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Author Correction: Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids.

Dubois P, Correia I, Le Chevalier F, Dubois S, Jacques I, Canu N, Moutiez M, Thai R, Gondry M, Lequin O, Belin P.

Sci Rep. 2019 Oct 15;9(1):15009. doi: 10.1038/s41598-019-51404-5.


Novel Matrix Metalloproteinase 12 selective radiotracers for vascular molecular imaging.

Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Yunpeng Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L.

J Med Chem. 2019 Oct 11. doi: 10.1021/acs.jmedchem.9b01186. [Epub ahead of print]


Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells.

Denèfle T, Pramil E, Gómez-Morales L, Levasseur MD, Lardé E, Newton C, Herry K, Herbi L, Lamotte Y, Odile E, Ancellin N, Grondin P, Martinez-Torres AC, Viviani F, Merle-Beral H, Lequin O, Susin SA, Karoyan P.

J Med Chem. 2019 Sep 12;62(17):7656-7668. doi: 10.1021/acs.jmedchem.9b00024. Epub 2019 Aug 26.


Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids.

Dubois P, Correia I, Le Chevalier F, Dubois S, Jacques I, Canu N, Moutiez M, Thai R, Gondry M, Lequin O, Belin P.

Sci Rep. 2019 Jun 25;9(1):9208. doi: 10.1038/s41598-019-45519-y. Erratum in: Sci Rep. 2019 Oct 15;9(1):15009.


A Photochromic Azobenzene Peptidomimetic of a β-Turn Model Peptide Structure as a Conformational Switch.

Nuti F, Gellini C, Larregola M, Squillantini L, Chelli R, Salvi PR, Lequin O, Pietraperzia G, Papini AM.

Front Chem. 2019 Mar 29;7:180. doi: 10.3389/fchem.2019.00180. eCollection 2019.


Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO.

Iatmanen-Harbi S, Senicourt L, Papadopoulos V, Lequin O, Lacapere JJ.

Int J Mol Sci. 2019 Mar 21;20(6). pii: E1444. doi: 10.3390/ijms20061444.


Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins.

Hostachy S, Masuda M, Miki T, Hamachi I, Sagan S, Lequin O, Medjoubi K, Somogyi A, Delsuc N, Policar C.

Chem Sci. 2018 Apr 13;9(19):4483-4487. doi: 10.1039/c8sc00886h. eCollection 2018 May 21.


Time dependence of NMR observables reveals salient differences in the accumulation of early aggregated species between human islet amyloid polypeptide and amyloid-β.

Hoffmann ARF, Caillon L, Salazar Vazquez LS, Spath PA, Carlier L, Khemtémourian L, Lequin O.

Phys Chem Chem Phys. 2018 Apr 4;20(14):9561-9573. doi: 10.1039/c7cp07516b.


The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands.

Xu Y, Correia I, Ha-Duong T, Kihal N, Soulier JL, Kaffy J, Crousse B, Lequin O, Ongeri S.

Beilstein J Org Chem. 2017 Dec 21;13:2842-2853. doi: 10.3762/bjoc.13.276. eCollection 2017.


A single mutation on the human amyloid polypeptide modulates fibril growth and affects the mechanism of amyloid-induced membrane damage.

Hoffmann ARF, Saravanan MS, Lequin O, Killian JA, Khemtemourian L.

Biochim Biophys Acta Biomembr. 2018 Feb 27. pii: S0005-2736(18)30059-2. doi: 10.1016/j.bbamem.2018.02.018. [Epub ahead of print]


Incorporation of Non-canonical Amino Acids into 2,5-Diketopiperazines by Cyclodipeptide Synthases.

Canu N, Belin P, Thai R, Correia I, Lequin O, Seguin J, Moutiez M, Gondry M.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3118-3122. doi: 10.1002/anie.201712536. Epub 2018 Feb 21.


Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent.

Raja Z, André S, Abbassi F, Humblot V, Lequin O, Bouceba T, Correia I, Casale S, Foulon T, Sereno D, Oury B, Ladram A.

PLoS One. 2017 Mar 20;12(3):e0174024. doi: 10.1371/journal.pone.0174024. eCollection 2017.


Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

Denèfle T, Boullet H, Herbi L, Newton C, Martinez-Torres AC, Guez A, Pramil E, Quiney C, Pourcelot M, Levasseur MD, Lardé E, Moumné R, Ogi FX, Grondin P, Merle-Beral H, Lequin O, Susin SA, Karoyan P.

J Med Chem. 2016 Sep 22;59(18):8412-21. doi: 10.1021/acs.jmedchem.6b00781. Epub 2016 Sep 2.


Designed Glycopeptidomimetics Disrupt Protein-Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability.

Kaffy J, Brinet D, Soulier JL, Correia I, Tonali N, Fera KF, Iacone Y, Hoffmann AR, Khemtémourian L, Crousse B, Taylor M, Allsop D, Taverna M, Lequin O, Ongeri S.

J Med Chem. 2016 Mar 10;59(5):2025-40. doi: 10.1021/acs.jmedchem.5b01629. Epub 2016 Feb 4.


Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation.

Khan SN, Charlier C, Augustyniak R, Salvi N, Déjean V, Bodenhausen G, Lequin O, Pelupessy P, Ferrage F.

Biophys J. 2015 Sep 1;109(5):988-99. doi: 10.1016/j.bpj.2015.06.069.


Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

Quévrain E, Maubert MA, Michon C, Chain F, Marquant R, Tailhades J, Miquel S, Carlier L, Bermúdez-Humarán LG, Pigneur B, Lequin O, Kharrat P, Thomas G, Rainteau D, Aubry C, Breyner N, Afonso C, Lavielle S, Grill JP, Chassaing G, Chatel JM, Trugnan G, Xavier R, Langella P, Sokol H, Seksik P.

Gut. 2016 Mar;65(3):415-425. doi: 10.1136/gutjnl-2014-307649. Epub 2015 Jun 4.


Antibody recognition in multiple sclerosis and Rett syndrome using a collection of linear and cyclic N-glucosylated antigenic probes.

Real Fernández F, Di Pisa M, Rossi G, Auberger N, Lequin O, Larregola M, Benchohra A, Mansuy C, Chassaing G, Lolli F, Hayek J, Lavielle S, Rovero P, Mallet JM, Papini AM.

Biopolymers. 2015 Sep;104(5):560-76. doi: 10.1002/bip.22677.


(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation.

Botz A, Gasparik V, Devillers E, Hoffmann AR, Caillon L, Chelain E, Lequin O, Brigaud T, Khemtemourian L.

Biopolymers. 2015 Sep;104(5):601-10. doi: 10.1002/bip.22670.


Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes.

Caillon L, Duma L, Lequin O, Khemtemourian L.

Mol Membr Biol. 2014 Nov-Dec;31(7-8):239-49. doi: 10.3109/09687688.2014.987182. Epub 2014 Dec 15.


Glaser oxidative coupling on peptides: stabilization of β-turn structure via a 1,3-butadiyne constraint.

Auberger N, Di Pisa M, Larregola M, Chassaing G, Peroni E, Lavielle S, Papini AM, Lequin O, Mallet JM.

Bioorg Med Chem. 2014 Dec 15;22(24):6924-32. doi: 10.1016/j.bmc.2014.10.026. Epub 2014 Oct 22.


Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides.

Carlier L, Joanne P, Khemtémourian L, Lacombe C, Nicolas P, El Amri C, Lequin O.

Biophys Chem. 2015 Jan;196:40-52. doi: 10.1016/j.bpc.2014.09.004. Epub 2014 Sep 28.


Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization.

Kaffy J, Brinet D, Soulier JL, Khemtémourian L, Lequin O, Taverna M, Crousse B, Ongeri S.

Eur J Med Chem. 2014 Oct 30;86:752-8. doi: 10.1016/j.ejmech.2014.09.031. Epub 2014 Sep 10.


Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

Asgatay S, Champion C, Marloie G, Drujon T, Senamaud-Beaufort C, Ceccaldi A, Erdmann A, Rajavelu A, Schambel P, Jeltsch A, Lequin O, Karoyan P, Arimondo PB, Guianvarc'h D.

J Med Chem. 2014 Jan 23;57(2):421-34. doi: 10.1021/jm401419p. Epub 2014 Jan 9.


Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9.

Caillon L, Killian JA, Lequin O, Khemtémourian L.

PLoS One. 2013 Oct 11;8(10):e75528. doi: 10.1371/journal.pone.0075528. eCollection 2013.


Investigation of homeodomain membrane translocation properties: insights from the structure determination of engrailed-2 homeodomain in aqueous and membrane-mimetic environments.

Carlier L, Balayssac S, Cantrelle FX, Khemtémourian L, Chassaing G, Joliot A, Lequin O.

Biophys J. 2013 Aug 6;105(3):667-78. doi: 10.1016/j.bpj.2013.06.024.


Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation.

Caillon L, Lequin O, Khemtémourian L.

Biochim Biophys Acta. 2013 Sep;1828(9):2091-8. doi: 10.1016/j.bbamem.2013.05.014. Epub 2013 May 23.


Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: insights from biochemical studies and crystal structures.

Fonvielle M, Le Du MH, Lequin O, Lecoq A, Jacquet M, Thai R, Dubois S, Grach G, Gondry M, Belin P.

J Biol Chem. 2013 Jun 14;288(24):17347-59. doi: 10.1074/jbc.M112.443853. Epub 2013 Apr 25.


3-Substituted prolines: from synthesis to structural applications, from peptides to foldamers.

Mothes C, Caumes C, Guez A, Boullet H, Gendrineau T, Darses S, Delsuc N, Moumné R, Oswald B, Lequin O, Karoyan P.

Molecules. 2013 Feb 19;18(2):2307-27. doi: 10.3390/molecules18022307. Review.


Tryptophan within basic peptide sequences triggers glycosaminoglycan-dependent endocytosis.

Bechara C, Pallerla M, Zaltsman Y, Burlina F, Alves ID, Lequin O, Sagan S.

FASEB J. 2013 Feb;27(2):738-49. doi: 10.1096/fj.12-216176. Epub 2012 Oct 15.


A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

Mann S, Eveleigh L, Lequin O, Ploux O.

Anal Biochem. 2013 Jan 15;432(2):90-6. doi: 10.1016/j.ab.2012.09.038. Epub 2012 Oct 12.


The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif.

Carlier L, Haase AS, Burgos Zepeda MY, Dassa E, Lequin O.

J Struct Biol. 2012 Dec;180(3):577-84. doi: 10.1016/j.jsb.2012.09.005. Epub 2012 Sep 17.


Membrane interactions of two arginine-rich peptides with different cell internalization capacities.

Walrant A, Vogel A, Correia I, Lequin O, Olausson BE, Desbat B, Sagan S, Alves ID.

Biochim Biophys Acta. 2012 Jul;1818(7):1755-63.


Biophysical studies of the interaction between calmodulin and the R²⁸⁷-T³¹¹ region of human estrogen receptor α reveals an atypical binding process.

Carlier L, Byrne C, Miclet E, Bourgoin-Voillard S, Nicaise M, Tabet JC, Desmadril M, Leclercq G, Lequin O, Jacquot Y.

Biochem Biophys Res Commun. 2012 Mar 9;419(2):356-61. doi: 10.1016/j.bbrc.2012.02.028. Epub 2012 Feb 10.


Secondary structure and NMR resonance assignments of the C-terminal DNA-binding domain of Uup protein.

Carlier L, Haase AS, Burgos Zepeda MY, Dassa E, Lequin O.

Biomol NMR Assign. 2012 Oct;6(2):197-200.


Rapid synthesis of new DNMT inhibitors derivatives of procainamide.

Halby L, Champion C, Sénamaud-Beaufort C, Ajjan S, Drujon T, Rajavelu A, Ceccaldi A, Jurkowska R, Lequin O, Nelson WG, Guy A, Jeltsch A, Guianvarc'h D, Ferroud C, Arimondo PB.

Chembiochem. 2012 Jan 2;13(1):157-65. doi: 10.1002/cbic.201100522. Epub 2011 Dec 14.


Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation.

Dorgeret B, Khemtémourian L, Correia I, Soulier JL, Lequin O, Ongeri S.

Eur J Med Chem. 2011 Dec;46(12):5959-69. doi: 10.1016/j.ejmech.2011.10.008. Epub 2011 Oct 12.


β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides.

Larregola M, Lequin O, Karoyan P, Guianvarc'h D, Lavielle S.

J Pept Sci. 2011 Sep;17(9):632-43. doi: 10.1002/psc.1382. Epub 2011 Jun 6.


Methods to determine slow diffusion coefficients of biomolecules: applications to Engrailed 2, a partially disordered protein.

Augustyniak R, Ferrage F, Paquin R, Lequin O, Bodenhausen G.

J Biomol NMR. 2011 Jul;50(3):209-18. doi: 10.1007/s10858-011-9510-8. Epub 2011 May 21.


1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein.

Augustyniak R, Balayssac S, Ferrage F, Bodenhausen G, Lequin O.

Biomol NMR Assign. 2011 Oct;5(2):229-31. doi: 10.1007/s12104-011-9306-5. Epub 2011 Apr 23.


The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water.

Guitot K, Larregola M, Pradhan TK, Vasse JL, Lavielle S, Bertus P, Szymoniak J, Lequin O, Karoyan P.

Chembiochem. 2011 May 2;12(7):1039-42. doi: 10.1002/cbic.201000707. Epub 2011 Mar 29. No abstract available.


Sequence-dependent enrichment of a model phosphopeptide: a combined MALDI-TOF and NMR study.

Matheron L, Sachon E, Burlina F, Sagan S, Lequin O, Bolbach G.

Anal Chem. 2011 Apr 15;83(8):3003-10. doi: 10.1021/ac103134e. Epub 2011 Mar 23. Erratum in: Anal Chem. 2011 Jun 15;83(12):5026. Lucréce, Matheron [corrected to Matheron, Lucréce]; Emmanuelle, Schon [corrected to Sachon, Emmanuelle]; Fabienne, Burlina [corrected to Burlina, Fabienne]; Sandrine, Sagan [corrected to Sagan, Sandrine]; Olivier, Lequin [corrected to Lequin, Olivier]; G.


Different membrane behaviour and cellular uptake of three basic arginine-rich peptides.

Walrant A, Correia I, Jiao CY, Lequin O, Bent EH, Goasdoué N, Lacombe C, Chassaing G, Sagan S, Alves ID.

Biochim Biophys Acta. 2011 Jan;1808(1):382-93. doi: 10.1016/j.bbamem.2010.09.009. Epub 2010 Oct 13.


Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide.

Abbassi F, Lequin O, Piesse C, Goasdoué N, Foulon T, Nicolas P, Ladram A.

J Biol Chem. 2010 May 28;285(22):16880-92. doi: 10.1074/jbc.M109.097204. Epub 2010 Mar 22.


Prolinoamino acids as tools to build bifunctionalized, stable beta-turns in water.

Mothes C, Larregola M, Quancard J, Goasdoué N, Lavielle S, Chassaing G, Lequin O, Karoyan P.

Chembiochem. 2010 Jan 4;11(1):55-8. doi: 10.1002/cbic.200900572. No abstract available.


Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

Méjean A, Mann S, Maldiney T, Vassiliadis G, Lequin O, Ploux O.

J Am Chem Soc. 2009 Jun 10;131(22):7512-3. doi: 10.1021/ja9024353.


Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.

Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courçon M, Masson C, Dugave C, Genet R, Pernodet JL, Gondry M.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7426-31. doi: 10.1073/pnas.0812191106. Epub 2009 Apr 22.


Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain.

Galanth C, Abbassi F, Lequin O, Ayala-Sanmartin J, Ladram A, Nicolas P, Amiche M.

Biochemistry. 2009 Jan 20;48(2):313-27. doi: 10.1021/bi802025a.


Solution structure and model membrane interactions of temporins-SH, antimicrobial peptides from amphibian skin. A NMR spectroscopy and differential scanning calorimetry study.

Abbassi F, Galanth C, Amiche M, Saito K, Piesse C, Zargarian L, Hani K, Nicolas P, Lequin O, Ladram A.

Biochemistry. 2008 Oct 7;47(40):10513-25. doi: 10.1021/bi8006884. Epub 2008 Sep 17.


High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide.

Jacquot Y, Broutin I, Miclet E, Nicaise M, Lequin O, Goasdoué N, Joss C, Karoyan P, Desmadril M, Ducruix A, Lavielle S.

Bioorg Med Chem. 2007 Feb 1;15(3):1439-47. Epub 2006 Nov 6.


Comparison of penetratin and other homeodomain-derived cell-penetrating peptides: interaction in a membrane-mimicking environment and cellular uptake efficiency.

Balayssac S, Burlina F, Convert O, Bolbach G, Chassaing G, Lequin O.

Biochemistry. 2006 Feb 7;45(5):1408-20.


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