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mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders.

Grace HE, Galdun P , III, Lesnefsky EJ, West FD, Iyer S.

Stem Cells Dev. 2019 May 20. doi: 10.1089/scd.2019.0045. [Epub ahead of print]


Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury.

Mohsin AA, Chen Q, Quan N, Rousselle T, Maceyka MW, Samidurai A, Thompson J, Hu Y, Li J, Lesnefsky EJ.

J Pharmacol Exp Ther. 2019 May;369(2):282-290. doi: 10.1124/jpet.118.254300. Epub 2019 Mar 7.


Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage.

Chen Q, Thompson J, Hu Y, Das A, Lesnefsky EJ.

Front Cardiovasc Med. 2019 Feb 19;6:10. doi: 10.3389/fcvm.2019.00010. eCollection 2019.


Mitochondrial health and muscle plasticity after spinal cord injury.

Gorgey AS, Witt O, O'Brien L, Cardozo C, Chen Q, Lesnefsky EJ, Graham ZA.

Eur J Appl Physiol. 2019 Feb;119(2):315-331. doi: 10.1007/s00421-018-4039-0. Epub 2018 Dec 11. Review.


Metformin as a modulator of myocardial fibrosis postmyocardial infarction via regulation of cardiomyocyte-fibroblast crosstalk.

Melendez GC, Chen Q, Lesnefsky EJ.

Transl Res. 2018 Sep;199:1-3. doi: 10.1016/j.trsl.2018.05.008. Epub 2018 Jun 13. No abstract available.


Accelerated Left Ventricular Interstitial Collagen Deposition After Receiving Doxorubicin in Hypertension.

Meléndez GC, Jordan JH, D'Agostino RB Jr, Lesnefsky EJ, Hundley WG.

J Am Coll Cardiol. 2018 Sep 25;72(13):1555-1557. doi: 10.1016/j.jacc.2018.07.028. No abstract available.


Cardiac protection by moving the mitochondria?

Chen Q, Aluri H, Lesnefsky EJ.

Int J Cardiol. 2018 Nov 15;271:256-257. doi: 10.1016/j.ijcard.2018.06.051. Epub 2018 Jun 18. No abstract available.


A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1.

Chen Q, Lesnefsky EJ.

Cardiovasc Res. 2018 May 1;114(6):771-772. doi: 10.1093/cvr/cvy062. No abstract available.


Plasma adiponectin levels are correlated with body composition, metabolic profiles, and mitochondrial markers in individuals with chronic spinal cord injury.

O'Brien LC, Graham ZA, Chen Q, Lesnefsky EJ, Cardozo C, Gorgey AS.

Spinal Cord. 2018 Sep;56(9):863-872. doi: 10.1038/s41393-018-0089-8. Epub 2018 Mar 20.


Intermediary metabolism and fatty acid oxidation: novel targets of electron transport chain-driven injury during ischemia and reperfusion.

Chen Q, Younus M, Thompson J, Hu Y, Hollander JM, Lesnefsky EJ.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H787-H795. doi: 10.1152/ajpheart.00531.2017. Epub 2017 Dec 29.


The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals.

Ma Y, Min HK, Oh U, Hawkridge AM, Wang W, Mohsin AA, Chen Q, Sanyal A, Lesnefsky EJ, Fang X.

J Biol Chem. 2017 Dec 22;292(51):20989-20997. doi: 10.1074/jbc.M117.812925. Epub 2017 Oct 18.


Metformin attenuates ER stress-induced mitochondrial dysfunction.

Chen Q, Thompson J, Hu Y, Das A, Lesnefsky EJ.

Transl Res. 2017 Dec;190:40-50. doi: 10.1016/j.trsl.2017.09.003. Epub 2017 Sep 28.


Skeletal muscle mitochondrial mass is linked to lipid and metabolic profile in individuals with spinal cord injury.

O'Brien LC, Chen Q, Savas J, Lesnefsky EJ, Gorgey AS.

Eur J Appl Physiol. 2017 Nov;117(11):2137-2147. doi: 10.1007/s00421-017-3687-9. Epub 2017 Sep 1.


Mitochondrial Dysfunction in Cardiovascular Aging.

Hoppel CL, Lesnefsky EJ, Chen Q, Tandler B.

Adv Exp Med Biol. 2017;982:451-464. doi: 10.1007/978-3-319-55330-6_24. Review.


Effects of Testosterone and Evoked Resistance Exercise after Spinal Cord Injury (TEREX-SCI): study protocol for a randomised controlled trial.

Gorgey AS, Khalil RE, Gill R, O'Brien LC, Lavis T, Castillo T, Cifu DX, Savas J, Khan R, Cardozo C, Lesnefsky EJ, Gater DR, Adler RA.

BMJ Open. 2017 Apr 4;7(4):e014125. doi: 10.1136/bmjopen-2016-014125.


A New Strategy to Treat Mitochondrial Disease Without Improvement of Mitochondrial Function?

Chen Q, Lesnefsky EJ.

EBioMedicine. 2017 Apr;18:19-20. doi: 10.1016/j.ebiom.2017.03.016. Epub 2017 Mar 14. No abstract available.


Mitochondrial mass and activity as a function of body composition in individuals with spinal cord injury.

O'Brien LC, Wade RC, Segal L, Chen Q, Savas J, Lesnefsky EJ, Gorgey AS.

Physiol Rep. 2017 Feb;5(3). pii: e13080. doi: 10.14814/phy2.13080.


Arts, Science, Engineering and Medicine Collaborate to Educate Public on Bioenergetics.

Tompkins E, Faris S, Hughes L, Maurakis E, Lesnefsky EJ, Rao RR, Iyer S.

Res Rep (Montgomery, Ala.). 2017;1. pii: Epub 2017 Aug 16.


Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies.

Lesnefsky EJ, Chen Q, Tandler B, Hoppel CL.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:535-565. doi: 10.1146/annurev-pharmtox-010715-103335. Review.


Mitochondrial Metabolism in Aging Heart.

Lesnefsky EJ, Chen Q, Hoppel CL.

Circ Res. 2016 May 13;118(10):1593-611. doi: 10.1161/CIRCRESAHA.116.307505. Review.


Mechanistic Insight of Bivalent Compound 21MO as Potential Neuroprotectant for Alzheimer's Disease.

Saathoff JM, Liu K, Chojnacki JE, He L, Chen Q, Lesnefsky EJ, Zhang S.

Molecules. 2016 Mar 25;21(4):412. doi: 10.3390/molecules21040412.


Acquired deficiency of tafazzin in the adult heart: Impact on mitochondrial function and response to cardiac injury.

Szczepanek K, Allegood J, Aluri H, Hu Y, Chen Q, Lesnefsky EJ.

Biochim Biophys Acta. 2016 Apr;1861(4):294-300. doi: 10.1016/j.bbalip.2015.12.004. Epub 2015 Dec 12.


The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes.

Sisler JD, Morgan M, Raje V, Grande RC, Derecka M, Meier J, Cantwell M, Szczepanek K, Korzun WJ, Lesnefsky EJ, Harris TE, Croniger CM, Larner AC.

PLoS One. 2015 Dec 21;10(12):e0144444. doi: 10.1371/journal.pone.0144444. eCollection 2015.


Pivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved Issues.

Zouein FA, Altara R, Chen Q, Lesnefsky EJ, Kurdi M, Booz GW.

Front Cardiovasc Med. 2015 Nov 30;2:36. doi: 10.3389/fcvm.2015.00036. eCollection 2015. Review.


Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release.

Thompson J, Hu Y, Lesnefsky EJ, Chen Q.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H376-84. doi: 10.1152/ajpheart.00748.2015. Epub 2015 Dec 4.


Bivalent Compound 17MN Exerts Neuroprotection through Interaction at Multiple Sites in a Cellular Model of Alzheimer's Disease.

Liu K, Chojnacki JE, Wade EE, Saathoff JM, Lesnefsky EJ, Chen Q, Zhang S.

J Alzheimers Dis. 2015;47(4):1021-33. doi: 10.3233/JAD-150242.


Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury.

Szczepanek K, Xu A, Hu Y, Thompson J, He J, Larner AC, Salloum FN, Chen Q, Lesnefsky EJ.

Basic Res Cardiol. 2015 Nov;110(6):53. doi: 10.1007/s00395-015-0509-2. Epub 2015 Sep 11.


Heart mitochondria and calpain 1: Location, function, and targets.

Chen Q, Lesnefsky EJ.

Biochim Biophys Acta. 2015 Nov;1852(11):2372-8. doi: 10.1016/j.bbadis.2015.08.004. Epub 2015 Aug 7. Review.


Inhibition of Bcl-2 sensitizes mitochondrial permeability transition pore (MPTP) opening in ischemia-damaged mitochondria.

Chen Q, Xu H, Xu A, Ross T, Bowler E, Hu Y, Lesnefsky EJ.

PLoS One. 2015 Mar 10;10(3):e0118834. doi: 10.1371/journal.pone.0118834. eCollection 2015.


A deficiency of apoptosis inducing factor (AIF) in Harlequin mouse heart mitochondria paradoxically reduces ROS generation during ischemia-reperfusion.

Chen Q, Szczepanek K, Hu Y, Thompson J, Lesnefsky EJ.

Front Physiol. 2014 Jul 22;5:271. doi: 10.3389/fphys.2014.00271. eCollection 2014.


Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during ischemia-reperfusion.

Aluri HS, Simpson DC, Allegood JC, Hu Y, Szczepanek K, Gronert S, Chen Q, Lesnefsky EJ.

Biochim Biophys Acta. 2014 Nov;1840(11):3199-207. doi: 10.1016/j.bbagen.2014.07.017. Epub 2014 Aug 1.


Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.

Dadabayev AR, Yin G, Latchoumycandane C, McIntyre TM, Lesnefsky EJ, Penn MS.

J Nutr. 2014 Jul;144(7):1030-6. doi: 10.3945/jn.113.184291. Epub 2014 Apr 23.


Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling.

Koka S, Aluri HS, Xi L, Lesnefsky EJ, Kukreja RC.

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1558-68. doi: 10.1152/ajpheart.00865.2013. Epub 2014 Apr 11.


Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury.

Xu A, Szczepanek K, Maceyka MW, Ross T, Bowler E, Hu Y, Kenny B, Mehfoud C, Desai PN, Baumgarten CM, Chen Q, Lesnefsky EJ.

Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1142-53. doi: 10.1152/ajpcell.00241.2013. Epub 2014 Apr 2.


Fatty acid chain elongation in palmitate-perfused working rat heart: mitochondrial acetyl-CoA is the source of two-carbon units for chain elongation.

Kerner J, Minkler PE, Lesnefsky EJ, Hoppel CL.

J Biol Chem. 2014 Apr 4;289(14):10223-34. doi: 10.1074/jbc.M113.524314. Epub 2014 Feb 20.


Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727.

Zhang Q, Raje V, Yakovlev VA, Yacoub A, Szczepanek K, Meier J, Derecka M, Chen Q, Hu Y, Sisler J, Hamed H, Lesnefsky EJ, Valerie K, Dent P, Larner AC.

J Biol Chem. 2013 Oct 25;288(43):31280-8. doi: 10.1074/jbc.M113.505057. Epub 2013 Sep 9.


Reverse electron flow-mediated ROS generation in ischemia-damaged mitochondria: role of complex I inhibition vs. depolarization of inner mitochondrial membrane.

Ross T, Szczepanek K, Bowler E, Hu Y, Larner A, Lesnefsky EJ, Chen Q.

Biochim Biophys Acta. 2013 Oct;1830(10):4537-42. doi: 10.1016/j.bbagen.2013.05.035. Epub 2013 Jun 6.


Cardioprotection by modulation of mitochondrial respiration during ischemia-reperfusion: role of apoptosis-inducing factor.

Xu A, Szczepanek K, Hu Y, Lesnefsky EJ, Chen Q.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):627-33. doi: 10.1016/j.bbrc.2013.05.033. Epub 2013 May 16.


Aging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulation.

Gao XH, Qanungo S, Pai HV, Starke DW, Steller KM, Fujioka H, Lesnefsky EJ, Kerner J, Rosca MG, Hoppel CL, Mieyal JJ.

Redox Biol. 2013 Nov 12;1:586-98. doi: 10.1016/j.redox.2013.10.010. eCollection 2013.


Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.

Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF.

Circ Heart Fail. 2013 Jan;6(1):136-44. doi: 10.1161/CIRCHEARTFAILURE.111.966127. Epub 2012 Nov 14.


Mitochondria-localized caveolin in adaptation to cellular stress and injury.

Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH.

FASEB J. 2012 Nov;26(11):4637-49. doi: 10.1096/fj.12-215798. Epub 2012 Aug 2.


Multi-tasking: nuclear transcription factors with novel roles in the mitochondria.

Szczepanek K, Lesnefsky EJ, Larner AC.

Trends Cell Biol. 2012 Aug;22(8):429-37. doi: 10.1016/j.tcb.2012.05.001. Epub 2012 Jun 14. Review.


Blockade of electron transport before ischemia protects mitochondria and decreases myocardial injury during reperfusion in aged rat hearts.

Tanaka-Esposito C, Chen Q, Lesnefsky EJ.

Transl Res. 2012 Sep;160(3):207-16. doi: 10.1016/j.trsl.2012.01.024. Epub 2012 Feb 17.


Blockade of electron transport at the onset of reperfusion decreases cardiac injury in aged hearts by protecting the inner mitochondrial membrane.

Chen Q, Ross T, Hu Y, Lesnefsky EJ.

J Aging Res. 2012;2012:753949. doi: 10.1155/2012/753949. Epub 2012 Apr 23.


Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.

Xi L, Zhu SG, Das A, Chen Q, Durrant D, Hobbs DC, Lesnefsky EJ, Kukreja RC.

Nitric Oxide. 2012 May 15;26(4):274-84. doi: 10.1016/j.niox.2012.03.006. Epub 2012 Apr 5. Review.


Activation of mitochondrial μ-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion.

Chen Q, Paillard M, Gomez L, Ross T, Hu Y, Xu A, Lesnefsky EJ.

Biochem Biophys Res Commun. 2011 Dec 2;415(4):533-8. doi: 10.1016/j.bbrc.2011.10.037. Epub 2011 Oct 25.


A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.

Gomez L, Paillard M, Price M, Chen Q, Teixeira G, Spiegel S, Lesnefsky EJ.

Basic Res Cardiol. 2011 Nov;106(6):1341-53. doi: 10.1007/s00395-011-0223-7. Epub 2011 Oct 15.


Decreased cytochrome c oxidase subunit VIIa in aged rat heart mitochondria: immunocytochemistry.

Fujioka H, Moghaddas S, Murdock DG, Lesnefsky EJ, Tandler B, Hoppel CL.

Anat Rec (Hoboken). 2011 Nov;294(11):1825-33. doi: 10.1002/ar.21486. Epub 2011 Oct 4.


Postconditioning modulates ischemia-damaged mitochondria during reperfusion.

Chen Q, Paillard M, Gomez L, Li H, Hu Y, Lesnefsky EJ.

J Cardiovasc Pharmacol. 2012 Jan;59(1):101-8. doi: 10.1097/FJC.0b013e31823827cc.


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