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Items: 1 to 50 of 84

1.

Blood neurofilament light chain as a biomarker of MS disease activity and treatment response.

Kuhle J, Kropshofer H, Haering DA, Kundu U, Meinert R, Barro C, Dahlke F, Tomic D, Leppert D, Kappos L.

Neurology. 2019 Feb 8. pii: 10.1212/WNL.0000000000007032. doi: 10.1212/WNL.0000000000007032. [Epub ahead of print]

PMID:
30737333
2.

Neurofilament light chain serum levels correlate with 10-year MRI outcomes in multiple sclerosis.

Chitnis T, Gonzalez C, Healy BC, Saxena S, Rosso M, Barro C, Michalak Z, Paul A, Kivisakk P, Diaz-Cruz C, Sattarnezhad N, Pierre IV, Glanz BI, Tomic D, Kropshofer H, Häring D, Leppert D, Kappos L, Bakshi R, Weiner HL, Kuhle J.

Ann Clin Transl Neurol. 2018 Oct 16;5(12):1478-1491. doi: 10.1002/acn3.638. eCollection 2018 Dec.

3.

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis.

Barro C, Benkert P, Disanto G, Tsagkas C, Amann M, Naegelin Y, Leppert D, Gobbi C, Granziera C, Yaldizli Ö, Michalak Z, Wuerfel J, Kappos L, Parmar K, Kuhle J.

Brain. 2018 Aug 1;141(8):2382-2391. doi: 10.1093/brain/awy154.

PMID:
29860296
4.

MIBG scintigraphy of the major salivary glands in multiple system atrophy.

Soboll L, Leppert D, Dillmann U, Schaefer-Schuler A, Fassbender K, Ezziddin S, Spiegel J.

Parkinsonism Relat Disord. 2018 Aug;53:112-114. doi: 10.1016/j.parkreldis.2018.04.034. Epub 2018 May 4.

PMID:
29752191
5.

Fluid biomarker and electrophysiological outcome measures for progressive MS trials.

Barro C, Leocani L, Leppert D, Comi G, Kappos L, Kuhle J.

Mult Scler. 2017 Oct;23(12):1600-1613. doi: 10.1177/1352458517732844. Review.

PMID:
29041870
6.

'Progressive MS - macro views': The need for novel clinical trial paradigms to enable drug development for progressive MS.

Zaratin P, Comi G, Leppert D.

Mult Scler. 2017 Oct;23(12):1649-1655. doi: 10.1177/1352458517729457. Review.

PMID:
29041866
7.

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, Giardiello A, Zecca C, Blennow K, Zetterberg H, Leppert D, Kappos L, Gobbi C, Kuhle J; Swiss Multiple Sclerosis Cohort Study Group.

Ann Neurol. 2017 Jun;81(6):857-870. doi: 10.1002/ana.24954.

8.

Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses.

Giovannoni G, Cutter G, Sormani MP, Belachew S, Hyde R, Koendgen H, Knappertz V, Tomic D, Leppert D, Herndon R, Wheeler-Kingshott CAM, Ciccarelli O, Selwood D, di Cantogno EV, Ben-Amor AF, Matthews P, Carassiti D, Baker D, Schmierer K.

Mult Scler Relat Disord. 2017 Feb;12:70-78. doi: 10.1016/j.msard.2017.01.007. Epub 2017 Jan 17. Review.

PMID:
28283111
9.

Bilateral Endoscopic Lung Volume Reduction in Patients with Severe Emphysema.

Trudzinski FC, Lepper PM, Leppert D, Langer F, Lensch C, Flaig M, Bals R, Wilkens H, Minko P, Fähndrich S.

Respiration. 2016;92(5):356-358. Epub 2016 Oct 5.

10.

Reduced MIBG accumulation of the parotid and submandibular glands in idiopathic Parkinson's disease.

Haqparwar J, Pepe A, Fassbender K, Dillmann U, Ezziddin S, Schaefer A, Leppert D, Spiegel J.

Parkinsonism Relat Disord. 2017 Jan;34:26-30. doi: 10.1016/j.parkreldis.2016.10.011. Epub 2016 Oct 15.

PMID:
27769648
11.

Endoscopic Lung Volume Reduction Using Endobronchial Valves in Patients with Severe Emphysema and Very Low FEV1.

Trudzinski FC, Höink AJ, Leppert D, Fähndrich S, Wilkens H, Graeter TP, Langer F, Bals R, Minko P, Lepper PM.

Respiration. 2016;92(4):258-265. Epub 2016 Sep 8.

12.

The effects of intrathecal rituximab on biomarkers in multiple sclerosis.

Topping J, Dobson R, Lapin S, Maslyanskiy A, Kropshofer H, Leppert D, Giovannoni G, Evdoshenko E.

Mult Scler Relat Disord. 2016 Mar;6:49-53. doi: 10.1016/j.msard.2016.01.001. Epub 2016 Jan 19.

PMID:
27063622
13.

The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis.

Liechti FD, Bächtold F, Grandgirard D, Leppert D, Leib SL.

J Neuroinflammation. 2015 Mar 4;12:43. doi: 10.1186/s12974-015-0257-0.

14.

(11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas.

Park E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O'Connor KC, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D.

Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1081-92. doi: 10.1007/s00259-015-3043-4. Epub 2015 Apr 2.

PMID:
25833352
15.

Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain.

Anthony DC, Dickens AM, Seneca N, Couch Y, Campbell S, Checa B, Kersemans V, Warren EA, Tredwell M, Sibson NR, Gouverneur V, Leppert D.

Ann Clin Transl Neurol. 2014 Sep;1(9):659-69. doi: 10.1002/acn3.94. Epub 2014 Sep 16.

16.

Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome.

Kuhle J, Gaiottino J, Leppert D, Petzold A, Bestwick JP, Malaspina A, Lu CH, Dobson R, Disanto G, Norgren N, Nissim A, Kappos L, Hurlbert J, Yong VW, Giovannoni G, Casha S.

J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):273-9. doi: 10.1136/jnnp-2013-307454. Epub 2014 Jun 16.

PMID:
24935984
17.

Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients.

Palanichamy A, Jahn S, Nickles D, Derstine M, Abounasr A, Hauser SL, Baranzini SE, Leppert D, von Büdingen HC.

J Immunol. 2014 Jul 15;193(2):580-586. doi: 10.4049/jimmunol.1400118. Epub 2014 Jun 13.

18.

Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis.

Villar LM, Casanova B, Ouamara N, Comabella M, Jalili F, Leppert D, de Andrés C, Izquierdo G, Arroyo R, Avşar T, Lapin SV, Johnson T, Montalbán X, Fernández O, Álvarez-Lafuente R, Masterman D, García-Sánchez MI, Coret F, Siva A, Evdoshenko E, Álvarez-Cermeño JC, Bar-Or A.

Ann Neurol. 2014 Aug;76(2):231-40. doi: 10.1002/ana.24190. Epub 2014 Jul 2.

PMID:
24909126
19.

Composite end points to assess delay of disability progression by MS treatments.

Zhang J, Waubant E, Cutter G, Wolinsky J, Leppert D.

Mult Scler. 2014 Oct;20(11):1494-501. doi: 10.1177/1352458514527180. Epub 2014 Mar 27.

PMID:
24675040
20.

Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis.

Liechti FD, Grandgirard D, Leppert D, Leib SL.

Infect Immun. 2014 Apr;82(4):1710-8. doi: 10.1128/IAI.00073-14. Epub 2014 Feb 3. Erratum in: Infect Immun. 2014 Oct;82(10):4435.

21.

Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker.

O'Brien ER, Kersemans V, Tredwell M, Checa B, Serres S, Soto MS, Gouverneur V, Leppert D, Anthony DC, Sibson NR.

J Nucl Med. 2014 Feb;55(2):275-80. doi: 10.2967/jnumed.113.127449. Epub 2014 Jan 16.

22.

Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model.

Anthony DC, Sibson NR, Losey P, Meier DP, Leppert D.

Neuropharmacology. 2014 Apr;79:534-41. doi: 10.1016/j.neuropharm.2013.12.022. Epub 2014 Jan 9.

PMID:
24412675
23.

Increased neurofilament light chain blood levels in neurodegenerative neurological diseases.

Gaiottino J, Norgren N, Dobson R, Topping J, Nissim A, Malaspina A, Bestwick JP, Monsch AU, Regeniter A, Lindberg RL, Kappos L, Leppert D, Petzold A, Giovannoni G, Kuhle J.

PLoS One. 2013 Sep 20;8(9):e75091. doi: 10.1371/journal.pone.0075091. eCollection 2013.

24.

Interferon beta 1b following natalizumab discontinuation: one year, randomized, prospective, pilot trial.

Gobbi C, Meier DS, Cotton F, Sintzel M, Leppert D, Guttmann CR, Zecca C.

BMC Neurol. 2013 Aug 2;13:101. doi: 10.1186/1471-2377-13-101.

25.

A comparative study of CSF neurofilament light and heavy chain protein in MS.

Kuhle J, Plattner K, Bestwick JP, Lindberg RL, Ramagopalan SV, Norgren N, Nissim A, Malaspina A, Leppert D, Giovannoni G, Kappos L.

Mult Scler. 2013 Oct;19(12):1597-603. doi: 10.1177/1352458513482374. Epub 2013 Mar 25.

PMID:
23529999
26.

On being a neurologist in industry.

Leppert D, Glanzman R.

Ann Neurol. 2013 Mar;73(3):319-26. doi: 10.1002/ana.23812. Epub 2013 Feb 19.

PMID:
23423974
27.

Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis.

Gensicke H, Leppert D, Yaldizli Ö, Lindberg RL, Mehling M, Kappos L, Kuhle J.

CNS Drugs. 2012 Jan 1;26(1):11-37. doi: 10.2165/11596920-000000000-00000. Review.

PMID:
22171583
28.

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial.

Kappos L, Li D, Calabresi PA, O'Connor P, Bar-Or A, Barkhof F, Yin M, Leppert D, Glanzman R, Tinbergen J, Hauser SL.

Lancet. 2011 Nov 19;378(9805):1779-87. doi: 10.1016/S0140-6736(11)61649-8. Epub 2011 Oct 31.

PMID:
22047971
29.

Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis.

Kuhle J, Leppert D, Petzold A, Regeniter A, Schindler C, Mehling M, Anthony DC, Kappos L, Lindberg RL.

Neurology. 2011 Apr 5;76(14):1206-13. doi: 10.1212/WNL.0b013e31821432ff. Epub 2011 Feb 23.

PMID:
21346223
30.

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Kasperaviciūte D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LM, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser HG, Steinhoff BJ, Krämer G, Hansen J, Dorn T, Kantanen AM, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kälviäinen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SM.

Brain. 2010 Jul;133(Pt 7):2136-47. doi: 10.1093/brain/awq130. Epub 2010 Jun 3.

31.

Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.

Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, Depondt C, Need AC, Walley NM, Nicoletti P, Ge D, Catarino CB, Duncan JS, Kasperaviciūte D, Tate SK, Caboclo LO, Sander JW, Clayton L, Linney KN, Shianna KV, Gumbs CE, Smith J, Cronin KD, Maia JM, Doherty CP, Pandolfo M, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Kälviäinen R, Eriksson K, Kantanen AM, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Wieser HG, Zumsteg D, Ortega M, Wood NW, Huxley-Jones J, Mikati M, Gallentine WB, Husain AM, Buckley PG, Stallings RL, Podgoreanu MV, Delanty N, Sisodiya SM, Goldstein DB.

Am J Hum Genet. 2010 May 14;86(5):707-18. doi: 10.1016/j.ajhg.2010.03.018. Epub 2010 Apr 15.

32.

A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein.

Kuhle J, Regeniter A, Leppert D, Mehling M, Kappos L, Lindberg RL, Petzold A.

J Neuroimmunol. 2010 Mar 30;220(1-2):114-9. doi: 10.1016/j.jneuroim.2010.01.004. Epub 2010 Feb 1.

PMID:
20117845
33.

AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis.

Zhang ZY, Zhang Z, Zug C, Nuesslein-Hildesheim B, Leppert D, Schluesener HJ.

J Neuroimmunol. 2009 Nov 30;216(1-2):59-65. doi: 10.1016/j.jneuroim.2009.09.010. Epub 2009 Oct 4.

PMID:
19804913
34.

Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.

Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL, Pelletier D.

Brain. 2009 Jan;132(Pt 1):250-9. doi: 10.1093/brain/awn301. Epub 2008 Nov 20.

35.

Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins.

Ishihara H, Kubota H, Lindberg RL, Leppert D, Gloor SM, Errede M, Virgintino D, Fontana A, Yonekawa Y, Frei K.

J Neuropathol Exp Neurol. 2008 May;67(5):435-48. doi: 10.1097/NEN.0b013e31816fd622.

PMID:
18431253
36.

Immunomodulatory effects of etanercept in a model of brain injury act through attenuation of the acute-phase response.

Campbell SJ, Jiang Y, Davis AE, Farrands R, Holbrook J, Leppert D, Anthony DC.

J Neurochem. 2007 Dec;103(6):2245-55. Epub 2007 Sep 18.

37.

PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis.

Lockhart A, Lamb JR, Osredkar T, Sue LI, Joyce JN, Ye L, Libri V, Leppert D, Beach TG.

Brain. 2007 Oct;130(Pt 10):2607-15. Epub 2007 Aug 13.

PMID:
17698496
38.

Matrix metalloproteinases in neuromuscular disease.

Renaud S, Leppert D.

Muscle Nerve. 2007 Jul;36(1):1-13. Review.

PMID:
17410592
39.

Antimyelin antibodies in clinically isolated syndromes correlate with inflammation in MRI and CSF.

Kuhle J, Lindberg RL, Regeniter A, Mehling M, Hoffmann F, Reindl M, Berger T, Radue EW, Leppert D, Kappos L.

J Neurol. 2007 Feb;254(2):160-8.

PMID:
17334662
40.

Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.

Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari PA, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, El Euch-Fayeche G, Middleton L, Burn DJ, Watts RL, Hentati F.

Mov Disord. 2007 Jan;22(1):55-61.

PMID:
17115391
41.

Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.

Ishihara L, Warren L, Gibson R, Amouri R, Lesage S, Dürr A, Tazir M, Wszolek ZK, Uitti RJ, Nichols WC, Griffith A, Hattori N, Leppert D, Watts R, Zabetian CP, Foroud TM, Farrer MJ, Brice A, Middleton L, Hentati F.

Arch Neurol. 2006 Sep;63(9):1250-4.

PMID:
16966502
42.

Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells.

Trog D, Yeghiazaryan K, Fountoulakis M, Friedlein A, Moenkemann H, Haertel N, Schueller H, Breipohl W, Schild H, Leppert D, Golubnitschaja O.

Eur J Pharmacol. 2006 Aug 7;542(1-3):8-15. Epub 2006 May 24.

PMID:
16806166
43.

Gene expression in cortex and hippocampus during acute pneumococcal meningitis.

Coimbra RS, Voisin V, de Saizieu AB, Lindberg RL, Wittwer M, Leppert D, Leib SL.

BMC Biol. 2006 Jun 2;4:15.

44.

Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children.

Lindberg RL, Sorsa T, Tervahartiala T, Hoffmann F, Mellanen L, Kappos L, Schaad UB, Leib SL, Leppert D.

Neuropathol Appl Neurobiol. 2006 Jun;32(3):304-17.

PMID:
16640649
45.

Differential regulation of metzincins in experimental chronic renal allograft rejection: potential markers and novel therapeutic targets.

Berthier CC, Lods N, Joosten SA, van Kooten C, Leppert D, Lindberg RL, Kappeler A, Raulf F, Sterchi EE, Lottaz D, Marti HP.

Kidney Int. 2006 Jan;69(2):358-68.

46.

CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells.

Liu X, Lindberg R, Xiao BG, Steffensen KR, Leppert D, Link H, Huang YM.

J Neuroimmunol. 2006 Mar;172(1-2):137-44. Epub 2005 Dec 27.

PMID:
16380169
47.

Syncope during EEG recording.

Schaer B, Osswald S, Fuhr P, Leppert D.

Neurology. 2004 Sep 14;63(5):E11. No abstract available.

PMID:
15365168
48.

A plea for "omics" research in complex diseases such as multiple sclerosis--a change of mind is needed.

Martin R, Leppert D.

J Neurol Sci. 2004 Jul 15;222(1-2):3-5. No abstract available.

PMID:
15240188
49.

Multiple sclerosis as a generalized CNS disease--comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS.

Lindberg RL, De Groot CJ, Certa U, Ravid R, Hoffmann F, Kappos L, Leppert D.

J Neuroimmunol. 2004 Jul;152(1-2):154-67.

PMID:
15223248
50.

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