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Repurposing papaverine as an antiviral agent against influenza viruses and paramyxoviruses.

Aggarwal M, Leser GP, Lamb RA.

J Virol. 2020 Jan 2. pii: JVI.01888-19. doi: 10.1128/JVI.01888-19. [Epub ahead of print]


Structure of the Paramyxovirus Parainfluenza Virus 5 Nucleoprotein in Complex with an Amino-Terminal Peptide of the Phosphoprotein.

Aggarwal M, Leser GP, Kors CA, Lamb RA.

J Virol. 2018 Feb 12;92(5). pii: e01304-17. doi: 10.1128/JVI.01304-17. Print 2018 Mar 1.


Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.

Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS.

Nat Commun. 2017 Oct 3;8(1):781. doi: 10.1038/s41467-017-00863-3.


Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane.

Leser GP, Lamb RA.

J Virol. 2017 Apr 13;91(9). pii: e02104-16. doi: 10.1128/JVI.02104-16. Print 2017 May 1.


A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV.

Wen X, Pickens J, Mousa JJ, Leser GP, Lamb RA, Crowe JE Jr, Jardetzky TS.

PLoS One. 2016 May 25;11(5):e0155917. doi: 10.1371/journal.pone.0155917. eCollection 2016.


Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex.

Alayyoubi M, Leser GP, Kors CA, Lamb RA.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1792-9. doi: 10.1073/pnas.1503941112. Epub 2015 Mar 23.


The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.

Bruns AM, Leser GP, Lamb RA, Horvath CM.

Mol Cell. 2014 Sep 4;55(5):771-81. doi: 10.1016/j.molcel.2014.07.003. Epub 2014 Aug 7.


Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies.

Welch BD, Paduch M, Leser GP, Bergman Z, Kors CA, Paterson RG, Jardetzky TS, Kossiakoff AA, Lamb RA.

J Virol. 2014 Oct;88(20):11713-25. doi: 10.1128/JVI.01707-14. Epub 2014 Aug 13.


Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting.

Poor TA, Jones LM, Sood A, Leser GP, Plasencia MD, Rempel DL, Jardetzky TS, Woods RJ, Gross ML, Lamb RA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2596-605. doi: 10.1073/pnas.1408983111. Epub 2014 Jun 9.


The amphipathic helix of influenza A virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles.

Roberts KL, Leser GP, Ma C, Lamb RA.

J Virol. 2013 Sep;87(18):9973-82. doi: 10.1128/JVI.01363-13. Epub 2013 Jul 10.


Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein.

Welch BD, Liu Y, Kors CA, Leser GP, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16672-7. doi: 10.1073/pnas.1213802109. Epub 2012 Sep 10.


Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering.

Bose S, Zokarkar A, Welch BD, Leser GP, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2625-34. Epub 2012 Sep 4.


Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence.

Yuan P, Paterson RG, Leser GP, Lamb RA, Jardetzky TS.

PLoS Pathog. 2012;8(8):e1002855. doi: 10.1371/journal.ppat.1002855. Epub 2012 Aug 9.


Filamentous influenza virus enters cells via macropinocytosis.

Rossman JS, Leser GP, Lamb RA.

J Virol. 2012 Oct;86(20):10950-60. Epub 2012 Aug 8.


Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.

Wen X, Krause JC, Leser GP, Cox RG, Lamb RA, Williams JV, Crowe JE Jr, Jardetzky TS.

Nat Struct Mol Biol. 2012 Mar 4;19(4):461-3. doi: 10.1038/nsmb.2250.


Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5.

Kim YH, Donald JE, Grigoryan G, Leser GP, Fadeev AY, Lamb RA, DeGrado WF.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20992-7. doi: 10.1073/pnas.1116034108. Epub 2011 Dec 16.


Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk.

Yuan P, Swanson KA, Leser GP, Paterson RG, Lamb RA, Jardetzky TS.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14920-5. doi: 10.1073/pnas.1111691108. Epub 2011 Aug 22.


Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin.

Watanabe R, Leser GP, Lamb RA.

Virology. 2011 Aug 15;417(1):50-6. doi: 10.1016/j.virol.2011.05.006. Epub 2011 May 28.


Influenza virus M2 protein mediates ESCRT-independent membrane scission.

Rossman JS, Jing X, Leser GP, Lamb RA.

Cell. 2010 Sep 17;142(6):902-13. doi: 10.1016/j.cell.2010.08.029.


A role for caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5.

Ravid D, Leser GP, Lamb RA.

J Virol. 2010 Oct;84(19):9749-59. doi: 10.1128/JVI.01079-10. Epub 2010 Jul 14.


Structure of the Newcastle disease virus F protein in the post-fusion conformation.

Swanson K, Wen X, Leser GP, Paterson RG, Lamb RA, Jardetzky TS.

Virology. 2010 Jul 5;402(2):372-9. doi: 10.1016/j.virol.2010.03.050. Epub 2010 May 2.


Influenza virus m2 ion channel protein is necessary for filamentous virion formation.

Rossman JS, Jing X, Leser GP, Balannik V, Pinto LH, Lamb RA.

J Virol. 2010 May;84(10):5078-88. doi: 10.1128/JVI.00119-10. Epub 2010 Mar 10.


Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering.

Connolly SA, Leser GP, Jardetzky TS, Lamb RA.

J Virol. 2009 Nov;83(21):10857-68. doi: 10.1128/JVI.01191-09. Epub 2009 Aug 26.


The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding.

Chen BJ, Leser GP, Jackson D, Lamb RA.

J Virol. 2008 Oct;82(20):10059-70. doi: 10.1128/JVI.01184-08. Epub 2008 Aug 13.


Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein.

Yuan P, Leser GP, Demeler B, Lamb RA, Jardetzky TS.

Virology. 2008 Sep 1;378(2):282-91. doi: 10.1016/j.virol.2008.05.023. Epub 2008 Jul 2.


Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins.

Backovic M, Leser GP, Lamb RA, Longnecker R, Jardetzky TS.

Virology. 2007 Nov 10;368(1):102-13. Epub 2007 Jul 25.


Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge.

Tompkins SM, Lin Y, Leser GP, Kramer KA, Haas DL, Howerth EW, Xu J, Kennett MJ, Durbin RK, Durbin JE, Tripp R, Lamb RA, He B.

Virology. 2007 May 25;362(1):139-50. Epub 2007 Jan 23.


Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy.

Connolly SA, Leser GP, Yin HS, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17903-8. Epub 2006 Nov 8.


Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus.

Schmitt AP, Leser GP, Morita E, Sundquist WI, Lamb RA.

J Virol. 2005 Mar;79(5):2988-97.


Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion.

Takeda M, Leser GP, Russell CJ, Lamb RA.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14610-7. Epub 2003 Oct 15.


Requirements for budding of paramyxovirus simian virus 5 virus-like particles.

Schmitt AP, Leser GP, Waning DL, Lamb RA.

J Virol. 2002 Apr;76(8):3952-64.


Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape.

Jin H, Leser GP, Zhang J, Lamb RA.

EMBO J. 1997 Mar 17;16(6):1236-47.


Influenza B virus NB glycoprotein is a component of the virion.

Brassard DL, Leser GP, Lamb RA.

Virology. 1996 Jun 15;220(2):350-60.


Palmitylation of the influenza virus hemagglutinin (H3) is not essential for virus assembly or infectivity.

Jin H, Subbarao K, Bagai S, Leser GP, Murphy BR, Lamb RA.

J Virol. 1996 Mar;70(3):1406-14.


The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions.

Paterson RG, Leser GP, Shaughnessy MA, Lamb RA.

Virology. 1995 Apr 1;208(1):121-31.


Distinctive properties of the purified Na-Ca exchanger from rod outer segments.

Leser GP, Nicoll DA, Applebury ML.

Ann N Y Acad Sci. 1991;639:222-33.


Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection.

Martin TE, Barghusen SC, Leser GP, Spear PG.

J Cell Biol. 1987 Nov;105(5):2069-82.


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