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Items: 29


Evaluation of inflammatory skin infiltrate following Aedes aegypti bites in sensitized and non-sensitized mice reveals saliva-dependent and immune-dependent phenotypes.

Henrique MO, Neto LS, Assis JB, Barros MS, Capurro ML, Lepique AP, Fonseca DM, Sá-Nunes A.

Immunology. 2019 Sep;158(1):47-59. doi: 10.1111/imm.13096.


Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population.

Silveira CRF, Cipelli M, Manzine C, Rabelo-Santos SH, Zeferino LC, Rodríguez Rodríguez G, de Assis JB, Hebster S, Bernadinelli I, Laginha F, Boccardo E, Villa LL, Termini L, Lepique AP.

PLoS One. 2019 Mar 6;14(3):e0213184. doi: 10.1371/journal.pone.0213184. eCollection 2019.


Lactate secreted by cervical cancer cells modulates macrophage phenotype.

Stone SC, Rossetti RAM, Alvarez KLF, Carvalho JP, Margarido PFR, Baracat EC, Tacla M, Boccardo E, Yokochi K, Lorenzi NP, Lepique AP.

J Leukoc Biol. 2019 May;105(5):1041-1054. doi: 10.1002/JLB.3A0718-274RR. Epub 2019 Feb 27.


HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS.

Cabeça TK, de Mello Abreu A, Andrette R, de Souza Lino V, Morale MG, Aguayo F, Termini L, Villa LL, Lepique AP, Boccardo E.

Int J Mol Sci. 2019 Jan 8;20(1). pii: E198. doi: 10.3390/ijms20010198.


B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.

Rossetti RAM, Lorenzi NPC, Yokochi K, Rosa MBSF, Benevides L, Margarido PFR, Baracat EC, Carvalho JP, Villa LL, Lepique AP.

PLoS One. 2018 Jul 5;13(7):e0199034. doi: 10.1371/journal.pone.0199034. eCollection 2018.


Platelet-Activating Factor Receptor Ligands Protect Tumor Cells from Radiation-Induced Cell Death.

da Silva-Junior IA, Dalmaso B, Herbster S, Lepique AP, Jancar S.

Front Oncol. 2018 Feb 5;8:10. doi: 10.3389/fonc.2018.00010. eCollection 2018.


Modulation of Tumor-Associated Macrophages (TAM) Phenotype by Platelet-Activating Factor (PAF) Receptor.

da Silva Junior IA, Stone SC, Rossetti RM, Jancar S, Lepique AP.

J Immunol Res. 2017;2017:5482768. doi: 10.1155/2017/5482768. Epub 2017 Dec 27.


Local and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils.

Alvarez KLF, Beldi M, Sarmanho F, Rossetti RAM, Silveira CRF, Mota GR, Andreoli MA, Caruso EDC, Kamillos MF, Souza AM, Mastrocalla H, Clavijo-Salomon MA, Barbuto JAM, Lorenzi NP, Longatto-Filho A, Baracat E, Lopez RVM, Villa LL, Tacla M, Lepique AP.

Sci Rep. 2017 Aug 21;7(1):9002. doi: 10.1038/s41598-017-09079-3.


Editorial: Macrophages Role in Integrating Tissue Signals and Biological Processes in Chronic Inflammation and Fibrosis.

Braga TT, Moura IC, Lepique AP, Camara NOS.

Front Immunol. 2017 Jul 21;8:845. doi: 10.3389/fimmu.2017.00845. eCollection 2017. No abstract available.


Platelet-activating factor (PAF) receptor as a promising target for cancer cell repopulation after radiotherapy.

da Silva IA Jr, Chammas R, Lepique AP, Jancar S.

Oncogenesis. 2017 Jan 30;6(1):e296. doi: 10.1038/oncsis.2016.90.


Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB/c and BALB/c nude mice.

Teixeira PC, Velasquez LG, Lepique AP, de Rezende E, Bonatto JM, Barcinski MA, Cunha-Neto E, Stolf BS.

PLoS Negl Trop Dis. 2015 Feb 18;9(2):e0003411. doi: 10.1371/journal.pntd.0003411. eCollection 2015 Feb.


Interferon regulatory factor (IRF)-1 is a master regulator of the cross talk between macrophages and L929 fibrosarcoma cells for nitric oxide dependent tumoricidal activity.

Nascimento FR, Gomes EA, Russo M, Lepique AP.

PLoS One. 2015 Feb 6;10(2):e0117782. doi: 10.1371/journal.pone.0117782. eCollection 2015.


Cancer research in Brazil - stuck in second gear?

Lepique AP, Bonorino C.

Braz J Med Biol Res. 2015 Feb;48(2):108-10. doi: 10.1590/1414-431X20144234. Epub 2015 Jan 13.


HPV associated tumor cells control tumor microenvironment and leukocytosis in experimental models.

Stone SC, Rossetti RA, Lima AM, Lepique AP.

Immun Inflamm Dis. 2014 Aug;2(2):63-75. doi: 10.1002/iid3.21. Epub 2014 May 18.


HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells.

Stone SC, Rossetti RA, Bolpetti A, Boccardo E, Souza PS, Lepique AP.

J Leukoc Biol. 2014 Oct;96(4):619-31. doi: 10.1189/jlb.3A0513-282R. Epub 2014 Jun 26.


Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.

Faustino L, Fonseca DM, Florsheim EB, Resende RR, Lepique AP, Faquim-Mauro E, Gomes E, Silva JS, Yagita H, Russo M.

Mucosal Immunol. 2014 Sep;7(5):1199-208. doi: 10.1038/mi.2014.9. Epub 2014 Feb 26.


Lymphocyte differentiation and effector functions.

Olsen Saraiva Camara N, Lepique AP, Basso AS.

Clin Dev Immunol. 2012;2012:510603. doi: 10.1155/2012/510603. Epub 2012 Dec 3. No abstract available.


Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected].

Moraes-Vieira PM, Bassi EJ, Larocca RA, Castoldi A, Burghos M, Lepique AP, Quintana FJ, Araujo RC, Basso AS, Strom TB, Câmara NO.

Am J Transplant. 2013 Jan;13(1):36-44. doi: 10.1111/j.1600-6143.2012.04283.x. Epub 2012 Sep 27. Erratum in: Am J Transplant. 2013 Aug;13(8):2231.


Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible protein 1 with the prion protein.

Santos TG, Silva IR, Costa-Silva B, Lepique AP, Martins VR, Lopes MH.

Stem Cells. 2011 Jul;29(7):1126-36. doi: 10.1002/stem.664.


The role of inflammation in HPV carcinogenesis.

Boccardo E, Lepique AP, Villa LL.

Carcinogenesis. 2010 Nov;31(11):1905-12. doi: 10.1093/carcin/bgq176. Epub 2010 Sep 5. Review.


Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth.

Bolpetti A, Silva JS, Villa LL, Lepique AP.

BMC Immunol. 2010 Jun 7;11:27. doi: 10.1186/1471-2172-11-27.


HPV16 tumor associated macrophages suppress antitumor T cell responses.

Lepique AP, Daghastanli KR, Cuccovia IM, Villa LL.

Clin Cancer Res. 2009 Jul 1;15(13):4391-400. doi: 10.1158/1078-0432.CCR-09-0489. Epub 2009 Jun 23.


HPV vaccination: the beginning of the end of cervical cancer? - A Review.

Lepique AP, Rabachini T, Villa LL.

Mem Inst Oswaldo Cruz. 2009 Feb;104(1):1-10. Review.


c-Myc protein is stabilized by fibroblast growth factor 2 and destabilized by ACTH to control cell cycle in mouse Y1 adrenocortical cells.

Lepique AP, Moraes MS, Rocha KM, Eichler CB, Hajj GN, Schwindt TT, Armelin HA.

J Mol Endocrinol. 2004 Dec;33(3):623-38.


Deconstructing the molecular mechanisms of cell cycle control in a mouse adrenocortical cell line: roles of ACTH.

Rocha KM, Forti FL, Lepique AP, Armelin HA.

Microsc Res Tech. 2003 Jun 15;61(3):268-74. Review.


Signal transduction in G0/G1-arrested mouse Y1 adrenocortical cells stimulated by ACTH and FGF2.

Lepique AP, Forti FL, Moraes MS, Armelin HA.

Endocr Res. 2000 Nov;26(4):825-32.


Proliferative signaling initiated in ACTH receptors.

Lotfi CF, Lepique AP, Forti FL, Schwindt TT, Eichler CB, Santos MO, Rebustini IT, Hajj GN, Juliano L, Armelin HA.

Braz J Med Biol Res. 2000 Oct;33(10):1133-40. Review.


Regulation of growth by ACTH in the Y-1 line of mouse adrenocortical cells.

Armelin HA, Lotfi CF, Lepique AP.

Endocr Res. 1996 Nov;22(4):373-83.


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