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Items: 19


Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.

Li XY, Moesta AK, Xiao C, Nakamura K, Casey M, Zhang H, Madore J, Lepletier A, Aguilera AR, Sundarrajan A, Jacoberger-Foissac C, Wong C, Dela Cruz T, Welch M, Lerner AG, Spatola BN, Soros VB, Corbin J, Anderson AC, Effern M, Hölzel M, Robson SC, Johnston RL, Waddell N, Smith C, Bald T, Geetha N, Beers C, Teng MWL, Smyth MJ.

Cancer Discov. 2019 Dec;9(12):1754-1773. doi: 10.1158/2159-8290.CD-19-0541. Epub 2019 Nov 7.


Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging.

Lepletier A, Hun ML, Hammett MV, Wong K, Naeem H, Hedger M, Loveland K, Chidgey AP.

Cell Rep. 2019 Jun 25;27(13):3887-3901.e4. doi: 10.1016/j.celrep.2019.05.045.


CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function.

Mittal D, Lepletier A, Madore J, Aguilera AR, Stannard K, Blake SJ, Whitehall VLJ, Liu C, Bettington ML, Takeda K, Long GV, Scolyer RA, Lan R, Siemers N, Korman A, Teng MWL, Johnston RJ, Dougall WC, Smyth MJ.

Cancer Immunol Res. 2019 Apr;7(4):559-571. doi: 10.1158/2326-6066.CIR-18-0637. Epub 2019 Mar 20.


The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells.

Lepletier A, Lutzky VP, Mittal D, Stannard K, Watkins TS, Ratnatunga CN, Smith C, McGuire HM, Kemp RA, Mukhopadhyay P, Waddell N, Smyth MJ, Dougall WC, Miles JJ.

Immunol Cell Biol. 2019 Feb;97(2):152-164. doi: 10.1111/imcb.12205. Epub 2018 Oct 17.


Lack of Galectin-3 Disrupts Thymus Homeostasis in Association to Increase of Local and Systemic Glucocorticoid Levels and Steroidogenic Machinery.

Oliveira-de-Abreu E, Silva-Dos-Santos D, Lepletier A, Ramos TDP, Ferreira-Reis R, Vasconcelos-Fontes L, Ramos MT, Torres RC, Cotta-de-Almeida V, Carvalho VF, Villa-Verde DMS.

Front Endocrinol (Lausanne). 2018 Jul 10;9:365. doi: 10.3389/fendo.2018.00365. eCollection 2018.


CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms.

Li XY, Das I, Lepletier A, Addala V, Bald T, Stannard K, Barkauskas D, Liu J, Aguilera AR, Takeda K, Braun M, Nakamura K, Jacquelin S, Lane SW, Teng MW, Dougall WC, Smyth MJ.

J Clin Invest. 2018 Jun 1;128(6):2613-2625. doi: 10.1172/JCI98769. Epub 2018 May 14.


Small interference ITGA6 gene targeting in the human thymic epithelium differentially regulates the expression of immunological synapse-related genes.

Golbert DCF, Santana-Van-Vliet E, Ribeiro-Alves M, Fonsêca MMBD, Lepletier A, Mendes-da-Cruz DA, Loss G, Cotta-de-Almeida V, Vasconcelos ATR, Savino W.

Cell Adh Migr. 2018 Mar 4;12(2):152-167. doi: 10.1080/19336918.2017.1327513. Epub 2017 Aug 30.


Inflammation and Thymus Ageing.

Lepletier A, Alsharif A, Chidgey AP.

Front Horm Res. 2017;48:19-36. doi: 10.1159/000452903. Epub 2017 Feb 28. Review.


A novel Foxn1eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations.

Barsanti M, Lim JM, Hun ML, Lister N, Wong K, Hammett MV, Lepletier A, Boyd RL, Giudice A, Chidgey AP.

Eur J Immunol. 2017 Feb;47(2):291-304. doi: 10.1002/eji.201646553. Epub 2016 Dec 7.


Hormonal control of T-cell development in health and disease.

Savino W, Mendes-da-Cruz DA, Lepletier A, Dardenne M.

Nat Rev Endocrinol. 2016 Feb;12(2):77-89. doi: 10.1038/nrendo.2015.168. Epub 2015 Oct 6. Review.


Perspectives for Improvement of the Thymic Microenvironment through Manipulation of Thymic Epithelial Cells: A Mini-Review.

Lepletier A, Chidgey AP, Savino W.

Gerontology. 2015;61(6):504-14. doi: 10.1159/000375160. Epub 2015 Mar 10. Review.


Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease.

Lepletier A, de Almeida L, Santos L, da Silva Sampaio L, Paredes B, González FB, Freire-de-Lima CG, Beloscar J, Bottasso O, Einicker-Lamas M, Pérez AR, Savino W, Morrot A.

PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3203. doi: 10.1371/journal.pntd.0003203. eCollection 2014 Oct.


Trypanosoma cruzi disrupts thymic homeostasis by altering intrathymic and systemic stress-related endocrine circuitries.

Lepletier A, de Carvalho VF, Rodrigues e Silva PM, Villar S, Pérez AR, Savino W, Morrot A.

PLoS Negl Trop Dis. 2013 Nov 14;7(11):e2470. doi: 10.1371/journal.pntd.0002470. eCollection 2013 Nov.


Tumor necrosis factor-α regulates glucocorticoid synthesis in the adrenal glands of Trypanosoma cruzi acutely-infected mice. the role of TNF-R1.

Villar SR, Ronco MT, Fernández Bussy R, Roggero E, Lepletier A, Manarin R, Savino W, Pérez AR, Bottasso O.

PLoS One. 2013 May 22;8(5):e63814. doi: 10.1371/journal.pone.0063814. Print 2013.


Thymic atrophy in acute experimental Chagas disease is associated with an imbalance of stress hormones.

Lepletier A, de Frias Carvalho V, Morrot A, Savino W.

Ann N Y Acad Sci. 2012 Jul;1262:45-50. doi: 10.1111/j.1749-6632.2012.06601.x. Review.


TNF-α is involved in the abnormal thymocyte migration during experimental Trypanosoma cruzi infection and favors the export of immature cells.

Pérez AR, Berbert LR, Lepletier A, Revelli S, Bottasso O, Silva-Barbosa SD, Savino W.

PLoS One. 2012;7(3):e34360. doi: 10.1371/journal.pone.0034360. Epub 2012 Mar 26.


Oestrogenic influence on brain AT1 receptor signalling on the thirst and sodium appetite in osmotically stimulated and sodium-depleted female rats.

Mecawi AS, Lepletier A, Araujo IG, Fonseca FV, Reis LC.

Exp Physiol. 2008 Aug;93(8):1002-10. doi: 10.1113/expphysiol.2008.042713. Epub 2008 Apr 25.


Assessment of brain AT1-receptor on the nocturnal basal and angiotensin-induced thirst and sodium appetite in ovariectomised rats.

Mecawi AS, Lepletier A, Araujo IG, Olivares EL, Reis LC.

J Renin Angiotensin Aldosterone Syst. 2007 Dec;8(4):169-75. doi: 10.3317/jraas.2007.032.


Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats.

Cedraz-Mercez PL, Mecawi AS, Lepletier A, Araújo IG, Costa-e-Sousa RH, Rocha FF, Olivares EL, Medeiros MA, Reis LC.

Exp Physiol. 2007 Sep;92(5):923-31. Epub 2007 Jun 25.

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