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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D.

Molecules. 2019 Dec 28;25(1). pii: E119. doi: 10.3390/molecules25010119.


Gonadotropin-inhibitory hormone in teleosts: New insights from a basal representative, the eel.

Maugars G, Pasquier J, Atkinson C, Lafont AG, Campo A, Kamech N, Lefranc B, Leprince J, Dufour S, Rousseau K.

Gen Comp Endocrinol. 2020 Feb 1;287:113350. doi: 10.1016/j.ygcen.2019.113350. Epub 2019 Nov 30.


Peptidomic analysis in the discovery of therapeutically valuable peptides in amphibian skin secretions.

Conlon JM, Mechkarska M, Leprince J.

Expert Rev Proteomics. 2019 Nov - Dec;16(11-12):897-908. doi: 10.1080/14789450.2019.1693894. Epub 2019 Nov 21.


Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles.

Namsi A, Nury T, Khan AS, Leprince J, Vaudry D, Caccia C, Leoni V, Atanasov AG, Tonon MC, Masmoudi-Kouki O, Lizard G.

Molecules. 2019 Sep 11;24(18). pii: E3310. doi: 10.3390/molecules24183310.


Endozepines and their receptors: Structure, functions and pathophysiological significance.

Tonon MC, Vaudry H, Chuquet J, Guillebaud F, Fan J, Masmoudi-Kouki O, Vaudry D, Lanfray D, Morin F, Prevot V, Papadopoulos V, Troadec JD, Leprince J.

Pharmacol Ther. 2019 Jul 5:107386. doi: 10.1016/j.pharmthera.2019.06.008. [Epub ahead of print] Review.


The neuropeptide 26RFa in the human gut and pancreas: potential involvement in glucose homeostasis.

Prévost G, Picot M, Le Solliec MA, Arabo A, Berrahmoune H, El Mehdi M, Cherifi S, Benani A, Nédélec E, Gobet F, Brunel V, Leprince J, Lefebvre H, Anouar Y, Chartrel N.

Endocr Connect. 2019 Jul;8(7):941-951. doi: 10.1530/EC-19-0247.


Characterization of an evolutionarily conserved calcitonin signalling system in a lophotrochozoan, the Pacific oyster (Crassostrea gigas).

Schwartz J, Réalis-Doyelle E, Dubos MP, Lefranc B, Leprince J, Favrel P.

J Exp Biol. 2019 Jul 5;222(Pt 13). pii: jeb201319. doi: 10.1242/jeb.201319.


Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice.

Prévost G, Arabo A, Le Solliec MA, Bons J, Picot M, Maucotel J, Berrahmoune H, El Mehdi M, Cherifi S, Benani A, Nédélec E, Coëffier M, Leprince J, Nordqvist A, Brunel V, Déchelotte P, Lefebvre H, Anouar Y, Chartrel N.

Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E147-E157. doi: 10.1152/ajpendo.00540.2018. Epub 2019 May 14.


Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system.

Hajji K, Mteyrek A, Sun J, Cassar M, Mezghani S, Leprince J, Vaudry D, Masmoudi-Kouki O, Birman S.

Hum Mol Genet. 2019 Jun 1;28(11):1905-1918. doi: 10.1093/hmg/ddz031.


Peptidomic analysis of the host-defense peptides in skin secretions of Rana graeca provides insight into phylogenetic relationships among Eurasian Rana species.

Mechkarska M, Kolodziejek J, Musale V, Coquet L, Leprince J, Jouenne T, Nowotny N, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2019 Mar;29:228-234. doi: 10.1016/j.cbd.2018.12.006. Epub 2018 Dec 27.


Neuroprotection with the Endozepine Octadecaneuropeptide, ODN.

Masmoudi-Kouki O, Hamdi Y, Ghouili I, Bahdoudi S, Kaddour H, Leprince J, Castel H, Vaudry H, Amri M, Vaudry D, Tonon MC.

Curr Pharm Des. 2018;24(33):3918-3925. doi: 10.2174/1381612824666181112111746. Review.


Design, Synthesis, Molecular Dynamics Simulation, and Functional Evaluation of a Novel Series of 26RFa Peptide Analogues Containing a Mono- or Polyalkyl Guanidino Arginine Derivative.

Alim K, Lefranc B, Sopkova-de Oliveira Santos J, Dubessy C, Picot M, Boutin JA, Vaudry H, Chartrel N, Vaudry D, Chuquet J, Leprince J.

J Med Chem. 2018 Nov 21;61(22):10185-10197. doi: 10.1021/acs.jmedchem.8b01332. Epub 2018 Nov 7.


Antioxidant and Anti-Apoptotic Activity of Octadecaneuropeptide Against 6-OHDA Toxicity in Cultured Rat Astrocytes.

Kaddour H, Hamdi Y, Amri F, Bahdoudi S, Bouannee I, Leprince J, Zekri S, Vaudry H, Tonon MC, Vaudry D, Amri M, Mezghani S, Masmoudi-Kouki O.

J Mol Neurosci. 2019 Sep;69(1):1-16. doi: 10.1007/s12031-018-1181-4. Epub 2018 Oct 20.


Comparison of the effects of PACAP-38 and its analog, acetyl-[Ala15, Ala20] PACAP-38-propylamide, on spatial memory, post-learning BDNF expression and oxidative stress in rat.

Ladjimi MH, Barbouche R, Ben Barka Z, Vaudry D, Lefranc B, Leprince J, Troadec JD, Ben Rhouma K, Sakly M, Tebourbi O, Save E.

Behav Brain Res. 2019 Feb 1;359:247-257. doi: 10.1016/j.bbr.2018.10.023. Epub 2018 Oct 19.


AMPK Activation of PGC-1α/NRF-1-Dependent SELENOT Gene Transcription Promotes PACAP-Induced Neuroendocrine Cell Differentiation Through Tolerance to Oxidative Stress.

Abid H, Cartier D, Hamieh A, François-Bellan AM, Bucharles C, Pothion H, Manecka DL, Leprince J, Adriouch S, Boyer O, Anouar Y, Lihrmann I.

Mol Neurobiol. 2019 Jun;56(6):4086-4101. doi: 10.1007/s12035-018-1352-x. Epub 2018 Sep 28.


Deciphering the Molecular Diversity of an Ant Venom Peptidome through a Venomics Approach.

Touchard A, Téné N, Song PCT, Lefranc B, Leprince J, Treilhou M, Bonnafé E.

J Proteome Res. 2018 Oct 5;17(10):3503-3516. doi: 10.1021/acs.jproteome.8b00452. Epub 2018 Sep 10.


Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae).

Mechkarska M, Coquet L, Leprince J, Auguste RJ, Jouenne T, Mangoni ML, Conlon JM.

Comp Biochem Physiol Part D Genomics Proteomics. 2018 Dec;28:72-79. doi: 10.1016/j.cbd.2018.06.006. Epub 2018 Jun 30.


Cell wall extensins in root-microbe interactions and root secretions.

Castilleux R, Plancot B, Ropitaux M, Carreras A, Leprince J, Boulogne I, Follet-Gueye ML, Popper ZA, Driouich A, Vicré M.

J Exp Bot. 2018 Aug 14;69(18):4235-4247. doi: 10.1093/jxb/ery238. Review.


Tachykinin-3 Genes and Peptides Characterized in a Basal Teleost, the European Eel: Evolutionary Perspective and Pituitary Role.

Campo A, Lafont AG, Lefranc B, Leprince J, Tostivint H, Kamech N, Dufour S, Rousseau K.

Front Endocrinol (Lausanne). 2018 Jun 11;9:304. doi: 10.3389/fendo.2018.00304. eCollection 2018.


Investigating the limits of resin-based luting composite photopolymerization through various thicknesses of indirect restorative materials.

Hardy CMF, Bebelman S, Leloup G, Hadis MA, Palin WM, Leprince JG.

Dent Mater. 2018 Sep;34(9):1278-1288. doi: 10.1016/ Epub 2018 May 29.


Different Dose-Dependent Modes of Action of C-Type Natriuretic Peptide on Pseudomonas aeruginosa Biofilm Formation.

Desriac F, Clamens T, Rosay T, Rodrigues S, Tahrioui A, Enault J, Roquigny L, Racine PJ, Taupin L, Bazire A, Dufour A, Leprince J, Bouffartigues E, Chevalier S, Feuilloley MGJ, Lesouhaitier O.

Pathogens. 2018 Apr 24;7(2). pii: E47. doi: 10.3390/pathogens7020047.


A selenoprotein T-derived peptide protects the heart against ischaemia/reperfusion injury through inhibition of apoptosis and oxidative stress.

Rocca C, Boukhzar L, Granieri MC, Alsharif I, Mazza R, Lefranc B, Tota B, Leprince J, Cerra MC, Anouar Y, Angelone T.

Acta Physiol (Oxf). 2018 Aug;223(4):e13067. doi: 10.1111/apha.13067. Epub 2018 Apr 17.


Shining a light on high volume photocurable materials.

Palin WM, Leprince JG, Hadis MA.

Dent Mater. 2018 May;34(5):695-710. doi: 10.1016/ Epub 2018 Mar 14. Review.


Identification of Components in Frog Skin Secretions with Therapeutic Potential as Antidiabetic Agents.

Conlon JM, Moffett RC, Leprince J, Flatt PR.

Methods Mol Biol. 2018;1719:319-333. doi: 10.1007/978-1-4939-7537-2_21.


Eel Kisspeptins: Identification, Functional Activity, and Inhibition on both Pituitary LH and GnRH Receptor Expression.

Pasquier J, Lafont AG, Denis F, Lefranc B, Dubessy C, Moreno-Herrera A, Vaudry H, Leprince J, Dufour S, Rousseau K.

Front Endocrinol (Lausanne). 2018 Jan 8;8:353. doi: 10.3389/fendo.2017.00353. eCollection 2017.


Evaluation of Emdogain® antimicrobial effectiveness against biofilms containing the keystone pathogen Porphyromonas gingivalis.

Lasserre J, Toma S, Dos Santos-Gonçalvez AM, Leprince J, Leloup G, Brecx M.

New Microbiol. 2018 Jan;41(1):73-76. Epub 2018 Jan 9.


Crustacean cardioactive peptides: Expression, localization, structure, and a possible involvement in regulation of egg-laying in the cuttlefish Sepia officinalis.

Endress M, Zatylny-Gaudin C, Corre E, Le Corguillé G, Benoist L, Leprince J, Lefranc B, Bernay B, Leduc A, Rangama J, Lafont AG, Bondon A, Henry J.

Gen Comp Endocrinol. 2018 May 1;260:67-79. doi: 10.1016/j.ygcen.2017.12.009. Epub 2017 Dec 24.


Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease.

Bahdoudi S, Ghouili I, Hmiden M, do Rego JL, Lefranc B, Leprince J, Chuquet J, do Rego JC, Marcher AB, Mandrup S, Vaudry H, Tonon MC, Amri M, Masmoudi-Kouki O, Vaudry D.

Cell Mol Life Sci. 2018 Jun;75(11):2075-2091. doi: 10.1007/s00018-017-2727-2. Epub 2017 Dec 20.


Mechanistic Investigations of PoyD, a Radical S-Adenosyl-l-methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis.

Parent A, Benjdia A, Guillot A, Kubiak X, Balty C, Lefranc B, Leprince J, Berteau O.

J Am Chem Soc. 2018 Feb 21;140(7):2469-2477. doi: 10.1021/jacs.7b08402. Epub 2018 Feb 6.


P17, an Original Host Defense Peptide from Ant Venom, Promotes Antifungal Activities of Macrophages through the Induction of C-Type Lectin Receptors Dependent on LTB4-Mediated PPARγ Activation.

Benmoussa K, Authier H, Prat M, AlaEddine M, Lefèvre L, Rahabi MC, Bernad J, Aubouy A, Bonnafé E, Leprince J, Pipy B, Treilhou M, Coste A.

Front Immunol. 2017 Nov 30;8:1650. doi: 10.3389/fimmu.2017.01650. eCollection 2017.


Peptidomic analysis of skin secretions of the Mexican burrowing toad Rhinophrynus dorsalis (Rhinophrynidae): Insight into the origin of host-defense peptides within the Pipidae and characterization of a proline-arginine-rich peptide.

Conlon JM, Guilhaudis L, Leprince J, Coquet L, Mangoni ML, Attoub S, Jouenne T, King JD.

Peptides. 2017 Nov;97:22-28. doi: 10.1016/j.peptides.2017.09.012. Epub 2017 Sep 23.


Effect of food deprivation on the hypothalamic gene expression of the secretogranin II-derived peptide EM66 in rat.

Trebak F, Dubuc I, Picot M, Alaoui A, Leprince J, Prévost G, Anouar Y, Magoul R, Chartrel N.

Neuroreport. 2017 Nov 8;28(16):1049-1053. doi: 10.1097/WNR.0000000000000889.


Holaphyllamine, a steroid, is able to induce defense responses in Arabidopsis thaliana and increases resistance against bacterial infection.

Zahid A, Jaber R, Laggoun F, Lehner A, Remy-Jouet I, Pamlard O, Beaupierre S, Leprince J, Follet-Gueye ML, Vicré-Gibouin M, Latour X, Richard V, Guillou C, Lerouge P, Driouich A, Mollet JC.

Planta. 2017 Dec;246(6):1109-1124. doi: 10.1007/s00425-017-2755-z. Epub 2017 Aug 16.


Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae).

Conlon JM, Musale V, Attoub S, Mangoni ML, Leprince J, Coquet L, Jouenne T, Abdel-Wahab YHA, Flatt PR, Rinaldi AC.

J Pept Sci. 2017 Oct;23(10):769-776. doi: 10.1002/psc.3025. Epub 2017 Jul 11.


Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival.

Ghouili I, Bahdoudi S, Morin F, Amri F, Hamdi Y, Coly PM, Walet-Balieu ML, Leprince J, Zekri S, Vaudry H, Vaudry D, Castel H, Amri M, Tonon MC, Masmoudi-Kouki O.

Mol Neurobiol. 2018 Jun;55(6):4596-4611. doi: 10.1007/s12035-017-0630-3. Epub 2017 Jul 11.


Post-translational modification of ribosomally synthesized peptides by a radical SAM epimerase in Bacillus subtilis.

Benjdia A, Guillot A, Ruffié P, Leprince J, Berteau O.

Nat Chem. 2017 Jul;9(7):698-707. doi: 10.1038/nchem.2714. Epub 2017 Feb 6.


Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death.

Louessard M, Bardou I, Lemarchand E, Thiebaut AM, Parcq J, Leprince J, Terrisse A, Carraro V, Fafournoux P, Bruhat A, Orset C, Vivien D, Ali C, Roussel BD.

Cell Death Differ. 2017 Sep;24(9):1518-1529. doi: 10.1038/cdd.2017.35. Epub 2017 Jun 23.


The Arg-Phe-amide peptide 26RFa/glutamine RF-amide peptide and its receptor: IUPHAR Review 24.

Leprince J, Bagnol D, Bureau R, Fukusumi S, Granata R, Hinuma S, Larhammar D, Primeaux S, Sopkova-de Oliveiras Santos J, Tsutsui K, Ukena K, Vaudry H.

Br J Pharmacol. 2017 Oct;174(20):3573-3607. doi: 10.1111/bph.13907. Epub 2017 Sep 8. Review.


Glial Endozepines Inhibit Feeding-Related Autonomic Functions by Acting at the Brainstem Level.

Guillebaud F, Girardet C, Abysique A, Gaigé S, Barbouche R, Verneuil J, Jean A, Leprince J, Tonon MC, Dallaporta M, Lebrun B, Troadec JD.

Front Neurosci. 2017 May 30;11:308. doi: 10.3389/fnins.2017.00308. eCollection 2017.


Investigations of octylglyceryl dextran-graft-poly(lactic acid) nanoparticles for peptide delivery to the brain.

Boussahel A, Ibegbu DM, Lamtahri R, Maucotel J, Chuquet J, Lefranc B, Leprince J, Roldo M, Mével JL, Gorecki D, Barbu E.

Nanomedicine (Lond). 2017 Apr;12(8):879-892. doi: 10.2217/nnm-2016-0406. Epub 2017 Mar 24.


Central and Peripheral Effects of Urotensin II and Urotensin II-Related Peptides on Cardiac Baroreflex Sensitivity in Trout.

Lancien F, Vanegas G, Leprince J, Vaudry H, Le Mével JC.

Front Neurosci. 2017 Feb 10;11:51. doi: 10.3389/fnins.2017.00051. eCollection 2017.


A potential role for the secretogranin II-derived peptide EM66 in the hypothalamic regulation of feeding behaviour.

Trebak F, Dubuc I, Arabo A, Alaoui A, Boukhzar L, Maucotel J, Picot M, Cherifi S, Duparc C, Leprince J, Prévost G, Anouar Y, Magoul R, Chartrel N.

J Neuroendocrinol. 2017 Mar;29(3). doi: 10.1111/jne.12459.


The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis.

Parent A, Guillot A, Benjdia A, Chartier G, Leprince J, Berteau O.

J Am Chem Soc. 2016 Dec 7;138(48):15515-15518. Epub 2016 Nov 29.


Correction: Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor.

Singh K, Senthil V, Arokiaraj AW, Leprince J, Lefranc B, Vaudry D, Allam AA, Ajarem J, Chow BK.

PLoS One. 2016 Oct 26;11(10):e0165770. doi: 10.1371/journal.pone.0165770. eCollection 2016.


Arabinogalactan Proteins From Baobab and Acacia Seeds Influence Innate Immunity of Human Keratinocytes In Vitro.

Zahid A, Despres J, Benard M, Nguema-Ona E, Leprince J, Vaudry D, Rihouey C, Vicré-Gibouin M, Driouich A, Follet-Gueye ML.

J Cell Physiol. 2017 Sep;232(9):2558-2568. doi: 10.1002/jcp.25646. Epub 2017 Apr 10.


Filler characteristics of modern dental resin composites and their influence on physico-mechanical properties.

Randolph LD, Palin WM, Leloup G, Leprince JG.

Dent Mater. 2016 Dec;32(12):1586-1599. doi: 10.1016/ Epub 2016 Oct 6.


Extracellular matrix-derived hydrogels for dental stem cell delivery.

Viswanath A, Vanacker J, Germain L, Leprince JG, Diogenes A, Shakesheff KM, White LJ, des Rieux A.

J Biomed Mater Res A. 2017 Jan;105(1):319-328. doi: 10.1002/jbm.a.35901. Epub 2016 Nov 5.


Progress with peptide scanning to study structure-activity relationships: the implications for drug discovery.

Eustache S, Leprince J, Tufféry P.

Expert Opin Drug Discov. 2016 Aug;11(8):771-84. doi: 10.1080/17460441.2016.1201058. Epub 2016 Jun 29. Review.


Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis.

Benjdia A, Guillot A, Lefranc B, Vaudry H, Leprince J, Berteau O.

Chem Commun (Camb). 2016 May 7;52(37):6249-6252. doi: 10.1039/c6cc01317a. Epub 2016 Apr 18.


Biochemical and biophysical combined study of bicarinalin, an ant venom antimicrobial peptide.

Téné N, Bonnafé E, Berger F, Rifflet A, Guilhaudis L, Ségalas-Milazzo I, Pipy B, Coste A, Leprince J, Treilhou M.

Peptides. 2016 May;79:103-13. doi: 10.1016/j.peptides.2016.04.001. Epub 2016 Apr 4.


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