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Items: 20


Regulatory mechanisms in T cell receptor signalling.

Gaud G, Lesourne R, Love PE.

Nat Rev Immunol. 2018 Aug;18(8):485-497. doi: 10.1038/s41577-018-0020-8. Review.


Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.

Garreau A, Blaize G, Argenty J, Rouquié N, Tourdès A, Wood SA, Saoudi A, Lesourne R.

J Immunol. 2017 Oct 15;199(8):2758-2766. doi: 10.4049/jimmunol.1700566. Epub 2017 Sep 6.


THEMIS: Two Models, Different Thresholds.

Choi S, Cornall R, Lesourne R, Love PE.

Trends Immunol. 2017 Sep;38(9):622-632. doi: 10.1016/ Epub 2017 Jul 8. Review.


Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.

Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L, Love PE.

Nat Immunol. 2017 May 18;18(6):705. doi: 10.1038/ni0617-705c. No abstract available.


Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.

Duguet F, Locard-Paulet M, Marcellin M, Chaoui K, Bernard I, Andreoletti O, Lesourne R, Burlet-Schiltz O, Gonzalez de Peredo A, Saoudi A.

Mol Cell Proteomics. 2017 Aug;16(8):1416-1432. doi: 10.1074/mcp.M116.062745. Epub 2017 Apr 3.


THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.

Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L, Love PE.

Nat Immunol. 2017 Apr;18(4):433-441. doi: 10.1038/ni.3692. Epub 2017 Feb 27. Erratum in: Nat Immunol. 2017 May 18;18(6):705.


Themis2 lowers the threshold for B cell activation during positive selection.

Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE, Cornall RJ.

Nat Immunol. 2017 Feb;18(2):205-213. doi: 10.1038/ni.3642. Epub 2016 Dec 19.


Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.

Zvezdova E, Mikolajczak J, Garreau A, Marcellin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R.

Sci Signal. 2016 May 17;9(428):ra51. doi: 10.1126/scisignal.aad1576.


An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development.

Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, Andréoletti O, Dejean AS, Lesourne R, Fournié GJ, Saoudi A.

J Immunol. 2015 Aug 15;195(4):1608-16. doi: 10.4049/jimmunol.1402562. Epub 2015 Jul 10.


TCR ITAM multiplicity is required for the generation of follicular helper T-cells.

Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE.

Nat Commun. 2015 May 11;6:6982. doi: 10.1038/ncomms7982.


Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.

Xiong Y, Castro E, Yagi R, Zhu J, Lesourne R, Love PE, Feigenbaum L, Bosselut R.

Eur J Immunol. 2013 Apr;43(4):918-28. doi: 10.1002/eji.201242944. Epub 2013 Feb 12.


Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.

Hwang S, Song KD, Lesourne R, Lee J, Pinkhasov J, Li L, El-Khoury D, Love PE.

J Exp Med. 2012 Sep 24;209(10):1781-95. Epub 2012 Sep 3.


Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.

J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049/jimmunol.1200123. Epub 2012 Jun 25.


Themis, a T cell-specific protein important for late thymocyte development.

Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE.

Nat Immunol. 2009 Aug;10(8):840-7. doi: 10.1038/ni.1768. Epub 2009 Jul 13. Erratum in: Nat Immunol. 2010 Jan;11(1):97.


Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells.

Dey-Guha I, Malik N, Lesourne R, Love PE, Westphal H.

J Cell Biochem. 2008 Apr 15;103(6):1856-65.


Negative signaling in Fc receptor complexes.

Daëron M, Lesourne R.

Adv Immunol. 2006;89:39-86. Review.


Linker for activation of T cells integrates positive and negative signaling in mast cells.

Malbec O, Malissen M, Isnardi I, Lesourne R, Mura AM, Fridman WH, Malissen B, Daëron M.

J Immunol. 2004 Oct 15;173(8):5086-94.


Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.

Isnardi I, Lesourne R, Bruhns P, Fridman WH, Cambier JC, Daëron M.

J Biol Chem. 2004 Dec 10;279(50):51931-8. Epub 2004 Sep 28.


Insufficient phosphorylation prevents fc gamma RIIB from recruiting the SH2 domain-containing protein-tyrosine phosphatase SHP-1.

Lesourne R, Bruhns P, Fridman WH, Daëron M.

J Biol Chem. 2001 Mar 2;276(9):6327-36. Epub 2000 Nov 30.

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