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Items: 34


Early transcriptome changes in response to chemical long-term potentiation induced via activation of synaptic NMDA receptors in mouse hippocampal neurons.

Bliim N, Leshchyns'ka I, Keable R, Chen BJ, Curry-Hyde A, Gray L, Sytnyk V, Janitz M.

Genomics. 2018 Nov 20. pii: S0888-7543(18)30371-9. doi: 10.1016/j.ygeno.2018.11.019. [Epub ahead of print]


Cell Adhesion Molecule Close Homolog of L1 (CHL1) Guides the Regrowth of Regenerating Motor Axons and Regulates Synaptic Coverage of Motor Neurons.

Guseva D, Jakovcevski I, Irintchev A, Leshchyns'ka I, Sytnyk V, Ponimaskin E, Schachner M.

Front Mol Neurosci. 2018 May 24;11:174. doi: 10.3389/fnmol.2018.00174. eCollection 2018.


Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.

Sheng L, Leshchyns'ka I, Sytnyk V.

Cereb Cortex. 2019 Apr 1;29(4):1439-1459. doi: 10.1093/cercor/bhy041.


Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation.

Tan RPA, Leshchyns'ka I, Sytnyk V.

Front Mol Neurosci. 2017 Nov 15;10:378. doi: 10.3389/fnmol.2017.00378. eCollection 2017. Review.


Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function.

Sytnyk V, Leshchyns'ka I, Schachner M.

Trends Neurosci. 2017 May;40(5):295-308. doi: 10.1016/j.tins.2017.03.003. Epub 2017 Mar 27. Review.


Transcriptional regulation of long-term potentiation.

Bliim N, Leshchyns'ka I, Sytnyk V, Janitz M.

Neurogenetics. 2016 Oct;17(4):201-210. Epub 2016 Jun 18. Review.


Synaptic Cell Adhesion Molecules in Alzheimer's Disease.

Leshchyns'ka I, Sytnyk V.

Neural Plast. 2016;2016:6427537. doi: 10.1155/2016/6427537. Epub 2016 May 3. Review.


Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.

Leshchyns'ka I, Sytnyk V.

Front Cell Dev Biol. 2016 Feb 16;4:9. doi: 10.3389/fcell.2016.00009. eCollection 2016. Review.


Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.

Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V.

Nat Commun. 2015 Nov 27;6:8836. doi: 10.1038/ncomms9836.


Intracellular transport and cell surface delivery of the neural cell adhesion molecule (NCAM).

Leshchyns'ka I, Sytnyk V.

Bioarchitecture. 2015;5(3-4):54-60. doi: 10.1080/19490992.2015.1118194. Review.


Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene.

Schmalbach B, Lepsveridze E, Djogo N, Papashvili G, Kuang F, Leshchyns'ka I, Sytnyk V, Nikonenko AG, Dityatev A, Jakovcevski I, Schachner M.

J Neurochem. 2015 Nov;135(4):830-44. doi: 10.1111/jnc.13284. Epub 2015 Sep 8.


Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface.

Wobst H, Schmitz B, Schachner M, Diestel S, Leshchyns'ka I, Sytnyk V.

J Cell Sci. 2015 Aug 1;128(15):2816-29. doi: 10.1242/jcs.169391. Epub 2015 Jun 22.


Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels.

Sheng L, Leshchyns'ka I, Sytnyk V.

J Neurosci. 2015 Jan 28;35(4):1739-52. doi: 10.1523/JNEUROSCI.1714-14.2015.


PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes.

Robinson JW, Leshchyns'ka I, Farghaian H, Hughes WE, Sytnyk V, Neely GG, Cole AR.

Biochem J. 2014 Nov 15;464(1):145-56. doi: 10.1042/BJ20140497.


Cell adhesion and intracellular calcium signaling in neurons.

Sheng L, Leshchyns'ka I, Sytnyk V.

Cell Commun Signal. 2013 Dec 13;11:94. doi: 10.1186/1478-811X-11-94. Review.


The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms.

Shetty A, Sytnyk V, Leshchyns'ka I, Puchkov D, Haucke V, Schachner M.

J Neurosci. 2013 Oct 16;33(42):16828-45. doi: 10.1523/JNEUROSCI.2192-13.2013.


The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).

Li S, Leshchyns'ka I, Chernyshova Y, Schachner M, Sytnyk V.

J Neurosci. 2013 Jan 9;33(2):790-803. doi: 10.1523/JNEUROSCI.1238-12.2013.


Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.

Tian N, Leshchyns'ka I, Welch JH, Diakowski W, Yang H, Schachner M, Sytnyk V.

J Biol Chem. 2012 Dec 28;287(53):44447-63. doi: 10.1074/jbc.M112.394973. Epub 2012 Nov 9.


L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth.

Poplawski GH, Tranziska AK, Leshchyns'ka I, Meier ID, Streichert T, Sytnyk V, Schachner M.

Mol Cell Neurosci. 2012 Jun;50(2):169-78. doi: 10.1016/j.mcn.2012.03.010. Epub 2012 Apr 6.


Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions.

Leshchyns'ka I, Tanaka MM, Schachner M, Sytnyk V.

J Biol Chem. 2011 Jul 1;286(26):23397-406. doi: 10.1074/jbc.M111.252098. Epub 2011 May 6.


The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones.

Chernyshova Y, Leshchyns'ka I, Hsu SC, Schachner M, Sytnyk V.

J Neurosci. 2011 Mar 9;31(10):3522-35. doi: 10.1523/JNEUROSCI.3109-10.2011.


NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation.

Puchkov D, Leshchyns'ka I, Nikonenko AG, Schachner M, Sytnyk V.

Cereb Cortex. 2011 Oct;21(10):2217-32. doi: 10.1093/cercor/bhq283. Epub 2011 Feb 21.


Clustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8- and -3-dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowth.

Westphal D, Sytnyk V, Schachner M, Leshchyns'ka I.

J Biol Chem. 2010 Dec 31;285(53):42046-57. doi: 10.1074/jbc.M110.177147. Epub 2010 Oct 20.


CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex.

Andreyeva A, Leshchyns'ka I, Knepper M, Betzel C, Redecke L, Sytnyk V, Schachner M.

PLoS One. 2010 Aug 11;5(8):e12018. doi: 10.1371/journal.pone.0012018.


Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.

Devanathan V, Jakovcevski I, Santuccione A, Li S, Lee HJ, Peles E, Leshchyns'ka I, Sytnyk V, Schachner M.

J Neurosci. 2010 Jul 7;30(27):9292-305. doi: 10.1523/JNEUROSCI.5657-09.2010.


NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

Bodrikov V, Sytnyk V, Leshchyns'ka I, den Hertog J, Schachner M.

J Cell Biol. 2008 Sep 22;182(6):1185-200. doi: 10.1083/jcb.200803045.


Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury.

Jakovcevski I, Wu J, Karl N, Leshchyns'ka I, Sytnyk V, Chen J, Irintchev A, Schachner M.

J Neurosci. 2007 Jul 4;27(27):7222-33.


The adhesion molecule CHL1 regulates uncoating of clathrin-coated synaptic vesicles.

Leshchyns'ka I, Sytnyk V, Richter M, Andreyeva A, Puchkov D, Schachner M.

Neuron. 2006 Dec 21;52(6):1011-25.


NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex.

Sytnyk V, Leshchyns'ka I, Nikonenko AG, Schachner M.

J Cell Biol. 2006 Sep 25;174(7):1071-85.


Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.

Santuccione A, Sytnyk V, Leshchyns'ka I, Schachner M.

J Cell Biol. 2005 Apr 25;169(2):341-54.


RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation.

Bodrikov V, Leshchyns'ka I, Sytnyk V, Overvoorde J, den Hertog J, Schachner M.

J Cell Biol. 2005 Jan 3;168(1):127-39. Epub 2004 Dec 28.


Trans-Golgi network delivery of synaptic proteins in synaptogenesis.

Sytnyk V, Leshchyns'ka I, Dityatev A, Schachner M.

J Cell Sci. 2004 Jan 26;117(Pt 3):381-8. Review.


Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts.

Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M.

J Cell Biol. 2002 Nov 25;159(4):649-61. Epub 2002 Nov 18.

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