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A cell-cell interaction format for selection of high-affinity antibodies to membrane proteins.

Yang Z, Wan Y, Tao P, Qiang M, Dong X, Lin CW, Yang G, Zheng T, Lerner RA.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14971-14978. doi: 10.1073/pnas.1908571116. Epub 2019 Jul 8.


A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function.

Ziraldo G, Buratto D, Kuang Y, Xu L, Carrer A, Nardin C, Chiani F, Salvatore AM, Paludetti G, Lerner RA, Yang G, Zonta F, Mammano F.

Front Physiol. 2019 Jun 11;10:392. doi: 10.3389/fphys.2019.00392. eCollection 2019.


Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1.

Liu T, Kuwana T, Zhang H, Vander Heiden MG, Lerner RA, Newmeyer DD.

PLoS Biol. 2019 Jun 10;17(6):e2004413. doi: 10.1371/journal.pbio.2004413. eCollection 2019 Jun.


Functionality-Independent DNA Encoding of Complex Natural Products.

Ma P, Xu H, Li J, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Liu ZJ, Yang G, Lerner RA.

Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9254-9261. doi: 10.1002/anie.201901485. Epub 2019 May 22. Review.


An agonist antibody prefers relapsed AML for induction of cells that kill each other.

Yea K, Jones TM, Jung D, Shin S, Arlian BM, Han KH, Zha Z, Kim MS, Oh YS, Zhang H, Lerner RA.

Sci Rep. 2019 Mar 5;9(1):3494. doi: 10.1038/s41598-019-40087-7.


Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma.

Stepanov AV, Markov OV, Chernikov IV, Gladkikh DV, Zhang H, Jones T, Sen'kova AV, Chernolovskaya EL, Zenkova MA, Kalinin RS, Rubtsova MP, Meleshko AN, Genkin DD, Belogurov AA Jr, Xie J, Gabibov AG, Lerner RA.

Sci Adv. 2018 Nov 14;4(11):eaau4580. doi: 10.1126/sciadv.aau4580. eCollection 2018 Nov.


Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death.

Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao L, Yuan C, Huang C, Tao P, Hu Q, Li WG, Hu W, Li J, Nie Y, Buratto D, Zonta F, Ma P, Yu Z, Liu L, Zhang Y, Yang B, Xie J, Xu TL, Qu Z, Yang G, Lerner RA.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7469-E7477. doi: 10.1073/pnas.1807233115. Epub 2018 Jul 24.


Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library.

Merkouris S, Barde YA, Binley KE, Allen ND, Stepanov AV, Wu NC, Grande G, Lin CW, Li M, Nan X, Chacon-Fernandez P, DiStefano PS, Lindsay RM, Lerner RA, Xie J.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7023-E7032. doi: 10.1073/pnas.1806660115. Epub 2018 Jul 9.


Antibody selection using clonal cocultivation of Escherichia coli and eukaryotic cells in miniecosystems.

Zheng T, Xie J, Yang Z, Tao P, Shi B, Douthit L, Wu P, Lerner RA.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6145-E6151. doi: 10.1073/pnas.1806718115. Epub 2018 Jun 18.


A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.

Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA.

Nat Commun. 2018 Mar 28;9(1):1264. doi: 10.1038/s41467-018-03663-5.


Affinity maturation of an TpoR targeting antibody in full-length IgG form for enhanced agonist activity.

Yang Z, Du M, Wang W, Xin X, Ma P, Zhang H, Lerner RA.

Protein Eng Des Sel. 2018 Jul 1;31(7-8):233-241. doi: 10.1093/protein/gzy002.


DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information.

Neri D, Lerner RA.

Annu Rev Biochem. 2018 Jun 20;87:479-502. doi: 10.1146/annurev-biochem-062917-012550. Epub 2018 Jan 12. Review.


Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β.

Han KH, Arlian BM, Macauley MS, Paulson JC, Lerner RA.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E372-E381. doi: 10.1073/pnas.1719259115. Epub 2018 Jan 2.


Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders.

Xu L, Carrer A, Zonta F, Qu Z, Ma P, Li S, Ceriani F, Buratto D, Crispino G, Zorzi V, Ziraldo G, Bruno F, Nardin C, Peres C, Mazzarda F, Salvatore AM, Raspa M, Scavizzi F, Chu Y, Xie S, Yang X, Liao J, Liu X, Wang W, Wang S, Yang G, Lerner RA, Mammano F.

Front Mol Neurosci. 2017 Sep 22;10:298. doi: 10.3389/fnmol.2017.00298. eCollection 2017.


Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem.

Lang S, Xie J, Zhu X, Wu NC, Lerner RA, Wilson IA.

Cell Rep. 2017 Sep 19;20(12):2935-2943. doi: 10.1016/j.celrep.2017.08.084.


Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries.

Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK.

Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11.


Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA.

Cell Host Microbe. 2017 Aug 9;22(2):247-248. doi: 10.1016/j.chom.2017.07.001. No abstract available.


Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation.

Zha Z, Bucher F, Nejatfard A, Zheng T, Zhang H, Yea K, Lerner RA.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6867-E6874. doi: 10.1073/pnas.1706915114. Epub 2017 Jul 31.


Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA.

Cell Host Microbe. 2017 Jun 14;21(6):742-753.e8. doi: 10.1016/j.chom.2017.05.011. Erratum in: Cell Host Microbe. 2017 Aug 9;22(2):247-248.


In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity.

Wu NC, Grande G, Turner HL, Ward AB, Xie J, Lerner RA, Wilson IA.

Nat Commun. 2017 May 15;8:15371. doi: 10.1038/ncomms15371.


Immunochemical engineering of cell surfaces to generate virus resistance.

Xie J, Sok D, Wu NC, Zheng T, Zhang W, Burton DR, Lerner RA.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4655-4660. doi: 10.1073/pnas.1702764114. Epub 2017 Apr 10.


A Proximity-Based Assay for Identification of Ligand and Membrane Protein Interaction in Living Cells.

Zhang H, Lerner RA.

Methods Mol Biol. 2017;1575:215-222. doi: 10.1007/978-1-4939-6857-2_13.


DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs.

Lerner RA, Brenner S.

Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1164-1165. doi: 10.1002/anie.201612143.


Robotic QM/MM-driven maturation of antibody combining sites.

Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA Jr, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA.

Sci Adv. 2016 Oct 19;2(10):e1501695. eCollection 2016 Oct.


Combinatorial antibody libraries: new advances, new immunological insights.

Lerner RA.

Nat Rev Immunol. 2016 Aug;16(8):498-508. doi: 10.1038/nri.2016.67. Epub 2016 Jul 4. Review.


Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries.

Zhang H, Du M, Xie J, Liu X, Sun J, Wang W, Xin X, Possani LD, Yea K, Lerner RA.

Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9306-10. doi: 10.1002/anie.201603052. Epub 2016 May 20.


Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects.

Zhang H, Sturchler E, Zhu J, Nieto A, Cistrone PA, Xie J, He L, Yea K, Jones T, Turn R, Di Stefano PS, Griffin PR, Dawson PE, McDonald PH, Lerner RA.

Nat Commun. 2015 Dec 1;6:8918. doi: 10.1038/ncomms9918.


Activating pleiotropic receptors to kill cancer cells.

Yea K, Zhang H, Lerner RA.

Cell Cycle. 2016;15(2):158-9. doi: 10.1080/15384101.2015.1118912. Epub 2015 Nov 20. No abstract available.


Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates.

Lerner RA, Grover RK, Zhang H, Xie J, Han KH, Peng Y, Yea K.

Q Rev Biophys. 2015 Nov;48(4):389-94. doi: 10.1017/S0033583515000049. Review.


Agonist antibody that induces human malignant cells to kill one another.

Yea K, Zhang H, Xie J, Jones TM, Lin CW, Francesconi W, Berton F, Fallahi M, Sauer K, Lerner RA.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6158-65. doi: 10.1073/pnas.1519079112. Epub 2015 Oct 20.


An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages.

Han KH, Gonzalez-Quintial R, Peng Y, Baccala R, Theofilopoulos AN, Lerner RA.

FASEB J. 2016 Feb;30(2):738-47. doi: 10.1096/fj.15-281329. Epub 2015 Oct 19.


Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

Kang YJ, Bang BR, Han KH, Hong L, Shim EJ, Ma J, Lerner RA, Otsuka M.

Nat Commun. 2015 Sep 18;6:8371. doi: 10.1038/ncomms9371.


A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions.

Peng Y, Zeng W, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA.

Chem Biol. 2015 Aug 20;22(8):1134-43. doi: 10.1016/j.chembiol.2015.07.011. Epub 2015 Aug 13.


Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic.

Yea K, Xie J, Zhang H, Zhang W, Lerner RA.

Curr Opin Chem Biol. 2015 Jun;26:1-7. doi: 10.1016/j.cbpa.2015.01.002. Epub 2015 Jan 23. Review.


A proximity based general method for identification of ligand and receptor interactions in living cells.

Zhang H, Xie J, Lerner RA.

Biochem Biophys Res Commun. 2014 Nov 7;454(1):251-5. doi: 10.1016/j.bbrc.2014.10.085. Epub 2014 Oct 24.


Gerald Maurice Edelman.

Lerner RA.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):10900-1. doi: 10.1073/pnas.1410861111. Epub 2014 Jul 21. No abstract available.


A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.

Grover RK, Zhu X, Nieusma T, Jones T, Boreo I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA.

Science. 2014 Feb 7;343(6171):656-661. doi: 10.1126/science.1246135.


Prevention of cell death by antibodies selected from intracellular combinatorial libraries.

Xie J, Yea K, Zhang H, Moldt B, He L, Zhu J, Lerner RA.

Chem Biol. 2014 Feb 20;21(2):274-83. doi: 10.1016/j.chembiol.2013.12.006. Epub 2014 Jan 16.


Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.

Yea K, Zhang H, Xie J, Jones TM, Yang G, Song BD, Lerner RA.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14966-71. doi: 10.1073/pnas.1313671110. Epub 2013 Aug 26.


Selecting agonists from single cells infected with combinatorial antibody libraries.

Zhang H, Yea K, Xie J, Ruiz D, Wilson IA, Lerner RA.

Chem Biol. 2013 May 23;20(5):734-41. doi: 10.1016/j.chembiol.2013.04.012.


Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells.

Xie J, Zhang H, Yea K, Lerner RA.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8099-104. doi: 10.1073/pnas.1306263110. Epub 2013 Apr 23.


Engineering cell surfaces for orthogonal selectability.

Peng Y, Kim DH, Jones TM, Ruiz DI, Lerner RA.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):336-40. doi: 10.1002/anie.201201844. Epub 2012 Dec 12.


Synthesis and evaluation of the aldolase antibody-derived chemical-antibodies targeting α5β1 integrin.

Goswami RK, Liu Y, Liu C, Lerner RA, Sinha SC.

Mol Pharm. 2013 Feb 4;10(2):538-43. doi: 10.1021/mp3004463. Epub 2012 Nov 14.


Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries.

Zhang H, Wilson IA, Lerner RA.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15728-33. Epub 2012 Sep 10.


Cross-neutralization of influenza A viruses mediated by a single antibody loop.

Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA.

Nature. 2012 Sep 27;489(7417):526-32. doi: 10.1038/nature11414. Epub 2012 Sep 16.


Plasma membrane associated transcription of cytoplasmic DNA.

Cheng J, Torkamani A, Peng Y, Jones TM, Lerner RA.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10827-31. doi: 10.1073/pnas.1208716109. Epub 2012 Jun 18.


The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys.

Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6036-41. doi: 10.1073/pnas.1202214109. Epub 2012 Apr 6. Erratum in: Proc Natl Acad Sci U S A. 2016 Oct 17;:.


Phenotype-information-phenotype cycle for deconvolution of combinatorial antibody libraries selected against complex systems.

Zhang H, Torkamani A, Jones TM, Ruiz DI, Pons J, Lerner RA.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13456-61. doi: 10.1073/pnas.1111218108. Epub 2011 Aug 8.


Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro.

Goswami RK, Bajjuri KM, Forsyth JS, Das S, Hassenpflug W, Huang ZZ, Lerner RA, Felding-Habermann B, Sinha SC.

Bioconjug Chem. 2011 Aug 17;22(8):1535-44. doi: 10.1021/bc2000879. Epub 2011 Aug 1.


Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids.

Gauba V, Grünewald J, Gorney V, Deaton LM, Kang M, Bursulaya B, Ou W, Lerner RA, Schmedt C, Geierstanger BH, Schultz PG, Ramirez-Montagut T.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12821-6. doi: 10.1073/pnas.1110042108. Epub 2011 Jul 18.

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