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Items: 35


Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.

Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE.

Science. 2019 Apr 5;364(6435). pii: eaau1330. doi: 10.1126/science.aau1330. Epub 2019 Mar 14.


INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI.

Elife. 2018 Oct 25;7. pii: e38539. doi: 10.7554/eLife.38539.


Host-Pathogen Interactions: What the EHEC Are We Learning from Host Genome-Wide Screens?

Lynch JP, Lesser CF.

MBio. 2018 Oct 9;9(5). pii: e01837-18. doi: 10.1128/mBio.01837-18.


High-Throughput Screening of Type III Secretion Determinants Reveals a Major Chaperone-Independent Pathway.

Ernst NH, Reeves AZ, Ramseyer JE, Lesser CF.

MBio. 2018 Jun 19;9(3). pii: e01050-18. doi: 10.1128/mBio.01050-18.


Synthetic bottom-up approach reveals the complex interplay of Shigella effectors in regulation of epithelial cell death.

Mou X, Souter S, Du J, Reeves AZ, Lesser CF.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6452-6457. doi: 10.1073/pnas.1801310115. Epub 2018 Jun 4.


Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility.

Piro AS, Hernandez D, Luoma S, Feeley EM, Finethy R, Yirga A, Frickel EM, Lesser CF, Coers J.

MBio. 2017 Dec 12;8(6). pii: e01979-17. doi: 10.1128/mBio.01979-17.


Rationale redesign of type III secretion systems: toward the development of non-pathogenic E. coli for in vivo delivery of therapeutic payloads.

González-Prieto C, Lesser CF.

Curr Opin Microbiol. 2018 Feb;41:1-7. doi: 10.1016/j.mib.2017.10.011. Epub 2017 Nov 12. Review.


Transfer of Large Contiguous DNA Fragments onto a Low Copy Plasmid or into the Bacterial Chromosome.

Reeves AZ, Lesser CF.

Bio Protoc. 2016 Nov 20;6(22). pii: e2002. doi: 10.21769/BioProtoc.2002.


QseC inhibition as an antivirulence approach for colitis-associated bacteria.

Rooks MG, Veiga P, Reeves AZ, Lavoie S, Yasuda K, Asano Y, Yoshihara K, Michaud M, Wardwell-Scott L, Gallini CA, Glickman JN, Sudo N, Huttenhower C, Lesser CF, Garrett WS.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):142-147. doi: 10.1073/pnas.1612836114. Epub 2016 Dec 15.


How to manage stress: Lessons from an intracellular pathogen.

Janakiraman A, Lesser CF.

Virulence. 2017 May 19;8(4):359-361. doi: 10.1080/21505594.2016.1256538. Epub 2016 Nov 3. No abstract available.


Identification and Characterization of a Candidate Wolbachia pipientis Type IV Effector That Interacts with the Actin Cytoskeleton.

Sheehan KB, Martin M, Lesser CF, Isberg RR, Newton IL.

MBio. 2016 Jul 5;7(4). pii: e00622-16. doi: 10.1128/mBio.00622-16.


The type III secretion system apparatus determines the intracellular niche of bacterial pathogens.

Du J, Reeves AZ, Klein JA, Twedt DJ, Knodler LA, Lesser CF.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4794-9. doi: 10.1073/pnas.1520699113. Epub 2016 Apr 12.


Engineering Escherichia coli into a protein delivery system for mammalian cells.

Reeves AZ, Spears WE, Du J, Tan KY, Wagers AJ, Lesser CF.

ACS Synth Biol. 2015 May 15;4(5):644-54. doi: 10.1021/acssynbio.5b00002. Epub 2015 Apr 24.


A multifunctional region of the Shigella type 3 effector IpgB1 is important for secretion from bacteria and membrane targeting in eukaryotic cells.

Costa SC, Lesser CF.

PLoS One. 2014 Apr 9;9(4):e93461. doi: 10.1371/journal.pone.0093461. eCollection 2014.


A new means to identify type 3 secreted effectors: functionally interchangeable class IB chaperones recognize a conserved sequence.

Costa SC, Schmitz AM, Jahufar FF, Boyd JD, Cho MY, Glicksman MA, Lesser CF.

MBio. 2012 Feb 14;3(1). pii: e00243-11. doi: 10.1128/mBio.00243-11. Print 2012.


Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.

de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE.

Structure. 2011 Sep 7;19(9):1294-306. doi: 10.1016/j.str.2011.06.015.


Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes.

Lesser CF, Leong JM.

Sci Signal. 2011 Jul 5;4(180):pe32. doi: 10.1126/scisignal.2002252.


Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli.

Durand-Heredia JM, Yu HH, De Carlo S, Lesser CF, Janakiraman A.

J Bacteriol. 2011 Mar;193(6):1405-13. doi: 10.1128/JB.01258-10. Epub 2011 Jan 7.


Anaplasma phagocytophilum AptA modulates Erk1/2 signalling.

Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E.

Cell Microbiol. 2011 Jan;13(1):47-61. doi: 10.1111/j.1462-5822.2010.01516.x. Epub 2010 Aug 27.


The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence.

McCoy MW, Marré ML, Lesser CF, Mecsas J.

Infect Immun. 2010 Jun;78(6):2584-98. doi: 10.1128/IAI.00141-10. Epub 2010 Apr 5.


Requirement for formin-induced actin polymerization during spread of Shigella flexneri.

Heindl JE, Saran I, Yi CR, Lesser CF, Goldberg MB.

Infect Immun. 2010 Jan;78(1):193-203. doi: 10.1128/IAI.00252-09. Epub 2009 Oct 19.


Protein interaction platforms: visualization of interacting proteins in yeast.

Schmitz AM, Morrison MF, Agunwamba AO, Nibert ML, Lesser CF.

Nat Methods. 2009 Jul;6(7):500-2. doi: 10.1038/nmeth.1337. Epub 2009 May 31.


GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors.

Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC.

PLoS Pathog. 2008 Nov;4(11):e1000228. doi: 10.1371/journal.ppat.1000228. Epub 2008 Nov 28.


The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth.

Huang J, Lesser CF, Lory S.

Nature. 2008 Nov 6;456(7218):112-5. doi: 10.1038/nature07355. Epub 2008 Oct 1.


The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins.

Siggers KA, Lesser CF.

Cell Host Microbe. 2008 Jul 17;4(1):8-15. doi: 10.1016/j.chom.2008.06.004. Review.


A functional genomic yeast screen to identify pathogenic bacterial proteins.

Slagowski NL, Kramer RW, Morrison MF, LaBaer J, Lesser CF.

PLoS Pathog. 2008 Jan;4(1):e9. doi: 10.1371/journal.ppat.0040009.


Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation.

Kramer RW, Slagowski NL, Eze NA, Giddings KS, Morrison MF, Siggers KA, Starnbach MN, Lesser CF.

PLoS Pathog. 2007 Feb;3(2):e21.


Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists.

Gottlieb GS, Lesser CF, Holmes KK, Wald A.

Clin Infect Dis. 2003 Sep 15;37(6):838-40. Epub 2003 Aug 23.


Rac, ruffle and rho: orchestration of Salmonella invasion.

Lesser CF, Scherer CA, Miller SI.

Trends Microbiol. 2000 Apr;8(4):151-2. No abstract available.


Mutations in U6 snRNA that alter splice site specificity: implications for the active site.

Lesser CF, Guthrie C.

Science. 1993 Dec 24;262(5142):1982-8.


Structural and regulatory divergence among site-specific recombination genes of lambdoid phage.

Leong JM, Nunes-Düby SE, Oser AB, Lesser CF, Youderian P, Susskind MM, Landy A.

J Mol Biol. 1986 Jun 20;189(4):603-16.


The phi 80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor.

Leong JM, Nunes-Düby S, Lesser CF, Youderian P, Susskind MM, Landy A.

J Biol Chem. 1985 Apr 10;260(7):4468-77.


Site-specific recombination systems of phages phi 80 and P22: binding sites of integration host factor and recombination-induced mutations.

Leong JM, Nunes-Duby S, Oser A, Lesser CF, Youderian P, Susskind MM, Landy A.

Cold Spring Harb Symp Quant Biol. 1984;49:707-14. No abstract available.


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