, Marshall M, Waheed W, Henderson RC, Szmukler G, Thornicroft G.

Qual Health Res. 2015 Dec;25(12):1637-47. doi: 10.1177/1049732314566320. Epub 2015 Jan 12.


Prophylactic administration of a combined prebiotic and probiotic, or therapeutic administration of enrofloxacin, to reduce the incidence of bacterial chondronecrosis with osteomyelitis in broilers.

Wideman RF Jr, Al-Rubaye A, Kwon YM, Blankenship J, Lester H, Mitchell KN, Pevzner IY, Lohrmann T, Schleifer J.

Poult Sci. 2015 Jan;94(1):25-36. doi: 10.3382/ps/peu025.


Allosteric activation of the 5-HT3AB receptor by mCPBG.

Miles TF, Lester HA, Dougherty DA.

Neuropharmacology. 2015 Apr;91:103-8. doi: 10.1016/j.neuropharm.2014.12.018. Epub 2014 Dec 23.


Comparing time use in individuals at different stages of psychosis and a non-clinical comparison group.

Hodgekins J, French P, Birchwood M, Mugford M, Christopher R, Marshall M, Everard L, Lester H, Jones P, Amos T, Singh S, Sharma V, Morrison AP, Fowler D.

Schizophr Res. 2015 Feb;161(2-3):188-93. doi: 10.1016/j.schres.2014.12.011. Epub 2014 Dec 23.


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