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Items: 1 to 50 of 135

1.

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.

Jaroensuk J, Wong YH, Zhong W, Liew CW, Maenpuen S, Sahili AE, Atichartpongkul S, Chionh YH, Nah Q, Thongdee N, McBee ME, Prestwich EG, DeMott MS, Chaiyen P, Mongkolsuk S, Dedon P, Lescar J, Fuangthong M.

RNA. 2019 Aug 9. pii: rna.066746.118. doi: 10.1261/rna.066746.118. [Epub ahead of print]

PMID:
31399541
2.

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis.

Zhong W, Guo J, Cui L, Chionh YH, Li K, El Sahili A, Cai Q, Yuan M, Michels PAM, Fothergill-Gilmore LA, Walkinshaw MD, Mu Y, Lescar J, Dedon PC.

J Mol Biol. 2019 Aug 2. pii: S0022-2836(19)30484-X. doi: 10.1016/j.jmb.2019.07.033. [Epub ahead of print]

PMID:
31381898
3.

Cell-active carbazole derivatives as inhibitors of the zika virus protease.

Rassias G, Zogali V, Swarbrick CMD, Ki Chan KW, Chan SA, Gwee CP, Wang S, Kaplanai E, Canko A, Kiousis D, Lescar J, Luo D, Matsoukas MT, Vasudevan SG.

Eur J Med Chem. 2019 Jul 17;180:536-545. doi: 10.1016/j.ejmech.2019.07.007. [Epub ahead of print]

PMID:
31344613
4.

Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa.

Li Y, Zhong W, Koay AZ, Ng HQ, Nah Q, Wong YH, Hill J, Lescar J, Dedon PC, Kang C.

Biomol NMR Assign. 2019 Jun 7. doi: 10.1007/s12104-019-09900-2. [Epub ahead of print]

PMID:
31175551
5.

Structural determinants for peptide-bond formation by asparaginyl ligases.

Hemu X, El Sahili A, Hu S, Wong K, Chen Y, Wong YH, Zhang X, Serra A, Goh BC, Darwis DA, Chen MW, Sze SK, Liu CF, Lescar J, Tam JP.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11737-11746. doi: 10.1073/pnas.1818568116. Epub 2019 May 23.

PMID:
31123145
6.

Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.

Dai L, Lin J, Said AB, Yau YH, Shochat SG, Ruiz-Carrillo D, Sun K, Chandrasekaran R, Sze SK, Lescar J, Cheung PC.

Biochem Biophys Res Commun. 2019 Jun 4;513(3):714-720. doi: 10.1016/j.bbrc.2019.03.095. Epub 2019 Apr 12.

PMID:
30987826
7.

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA.

Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1.

8.

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.

Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong YH, Chionh YH, Ng HQ, Koh-Stenta X, Poulsen A, Foo K, McBee M, Choong ML, El Sahili A, Kang C, Matter A, Lescar J, Hill J, Dedon P.

ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. Epub 2019 Feb 4.

PMID:
30682246
9.

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018.

Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R.

Antiviral Res. 2019 Feb;162:142-150. doi: 10.1016/j.antiviral.2018.12.015. Epub 2018 Dec 28. Review.

PMID:
30597184
10.

Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase.

Li Y, Zhong W, Koay AZ, Ng HQ, Koh-Stenta X, Nah Q, Lim SH, Larsson A, Lescar J, Hill J, Dedon PC, Kang C.

Biomol NMR Assign. 2019 Apr;13(1):49-53. doi: 10.1007/s12104-018-9849-9. Epub 2018 Oct 8.

PMID:
30298375
11.

Supramolecular propensity of suckerin proteins is driven by β-sheets and aromatic interactions as revealed by solution NMR.

Kumar A, Mohanram H, Kong KW, Goh R, Hoon S, Lescar J, Miserez A.

Biomater Sci. 2018 Aug 21;6(9):2440-2447. doi: 10.1039/c8bm00556g.

PMID:
30042992
12.

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.

Wong YH, Kumar A, Liew CW, Tharakaraman K, Srinivasaraghavan K, Sasisekharan R, Verma C, Lescar J.

Sci Rep. 2018 May 31;8(1):8449. doi: 10.1038/s41598-018-26800-y.

13.

The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity.

Lescar J, Soh S, Lee LT, Vasudevan SG, Kang C, Lim SP.

Adv Exp Med Biol. 2018;1062:115-129. doi: 10.1007/978-981-10-8727-1_9. Review.

PMID:
29845529
14.

Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.

Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Gan ES, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R.

Cell Host Microbe. 2018 May 9;23(5):618-627.e6. doi: 10.1016/j.chom.2018.04.004.

15.

The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.

Ruiz-Carrillo D, Lin J, El Sahili A, Wei M, Sze SK, Cheung PCF, Doerig C, Lescar J.

Sci Rep. 2018 May 9;8(1):7365. doi: 10.1038/s41598-018-25738-5.

16.

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.

Zhong W, Cui L, Goh BC, Cai Q, Ho P, Chionh YH, Yuan M, Sahili AE, Fothergill-Gilmore LA, Walkinshaw MD, Lescar J, Dedon PC.

Nat Commun. 2017 Dec 7;8(1):1986. doi: 10.1038/s41467-017-02086-y.

17.

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

Swarbrick CMD, Basavannacharya C, Chan KWK, Chan SA, Singh D, Wei N, Phoo WW, Luo D, Lescar J, Vasudevan SG.

Nucleic Acids Res. 2017 Dec 15;45(22):12904-12920. doi: 10.1093/nar/gkx1127.

18.

Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.

Liu C, Liew CW, Wong YH, Tan ST, Poh WH, Manimekalai MSS, Rajan S, Xin L, Liang ZX, Grüber G, Rice SA, Lescar J.

J Bacteriol. 2018 Jan 10;200(3). pii: e00515-17. doi: 10.1128/JB.00515-17. Print 2018 Feb 1.

19.

Structural Mimicry of the Dengue Virus Envelope Glycoprotein Revealed by the Crystallographic Study of an Idiotype-Anti-idiotype Fab Complex.

Wong YH, Goh BC, Lim SY, Teo EW, Lim APC, Dedon PC, Hanson BJ, MacAry PA, Lescar J.

J Virol. 2017 Aug 10;91(17). pii: e00406-17. doi: 10.1128/JVI.00406-17. Print 2017 Sep 1.

20.

Plasmodium P36 determines host cell receptor usage during sporozoite invasion.

Manzoni G, Marinach C, Topçu S, Briquet S, Grand M, Tolle M, Gransagne M, Lescar J, Andolina C, Franetich JF, Zeisel MB, Huby T, Rubinstein E, Snounou G, Mazier D, Nosten F, Baumert TF, Silvie O.

Elife. 2017 May 16;6. pii: e25903. doi: 10.7554/eLife.25903.

21.

Dengue Virus Non-Structural Protein 5.

El Sahili A, Lescar J.

Viruses. 2017 Apr 24;9(4). pii: E91. doi: 10.3390/v9040091. Review.

22.

P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC.

Aniweh Y, Gao X, Hao P, Meng W, Lai SK, Gunalan K, Chu TT, Sinha A, Lescar J, Chandramohanadas R, Li HY, Sze SK, Preiser PR.

Cell Microbiol. 2017 Sep;19(9). doi: 10.1111/cmi.12747. Epub 2017 May 9.

PMID:
28409866
23.

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities.

Chen MW, Tan YB, Zheng J, Zhao Y, Lim BT, Cornvik T, Lescar J, Ng LFP, Luo D.

Antiviral Res. 2017 Jul;143:38-47. doi: 10.1016/j.antiviral.2017.04.001. Epub 2017 Apr 5.

PMID:
28390873
24.

Engineering a Catalytically Efficient Recombinant Protein Ligase.

Yang R, Wong YH, Nguyen GKT, Tam JP, Lescar J, Wu B.

J Am Chem Soc. 2017 Apr 19;139(15):5351-5358. doi: 10.1021/jacs.6b12637. Epub 2017 Mar 1.

PMID:
28199119
25.

Thiazolidine-Masked α-Oxo Aldehyde Functionality for Peptide and Protein Modification.

Bi X, Pasunooti KK, Lescar J, Liu CF.

Bioconjug Chem. 2017 Feb 15;28(2):325-329. doi: 10.1021/acs.bioconjchem.6b00667. Epub 2016 Dec 27.

PMID:
28026933
26.

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage.

Phoo WW, Li Y, Zhang Z, Lee MY, Loh YR, Tan YB, Ng EY, Lescar J, Kang C, Luo D.

Nat Commun. 2016 Nov 15;7:13410. doi: 10.1038/ncomms13410.

27.

Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.

Jaroensuk J, Atichartpongkul S, Chionh YH, Wong YH, Liew CW, McBee ME, Thongdee N, Prestwich EG, DeMott MS, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M.

Nucleic Acids Res. 2016 Dec 15;44(22):10834-10848. Epub 2016 Sep 28.

28.

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.

Tay MY, Smith K, Ng IH, Chan KW, Zhao Y, Ooi EE, Lescar J, Luo D, Jans DA, Forwood JK, Vasudevan SG.

PLoS Pathog. 2016 Sep 13;12(9):e1005886. doi: 10.1371/journal.ppat.1005886. eCollection 2016 Sep.

29.

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles.

Li Y, Wong YL, Lee MY, Li Q, Wang QY, Lescar J, Shi PY, Kang C.

Angew Chem Int Ed Engl. 2016 Sep 19;55(39):12068-72. doi: 10.1002/anie.201606609. Epub 2016 Aug 24.

PMID:
27554985
30.

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

Lim SP, Noble CG, Seh CC, Soh TS, El Sahili A, Chan GK, Lescar J, Arora R, Benson T, Nilar S, Manjunatha U, Wan KF, Dong H, Xie X, Shi PY, Yokokawa F.

PLoS Pathog. 2016 Aug 8;12(8):e1005737. doi: 10.1371/journal.ppat.1005737. eCollection 2016 Aug.

31.

Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases.

Qian X, Hamid FM, El Sahili A, Darwis DA, Wong YH, Bhushan S, Makeyev EV, Lescar J.

J Biol Chem. 2016 Apr 22;291(17):9295-309. doi: 10.1074/jbc.M115.685933. Epub 2016 Feb 23.

32.

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5).

Zhao Y, Soh TS, Lim SP, Chung KY, Swaminathan K, Vasudevan SG, Shi PY, Lescar J, Luo D.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14834-9. doi: 10.1073/pnas.1514978112. Epub 2015 Nov 17.

33.

Crystallization and X-ray diffraction analysis of the HMG domain of the chondrogenesis master regulator Sox9 in complex with a ChIP-Seq-identified DNA element.

Vivekanandan S, Moovarkumudalvan B, Lescar J, Kolatkar PR.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1437-41. doi: 10.1107/S2053230X1501969X. Epub 2015 Oct 30.

34.

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids.

Li Y, Kim YM, Zou J, Wang QY, Gayen S, Wong YL, Lee le T, Xie X, Huang Q, Lescar J, Shi PY, Kang C.

Biochim Biophys Acta. 2015 Dec;1848(12):3150-7. doi: 10.1016/j.bbamem.2015.09.016. Epub 2015 Sep 25.

35.

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication.

Zhao Y, Soh TS, Chan KW, Fung SS, Swaminathan K, Lim SP, Shi PY, Huber T, Lescar J, Luo D, Vasudevan SG.

J Virol. 2015 Oct;89(20):10717-21. doi: 10.1128/JVI.01239-15. Epub 2015 Aug 12.

36.

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope.

Robinson LN, Tharakaraman K, Rowley KJ, Costa VV, Chan KR, Wong YH, Ong LC, Tan HC, Koch T, Cain D, Kirloskar R, Viswanathan K, Liew CW, Tissire H, Ramakrishnan B, Myette JR, Babcock GJ, Sasisekharan V, Alonso S, Chen J, Lescar J, Shriver Z, Ooi EE, Sasisekharan R.

Cell. 2015 Jul 30;162(3):493-504. doi: 10.1016/j.cell.2015.06.057. Epub 2015 Jul 16.

37.

Discovery of Dengue Virus NS4B Inhibitors.

Wang QY, Dong H, Zou B, Karuna R, Wan KF, Zou J, Susila A, Yip A, Shan C, Yeo KL, Xu H, Ding M, Chan WL, Gu F, Seah PG, Liu W, Lakshminarayana SB, Kang C, Lescar J, Blasco F, Smith PW, Shi PY.

J Virol. 2015 Aug;89(16):8233-44.

38.

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.

Niyomrattanakit P, Wan KF, Chung KY, Abas SN, Seh CC, Dong H, Lim CC, Chao AT, Lee CB, Nilar S, Lescar J, Shi PY, Beer D, Lim SP.

Antiviral Res. 2015 Jul;119:36-46. doi: 10.1016/j.antiviral.2015.04.007. Epub 2015 Apr 18.

PMID:
25896272
39.

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development.

Luo D, Vasudevan SG, Lescar J.

Antiviral Res. 2015 Jun;118:148-58. doi: 10.1016/j.antiviral.2015.03.014. Epub 2015 Apr 2. Review.

PMID:
25842996
40.

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.

Zhao Y, Soh TS, Zheng J, Chan KW, Phoo WW, Lee CC, Tay MY, Swaminathan K, Cornvik TC, Lim SP, Shi PY, Lescar J, Vasudevan SG, Luo D.

PLoS Pathog. 2015 Mar 16;11(3):e1004682. doi: 10.1371/journal.ppat.1004682. eCollection 2015 Mar.

41.

Mapping the Interactions between the NS4B and NS3 proteins of dengue virus.

Zou J, Lee le T, Wang QY, Xie X, Lu S, Yau YH, Yuan Z, Geifman Shochat S, Kang C, Lescar J, Shi PY.

J Virol. 2015 Apr;89(7):3471-83. doi: 10.1128/JVI.03454-14. Epub 2015 Jan 14.

42.

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication.

Tay MY, Saw WG, Zhao Y, Chan KW, Singh D, Chong Y, Forwood JK, Ooi EE, Grüber G, Lescar J, Luo D, Vasudevan SG.

J Biol Chem. 2015 Jan 23;290(4):2379-94. doi: 10.1074/jbc.M114.607341. Epub 2014 Dec 8.

43.

Crystallization and preliminary crystallographic analysis of human aquaporin 1 at a resolution of 3.28 Å.

Ruiz Carrillo D, To Yiu Ying J, Darwis D, Soon CH, Cornvik T, Torres J, Lescar J.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1657-63. doi: 10.1107/S2053230X14024558. Epub 2014 Nov 14.

44.

Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability.

Deepthi A, Liew CW, Liang ZX, Swaminathan K, Lescar J.

PLoS One. 2014 Oct 31;9(10):e110912. doi: 10.1371/journal.pone.0110912. eCollection 2014.

45.

Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides.

Choo JA, Thong SY, Yap J, van Esch WJ, Raida M, Meijers R, Lescar J, Verhelst SH, Grotenbreg GM.

Angew Chem Int Ed Engl. 2014 Dec 1;53(49):13390-4. doi: 10.1002/anie.201406295. Epub 2014 Oct 27.

PMID:
25348595
46.

Aspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole.

Lescar J, Meyer I, Akshita K, Srinivasaraghavan K, Verma C, Palous M, Mazier D, Datry A, Fekkar A.

J Antimicrob Chemother. 2014 Dec;69(12):3244-7. doi: 10.1093/jac/dku316. Epub 2014 Aug 13.

PMID:
25125676
47.

Biomimetic production of silk-like recombinant squid sucker ring teeth proteins.

Ding D, Guerette PA, Hoon S, Kong KW, Cornvik T, Nilsson M, Kumar A, Lescar J, Miserez A.

Biomacromolecules. 2014 Sep 8;15(9):3278-89. doi: 10.1021/bm500670r. Epub 2014 Aug 5.

PMID:
25068184
48.

Discovery and characterization of pseudocyclic cystine-knot α-amylase inhibitors with high resistance to heat and proteolytic degradation.

Nguyen PQ, Wang S, Kumar A, Yap LJ, Luu TT, Lescar J, Tam JP.

FEBS J. 2014 Oct;281(19):4351-66. doi: 10.1111/febs.12939. Epub 2014 Aug 8.

49.

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.

Coutard B, Decroly E, Li C, Sharff A, Lescar J, Bricogne G, Barral K.

Antiviral Res. 2014 Jun;106:61-70. doi: 10.1016/j.antiviral.2014.03.013. Epub 2014 Apr 1.

PMID:
24704437
50.

Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I.

Kwok J, Hui KP, Lescar J, Kotaka M.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):248-51. doi: 10.1107/S2053230X14000430. Epub 2014 Jan 22.

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