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Items: 1 to 50 of 90

1.

ATP synthase from Trypanosoma brucei has an elaborated canonical F1-domain and conventional catalytic sites.

Montgomery MG, Gahura O, Leslie AGW, Zíková A, Walker JE.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2102-2107. doi: 10.1073/pnas.1720940115. Epub 2018 Feb 12.

2.

Integrating macromolecular X-ray diffraction data with the graphical user interface iMosflm.

Powell HR, Battye TGG, Kontogiannis L, Johnson O, Leslie AGW.

Nat Protoc. 2017 Jul;12(7):1310-1325. doi: 10.1038/nprot.2017.037. Epub 2017 Jun 1.

3.

Erratum: Structure of the adenosine A2A receptor bound to an engineered G protein.

Carpenter B, Nehmé R, Warne T, Leslie AG, Tate CG.

Nature. 2016 Oct 27;538(7626):542. doi: 10.1038/nature19803. Epub 2016 Sep 14. No abstract available.

PMID:
27629518
4.

Regulation of the thermoalkaliphilic F1-ATPase from Caldalkalibacillus thermarum.

Ferguson SA, Cook GM, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10860-5. doi: 10.1073/pnas.1612035113. Epub 2016 Sep 12.

5.

Structure of the adenosine A(2A) receptor bound to an engineered G protein.

Carpenter B, Nehmé R, Warne T, Leslie AG, Tate CG.

Nature. 2016 Aug 4;536(7614):104-7. Epub 2016 Jul 27.

6.

Ligand occupancy in crystal structure of β1-adrenergic G protein-coupled receptor.

Leslie AG, Warne T, Tate CG.

Nat Struct Mol Biol. 2015 Dec;22(12):941-2. doi: 10.1038/nsmb.3130. No abstract available.

7.

Structure of ATP synthase from Paracoccus denitrificans determined by X-ray crystallography at 4.0 Å resolution.

Morales-Rios E, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13231-6. doi: 10.1073/pnas.1517542112. Epub 2015 Oct 12.

8.

Structure of a catalytic dimer of the α- and β-subunits of the F-ATPase from Paracoccus denitrificans at 2.3 Å resolution.

Morales-Ríos E, Montgomery MG, Leslie AG, García-Trejo JJ, Walker JE.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1309-17. doi: 10.1107/S2053230X15016076. Epub 2015 Sep 23.

9.

Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor.

Sato T, Baker J, Warne T, Brown GA, Leslie AG, Congreve M, Tate CG.

Mol Pharmacol. 2015 Dec;88(6):1024-34. doi: 10.1124/mol.115.101030. Epub 2015 Sep 18.

10.

Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments.

Zhu J, King MS, Yu M, Klipcan L, Leslie AG, Hirst J.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12087-92. doi: 10.1073/pnas.1510577112. Epub 2015 Sep 14.

11.

MicroED data collection and processing.

Hattne J, Reyes FE, Nannenga BL, Shi D, de la Cruz MJ, Leslie AG, Gonen T.

Acta Crystallogr A Found Adv. 2015 Jul;71(Pt 4):353-60. doi: 10.1107/S2053273315010669. Epub 2015 Jul 1.

12.

How release of phosphate from mammalian F1-ATPase generates a rotary substep.

Bason JV, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6009-14. doi: 10.1073/pnas.1506465112. Epub 2015 Apr 27.

13.

Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor.

Lebon G, Edwards PC, Leslie AG, Tate CG.

Mol Pharmacol. 2015 Jun;87(6):907-15. doi: 10.1124/mol.114.097360. Epub 2015 Mar 11.

14.

High-resolution structure determination by continuous-rotation data collection in MicroED.

Nannenga BL, Shi D, Leslie AGW, Gonen T.

Nat Methods. 2014 Sep;11(9):927-930. doi: 10.1038/nmeth.3043. Epub 2014 Aug 3.

15.

Pathway of binding of the intrinsically disordered mitochondrial inhibitor protein to F1-ATPase.

Bason JV, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11305-10. doi: 10.1073/pnas.1411560111. Epub 2014 Jul 21.

16.

The 2.1 Å resolution structure of cyanopindolol-bound β1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor.

Miller-Gallacher JL, Nehmé R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG.

PLoS One. 2014 Mar 24;9(3):e92727. doi: 10.1371/journal.pone.0092727. eCollection 2014.

17.

Structures of an apo and a binary complex of an evolved archeal B family DNA polymerase capable of synthesising highly cy-dye labelled DNA.

Wynne SA, Pinheiro VB, Holliger P, Leslie AG.

PLoS One. 2013 Aug 5;8(8):e70892. doi: 10.1371/journal.pone.0070892. Print 2013.

18.

Autoindexing diffraction images with iMosflm.

Powell HR, Johnson O, Leslie AG.

Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1195-203. doi: 10.1107/S0907444912048524. Epub 2013 Jun 13.

19.

The structure of F₁-ATPase from Saccharomyces cerevisiae inhibited by its regulatory protein IF₁.

Robinson GC, Bason JV, Montgomery MG, Fearnley IM, Mueller DM, Leslie AG, Walker JE.

Open Biol. 2013 Feb 13;3(2):120164. doi: 10.1098/rsob.120164.

20.

Structural evidence of a new catalytic intermediate in the pathway of ATP hydrolysis by F1-ATPase from bovine heart mitochondria.

Rees DM, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11139-43. doi: 10.1073/pnas.1207587109. Epub 2012 Jun 25.

21.

Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol.

Warne T, Edwards PC, Leslie AG, Tate CG.

Structure. 2012 May 9;20(5):841-9. doi: 10.1016/j.str.2012.03.014.

22.

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.

Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG.

Nature. 2011 May 18;474(7352):521-5. doi: 10.1038/nature10136.

23.

Two distinct conformations of helix 6 observed in antagonist-bound structures of a beta1-adrenergic receptor.

Moukhametzianov R, Warne T, Edwards PC, Serrano-Vega MJ, Leslie AG, Tate CG, Schertler GF.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8228-32. doi: 10.1073/pnas.1100185108. Epub 2011 May 3.

24.

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM.

Battye TG, Kontogiannis L, Johnson O, Powell HR, Leslie AG.

Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):271-81. doi: 10.1107/S0907444910048675. Epub 2011 Mar 18.

25.

Overview of the CCP4 suite and current developments.

Winn MD, Ballard CC, Cowtan KD, Dodson EJ, Emsley P, Evans PR, Keegan RM, Krissinel EB, Leslie AG, McCoy A, McNicholas SJ, Murshudov GN, Pannu NS, Potterton EA, Powell HR, Read RJ, Vagin A, Wilson KS.

Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42. doi: 10.1107/S0907444910045749. Epub 2011 Mar 18.

26.

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.

Warne T, Moukhametzianov R, Baker JG, Nehmé R, Edwards PC, Leslie AG, Schertler GF, Tate CG.

Nature. 2011 Jan 13;469(7329):241-4. doi: 10.1038/nature09746.

27.

Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria.

Watt IN, Montgomery MG, Runswick MJ, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16823-7. doi: 10.1073/pnas.1011099107. Epub 2010 Sep 16.

28.

The structure of the membrane extrinsic region of bovine ATP synthase.

Rees DM, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21597-601. doi: 10.1073/pnas.0910365106. Epub 2009 Dec 7.

29.

Asymmetric structure of the yeast F1 ATPase in the absence of bound nucleotides.

Kabaleeswaran V, Shen H, Symersky J, Walker JE, Leslie AG, Mueller DM.

J Biol Chem. 2009 Apr 17;284(16):10546-51. doi: 10.1074/jbc.M900544200. Epub 2009 Feb 20.

30.

Structure of a beta1-adrenergic G-protein-coupled receptor.

Warne T, Serrano-Vega MJ, Baker JG, Moukhametzianov R, Edwards PC, Henderson R, Leslie AG, Tate CG, Schertler GF.

Nature. 2008 Jul 24;454(7203):486-91. doi: 10.1038/nature07101. Epub 2008 Jun 25.

31.

Macromolecular assemblages. Editorial overview.

Egelman EH, Leslie AG.

Curr Opin Struct Biol. 2008 Apr;18(2):200-2. doi: 10.1016/j.sbi.2008.03.002. Epub 2008 Apr 9. No abstract available.

PMID:
18406134
32.

How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria.

Gledhill JR, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15671-6. Epub 2007 Sep 25.

33.

Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols.

Gledhill JR, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13632-7. Epub 2007 Aug 13.

34.

Ground state structure of F1-ATPase from bovine heart mitochondria at 1.9 A resolution.

Bowler MW, Montgomery MG, Leslie AG, Walker JE.

J Biol Chem. 2007 May 11;282(19):14238-42. Epub 2007 Mar 9.

35.

Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase.

Kabaleeswaran V, Puri N, Walker JE, Leslie AG, Mueller DM.

EMBO J. 2006 Nov 15;25(22):5433-42. Epub 2006 Nov 2.

36.

Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F(1)-ATPase by controlled dehydration.

Bowler MW, Montgomery MG, Leslie AG, Walker JE.

Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):991-5. Epub 2006 Aug 19.

PMID:
16929099
37.

On the structure of the stator of the mitochondrial ATP synthase.

Dickson VK, Silvester JA, Fearnley IM, Leslie AG, Walker JE.

EMBO J. 2006 Jun 21;25(12):2911-8. Epub 2006 Jun 8.

38.

The expression, purification, crystallization and preliminary X-ray analysis of a subcomplex of the peripheral stalk of ATP synthase from bovine mitochondria.

Silvester JA, Dickson VK, Runswick MJ, Leslie AG, Walker JE.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):530-3. Epub 2006 May 5.

39.

How azide inhibits ATP hydrolysis by the F-ATPases.

Bowler MW, Montgomery MG, Leslie AG, Walker JE.

Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8646-9. Epub 2006 May 25.

40.

The integration of macromolecular diffraction data.

Leslie AG.

Acta Crystallogr D Biol Crystallogr. 2006 Jan;62(Pt 1):48-57. Epub 2005 Dec 14. Review.

PMID:
16369093
41.

Structure of the rotor of the V-Type Na+-ATPase from Enterococcus hirae.

Murata T, Yamato I, Kakinuma Y, Leslie AG, Walker JE.

Science. 2005 Apr 29;308(5722):654-9. Epub 2005 Mar 31.

42.

Ni-chelate-affinity purification and crystallization of the yeast mitochondrial F1-ATPase.

Mueller DM, Puri N, Kabaleeswaran V, Terry C, Leslie AG, Walker JE.

Protein Expr Purif. 2004 Oct;37(2):479-85.

PMID:
15358374
43.

Crystallization and preliminary crystallographic studies of the mitochondrial F1-ATPase from the yeast Saccharomyces cerevisiae.

Mueller DM, Puri N, Kabaleeswaran V, Terry C, Leslie AG, Walker JE.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1441-4. Epub 2004 Jul 21.

PMID:
15272171
44.

The structure of bovine F1-ATPase inhibited by ADP and beryllium fluoride.

Kagawa R, Montgomery MG, Braig K, Leslie AG, Walker JE.

EMBO J. 2004 Jul 21;23(14):2734-44. Epub 2004 Jul 1.

45.

The structure of bovine F1-ATPase in complex with its regulatory protein IF1.

Cabezón E, Montgomery MG, Leslie AG, Walker JE.

Nat Struct Biol. 2003 Sep;10(9):744-50. Epub 2003 Aug 17.

PMID:
12923572
46.

Automation of the collection and processing of X-ray diffraction data -- a generic approach.

Leslie AG, Powell HR, Winter G, Svensson O, Spruce D, McSweeney S, Love D, Kinder S, Duke E, Nave C.

Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1924-8. Epub 2002 Oct 21. Review.

PMID:
12393923
47.

A dynamic analysis of the rotation mechanism for conformational change in F(1)-ATPase.

Ma J, Flynn TC, Cui Q, Leslie AG, Walker JE, Karplus M.

Structure. 2002 Jul;10(7):921-31. Erratum in: Structure (Camb). 2002 Sep;10(9):1284.

48.

The structure of bovine IF(1), the regulatory subunit of mitochondrial F-ATPase.

Cabezón E, Runswick MJ, Leslie AG, Walker JE.

EMBO J. 2001 Dec 17;20(24):6990-6.

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