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Physiology and Pathophysiology of Itch.

Cevikbas F, Lerner EA.

Physiol Rev. 2019 Dec 23. doi: 10.1152/physrev.00017.2019. [Epub ahead of print]


Why do we itch?

Lerner EA.

Exp Dermatol. 2019 Dec;28(12):1474-1475. doi: 10.1111/exd.14004. Epub 2019 Aug 28.


Targeting PAR2 with Pepducins.

Lee MS, Lerner EA.

J Invest Dermatol. 2019 Feb;139(2):282-284. doi: 10.1016/j.jid.2018.09.008. Epub 2018 Nov 22.


Is the Nervous System More Important Than the Immune System in Itch and Atopic Dermatitis?

Lerner EA.

J Investig Dermatol Symp Proc. 2018 Dec;19(2):S94. doi: 10.1016/j.jisp.2018.10.002.


Pathophysiology of Itch.

Lerner EA.

Dermatol Clin. 2018 Jul;36(3):175-177. doi: 10.1016/j.det.2018.02.001. Epub 2018 Mar 20. Review.


Role of mast cells and basophils in pruritus.

Steinhoff M, Buddenkotte J, Lerner EA.

Immunol Rev. 2018 Mar;282(1):248-264. doi: 10.1111/imr.12635. Review.


Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.

Reddy VB, Azimi E, Chu L, Lerner EA.

J Invest Dermatol. 2018 Feb;138(2):461-464. doi: 10.1016/j.jid.2017.05.042. Epub 2017 Oct 4. No abstract available.


FRT - FONDATION RENE TOURAINE: An International Foundation For Dermatology.

Carstens E, Schmelz M, Hunter HJA, Lerner EA, Misery L, Steinhoff M, Yosipovitch G, Ständer S.

Exp Dermatol. 2017 Oct;26(10):972-985. doi: 10.1111/exd.13406. No abstract available.


Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.

Reddy VB, Lerner EA.

J Biol Chem. 2017 Oct 20;292(42):17399-17406. doi: 10.1074/jbc.M117.787887. Epub 2017 Aug 2.


A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens.

Reddy VB, Graham TA, Azimi E, Lerner EA.

J Allergy Clin Immunol. 2017 Dec;140(6):1726-1728. doi: 10.1016/j.jaci.2017.05.046. Epub 2017 Jul 6. No abstract available.


Brief communication: MRGPRX2, atopic dermatitis and red man syndrome.

Azimi E, Reddy VB, Lerner EA.

Itch (Phila). 2017 Mar;2(1). pii: e5. doi: 10.1097/itx.0000000000000005.


Gate Control Theory Springs a Leak.

Pereira PJS, Lerner EA.

Neuron. 2017 Feb 22;93(4):723-724. doi: 10.1016/j.neuron.2017.02.016. Review.


Substance P activates Mas-related G protein-coupled receptors to induce itch.

Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA.

J Allergy Clin Immunol. 2017 Aug;140(2):447-453.e3. doi: 10.1016/j.jaci.2016.12.980. Epub 2017 Feb 20.


Maxadilan-simile expression in Nyssomyia neivai, a sandfly vector in an endemic region of Brazil, and its immunogenicity in patients with American tegumentary leishmaniasis.

Aires J, Casanova C, Vernal S, Nascimento M, Rodrigues S, Lerner EA, Roselino AM.

Mem Inst Oswaldo Cruz. 2017 Feb;112(2):116-122. doi: 10.1590/0074-02760160351.


Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.

Haddadi NS, Foroutan A, Ostadhadi S, Azimi E, Rahimi N, Nateghpour M, Lerner EA, Dehpour AR.

Acta Derm Venereol. 2017 May 8;97(5):571-577. doi: 10.2340/00015555-2617.


Implications of MRGPRX2 in human and experimental cardiometabolic diseases.

Azimi E, Lerner EA.

Nat Rev Cardiol. 2017 Feb;14(2):124. doi: 10.1038/nrcardio.2016.212. Epub 2017 Jan 5. No abstract available.


Dual action of neurokinin-1 antagonists on Mas-related GPCRs.

Azimi E, Reddy VB, Shade KC, Anthony RM, Talbot S, Pereira PJS, Lerner EA.

JCI Insight. 2016 Oct 6;1(16):e89362. doi: 10.1172/jci.insight.89362.


Peripheral Mechanisms of Itch.

Azimi E, Xia J, Lerner EA.

Curr Probl Dermatol. 2016;50:18-23. doi: 10.1159/000446012. Epub 2016 Aug 23. Review.


Are itch and scratching the nausea and vomiting of skin?

Ostadhadi S, Azimi E, Lerner EA, Dehpour AR.

Exp Dermatol. 2016 May;25(5):340-3. doi: 10.1111/exd.12935. Epub 2016 Feb 26.


GRPR/PI3Kγ: Partners in Central Transmission of Itch.

Pereira PJ, Machado GD, Danesi GM, Canevese FF, Reddy VB, Pereira TC, Bogo MR, Cheng YC, Laedermann C, Talbot S, Lerner EA, Campos MM.

J Neurosci. 2015 Dec 9;35(49):16272-81. doi: 10.1523/JNEUROSCI.2310-15.2015.


The imagined itch: brain circuitry supporting nocebo-induced itch in atopic dermatitis patients.

Napadow V, Li A, Loggia ML, Kim J, Mawla I, Desbordes G, Schalock PC, Lerner EA, Tran TN, Ring J, Rosen BR, Kaptchuk TJ, Pfab F.

Allergy. 2015 Nov;70(11):1485-92. doi: 10.1111/all.12727. Epub 2015 Sep 10.


Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.

Reddy VB, Sun S, Azimi E, Elmariah SB, Dong X, Lerner EA.

Nat Commun. 2015 Jul 28;6:7864. doi: 10.1038/ncomms8864.


Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis.

Garibyan L, Cornelissen L, Sipprell W, Pruessner J, Elmariah S, Luo T, Lerner EA, Jung Y, Evans C, Zurakowski D, Berde CB, Rox Anderson R.

J Invest Dermatol. 2015 Nov;135(11):2623-2631. doi: 10.1038/jid.2015.233. Epub 2015 Jun 22.


Protease-activated receptors and itch.

Akiyama T, Lerner EA, Carstens E.

Handb Exp Pharmacol. 2015;226:219-35. doi: 10.1007/978-3-662-44605-8_13. Review.


Altered manifestations of skin disease at sites affected by neurological deficit.

Azimi E, Lerner EA, Elmariah SB.

Br J Dermatol. 2015 Apr;172(4):988-93. doi: 10.1111/bjd.13352. Epub 2015 Feb 25. Review.


Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist.

Elmariah SB, Reddy VB, Lerner EA.

PLoS One. 2014 Jun 25;9(6):e99702. doi: 10.1371/journal.pone.0099702. eCollection 2014.


The 7th World Congress on Itch.

Azimi E, Lerner EA.

J Invest Dermatol. 2014 Jul;134(7):1786-1788. doi: 10.1038/jid.2014.91.


Interneurons scratch an itch.

Pereira PJ, Lerner EA.

Neuron. 2014 May 7;82(3):503-5. doi: 10.1016/j.neuron.2014.04.026.


The missing link between itch and inflammation in atopic dermatitis.

Elmariah SB, Lerner EA.

Cell. 2013 Oct 10;155(2):267-9. doi: 10.1016/j.cell.2013.09.038.


Cowhage can induce itch in the atopic dog.

Olivry T, Bizikova P, Paps JS, Dunston S, Lerner EA, Yosipovitch G.

Exp Dermatol. 2013 Jun;22(6):435-7. doi: 10.1111/exd.12158.


Understanding the pathophysiology of itch.

Garibyan L, Rheingold CG, Lerner EA.

Dermatol Ther. 2013 Mar-Apr;26(2):84-91. doi: 10.1111/dth.12025. Review.


Activation of PAC(1) and VPAC receptor subtypes elicits differential physiological responses from sympathetic preganglionic neurons in the anaesthetized rat.

Inglott MA, Lerner EA, Pilowsky PM, Farnham MM.

Br J Pharmacol. 2012 Nov;167(5):1089-98. doi: 10.1111/j.1476-5381.2012.02045.x.


Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway.

Svensjö E, Saraiva EM, Amendola RS, Barja-Fidalgo C, Bozza MT, Lerner EA, Teixeira MM, Scharfstein J.

Microvasc Res. 2012 Mar;83(2):185-93. doi: 10.1016/j.mvr.2011.10.003. Epub 2011 Oct 19.


Topical therapies for pruritus.

Elmariah SB, Lerner EA.

Semin Cutan Med Surg. 2011 Jun;30(2):118-26. doi: 10.1016/j.sder.2011.04.008. Review.


Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice.

Lauenstein HD, Quarcoo D, Plappert L, Schleh C, Nassimi M, Pilzner C, Rochlitzer S, Brabet P, Welte T, Hoymann HG, Krug N, Müller M, Lerner EA, Braun A, Groneberg DA.

Clin Exp Allergy. 2011 Apr;41(4):592-601. doi: 10.1111/j.1365-2222.2010.03636.x. Epub 2010 Nov 9.


A tribute to Walter Shelley, a pioneer itch researcher (1917-2009).

Lerner EA, Yosipovitch G.

Arch Dermatol. 2010 Jul;146(7):788. doi: 10.1001/archdermatol.2010.97. No abstract available.


Plant cysteine proteases that evoke itch activate protease-activated receptors.

Reddy VB, Lerner EA.

Br J Dermatol. 2010 Sep;163(3):532-5. doi: 10.1111/j.1365-2133.2010.09862.x. Epub 2010 Aug 12.


Cathepsin S elicits itch and signals via protease-activated receptors.

Reddy VB, Shimada SG, Sikand P, Lamotte RH, Lerner EA.

J Invest Dermatol. 2010 May;130(5):1468-70. doi: 10.1038/jid.2009.430. Epub 2010 Jan 14. No abstract available.


Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.

Svensjö E, Saraiva EM, Bozza MT, Oliveira SM, Lerner EA, Scharfstein J.

J Vasc Res. 2009;46(5):435-46. doi: 10.1159/000197866. Epub 2009 Jan 29.


Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission.

Yang K, Trepanier CH, Li H, Beazely MA, Lerner EA, Jackson MF, MacDonald JF.

Hippocampus. 2009 Sep;19(9):779-89. doi: 10.1002/hipo.20559.


Grass carp somatolactin: I. Evidence for PACAP induction of somatolactin-alpha and -beta gene expression via activation of pituitary PAC-I receptors.

Jiang Q, Ko WK, Lerner EA, Chan KM, Wong AO.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E463-76. doi: 10.1152/ajpendo.90385.2008. Epub 2008 Jun 3.


Maxadilan, the PAC1 receptor, and leishmaniasis.

Reddy VB, Li Y, Lerner EA.

J Mol Neurosci. 2008 Nov;36(1-3):241-4. doi: 10.1007/s12031-008-9079-1. Epub 2008 May 29. Review.


Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors.

Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA.

J Neurosci. 2008 Apr 23;28(17):4331-5. doi: 10.1523/JNEUROSCI.0716-08.2008.


In vivo assessment of pigmentary and vascular compartments changes in UVA exposed skin by reflectance-mode confocal microscopy.

Yamashita T, Akita H, Astner S, Miyakawa M, Lerner EA, González S.

Exp Dermatol. 2007 Nov;16(11):905-11.


Maxadilan, a PAC1 receptor agonist from sand flies.

Lerner EA, Iuga AO, Reddy VB.

Peptides. 2007 Sep;28(9):1651-4. Epub 2007 Jun 28. Review.


TRP-ing up melanophores: TRPM7, melanin synthesis, and pigment cell survival.

Iuga AO, Lerner EA.

J Invest Dermatol. 2007 Aug;127(8):1855-6.


Functional analysis of recombinant mutants of maxadilan with a PAC1 receptor-expressing melanophore cell line.

Reddy VB, Iuga AO, Kounga K, Lerner EA.

J Biol Chem. 2006 Jun 16;281(24):16197-201. Epub 2006 Mar 28.


Identification of novel hexapeptide agonists at the Xenopus laevis melanophore melanocortin receptor.

Iuga AO, Reddy VB, Lerner EA.

Peptides. 2005 Nov;26(11):2124-8. Epub 2005 Apr 20.


Nitric oxide is toxic to melanocytes in vitro.

Iuga AO, Qureshi AA, Lerner EA.

Pigment Cell Res. 2004 Jun;17(3):302-6.


Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum.

Gower WR Jr, Dietz JR, McCuen RW, Fabri PJ, Lerner EA, Schubert ML.

Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G68-74.

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