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Items: 21


Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G.

Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25.


A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.

Acevedo M, Vernier M, Mignacca L, Lessard F, Huot G, Moiseeva O, Bourdeau V, Ferbeyre G.

Cancer Res. 2016 Jun 1;76(11):3252-64. doi: 10.1158/0008-5472.CAN-15-2347. Epub 2016 Mar 29.


Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase.

Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G.

Aging (Albany NY). 2016 Feb;8(2):366-81.


Mutant lamin A links prophase to a p53 independent senescence program.

Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos YS, Ferbeyre G.

Cell Cycle. 2015 Aug 3;14(15):2408-21. doi: 10.1080/15384101.2015.1053671. Epub 2015 Jun 1.


Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body.

Hamdane N, Stefanovsky VY, Tremblay MG, Németh A, Paquet E, Lessard F, Sanij E, Hannan R, Moss T.

PLoS Genet. 2014 Aug 14;10(8):e1004505. doi: 10.1371/journal.pgen.1004505. eCollection 2014 Aug.


Cellular senescence and protein degradation: breaking down cancer.

Deschênes-Simard X, Lessard F, Gaumont-Leclerc MF, Bardeesy N, Ferbeyre G.

Cell Cycle. 2014;13(12):1840-58. doi: 10.4161/cc.29335. Epub 2014 May 27.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


Validating plastic scintillation detectors for photon dosimetry in the radiologic energy range.

Lessard F, Archambault L, Plamondon M, Despres P, Therriault-Proulx F, Beddar S, Beaulieu L.

Med Phys. 2012 Sep;39(9):5308-16.


Sci-Sat AM: Brachy - 07: Plastic scintillation detector validation for kV dosimetry.

Lessard F, Archambault L, Plamondon M, Després P, Therriault-Proulx F, Beddar S, Beaulieu L.

Med Phys. 2012 Jul;39(7Part4):4646. doi: 10.1118/1.4740214.


The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation.

Lessard F, Stefanovsky V, Tremblay MG, Moss T.

Nucleic Acids Res. 2012 Jul;40(12):5357-67. doi: 10.1093/nar/gks198. Epub 2012 Mar 1.


A model for the topology of active ribosomal RNA genes.

Denissov S, Lessard F, Mayer C, Stefanovsky V, van Driel M, Grummt I, Moss T, Stunnenberg HG.

EMBO Rep. 2011 Mar;12(3):231-7. doi: 10.1038/embor.2011.8. Epub 2011 Feb 18.


The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.

Lessard F, Morin F, Ivanchuk S, Langlois F, Stefanovsky V, Rutka J, Moss T.

Mol Cell. 2010 May 28;38(4):539-50. doi: 10.1016/j.molcel.2010.03.015.


Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processing.

Gagnon-Kugler T, Langlois F, Stefanovsky V, Lessard F, Moss T.

Mol Cell. 2009 Aug 28;35(4):414-25. doi: 10.1016/j.molcel.2009.07.008.


Practical aspects of the addition of sodium bicarbonate to peritoneal dialysate.

Dorval M, Legault L, Lessard F, Roy L.

Perit Dial Int. 2000 Nov-Dec;20(6):791-3. No abstract available.


Analysis for alpha-amylase isoenzymes by automated isoelectric focusing.

Lessard F, Dion R.

Clin Chem. 1989 Oct;35(10):2116-8.


[Cyclosporin: an update].

Lessard F, Bannon P, Lepage R.

Union Med Can. 1986 Mar;115(3):162-4. French. No abstract available.


Comparison of three methods for the elimination of the labile fraction of HbA1.

Bannon P, Joly JG, Lessard F, Lepage R.

Clin Biochem. 1985 Apr;18(2):114-7.


Light chain disease and massive proteinuria.

Lessard F, Bannon P, Lepage R, Joly JG.

Clin Chem. 1985 Mar;31(3):475-7.


[Over-utilization of tests: the responsibility of the laboratory].

Lepage R, Lessard F, Bannon P, Gauthier Y, Miron M, Joly JG.

Union Med Can. 1984 Jun;113(6):526-32. French. No abstract available.


Glycated hemoglobin in uremic patients as measured by affinity and ion-exchange chromatography.

Bannon P, Lessard F, Lepage R, Joly JG, Dufresne L.

Clin Chem. 1984 Mar;30(3):485-6.


[Nutritional evaluation of the hospitalized patient: diagnostic technics accessible to all].

Lessard F, Lepage R.

Union Med Can. 1983 Aug;112(8):728-30. French. No abstract available.


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