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Targeted temperature management in patients undergoing extracorporeal life support after out-of-hospital cardiac arrest: an EURO-ELSO 2018 annual conference survey.

Rolfes C, Muellenbach RM, Lepper PM, Spangenberg T, Swol J, Lorusso R, Weber K, Foerstner S, Lotz C, Belohlavek J.

Perfusion. 2019 May 31:267659119847033. doi: 10.1177/0267659119847033. [Epub ahead of print]


Impact of different intraoperative CO2 pressure levels (8 and 15 mmHg) during laparoscopic hysterectomy performed due to benign uterine pathologies on postoperative pain and arterial pCO2 : a prospective randomised controlled clinical trial.

Radosa JC, Radosa MP, Schweitzer PA, Radosa CG, Stotz L, Hamza A, Takacs Z, Lepper PM, Wagenpfeil S, Linxweiler M, Morinello E, Solomayer EF.

BJOG. 2019 Sep;126(10):1276-1285. doi: 10.1111/1471-0528.15826.


Pulmonary nocardiosis in Western Europe-Clinical evaluation of 43 patients and population-based estimates of hospitalization rates.

Ott SR, Meier N, Kolditz M, Bauer TT, Rohde G, Presterl E, Schürmann D, Lepper PM, Ringshausen FC, Flick H, Leib SL, Pletz MW; OPINION Study Group.

Int J Infect Dis. 2019 Apr;81:140-148. doi: 10.1016/j.ijid.2018.12.010. Epub 2019 Jan 15. Review.


Itaconic acid indicates cellular but not systemic immune system activation.

Meiser J, Kraemer L, Jaeger C, Madry H, Link A, Lepper PM, Hiller K, Schneider JG.

Oncotarget. 2018 Aug 14;9(63):32098-32107. doi: 10.18632/oncotarget.25956. eCollection 2018 Aug 14.


Improving Outcomes in Bridge-to-Transplant: Extended Extracorporeal Membrane Oxygenation Support to Obtain Optimal Donor Lungs for Marginal Recipients.

Langer F, Aliyev P, Schäfers HJ, Trudzinski FC, Seiler F, Bals R, Wilkens H, Lepper PM.

ASAIO J. 2019 Jul;65(5):516-521. doi: 10.1097/MAT.0000000000000843.


Weaning from prolonged veno-venous extracorporeal membrane oxygenation (ECMO) after transfer to a specialized center: a retrospective study.

Seiler F, Trudzinski FC, Hörsch SI, Kamp A, Metz C, Flaig M, Alqudrah M, Wehrfritz H, Kredel M, Muellenbach RM, Haake H, Bals R, Lepper PM.

J Artif Organs. 2018 Sep;21(3):300-307. doi: 10.1007/s10047-018-1046-1. Epub 2018 May 15.


Percutaneous Mechanical Circulation Support Combined with Extracorporeal Membrane Oxygenation (oxyRVAD) in Secondary Right Heart Failure.

Lepper PM, Hörsch SI, Seiler F, Kamp A, Becker SL, Lensch C, Conzelmann LO, Haake H, Muellenbach RM, Bals R, Kredel M, Langer F, Wilkens H, Trudzinski FC.

ASAIO J. 2018 Jul/Aug;64(4):e64-e67. doi: 10.1097/MAT.0000000000000754.


Microbiological airway colonization in COPD patients with severe emphysema undergoing endoscopic lung volume reduction.

Trudzinski FC, Seiler F, Wilkens H, Metz C, Kamp A, Bals R, Gärtner B, Lepper PM, Becker SL.

Int J Chron Obstruct Pulmon Dis. 2017 Dec 19;13:29-35. doi: 10.2147/COPD.S150705. eCollection 2018.


Intensive smoking diminishes the differences in quality of life and exacerbation frequency between the alpha-1-antitrypsin deficiency genotypes PiZZ and PiSZ.

Bernhard N, Lepper PM, Vogelmeier C, Seibert M, Wagenpfeil S, Bals R, Fähndrich S.

Respir Med. 2017 Sep;130:1-8. doi: 10.1016/j.rmed.2017.07.004. Epub 2017 Jul 8.


Extracorporeal membrane oxygenation (ECMO) as salvage treatment for pulmonary Echinococcus granulosus infection with acute cyst rupture.

Becker SL, Fähndrich S, Trudzinski FC, Gärtner B, Langer F, Becker TK, Bals R, Lepper PM, Lensch C.

Int J Infect Dis. 2017 Nov;64:47-49. doi: 10.1016/j.ijid.2017.09.001. Epub 2017 Sep 8.


[Extracorporeal membrane oxygenation for treatment of acute respiratory failure : Outcome of patients with interstitial lung disease].

Trudzinski FC, Lepper PM.

Med Klin Intensivmed Notfmed. 2017 Sep;112(6):552-556. doi: 10.1007/s00063-017-0326-5. Epub 2017 Aug 15. German. No abstract available.


High Serum Bilirubin Levels, NT-pro-BNP, and Lactate Predict Mortality in Long-Term, Severely Ill Respiratory ECMO Patients.

Kaestner F, Rapp D, Trudzinski FC, Olewczynska N, Wagenpfeil S, Langer F, Flaig M, Wilkens H, Bals R, Klingele M, Lensch C, Fähndrich S, Lepper PM.

ASAIO J. 2018 Mar/Apr;64(2):232-237. doi: 10.1097/MAT.0000000000000610.


[Treatment of an uncommon case of a cardiogenic shock : Simultaneous use of a VA-ECMO and an Impella-CP®].

Haake H, Grün-Himmelmann K, Kania U, Trudzinski F, Lepper PM, Vom Dahl J.

Med Klin Intensivmed Notfmed. 2018 Mar;113(2):131-134. doi: 10.1007/s00063-017-0324-7. Epub 2017 Aug 2. German.


Exacerbations and duration of smoking abstinence are associated with the annual loss of FEV1 in individuals with PiZZ alpha-1-antitrypsin deficiency.

Fähndrich S, Bernhard N, Lepper PM, Vogelmeier C, Seibert M, Wagenpfeil S, Bals R.

Respir Med. 2017 Aug;129:8-15. doi: 10.1016/j.rmed.2017.05.011. Epub 2017 May 24.


[Update: acute hypercapnic respiratory failure].

Seiler F, Trudzinski FC, Kredel M, Lotz C, Lepper PM, Muellenbach RM.

Med Klin Intensivmed Notfmed. 2019 Apr;114(3):234-239. doi: 10.1007/s00063-017-0318-5. Epub 2017 Jul 13. Review. German.


Double Peripheral Venous and Arterial Cannulation for Extracorporeal Membrane Oxygenation in Combined Septic and Cardiogenic Shock.

Kredel M, Kunzmann S, Schlegel PG, Wölfl M, Nordbeck P, Bühler C, Lotz C, Lepper PM, Wirbelauer J, Roewer N, Muellenbach RM.

Am J Case Rep. 2017 Jun 28;18:723-727.


Deterioration of quality of life is associated with the exacerbation frequency in individuals with alpha-1-antitrypsin deficiency - analysis from the German Registry.

Bernhard N, Lepper PM, Vogelmeier C, Seibert M, Wagenpfeil S, Bals R, Fähndrich S.

Int J Chron Obstruct Pulmon Dis. 2017 May 12;12:1427-1437. doi: 10.2147/COPD.S130925. eCollection 2017.


Lung Transplant Candidates on Extracorporeal Support.

Trudzinski FC, Wilkens H, Moerer O, Muellenbach RM, Langer F, Hoopes CW, Zwischenberger JB, Lepper PM.

Chest. 2017 May;151(5):1177-1178. doi: 10.1016/j.chest.2016.12.035. No abstract available.


The ICM research agenda on extracorporeal life support.

Combes A, Brodie D, Chen YS, Fan E, Henriques JPS, Hodgson C, Lepper PM, Leprince P, Maekawa K, Muller T, Nuding S, Ouweneel DM, Roch A, Schmidt M, Takayama H, Vuylsteke A, Werdan K, Papazian L.

Intensive Care Med. 2017 Sep;43(9):1306-1318. doi: 10.1007/s00134-017-4803-3. Epub 2017 May 3. Review.


Hypoxia and the hypoxia-regulated transcription factor HIF-1α suppress the host defence of airway epithelial cells.

Polke M, Seiler F, Lepper PM, Kamyschnikow A, Langer F, Monz D, Herr C, Bals R, Beisswenger C.

Innate Immun. 2017 May;23(4):373-380. doi: 10.1177/1753425917698032. Epub 2017 Mar 8.


Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease.

Zewinger S, Kleber ME, Rohrer L, Lehmann M, Triem S, Jennings RT, Petrakis I, Dressel A, Lepper PM, Scharnagl H, Ritsch A, Thorand B, Heier M, Meisinger C, de Las Heras Gala T, Koenig W, Wagenpfeil S, Schwedhelm E, Böger RH, Laufs U, von Eckardstein A, Landmesser U, Lüscher TF, Fliser D, März W, Meinitzer A, Speer T.

Eur Heart J. 2017 May 21;38(20):1597-1607. doi: 10.1093/eurheartj/ehx118.


Allergic airway inflammation induces migration of mast cell populations into the mouse airway.

Schmit D, Le DD, Heck S, Bischoff M, Tschernig T, Herr C, Beisswenger C, Kobelt P, Lepper PM, Chung KF, Bals R, Dinh QT.

Cell Tissue Res. 2017 Aug;369(2):331-340. doi: 10.1007/s00441-017-2597-9. Epub 2017 Mar 25.


Inhaled Sedation in Patients With Acute Respiratory Distress Syndrome Undergoing Extracorporeal Membrane Oxygenation.

Meiser A, Bomberg H, Lepper PM, Trudzinski FC, Volk T, Groesdonk HV.

Anesth Analg. 2017 Oct;125(4):1235-1239. doi: 10.1213/ANE.0000000000001915.


Therapeutic Interventions and Risk Factors of Bleeding During Extracorporeal Membrane Oxygenation.

Lotz C, Streiber N, Roewer N, Lepper PM, Muellenbach RM, Kredel M.

ASAIO J. 2017 Sep/Oct;63(5):624-630. doi: 10.1097/MAT.0000000000000525.


The Homburg Lung: Efficacy and Safety of a Minimal-Invasive Pump-Driven Device for Veno-Venous Extracorporeal Carbon Dioxide Removal.

Seiler F, Trudzinski FC, Hennemann K, Niermeyer T, Schmoll C, Kamp A, Bals R, Muellenbach RM, Haake H, Lepper PM.

ASAIO J. 2017 Sep/Oct;63(5):659-665. doi: 10.1097/MAT.0000000000000522.


Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016.

Trudzinski FC, Schlotthauer U, Kamp A, Hennemann K, Muellenbach RM, Reischl U, Gärtner B, Wilkens H, Bals R, Herrmann M, Lepper PM, Becker SL.

Euro Surveill. 2016 Nov 17;21(46). doi: 10.2807/1560-7917.ES.2016.21.46.30398.


[Severe hypercapnic respiratory failure in acute exacerbation of COPD: significance of ventilation and extracorporal CO2 removal].

Westhoff M, Bachmann M, Braune S, Karagiannidis C, Kluge S, Lepper PM, Müller T, Schönhofer B.

Dtsch Med Wochenschr. 2016 Nov;141(24):1758-1762. Epub 2016 Nov 30. Review. German.


Bilateral Endoscopic Lung Volume Reduction in Patients with Severe Emphysema.

Trudzinski FC, Lepper PM, Leppert D, Langer F, Lensch C, Flaig M, Bals R, Wilkens H, Minko P, Fähndrich S.

Respiration. 2016;92(5):356-358. Epub 2016 Oct 5.


Endoscopic Lung Volume Reduction Using Endobronchial Valves in Patients with Severe Emphysema and Very Low FEV1.

Trudzinski FC, Höink AJ, Leppert D, Fähndrich S, Wilkens H, Graeter TP, Langer F, Bals R, Minko P, Lepper PM.

Respiration. 2016;92(4):258-265. Epub 2016 Sep 8.


Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis.

Trudzinski FC, Minko P, Rapp D, Fähndrich S, Haake H, Haab M, Bohle RM, Flaig M, Kaestner F, Bals R, Wilkens H, Muellenbach RM, Link A, Groesdonk HV, Lensch C, Langer F, Lepper PM.

Ann Intensive Care. 2016 Dec;6(1):66. doi: 10.1186/s13613-016-0172-2. Epub 2016 Jul 19.


Outcome of Patients with Interstitial Lung Disease Treated with Extracorporeal Membrane Oxygenation for Acute Respiratory Failure.

Trudzinski FC, Kaestner F, Schäfers HJ, Fähndrich S, Seiler F, Böhmer P, Linn O, Kaiser R, Haake H, Langer F, Bals R, Wilkens H, Lepper PM.

Am J Respir Crit Care Med. 2016 Mar 1;193(5):527-33. doi: 10.1164/rccm.201508-1701OC.


Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk.

Zewinger S, Drechsler C, Kleber ME, Dressel A, Riffel J, Triem S, Lehmann M, Kopecky C, Säemann MD, Lepper PM, Silbernagel G, Scharnagl H, Ritsch A, Thorand B, de las Heras Gala T, Wagenpfeil S, Koenig W, Peters A, Laufs U, Wanner C, Fliser D, Speer T, März W.

Eur Heart J. 2015 Nov 14;36(43):3007-16. doi: 10.1093/eurheartj/ehv352. Epub 2015 Aug 6.


Il-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema.

Voss M, Wolf L, Kamyschnikow A, Wonnenberg B, Honecker A, Herr C, Lepper PM, Wegmann M, Menger MD, Bals R, Beisswenger C.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L188-95. doi: 10.1152/ajplung.00388.2014. Epub 2015 May 29.


Sex differences in alpha-1-antitrypsin deficiency lung disease-analysis from the German registry.

Fähndrich S, Herr C, Greulich T, Seibert M, Lepper PM, Bernhard N, Lützow C, Vogelmeier C, Bals R.

COPD. 2015 May;12 Suppl 1:58-62. doi: 10.3109/15412555.2015.1023785.


Diagnostic and prognostic validity of different biomarkers in patients with suspected myocarditis.

Ukena C, Kindermann M, Mahfoud F, Geisel J, Lepper PM, Kandolf R, Böhm M, Kindermann I.

Clin Res Cardiol. 2014 Sep;103(9):743-51. doi: 10.1007/s00392-014-0709-z. Epub 2014 Apr 30.


HDL cholesterol is not associated with lower mortality in patients with kidney dysfunction.

Zewinger S, Speer T, Kleber ME, Scharnagl H, Woitas R, Lepper PM, Pfahler K, Seiler S, Heine GH, März W, Silbernagel G, Fliser D.

J Am Soc Nephrol. 2014 May;25(5):1073-82. doi: 10.1681/ASN.2013050482. Epub 2014 Mar 7.


Mechanisms and potential therapeutic targets in allergic inflammation: recent insights.

von Gunten S, Cortinas-Elizondo F, Kollarik M, Beisswenger C, Lepper PM.

Allergy. 2013 Dec;68(12):1487-98. doi: 10.1111/all.12312. Epub 2013 Nov 12. Review.


Regulation and function of antimicrobial peptides in immunity and diseases of the lung.

Seiler F, Lepper PM, Bals R, Beisswenger C.

Protein Pept Lett. 2014 Apr;21(4):341-51. Review.


Alpha1-antitrypsin deficiency - diagnostic testing and disease awareness in Germany and Italy.

Greulich T, Ottaviani S, Bals R, Lepper PM, Vogelmeier C, Luisetti M, Ferrarotti I.

Respir Med. 2013 Sep;107(9):1400-8. doi: 10.1016/j.rmed.2013.04.023. Epub 2013 Jun 17.


Pulmonary embolism in deceivingly stable patients with high thrombus load-when is stable really safe?

Lepper PM, Wilkens H, Link A, Bals R, Schäfers HJ.

Thorac Cardiovasc Surg. 2014 Feb;62(1):85-8. doi: 10.1055/s-0032-1331286. Epub 2013 Feb 20.


FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells.

Seiler F, Hellberg J, Lepper PM, Kamyschnikow A, Herr C, Bischoff M, Langer F, Schäfers HJ, Lammert F, Menger MD, Bals R, Beisswenger C.

J Immunol. 2013 Feb 15;190(4):1603-13. doi: 10.4049/jimmunol.1200596. Epub 2013 Jan 11.


IL-17C is a mediator of respiratory epithelial innate immune response.

Pfeifer P, Voss M, Wonnenberg B, Hellberg J, Seiler F, Lepper PM, Bischoff M, Langer F, Schäfers HJ, Menger MD, Bals R, Beisswenger C.

Am J Respir Cell Mol Biol. 2013 Apr;48(4):415-21. doi: 10.1165/rcmb.2012-0232OC.


Natural killer cells in pulmonary arterial hypertension: a force on the dim or the bright side?

Lepper PM, Bals R, Wilkens H.

Circulation. 2012 Aug 28;126(9):1020-2. doi: 10.1161/CIRCULATIONAHA.112.126441. No abstract available.


Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study.

Lepper PM, Ott S, Nüesch E, von Eynatten M, Schumann C, Pletz MW, Mealing NM, Welte T, Bauer TT, Suttorp N, Jüni P, Bals R, Rohde G; German Community Acquired Pneumonia Competence Network.

BMJ. 2012 May 28;344:e3397. doi: 10.1136/bmj.e3397.


Oxygen transport and mitochondrial function in porcine septic shock, cardiogenic shock, and hypoxaemia.

Regueira T, Djafarzadeh S, Brandt S, Gorrasi J, Borotto E, Porta F, Takala J, Bracht H, Shaw S, Lepper PM, Jakob SM.

Acta Anaesthesiol Scand. 2012 Aug;56(7):846-59. doi: 10.1111/j.1399-6576.2012.02706.x. Epub 2012 May 9.


On the edge: targeting Toll-like receptor 2 in ischemia/reperfusion injury.

Lepper PM, Bals R.

Circ Cardiovasc Interv. 2012 Apr;5(2):146-9. doi: 10.1161/CIRCINTERVENTIONS.112.968495. No abstract available.


Serum proteins modulate lipopolysaccharide and lipoteichoic acid-induced activation and contribute to the clinical outcome of sepsis.

Triantafilou M, Mouratis MA, Lepper PM, Haston RM, Baldwin F, Lowes S, Ahmed MA, Schumann C, Boyd O, Triantafilou K.

Virulence. 2012 Mar-Apr;3(2):136-45. doi: 10.4161/viru.19077. Epub 2012 Mar 1.


Expression of CD163 on human histiocytic cells is different in tuberculosis-induced and schistosomiasis-induced granulomas.

Strebel BM, Lepper PM, Schaer DJ, Sendensky AH, Kurrer MO.

Histopathology. 2012 Feb;60(3):511-4. doi: 10.1111/j.1365-2559.2011.04059.x. Epub 2011 Dec 14. No abstract available.


Treatment failure in pneumonia: impact of antibiotic treatment and cost analysis.

Ott SR, Hauptmeier BM, Ernen C, Lepper PM, Nüesch E, Pletz MW, Hecht J, Welte T, Bauer TT.

Eur Respir J. 2012 Mar;39(3):611-8. doi: 10.1183/09031936.00098411. Epub 2011 Sep 29.


Location, location, location: is membrane partitioning everything when it comes to innate immune activation?

Triantafilou M, Lepper PM, Olden R, Dias IS, Triantafilou K.

Mediators Inflamm. 2011;2011:186093. doi: 10.1155/2011/186093. Epub 2011 Jun 21. Review.

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