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Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.

Bellver-Landete V, Bretheau F, Mailhot B, Vallières N, Lessard M, Janelle ME, Vernoux N, Tremblay MÈ, Fuehrmann T, Shoichet MS, Lacroix S.

Nat Commun. 2019 Jan 31;10(1):518. doi: 10.1038/s41467-019-08446-0.


Piglet weight gain during the first two weeks of lactation influences the immune system development.

Lessard M, Blais M, Beaudoin F, Deschene K, Verso LL, Bissonnette N, Lauzon K, Guay F.

Vet Immunol Immunopathol. 2018 Dec;206:25-34. doi: 10.1016/j.vetimm.2018.11.005. Epub 2018 Nov 5.


3D mapping of nanoscale crosslink heterogeneities in microgels.

Karanastasis AA, Zhang Y, Kenath GS, Lessard MD, Bewersdorf J, Ullal CK.

Mater Horiz. 2018 Nov 1;5(6):1130-1136. doi: 10.1039/c8mh00644j. Epub 2018 Sep 5.


Assessing photodamage in live-cell STED microscopy.

Kilian N, Goryaynov A, Lessard MD, Hooker G, Toomre D, Rothman JE, Bewersdorf J.

Nat Methods. 2018 Oct;15(10):755-756. doi: 10.1038/s41592-018-0145-5. No abstract available.


Direct-fed microbial supplementation influences the bacteria community composition of the gastrointestinal tract of pre- and post-weaned calves.

Fomenky BE, Do DN, Talbot G, Chiquette J, Bissonnette N, Chouinard YP, Lessard M, Ibeagha-Awemu EM.

Sci Rep. 2018 Sep 20;8(1):14147. doi: 10.1038/s41598-018-32375-5.


Understanding the patient perspective on research access to national health records databases for conduct of randomized registry trials.

Avram R, Marquis-Gravel G, Simard F, Pacheco C, Couture É, Tremblay-Gravel M, Desplantie O, Malhamé I, Bibas L, Mansour S, Parent MC, Farand P, Harvey L, Lessard MG, Ly H, Liu G, Hay AE, Marc Jolicoeur E.

Int J Cardiol. 2018 Jul 1;262:110-116. doi: 10.1016/j.ijcard.2017.12.074.


International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.

Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO.

Ann Am Thorac Soc. 2018 Apr;15(4):494-502. doi: 10.1513/AnnalsATS.201705-410OC. Erratum in: Ann Am Thorac Soc. 2018 Jul;15(7):894.


Histomorphologic Analysis of the Late-term Rat Fetus and Placenta.

Charest PL, Vrolyk V, Herst P, Lessard M, Sloboda DM, Dalvai M, Haruna J, Bailey JL, Benoit-Biancamano MO.

Toxicol Pathol. 2018 Feb;46(2):158-168. doi: 10.1177/0192623318755135. Epub 2018 Feb 5.


Transthoracic echocardiographic evaluation of the heart and great vessels.

Denault AY, Langevin S, Lessard MR, Courval JF, Desjardins G.

Can J Anaesth. 2018 Apr;65(4):449-472. doi: 10.1007/s12630-018-1068-4. Epub 2018 Jan 19. Review.


Use of the spectrophotometric color method for the determination of the age of skin lesions on the pig carcass and its relationship with gene expression and histological and histochemical parameters.

Vitali M, Conte S, Lessard M, Deschêne K, Benoit-Biancamano MO, Celeste C, Martelli G, Sardi L, Guay F, Faucitano L.

J Anim Sci. 2017 Sep;95(9):3873-3884. doi: 10.2527/jas2017.1813.


Growth performance of piglets during the first two weeks of lactation affects the development of the intestinal microbiota.

Morissette B, Talbot G, Beaulieu C, Lessard M.

J Anim Physiol Anim Nutr (Berl). 2018 Apr;102(2):525-532. doi: 10.1111/jpn.12784. Epub 2017 Oct 9.


Oxytocin injections in the postpartal period affect mammary tight junctions in sows.

Farmer C, Lessard M, Knight CH, Quesnel H.

J Anim Sci. 2017 Aug;95(8):3532-3539. doi: 10.2527/jas.2017.1700.


Isolation and Selection of Potential Probiotic Bacteria from the Pig Gastrointestinal Tract.

Lo Verso L, Lessard M, Talbot G, Fernandez B, Fliss I.

Probiotics Antimicrob Proteins. 2018 Jun;10(2):299-312. doi: 10.1007/s12602-017-9309-3.


A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi.

Bottanelli F, Kilian N, Ernst AM, Rivera-Molina F, Schroeder LK, Kromann EB, Lessard MD, Erdmann RS, Schepartz A, Baddeley D, Bewersdorf J, Toomre D, Rothman JE.

Mol Biol Cell. 2017 Jun 15;28(12):1676-1687. doi: 10.1091/mbc.E16-12-0863. Epub 2017 Apr 20.


Localization of ectopic fibroblast growth factor 23 production in tumor-induced osteomalacia using selective venous samplings.

Pelletier K, Troyanov S, Guité JF, Sainte-Marie LG, Roberge D, Lessard M.

Clin Nephrol. 2017 Feb;87 (2017)(2):107-110. doi: 10.5414/CN108981. No abstract available.


African-American patients with cancer Talking About Clinical Trials (TACT) with oncologists during consultations: evaluating the efficacy of tailored health messages in a randomised controlled trial-the TACT study protocol.

Brown RF, Davis R, Wilson Genderson M, Grant S, Cadet D, Lessard M, Alpert J, Ward J, Ginder G.

BMJ Open. 2016 Dec 16;6(12):e012864. doi: 10.1136/bmjopen-2016-012864.


Biofouling of ultrafiltration membrane by dairy fluids: Characterization of pioneer colonizer bacteria using a DNA metabarcoding approach.

Chamberland J, Lessard MH, Doyen A, Labrie S, Pouliot Y.

J Dairy Sci. 2017 Feb;100(2):981-990. doi: 10.3168/jds.2016-11829. Epub 2016 Nov 23.


Effect of a post-weaning diet supplemented with functional feed additives on ileal transcriptome activity and serum cytokines in piglets challenged with lipopolysaccharide.

Bissonnette N, Jiang XR, Matte JJ, Guay F, Talbot G, Bontempo V, Gong J, Wang Q, Lessard M.

Vet Immunol Immunopathol. 2016 Dec;182:136-149. doi: 10.1016/j.vetimm.2016.10.004. Epub 2016 Oct 17.


Ultra-High Resolution 3D Imaging of Whole Cells.

Huang F, Sirinakis G, Allgeyer ES, Schroeder LK, Duim WC, Kromann EB, Phan T, Rivera-Molina FE, Myers JR, Irnov I, Lessard M, Zhang Y, Handel MA, Jacobs-Wagner C, Lusk CP, Rothman JE, Toomre D, Booth MJ, Bewersdorf J.

Cell. 2016 Aug 11;166(4):1028-1040. doi: 10.1016/j.cell.2016.06.016. Epub 2016 Jul 7.


Including sheath effects in the interpretation of planar retarding potential analyzer's low-energy ion data.

Fisher LE, Lynch KA, Fernandes PA, Bekkeng TA, Moen J, Zettergren M, Miceli RJ, Powell S, Lessard MR, Horak P.

Rev Sci Instrum. 2016 Apr;87(4):043504. doi: 10.1063/1.4944416.


The potential effects of antioxidant feed additives in mitigating the adverse effects of corn naturally contaminated with Fusarium mycotoxins on antioxidant systems in the intestinal mucosa, plasma, and liver in weaned pigs.

Van Le Thanh B, Lemay M, Bastien A, Lapointe J, Lessard M, Chorfi Y, Guay F.

Mycotoxin Res. 2016 May;32(2):99-116. doi: 10.1007/s12550-016-0245-y. Epub 2016 Mar 29.


Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering.

Plecitá-Hlavatá L, Engstová H, Alán L, Špaček T, Dlasková A, Smolková K, Špačková J, Tauber J, Strádalová V, Malínský J, Lessard M, Bewersdorf J, Ježek P.

FASEB J. 2016 May;30(5):1941-57. doi: 10.1096/fj.201500176. Epub 2016 Feb 17.


The case for plant-made veterinary immunotherapeutics.

Topp E, Irwin R, McAllister T, Lessard M, Joensuu JJ, Kolotilin I, Conrad U, Stöger E, Mor T, Warzecha H, Hall JC, McLean MD, Cox E, Devriendt B, Potter A, Depicker A, Virdi V, Holbrook L, Doshi K, Dussault M, Friendship R, Yarosh O, Yoo HS, MacDonald J, Menassa R.

Biotechnol Adv. 2016 Sep-Oct;34(5):597-604. doi: 10.1016/j.biotechadv.2016.02.007. Epub 2016 Feb 12. Review.


Effects of probiotics Pediococcus acidilactici strain MA18/5M and Saccharomyces cerevisiae subsp. boulardii strain SB-CNCM I-1079 on fecal and intestinal microbiota of nursing and weanling piglets.

Brousseau JP, Talbot G, Beaudoin F, Lauzon K, Roy D, Lessard M.

J Anim Sci. 2015 Nov;93(11):5313-26. doi: 10.2527/jas.2015-9190.


IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3.

Bastien D, Bellver Landete V, Lessard M, Vallières N, Champagne M, Takashima A, Tremblay MÈ, Doyon Y, Lacroix S.

J Neurosci. 2015 Jul 29;35(30):10715-30. doi: 10.1523/JNEUROSCI.0498-15.2015.


Distribution of mitochondrial DNA nucleoids inside the linear tubules vs. bulk parts of mitochondrial network as visualized by 4Pi microscopy.

Dlasková A, Engstová H, Plecitá-Hlavatá L, Lessard M, Alán L, Reguera DP, Jabůrek M, Ježek P.

J Bioenerg Biomembr. 2015 Jun;47(3):255-63. doi: 10.1007/s10863-015-9610-3. Epub 2015 Apr 2.


Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eye.

Kinard KI, Smith AG, Singleton JR, Lessard MK, Katz BJ, Warner JE, Crum AV, Mifflin MD, Brennan KC, Digre KB.

Headache. 2015 Apr;55(4):543-9. doi: 10.1111/head.12547. Epub 2015 Mar 31.


Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine.

Lessard M, Savard C, Deschene K, Lauzon K, Pinilla VA, Gagnon CA, Lapointe J, Guay F, Chorfi Y.

Food Chem Toxicol. 2015 Jun;80:7-16. doi: 10.1016/j.fct.2015.02.013. Epub 2015 Feb 17.


Colostrum whey down-regulates the expression of early and late inflammatory response genes induced by Escherichia coli and Salmonella enterica Typhimurium components in intestinal epithelial cells.

Blais M, Fortier M, Pouliot Y, Gauthier SF, Boutin Y, Asselin C, Lessard M.

Br J Nutr. 2015 Jan 28;113(2):200-11. doi: 10.1017/S0007114514003481. Epub 2014 Dec 4.


Homocysteine metabolism, growth performance, and immune responses in suckling and weanling piglets.

Audet I, Girard CL, Lessard M, Lo Verso L, Beaudoin F, Matte JJ.

J Anim Sci. 2015 Jan;93(1):147-57. doi: 10.2527/jas.2014-7872. Epub 2014 Nov 20.


Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients.

Singleton JR, Marcus RL, Lessard MK, Jackson JE, Smith AG.

Ann Neurol. 2015 Jan;77(1):146-53. doi: 10.1002/ana.24310. Epub 2014 Dec 4.


p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

Zuo W, Zhang T, Wu DZ, Guan SP, Liew AA, Yamamoto Y, Wang X, Lim SJ, Vincent M, Lessard M, Crum CP, Xian W, McKeon F.

Nature. 2015 Jan 29;517(7536):616-20. doi: 10.1038/nature13903. Epub 2014 Nov 12.


Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults.

Burns KE, Lellouche F, Nisenbaum R, Lessard MR, Friedrich JO.

Cochrane Database Syst Rev. 2014 Sep 9;(9):CD008638. doi: 10.1002/14651858.CD008638.pub2. Review.


Development of a patient decision aid for people with refractory angina: protocol for a three-phase pilot study.

McGillion MH, Carroll SL, Metcalfe K, Arthur HM, Victor JC, McKelvie R, Jolicoeur EM, Lessard MG, Stone J, Svorkdal N, Hanlon JG, Andrade A, Niznick J, Malysh L, McDonald W, Stevens B, Coyte P, Stacey D.

Health Qual Life Outcomes. 2014 Jun 11;12:93. doi: 10.1186/1477-7525-12-93.


3-Dimensional histological reconstruction and imaging of the murine pancreas.

Ciciotte SL, Lessard M, Akeson EC, Cameron E, Stearns TM, Denegre JM, Ruberte J, Svenson KL.

Mamm Genome. 2014 Oct;25(9-10):539-48. doi: 10.1007/s00335-014-9522-2. Epub 2014 May 18.


Effect of bovine colostrum, cheese whey, and spray-dried porcine plasma on the in vitro growth of probiotic bacteria and Escherichia coli.

Champagne CP, Raymond Y, Pouliot Y, Gauthier SF, Lessard M.

Can J Microbiol. 2014 May;60(5):287-95. doi: 10.1139/cjm-2014-0130. Epub 2014 Mar 18.


Non-traumatic hypertrophic callus of the fibula mimicking osteosarcoma in osteogenesis imperfecta type V: a case report.

Radu A, Kanza RE, Barabas D, Lessard M, Berube M.

Skeletal Radiol. 2014 Sep;43(9):1333-6. doi: 10.1007/s00256-014-1884-8. Epub 2014 Apr 15.


Increased blood-circulating interferon-γ, interleukin-17, and osteopontin levels in bovine paratuberculosis.

Dudemaine PL, Fecteau G, Lessard M, Labrecque O, Roy JP, Bissonnette N.

J Dairy Sci. 2014;97(6):3382-93. doi: 10.3168/jds.2013-7059. Epub 2014 Mar 27.


The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathy.

Smith AG, Lessard M, Reyna S, Doudova M, Singleton JR.

J Diabetes Complications. 2014 Jul-Aug;28(4):511-6. doi: 10.1016/j.jdiacomp.2014.02.013. Epub 2014 Mar 6.


Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults.

Burns KE, Lellouche F, Lessard MR, Friedrich JO.

Cochrane Database Syst Rev. 2014 Feb 13;(2):CD008639. doi: 10.1002/14651858.CD008639.pub2. Review.


Comparison of oral and intravenous alfacalcidol in chronic hemodialysis patients.

Lessard M, Ouimet D, Leblanc M, Nadeau-Fredette AC, Bell R, Lafrance JP, Pichette V, Vallée M.

BMC Nephrol. 2014 Feb 4;15:27. doi: 10.1186/1471-2369-15-27.


The effect of birth weight and age at tail docking and ear notching on the behavioral and physiological responses of piglets.

Bovey KE, Widowski TM, Dewey CE, Devillers N, Farmer C, Lessard M, Torrey S.

J Anim Sci. 2014 Apr;92(4):1718-27. doi: 10.2527/jas.2013-7063. Epub 2014 Feb 3.


Human papillomavirus vaccination and sexual behavior in young women.

Rysavy MB, Kresowik JD, Liu D, Mains L, Lessard M, Ryan GL.

J Pediatr Adolesc Gynecol. 2014 Apr;27(2):67-71. doi: 10.1016/j.jpag.2013.08.009. Epub 2014 Jan 7.


A gene expression programme induced by bovine colostrum whey promotes growth and wound-healing processes in intestinal epithelial cells.

Blais M, Pouliot Y, Gauthier S, Boutin Y, Lessard M.

J Nutr Sci. 2014 Nov 13;3:e57. doi: 10.1017/jns.2014.56. eCollection 2014.


A new approach for the study of the chemical composition of bordered pit membranes: 4Pi and confocal laser scanning microscopy.

Maschek D, Goodell B, Jellison J, Lessard M, Militz H.

Am J Bot. 2013 Sep;100(9):1751-6. doi: 10.3732/ajb.1300004. Epub 2013 Sep 9.


Incremental cost-effectiveness of pharmacotherapy and two brief cognitive-behavioral therapies compared with usual care for panic disorder and noncardiac chest pain.

Poirier-Bisson J, Marchand A, Pelland ME, Lessard MJ, Dupuis G, Fleet R, Roberge P.

J Nerv Ment Dis. 2013 Sep;201(9):753-9. doi: 10.1097/NMD.0b013e3182a2127d.


Adherence to antihypertensive agents improves risk reduction of end-stage renal disease.

Roy L, White-Guay B, Dorais M, Dragomir A, Lessard M, Perreault S.

Kidney Int. 2013 Sep;84(3):570-7. doi: 10.1038/ki.2013.103. Epub 2013 May 22.


Wean earlier and automatically with new technology (the WEAN study). A multicenter, pilot randomized controlled trial.

Burns KE, Meade MO, Lessard MR, Hand L, Zhou Q, Keenan SP, Lellouche F.

Am J Respir Crit Care Med. 2013 Jun 1;187(11):1203-11. doi: 10.1164/rccm.201206-1026OC.


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