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Items: 1 to 50 of 56


New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity.

Bisetto S, Wright MC, Nowak RA, Lepore AC, Khurana TS, Loro E, Philp NJ.

iScience. 2019 Dec 20;22:507-518. doi: 10.1016/j.isci.2019.11.041. Epub 2019 Nov 26.


AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury.

Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S, Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC.

FASEB J. 2019 Dec;33(12):13775-13793. doi: 10.1096/fj.201901730R. Epub 2019 Oct 2.


Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.

Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA.

Brain Struct Funct. 2019 Nov;224(8):2983-2999. doi: 10.1007/s00429-019-01949-y. Epub 2019 Sep 4.


Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury.

Urban MW, Ghosh B, Block CG, Strojny LR, Charsar BA, Goulão M, Komaravolu SS, Smith GM, Wright MC, Li S, Lepore AC.

eNeuro. 2019 Sep 26;6(5). pii: ENEURO.0096-19.2019. doi: 10.1523/ENEURO.0096-19.2019. Print 2019 Sep/Oct.


Protein Tyrosine Phosphatase σ Inhibitory Peptide Promotes Recovery of Diaphragm Function and Sprouting of Bulbospinal Respiratory Axons after Cervical Spinal Cord Injury.

Urban MW, Ghosh B, Block CG, Charsar BA, Smith GM, Wright MC, Li S, Lepore AC.

J Neurotrauma. 2020 Feb 1;37(3):572-579. doi: 10.1089/neu.2019.6586. Epub 2019 Sep 18.


A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function.

Ghosh B, Nong J, Wang Z, Urban MW, Heinsinger NM, Trovillion VA, Wright MC, Lepore AC, Zhong Y.

Neurobiol Dis. 2019 Jul;127:591-604. doi: 10.1016/j.nbd.2019.04.014. Epub 2019 Apr 25.


Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury.

Goulão M, Ghosh B, Urban MW, Sahu M, Mercogliano C, Charsar BA, Komaravolu S, Block CG, Smith GM, Wright MC, Lepore AC.

Glia. 2019 Mar;67(3):452-466. doi: 10.1002/glia.23555. Epub 2018 Dec 11.


Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function.

Ghosh B, Wang Z, Nong J, Urban MW, Zhang Z, Trovillion VA, Wright MC, Zhong Y, Lepore AC.

J Neurosci. 2018 Jun 27;38(26):5982-5995. doi: 10.1523/JNEUROSCI.3084-17.2018. Epub 2018 Jun 11.


Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.

Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M.

J Neurosci. 2018 Apr 11;38(15):3729-3740. doi: 10.1523/JNEUROSCI.3212-17.2018. Epub 2018 Mar 14.


Differential Response in Novel Stem Cell Niches of the Brain after Cervical Spinal Cord Injury and Traumatic Brain Injury.

Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC.

J Neurotrauma. 2018 Sep 15;35(18):2195-2207. doi: 10.1089/neu.2017.5497. Epub 2018 Jun 7.


Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI.

Urban MW, Ghosh B, Strojny LR, Block CG, Blazejewski SM, Wright MC, Smith GM, Lepore AC.

Exp Neurol. 2018 May;303:108-119. doi: 10.1016/j.expneurol.2018.02.007. Epub 2018 Feb 14.


Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair.

Gomes ED, Mendes SS, Assunção-Silva RC, Teixeira FG, Pires AO, Anjo SI, Manadas B, Leite-Almeida H, Gimble JM, Sousa N, Lepore AC, Silva NA, Salgado AJ.

Stem Cells. 2018 May;36(5):696-708. doi: 10.1002/stem.2785. Epub 2018 Feb 5.


Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons.

Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M.

J Neurosci. 2017 Aug 23;37(34):8256-8272. doi: 10.1523/JNEUROSCI.0434-17.2017. Epub 2017 Jul 27.


Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.

Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D.

Exp Neurol. 2017 Jun;292:145-153. doi: 10.1016/j.expneurol.2017.03.014. Epub 2017 Mar 22.


MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons.

Tymanskyj SR, Yang B, Falnikar A, Lepore AC, Ma L.

J Neurosci. 2017 Feb 8;37(6):1648-1661. doi: 10.1523/JNEUROSCI.3260-16.2017. Epub 2017 Jan 9.


Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury.

Lane MA, Lepore AC, Fischer I.

Expert Rev Neurother. 2017 May;17(5):433-440. doi: 10.1080/14737175.2017.1270206. Epub 2016 Dec 21. Review.


Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury.

Charsar BA, Urban MW, Lepore AC.

Exp Neurol. 2017 Jan;287(Pt 2):268-275. doi: 10.1016/j.expneurol.2016.08.009. Epub 2016 Aug 13. Review.


Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease.

Hazra A, Corbett BF, You JC, Aschmies S, Zhao L, Li K, Lepore AC, Marsh ED, Chin J.

Neurobiol Aging. 2016 Aug;44:96-107. doi: 10.1016/j.neurobiolaging.2016.04.016. Epub 2016 Apr 29.


Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury.

Li K, Javed E, Scura D, Hala TJ, Seetharam S, Falnikar A, Richard JP, Chorath A, Maragakis NJ, Wright MC, Lepore AC.

Exp Neurol. 2015 Sep;271:479-92. doi: 10.1016/j.expneurol.2015.07.020. Epub 2015 Jul 26.


iPS cell transplantation for traumatic spinal cord injury.

Goulão M, Lepore AC.

Curr Stem Cell Res Ther. 2016;11(4):321-8. Review.


Functional and morphological assessment of diaphragm innervation by phrenic motor neurons.

Martin M, Li K, Wright MC, Lepore AC.

J Vis Exp. 2015 May 25;(99):e52605. doi: 10.3791/52605.


Kv3.4 channel function and dysfunction in nociceptors.

Ritter DM, Zemel BM, Lepore AC, Covarrubias M.

Channels (Austin). 2015;9(4):209-17. doi: 10.1080/19336950.2015.1056949. Epub 2015 Jun 3.


GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease.

Li K, Hala TJ, Seetharam S, Poulsen DJ, Wright MC, Lepore AC.

Neurobiol Dis. 2015 Jun;78:12-23. doi: 10.1016/j.nbd.2015.03.010. Epub 2015 Mar 25.


Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury.

Nicaise C, Mitrecic D, Falnikar A, Lepore AC.

World J Stem Cells. 2015 Mar 26;7(2):380-98. doi: 10.4252/wjsc.v7.i2.380. Review.


Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury.

Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M.

J Neurosci. 2015 Jan 21;35(3):1260-73. doi: 10.1523/JNEUROSCI.1594-14.2015.


Inhibiting drug efflux transporters improves efficacy of ALS therapeutics.

Jablonski MR, Markandaiah SS, Jacob D, Meng NJ, Li K, Gennaro V, Lepore AC, Trotti D, Pasinelli P.

Ann Clin Transl Neurol. 2014 Dec;1(12):996-1005. doi: 10.1002/acn3.141. Epub 2014 Nov 21.


Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI.

Li K, Javed E, Hala TJ, Sannie D, Regan KA, Maragakis NJ, Wright MC, Poulsen DJ, Lepore AC.

Mol Ther. 2015 Mar;23(3):533-48. doi: 10.1038/mt.2014.236. Epub 2014 Dec 10.


Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury.

Watson JL, Hala TJ, Putatunda R, Sannie D, Lepore AC.

PLoS One. 2014 Sep 30;9(9):e109099. doi: 10.1371/journal.pone.0109099. eCollection 2014.


Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury.

Falnikar A, Li K, Lepore AC.

Brain Res. 2015 Sep 4;1619:91-103. doi: 10.1016/j.brainres.2014.09.037. Epub 2014 Sep 22. Review.


Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells.

Allard J, Li K, Lopez XM, Blanchard S, Barbot P, Rorive S, Decaestecker C, Pochet R, Bohl D, Lepore AC, Salmon I, Nicaise C.

Regen Med. 2014;9(4):437-52. doi: 10.2217/rme.14.26.


Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.

Li K, Nicaise C, Sannie D, Hala TJ, Javed E, Parker JL, Putatunda R, Regan KA, Suain V, Brion JP, Rhoderick F, Wright MC, Poulsen DJ, Lepore AC.

J Neurosci. 2014 May 28;34(22):7622-38. doi: 10.1523/JNEUROSCI.4690-13.2014.


Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion.

Nicaise C, Frank DM, Hala TJ, Authelet M, Pochet R, Adriaens D, Brion JP, Wright MC, Lepore AC.

J Neurotrauma. 2013 Jun 15;30(12):1092-9. doi: 10.1089/neu.2012.2728.


Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice.

Nicaise C, Putatunda R, Hala TJ, Regan KA, Frank DM, Brion JP, Leroy K, Pochet R, Wright MC, Lepore AC.

J Neurotrauma. 2012 Dec 10;29(18):2748-60. doi: 10.1089/neu.2012.2467. Epub 2012 Nov 23.


Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury.

Nicaise C, Hala TJ, Frank DM, Parker JL, Authelet M, Leroy K, Brion JP, Wright MC, Lepore AC.

Exp Neurol. 2012 Jun;235(2):539-52. doi: 10.1016/j.expneurol.2012.03.007. Epub 2012 Mar 23.


Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.

Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ.

PLoS One. 2011;6(10):e25968. doi: 10.1371/journal.pone.0025968. Epub 2011 Oct 5.


Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

Papadeas ST, Kraig SE, O'Banion C, Lepore AC, Maragakis NJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17803-8. doi: 10.1073/pnas.1103141108. Epub 2011 Oct 3.


Stem cell transplantation for spinal cord neurodegeneration.

Lepore AC, Maragakis NJ.

Methods Mol Biol. 2011;793:479-93. doi: 10.1007/978-1-61779-328-8_31.


Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury.

Lepore AC, O'Donnell J, Kim AS, Yang EJ, Tuteja A, Haidet-Phillips A, O'Banion CP, Maragakis NJ.

Glia. 2011 Dec;59(12):1996-2005. doi: 10.1002/glia.21241. Epub 2011 Aug 31.


Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.

Lepore AC, O'Donnell J, Bonner JF, Paul C, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ.

J Neurosci Res. 2011 Jul;89(7):1001-17. doi: 10.1002/jnr.22624. Epub 2011 Apr 12.


Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats.

Lepore AC, Tolmie C, O'Donnell J, Wright MC, Dejea C, Rauck B, Hoke A, Ignagni AR, Onders RP, Maragakis NJ.

Neurobiol Dis. 2010 Sep;39(3):252-64. doi: 10.1016/j.nbd.2010.03.021. Epub 2010 Apr 8.


Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease.

Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, Maragakis NJ.

Nat Neurosci. 2008 Nov;11(11):1294-301. doi: 10.1038/nn.2210. Epub 2008 Oct 19.


Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration.

Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ.

Exp Neurol. 2008 Jun;211(2):423-32. doi: 10.1016/j.expneurol.2008.02.020. Epub 2008 Mar 7.


Adult glial precursor proliferation in mutant SOD1G93A mice.

Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ.

Glia. 2008 Jan 15;56(2):200-8.


Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS.

Lepore AC, Haenggeli C, Gasmi M, Bishop KM, Bartus RT, Maragakis NJ, Rothstein JD.

Brain Res. 2007 Dec 14;1185:256-65. Epub 2007 Sep 22.


Long-term fate of neural precursor cells following transplantation into developing and adult CNS.

Lepore AC, Neuhuber B, Connors TM, Han SS, Liu Y, Daniels MP, Rao MS, Fischer I.

Neuroscience. 2006 Sep 29;142(1):287-304.


Targeted stem cell transplantation strategies in ALS.

Lepore AC, Maragakis NJ.

Neurochem Int. 2007 Jun;50(7-8):966-75. Epub 2006 Oct 20. Review.


MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord.

Lepore AC, Walczak P, Rao MS, Fischer I, Bulte JW.

Exp Neurol. 2006 Sep;201(1):49-59. Epub 2006 Jun 9.


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