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Items: 50

1.

A Randomized, Placebo-Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High-Density Lipoprotein Cholesterol in Subjects With Dyslipidemia.

Olson EJ, Mahar KM, Haws TF, Fossler MJ, Gao F, de Gouville AC, Sprecher DL, Lepore JJ.

Clin Pharmacol Drug Dev. 2019 Oct;8(7):871-883. doi: 10.1002/cpdd.704. Epub 2019 Jul 3.

PMID:
31268250
2.

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis.

Meadowcroft AM, Cizman B, Holdstock L, Biswas N, Johnson BM, Jones D, Nossuli AK, Lepore JJ, Aarup M, Cobitz AR.

Clin Kidney J. 2019 Feb;12(1):139-148. doi: 10.1093/ckj/sfy014. Epub 2018 Mar 19.

3.

Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease.

Holdstock L, Cizman B, Meadowcroft AM, Biswas N, Johnson BM, Jones D, Kim SG, Zeig S, Lepore JJ, Cobitz AR.

Clin Kidney J. 2019 Feb;12(1):129-138. doi: 10.1093/ckj/sfy013. Epub 2018 Mar 9.

4.

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.

O'Donoghue ML, Glaser R, Cavender MA, Aylward PE, Bonaca MP, Budaj A, Davies RY, Dellborg M, Fox KA, Gutierrez JA, Hamm C, Kiss RG, Kovar F, Kuder JF, Im KA, Lepore JJ, Lopez-Sendon JL, Ophuis TO, Parkhomenko A, Shannon JB, Spinar J, Tanguay JF, Ruda M, Steg PG, Theroux P, Wiviott SD, Laws I, Sabatine MS, Morrow DA; LATITUDE-TIMI 60 Investigators.

JAMA. 2016 Apr 19;315(15):1591-9. doi: 10.1001/jama.2016.3609.

PMID:
27043082
5.

Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction.

Lepore JJ, Olson E, Demopoulos L, Haws T, Fang Z, Barbour AM, Fossler M, Davila-Roman VG, Russell SD, Gropler RJ.

JACC Heart Fail. 2016 Jul;4(7):559-566. doi: 10.1016/j.jchf.2016.01.008. Epub 2016 Mar 30.

6.

Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia.

Holdstock L, Meadowcroft AM, Maier R, Johnson BM, Jones D, Rastogi A, Zeig S, Lepore JJ, Cobitz AR.

J Am Soc Nephrol. 2016 Apr;27(4):1234-44. doi: 10.1681/ASN.2014111139. Epub 2015 Oct 22.

7.

Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart.

Aravindhan K, Bao W, Harpel MR, Willette RN, Lepore JJ, Jucker BM.

PLoS One. 2015 Jun 22;10(6):e0130894. doi: 10.1371/journal.pone.0130894. eCollection 2015.

8.

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.

Newby LK, Marber MS, Melloni C, Sarov-Blat L, Aberle LH, Aylward PE, Cai G, de Winter RJ, Hamm CW, Heitner JF, Kim R, Lerman A, Patel MR, Tanguay JF, Lepore JJ, Al-Khalidi HR, Sprecher DL, Granger CB; SOLSTICE Investigators.

Lancet. 2014 Sep 27;384(9949):1187-95. doi: 10.1016/S0140-6736(14)60417-7. Epub 2014 Jun 12. Erratum in: Lancet. 2014 Sep 27;384(9949):1186.

PMID:
24930728
9.

Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials.

Shaddinger BC, Xu Y, Roger JH, Macphee CH, Handel M, Baidoo CA, Magee M, Lepore JJ, Sprecher DL.

PLoS One. 2014 Jan 27;9(1):e83094. doi: 10.1371/journal.pone.0083094. eCollection 2014.

10.

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.

Seo K, Rainer PP, Shalkey Hahn V, Lee DI, Jo SH, Andersen A, Liu T, Xu X, Willette RN, Lepore JJ, Marino JP Jr, Birnbaumer L, Schnackenberg CG, Kass DA.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. doi: 10.1073/pnas.1308963111. Epub 2014 Jan 22. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6115.

11.

Ephrin-B2 controls PDGFRβ internalization and signaling.

Nakayama A, Nakayama M, Turner CJ, Höing S, Lepore JJ, Adams RH.

Genes Dev. 2013 Dec 1;27(23):2576-89. doi: 10.1101/gad.224089.113.

12.

Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart.

Vagnozzi RJ, Gatto GJ Jr, Kallander LS, Hoffman NE, Mallilankaraman K, Ballard VL, Lawhorn BG, Stoy P, Philp J, Graves AP, Naito Y, Lepore JJ, Gao E, Madesh M, Force T.

Sci Transl Med. 2013 Oct 16;5(207):207ra141. doi: 10.1126/scitranslmed.3006479.

13.

Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat.

Bao W, Holt LJ, Prince RD, Jones GX, Aravindhan K, Szapacs M, Barbour AM, Jolivette LJ, Lepore JJ, Willette RN, DeAngelis E, Jucker BM.

Cardiovasc Diabetol. 2013 Oct 14;12:148. doi: 10.1186/1475-2840-12-148.

14.

Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.

Ivashchenko CY, Pipes GC, Lozinskaya IM, Lin Z, Xiaoping X, Needle S, Grygielko ET, Hu E, Toomey JR, Lepore JJ, Willette RN.

Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H913-22. doi: 10.1152/ajpheart.00819.2012. Epub 2013 Jul 5.

15.

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.

16.

Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.

Elkhawad M, Rudd JH, Sarov-Blat L, Cai G, Wells R, Davies LC, Collier DJ, Marber MS, Choudhury RP, Fayad ZA, Tawakol A, Gleeson FV, Lepore JJ, Davis B, Willette RN, Wilkinson IB, Sprecher DL, Cheriyan J.

JACC Cardiovasc Imaging. 2012 Sep;5(9):911-22. doi: 10.1016/j.jcmg.2012.02.016.

17.

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

Costell MH, Ancellin N, Bernard RE, Zhao S, Upson JJ, Morgan LA, Maniscalco K, Olzinski AR, Ballard VL, Herry K, Grondin P, Dodic N, Mirguet O, Bouillot A, Gellibert F, Coatney RW, Lepore JJ, Jucker BM, Jolivette LJ, Willette RN, Schnackenberg CG, Behm DJ.

Front Pharmacol. 2012 Jul 5;3:128. doi: 10.3389/fphar.2012.00128. eCollection 2012.

18.

Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency.

Bao W, Aravindhan K, Alsaid H, Chendrimada T, Szapacs M, Citerone DR, Harpel MR, Willette RN, Lepore JJ, Jucker BM.

PLoS One. 2011;6(8):e23570. doi: 10.1371/journal.pone.0023570. Epub 2011 Aug 26.

19.

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.

Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD Jr, Dedhar S, Parmacek MS, Gerszten RE.

Circ Res. 2011 Sep 2;109(6):616-28. doi: 10.1161/CIRCRESAHA.110.239343. Epub 2011 Jul 21.

20.

Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.

Cheriyan J, Webb AJ, Sarov-Blat L, Elkhawad M, Wallace SM, Mäki-Petäjä KM, Collier DJ, Morgan J, Fang Z, Willette RN, Lepore JJ, Cockcroft JR, Sprecher DL, Wilkinson IB.

Circulation. 2011 Feb 8;123(5):515-23. doi: 10.1161/CIRCULATIONAHA.110.971986. Epub 2011 Jan 24.

PMID:
21262998
21.

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

Bao W, Qin P, Needle S, Erickson-Miller CL, Duffy KJ, Ariazi JL, Zhao S, Olzinski AR, Behm DJ, Pipes GC, Jucker BM, Hu E, Lepore JJ, Willette RN.

J Cardiovasc Pharmacol. 2010 Aug;56(2):147-55. doi: 10.1097/FJC.0b013e3181e2bfef.

PMID:
20714241
22.

Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans.

Sarov-Blat L, Morgan JM, Fernandez P, James R, Fang Z, Hurle MR, Baidoo C, Willette RN, Lepore JJ, Jensen SE, Sprecher DL.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2256-63. doi: 10.1161/ATVBAHA.110.209205. Epub 2010 Aug 5.

PMID:
20689074
23.

Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.

Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE.

Dev Cell. 2010 Feb 16;18(2):275-87. doi: 10.1016/j.devcel.2010.01.008.

24.

BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis.

Beppu H, Malhotra R, Beppu Y, Lepore JJ, Parmacek MS, Bloch KD.

Dev Biol. 2009 Jul 15;331(2):167-75. doi: 10.1016/j.ydbio.2009.04.032. Epub 2009 May 3.

25.

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration.

Zhang Y, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo FJ, Whitsett JA, Parmacek MS, Morrisey EE.

Nat Genet. 2008 Jul;40(7):862-70. doi: 10.1038/ng.157. Epub 2008 Jun 8.

26.

Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature.

Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16275-80. Epub 2007 Oct 1.

27.

The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.

Huggins GS, Lepore JJ, Greytak S, Patten R, McNamee R, Aronovitz M, Wang PJ, Reed GL.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1877-82. Epub 2007 Jul 6.

28.

Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling.

Cohen ED, Wang Z, Lepore JJ, Lu MM, Taketo MM, Epstein DJ, Morrisey EE.

J Clin Invest. 2007 Jul;117(7):1794-804.

29.

Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure.

Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, Systrom DM, Bloch KD, Semigran MJ.

Circulation. 2007 Jan 2;115(1):59-66. Epub 2006 Dec 18.

PMID:
17179022
30.

Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML.

Dev Cell. 2006 Dec;11(6):845-57.

31.

Impaired notch signaling promotes de novo squamous cell carcinoma formation.

Proweller A, Tu L, Lepore JJ, Cheng L, Lu MM, Seykora J, Millar SE, Pear WS, Parmacek MS.

Cancer Res. 2006 Aug 1;66(15):7438-44.

32.

GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis.

Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS.

J Clin Invest. 2006 Apr;116(4):929-39. Epub 2006 Mar 23.

33.

Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients.

Lepore JJ, Dec GW, Zapol WM, Bloch KD, Semigran MJ.

J Heart Lung Transplant. 2005 Nov;24(11):1950-6. Epub 2005 Aug 31.

PMID:
16297803
34.

Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide.

Lepore JJ, Maroo A, Bigatello LM, Dec GW, Zapol WM, Bloch KD, Semigran MJ.

Chest. 2005 May;127(5):1647-53.

PMID:
15888841
35.

MRL mice fail to heal the heart in response to ischemia-reperfusion injury.

Abdullah I, Lepore JJ, Epstein JA, Parmacek MS, Gruber PJ.

Wound Repair Regen. 2005 Mar-Apr;13(2):205-8.

PMID:
15828946
36.

High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice.

Lepore JJ, Cheng L, Min Lu M, Mericko PA, Morrisey EE, Parmacek MS.

Genesis. 2005 Apr;41(4):179-84.

PMID:
15789423
37.

GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells.

Lepore JJ, Cappola TP, Mericko PA, Morrisey EE, Parmacek MS.

Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):309-14. Epub 2004 Dec 9.

PMID:
15591218
38.

Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression.

Horwitz PA, Tsai EJ, Putt ME, Gilmore JM, Lepore JJ, Parmacek MS, Kao AC, Desai SS, Goldberg LR, Brozena SC, Jessup ML, Epstein JA, Cappola TP.

Circulation. 2004 Dec 21;110(25):3815-21. Epub 2004 Dec 6.

PMID:
15583081
39.

Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock.

Inglessis I, Shin JT, Lepore JJ, Palacios IF, Zapol WM, Bloch KD, Semigran MJ.

J Am Coll Cardiol. 2004 Aug 18;44(4):793-8.

40.

Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells.

Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS.

J Biol Chem. 2004 Apr 23;279(17):17578-86. Epub 2004 Feb 17.

41.
42.

Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop.

Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA.

J Clin Invest. 2003 Sep;112(6):863-71.

43.

Adenovirus-catheter compatibility increases gene expression after delivery to porcine myocardium.

Naimark WA, Lepore JJ, Klugherz BD, Wang Z, Guy TS, Osman H, Moainie SL, Gorman RC, Reed G, Gorman JH 3rd, Palasis M, Parmacek MS, Wilensky RL.

Hum Gene Ther. 2003 Jan 20;14(2):161-6.

PMID:
12614567
44.

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML.

Science. 2003 Jan 10;299(5604):247-51.

45.

Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension.

Lepore JJ, Maroo A, Pereira NL, Ginns LC, Dec GW, Zapol WM, Bloch KD, Semigran MJ.

Am J Cardiol. 2002 Sep 15;90(6):677-80. No abstract available.

PMID:
12231108
46.

Oxygen therapy improves cardiac index and pulmonary vascular resistance in patients with pulmonary hypertension.

Roberts DH, Lepore JJ, Maroo A, Semigran MJ, Ginns LC.

Chest. 2001 Nov;120(5):1547-55.

PMID:
11713133
48.

Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17.

Bloch KD, Wolfram JR, Brown DM, Roberts JD Jr, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Jacob HJ, Bloch DB.

Genomics. 1995 Jun 10;27(3):526-30.

PMID:
7558036
49.

Ketocholanic acids as an adjunct in management of high fat diet allergies.

LEPORE JJ.

Am J Dig Dis. 1955 Nov;22(11):318-9. No abstract available.

PMID:
13268386
50.

Suprarenal hemorrhage in pregnancy; report of a case with a review of the literature.

ARNOLD G, RICHER AG, LEPORE JJ.

N Engl J Med. 1949 Jun 30;240(26):1040-3. No abstract available.

PMID:
18152490

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