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Items: 41


Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania.

Bhattacharya A, Leprohon P, Bigot S, Padmanabhan PK, Mukherjee A, Roy G, Gingras H, Mestdagh A, Papadopoulou B, Ouellette M.

Nat Commun. 2019 Dec 9;10(1):5627. doi: 10.1038/s41467-019-13344-6.


Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

El Khoury JY, Maure A, Gingras H, Leprohon P, Ouellette M.

mSystems. 2019 Nov 19;4(6). pii: e00465-19. doi: 10.1128/mSystems.00465-19.


Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum.

Bhattacharya A, Sharma M, Pakkinathan C, Rosen BP, Leprohon P, Ouellette M.

mSystems. 2019 Oct 15;4(5). pii: e00416-19. doi: 10.1128/mSystems.00416-19.


Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania.

Potvin JE, Leprohon P, Gazanion E, Sharma M, Fernandez-Prada C, Ouellette M.

Methods Mol Biol. 2019;1971:141-167. doi: 10.1007/978-1-4939-9210-2_7.


Gain- and Loss-of-Function Screens Coupled to Next-Generation Sequencing for Antibiotic Mode of Action and Resistance Studies in Streptococcus pneumoniae.

Gingras H, Patron K, Bhattacharya A, Leprohon P, Ouellette M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02381-18. doi: 10.1128/AAC.02381-18. Print 2019 May.


High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.

Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M.

Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):165-173. doi: 10.1016/j.ijpddr.2018.03.004. Epub 2018 Mar 16.


Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli.

Gingras H, Dridi B, Leprohon P, Ouellette M.

Microb Genom. 2018 Feb;4(2). doi: 10.1099/mgen.0.000148. Epub 2018 Jan 10.


Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae.

El Khoury JY, Boucher N, Bergeron MG, Leprohon P, Ouellette M.

Sci Rep. 2017 Nov 6;7(1):14587. doi: 10.1038/s41598-017-15035-y.


Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

Fernandez-Prada C, Vincent IM, Brotherton MC, Roberts M, Roy G, Rivas L, Leprohon P, Smith TK, Ouellette M.

PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005171. doi: 10.1371/journal.pntd.0005171. eCollection 2016 Dec.


Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance.

Laffitte MN, Leprohon P, Papadopoulou B, Ouellette M.

F1000Res. 2016 Sep 20;5:2350. doi: 10.12688/f1000research.9218.1. eCollection 2016. Review.


Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance.

Laffitte MC, Leprohon P, Légaré D, Ouellette M.

Parasitol Res. 2016 Oct;115(10):3699-703. doi: 10.1007/s00436-016-5195-y. Epub 2016 Jul 26.


Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism.

Laffitte MC, Leprohon P, Hainse M, Légaré D, Masson JY, Ouellette M.

PLoS Genet. 2016 Jun 17;12(6):e1006117. doi: 10.1371/journal.pgen.1006117. eCollection 2016 Jun.


Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.

Gazanion É, Fernández-Prada C, Papadopoulou B, Leprohon P, Ouellette M.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3012-21. doi: 10.1073/pnas.1520693113. Epub 2016 May 9.


A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages.

Leprohon P, Gingras H, Ouennane S, Moineau S, Ouellette M.

BMC Genomics. 2015 Nov 18;16:972. doi: 10.1186/s12864-015-2134-8.


The initial state of the human gut microbiome determines its reshaping by antibiotics.

Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B, Leprohon P, Plante PL, Giroux R, Bérubé È, Frenette J, Boudreau DK, Simard JL, Chabot I, Domingo MC, Trottier S, Boissinot M, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J.

ISME J. 2016 Mar;10(3):707-20. doi: 10.1038/ismej.2015.148. Epub 2015 Sep 11.


Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA.

Lupien A, Gingras H, Leprohon P, Ouellette M.

J Antimicrob Chemother. 2015 Nov;70(11):2973-80. doi: 10.1093/jac/dkv211. Epub 2015 Jul 16.


Differences in antibiotic-induced oxidative stress responses between laboratory and clinical isolates of Streptococcus pneumoniae.

Dridi B, Lupien A, Bergeron MG, Leprohon P, Ouellette M.

Antimicrob Agents Chemother. 2015 Sep;59(9):5420-6. doi: 10.1128/AAC.00316-15. Epub 2015 Jun 22.


Drug resistance analysis by next generation sequencing in Leishmania.

Leprohon P, Fernandez-Prada C, Gazanion É, Monte-Neto R, Ouellette M.

Int J Parasitol Drugs Drug Resist. 2014 Sep 22;5(1):26-35. doi: 10.1016/j.ijpddr.2014.09.005. eCollection 2015 Apr. Review.


Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing.

Lupien A, Gingras H, Bergeron MG, Leprohon P, Ouellette M.

J Antimicrob Chemother. 2015 Jul;70(7):1946-59. doi: 10.1093/jac/dkv060. Epub 2015 Apr 9.


Diverse virulent pneumophages infect Streptococcus mitis.

Ouennane S, Leprohon P, Moineau S.

PLoS One. 2015 Feb 18;10(2):e0118807. doi: 10.1371/journal.pone.0118807. eCollection 2015.


Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis.

Monte-Neto R, Laffitte MC, Leprohon P, Reis P, Frézard F, Ouellette M.

PLoS Negl Trop Dis. 2015 Feb 13;9(2):e0003476. doi: 10.1371/journal.pntd.0003476. eCollection 2015 Feb.


Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania.

Ubeda JM, Raymond F, Mukherjee A, Plourde M, Gingras H, Roy G, Lapointe A, Leprohon P, Papadopoulou B, Corbeil J, Ouellette M.

PLoS Biol. 2014 May 20;12(5):e1001868. doi: 10.1371/journal.pbio.1001868. eCollection 2014 May.


Genomic analyses of DNA transformation and penicillin resistance in Streptococcus pneumoniae clinical isolates.

Fani F, Leprohon P, Zhanel GG, Bergeron MG, Ouellette M.

Antimicrob Agents Chemother. 2014;58(3):1397-403. doi: 10.1128/AAC.01311-13. Epub 2013 Dec 16.


Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant.

Brotherton MC, Bourassa S, Leprohon P, Légaré D, Poirier GG, Droit A, Ouellette M.

PLoS One. 2013 Nov 27;8(11):e81899. doi: 10.1371/journal.pone.0081899. eCollection 2013.


Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.

Ritt JF, Raymond F, Leprohon P, Légaré D, Corbeil J, Ouellette M.

PLoS Negl Trop Dis. 2013 Nov 21;7(11):e2564. doi: 10.1371/journal.pntd.0002564. eCollection 2013 Nov.


Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae.

Lupien A, Billal DS, Fani F, Soualhine H, Zhanel GG, Leprohon P, Ouellette M.

Antimicrob Agents Chemother. 2013 Oct;57(10):4911-9. doi: 10.1128/AAC.00418-13. Epub 2013 Jul 22.


Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae.

Fani F, Brotherton MC, Leprohon P, Ouellette M.

J Antimicrob Chemother. 2013 Aug;68(8):1718-27. doi: 10.1093/jac/dkt113. Epub 2013 Apr 21.


Generation of Leishmania hybrids by whole genomic DNA transformation.

Coelho AC, Leprohon P, Ouellette M.

PLoS Negl Trop Dis. 2012;6(9):e1817. doi: 10.1371/journal.pntd.0001817. Epub 2012 Sep 20.


Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes.

Brotherton MC, Racine G, Ouameur AA, Leprohon P, Papadopoulou B, Ouellette M.

J Proteome Res. 2012 Aug 3;11(8):3974-85. doi: 10.1021/pr201248h. Epub 2012 Jul 10.


Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing.

Coelho AC, Boisvert S, Mukherjee A, Leprohon P, Corbeil J, Ouellette M.

PLoS Negl Trop Dis. 2012;6(2):e1512. doi: 10.1371/journal.pntd.0001512. Epub 2012 Feb 14.


Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease.

Fani F, Leprohon P, Légaré D, Ouellette M.

Genome Biol. 2011 Nov 22;12(11):R115. doi: 10.1186/gb-2011-12-11-r115. No abstract available.


Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.

Billal DS, Feng J, Leprohon P, Légaré D, Ouellette M.

BMC Genomics. 2011 Oct 17;12:512. doi: 10.1186/1471-2164-12-512.


ABC transporters involved in drug resistance in human parasites.

Leprohon P, Légaré D, Ouellette M.

Essays Biochem. 2011 Sep 7;50(1):121-44. doi: 10.1042/bse0500121. Review.


Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania.

Moreira W, Leprohon P, Ouellette M.

Cell Death Dis. 2011 Sep 1;2:e201. doi: 10.1038/cddis.2011.83.


Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae.

Feng J, Billal DS, Lupien A, Racine G, Winstall E, Légaré D, Leprohon P, Ouellette M.

J Proteome Res. 2011 Oct 7;10(10):4439-52. doi: 10.1021/pr200221s. Epub 2011 Sep 13.


Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials.

Leprohon P, Légaré D, Ouellette M.

Antimicrob Agents Chemother. 2009 Jun;53(6):2646-9. doi: 10.1128/AAC.01474-08. Epub 2009 Mar 23.


Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.

Leprohon P, Légaré D, Raymond F, Madore E, Hardiman G, Corbeil J, Ouellette M.

Nucleic Acids Res. 2009 Apr;37(5):1387-99. doi: 10.1093/nar/gkn1069. Epub 2009 Jan 7.


Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum.

Lachaud L, Bourgeois N, Plourde M, Leprohon P, Bastien P, Ouellette M.

Clin Infect Dis. 2009 Jan 15;48(2):e16-22. doi: 10.1086/595710.


Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites.

Leprohon P, Légaré D, Girard I, Papadopoulou B, Ouellette M.

Eukaryot Cell. 2006 Oct;5(10):1713-25.


Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.

El Fadili K, Messier N, Leprohon P, Roy G, Guimond C, Trudel N, Saravia NG, Papadopoulou B, Légaré D, Ouellette M.

Antimicrob Agents Chemother. 2005 May;49(5):1988-93.


Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance.

Richard D, Leprohon P, Drummelsmith J, Ouellette M.

J Biol Chem. 2004 Dec 24;279(52):54494-501. Epub 2004 Oct 4.

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