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Items: 44


The lipid raft protein NTAL participates in AKT signaling in mantle cell lymphoma.

Ferreira GA, Thomé CH, Simão AMS, Scheucher PS, Silva CLA, Chahud F, Ciancaglini P, Leopoldino AM, Rego EM, Faça VM, Dos Santos GA.

Leuk Lymphoma. 2019 May 7:1-11. doi: 10.1080/10428194.2019.1607326. [Epub ahead of print]


Generation of integration-free induced pluripotent stem cells from blood-derived cells isolated from patient with severe haemophilia A.

Ferreira AF, Ferreira FU, Costa PNMD, Catelli LF, Favarin Macedo MDC, Santos TPMD, Leopoldino AM, Picanço-Castro V, Kashima S, Covas DT.

Haemophilia. 2019 May;25(3):e195-e199. doi: 10.1111/hae.13716. Epub 2019 Mar 13. No abstract available.


SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy.

Ouchida AT, Uyemura VT, Queiroz AL, Brauer VS, Cavalcanti-Neto MP, Sousa LO, Uyemura SA, Curti C, Leopoldino AM.

Biochim Biophys Acta Mol Cell Res. 2019 Apr;1866(4):623-637. doi: 10.1016/j.bbamcr.2019.01.005. Epub 2019 Jan 16.


Cytotoxicity of Structurally Diverse Anthranoids and Correlation with Mechanism of Action and Side Effects.

Demarque DP, Silva RMP, Santos LF, Leopoldino AM, Espreafico EM, Lopes NP.

J Pharm Pharm Sci. 2018;21(1):347-353. doi: 10.18433/jpps30077.


Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma.

Araujo LF, Siena ADD, Plaça JR, Brotto DB, Barros II, Muys BR, Biagi CAO Jr, Peronni KC, Sousa JF, Molfetta GA, West LC, West AP, Leopoldino AM, Espreafico EM, Silva WA Jr.

Sci Rep. 2018 Sep 21;8(1):14190. doi: 10.1038/s41598-018-31170-6.


Differentially expressed proteins in positive versus negative HNSCC lymph nodes.

Vidotto A, Polachini GM, de Paula-Silva M, Oliani SM, Henrique T, López RVM, Cury PM, Nunes FD, Góis-Filho JF, de Carvalho MB, Leopoldino AM, Tajara EH.

BMC Med Genomics. 2018 Aug 29;11(1):73. doi: 10.1186/s12920-018-0382-6.


TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.

Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S.

Autophagy. 2018;14(6):942-957. doi: 10.1080/15548627.2018.1429875. Epub 2018 Mar 11.


Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma.

Goto RN, Sobral LM, Sousa LO, Garcia CB, Lopes NP, Marín-Prida J, Ochoa-Rodríguez E, Verdecia-Reyes Y, Pardo-Andreu GL, Curti C, Leopoldino AM.

Eur J Pharmacol. 2018 Jan 15;819:198-206. doi: 10.1016/j.ejphar.2017.12.009. Epub 2017 Dec 6.


Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats.

Brasilino MDS, Stringhetta-Garcia CT, Pereira CS, Pereira AAF, Stringhetta K, Leopoldino AM, Crivelini MM, Ervolino E, Dornelles RCM, de Melo Stevanato Nakamune AC, Chaves-Neto AH.

Clin Oral Investig. 2018 Apr;22(3):1449-1461. doi: 10.1007/s00784-017-2249-1. Epub 2017 Oct 14.


Pre-culture in endothelial growth medium enhances the angiogenic properties of adipose-derived stem/stromal cells.

Souza LEB, Beckenkamp LR, Sobral LM, Fantacini DMC, Melo FUF, Borges JS, Leopoldino AM, Kashima S, Covas DT.

Angiogenesis. 2018 Feb;21(1):15-22. doi: 10.1007/s10456-017-9579-0. Epub 2017 Oct 7.


Relevance of CCL3/CCR5 axis in oral carcinogenesis.

da Silva JM, Moreira Dos Santos TP, Sobral LM, Queiroz-Junior CM, Rachid MA, Proudfoot AEI, Garlet GP, Batista AC, Teixeira MM, Leopoldino AM, Russo RC, Silva TA.

Oncotarget. 2017 Apr 6;8(31):51024-51036. doi: 10.18632/oncotarget.16882. eCollection 2017 Aug 1.


llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause.

Pereira CS, Stringhetta-Garcia CT, da Silva Xavier L, Tirapeli KG, Pereira AAF, Kayahara GM, Tramarim JM, Crivelini MM, Padovani KS, Leopoldino AM, Louzada MJQ, Belló-Klein A, Llesuy SF, Ervolino E, Dornelles RCM, Chaves-Neto AH, Nakamune ACMS.

Exp Gerontol. 2017 Nov;98:148-152. doi: 10.1016/j.exger.2017.07.006. Epub 2017 Jul 21.


SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line.

Sobral LM, Coletta RD, Alberici LC, Curti C, Leopoldino AM.

FEBS J. 2017 Sep;284(17):2774-2785. doi: 10.1111/febs.14148. Epub 2017 Jul 17.


SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation.

Almeida LO, Neto MPC, Sousa LO, Tannous MA, Curti C, Leopoldino AM.

Oncotarget. 2017 Apr 18;8(16):26802-26818. doi: 10.18632/oncotarget.15818.


ANXA1Ac2-26 peptide, a possible therapeutic approach in inflammatory ocular diseases.

Cardin LT, Sonehara NM, Mimura KK, Ramos Dinarte Dos Santos A, da Silva WA Junior, Sobral LM, Leopoldino AM, da Cunha BR, Tajara EH, Oliani SM, Rodrigues-Lisoni FC.

Gene. 2017 May 30;614:26-36. doi: 10.1016/j.gene.2017.02.032. Epub 2017 Feb 28.


Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma.

Sousa LO, Sobral LM, Matsumoto CS, Saggioro FP, López RV, Panepucci RA, Curti C, Silva WA Jr, Greene LJ, Leopoldino AM.

BBA Clin. 2016 Nov 5;6:159-164. eCollection 2016 Dec.


PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.

Matsumoto CS, Almeida LO, Guimarães DM, Martins MD, Papagerakis P, Papagerakis S, Leopoldino AM, Castilho RM, Squarize CH.

Oncotarget. 2016 Jul 5;7(27):42393-42407. doi: 10.18632/oncotarget.9877.


Topical Skin Cancer Therapy Using Doxorubicin-Loaded Cationic Lipid Nanoparticles and lontophoresis.

Huber LA, Pereira TA, Ramos DN, Rezende LC, Emery FS, Sobral LM, Leopoldino AM, Lopez RF.

J Biomed Nanotechnol. 2015 Nov;11(11):1975-88.


Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.

Campos LS, Rodriguez YI, Leopoldino AM, Hait NC, Lopez Bergami P, Castro MG, Sanchez ES, Maceyka M, Spiegel S, Alvarez SE.

Mol Cell Biol. 2015 Nov 9;36(2):320-9. doi: 10.1128/MCB.00554-15. Print 2016 Jan 15.


Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring.

de Brito Alves JL, Nogueira VO, Cavalcanti Neto MP, Leopoldino AM, Curti C, Colombari DS, Colombari E, Wanderley AG, Leandro CG, Zoccal DB, Costa-Silva JH.

J Nutr. 2015 May;145(5):907-14. doi: 10.3945/jn.114.202804. Epub 2015 Feb 18.


SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario.

Almeida LO, Goto RN, Neto MP, Sousa LO, Curti C, Leopoldino AM.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):300-6. doi: 10.1016/j.bbrc.2015.01.104. Epub 2015 Feb 3.


Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models.

Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C, Leopoldino AM.

Mol Cancer. 2014 Feb 20;13:32. doi: 10.1186/1476-4598-13-32.


Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation.

Almeida LO, Garcia CB, Matos-Silva FA, Curti C, Leopoldino AM.

Biochem Biophys Res Commun. 2014 Feb 28;445(1):196-202. doi: 10.1016/j.bbrc.2014.01.175. Epub 2014 Feb 4.


NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC).

Almeida LO, Abrahao AC, Rosselli-Murai LK, Giudice FS, Zagni C, Leopoldino AM, Squarize CH, Castilho RM.

FEBS Open Bio. 2013 Dec 30;4:96-104. doi: 10.1016/j.fob.2013.12.003. eCollection 2014.


Proteomic approaches identify members of cofilin pathway involved in oral tumorigenesis.

Polachini GM, Sobral LM, Mercante AM, Paes-Leme AF, Xavier FC, Henrique T, Guimarães DM, Vidotto A, Fukuyama EE, Góis-Filho JF, Cury PM, Curioni OA, Michaluart P Jr, Silva AM, Wünsch-Filho V, Nunes FD, Leopoldino AM, Tajara EH.

PLoS One. 2012;7(12):e50517. doi: 10.1371/journal.pone.0050517. Epub 2012 Dec 5.


SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates.

Almeida LO, Goto RN, Pestana CR, Uyemura SA, Gutkind S, Curti C, Leopoldino AM.

FEBS J. 2012 Dec;279(24):4615-28. doi: 10.1111/febs.12047. Epub 2012 Nov 23.


Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.

Thomé CH, dos Santos GA, Ferreira GA, Scheucher PS, Izumi C, Leopoldino AM, Simão AM, Ciancaglini P, de Oliveira KT, Chin A, Hanash SM, Falcão RP, Rego EM, Greene LJ, Faça VM.

Mol Cell Proteomics. 2012 Dec;11(12):1898-912. doi: 10.1074/mcp.M112.019661. Epub 2012 Sep 22.


C-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca2+/phosphate-induced impairment.

Marín-Prida J, Pentón-Rol G, Rodrigues FP, Alberici LC, Stringhetta K, Leopoldino AM, Naal Z, Polizello AC, Llópiz-Arzuaga A, Rosa MN, Liberato JL, Santos WF, Uyemura SA, Pentón-Arias E, Curti C, Pardo-Andreu GL.

Brain Res Bull. 2012 Dec 1;89(5-6):159-67. doi: 10.1016/j.brainresbull.2012.08.011. Epub 2012 Sep 7.


Prognostic significance of NDRG1 expression in oral and oropharyngeal squamous cell carcinoma.

Dos Santos M, da Cunha Mercante AM, Nunes FD, Leopoldino AM, de Carvalho MB, Gazito D, López RV, Chiappini PB, de Carvalho Neto PB, Fukuyama EE; Head Neck Genome Project/GENCAPO, Tajara EH, Louro ID, da Silva AM.

Mol Biol Rep. 2012 Dec;39(12):10157-65. doi: 10.1007/s11033-012-1889-0. Epub 2012 Sep 13.


SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification.

Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Sobral LM, Uyemura SA, Tajara EH, Silvio Gutkind J, Curti C.

Oral Oncol. 2012 Nov;48(11):1106-13. doi: 10.1016/j.oraloncology.2012.05.014. Epub 2012 Jun 26.


Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling.

Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Polizello AC, Uyemura SA, Tajara EH, Gutkind JS, Curti C.

Mol Cell Biochem. 2012 Apr;363(1-2):65-74. doi: 10.1007/s11010-011-1158-x. Epub 2011 Dec 6.


Expression of human protein S100A7 (psoriasin), preparation of antibody and application to human larynx squamous cell carcinoma.

Barbieri MR, Andrade CD, Silva WA Jr, Marques AA, Leopoldino AM, Montes MB, Dias-Baruffi M, Soares IC, Wakamatsu A, Alves VA, Laure HJ, Zago MA, Greene LJ.

BMC Res Notes. 2011 Nov 14;4:494. doi: 10.1186/1756-0500-4-494.


The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: ensuing energetic and oxidative stress implications.

Pardo-Andreu GL, Nuñez-Figueredo Y, Tudella VG, Cuesta-Rubio O, Rodrigues FP, Pestana CR, Uyemura SA, Leopoldino AM, Alberici LC, Curti C.

Toxicol Appl Pharmacol. 2011 Jun 15;253(3):282-9. doi: 10.1016/j.taap.2011.04.011. Epub 2011 Apr 27.


The anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler.

Pardo-Andreu GL, Nuñez-Figueredo Y, Tudella VG, Cuesta-Rubio O, Rodrigues FP, Pestana CR, Uyemura SA, Leopoldino AM, Alberici LC, Curti C.

Mitochondrion. 2011 Mar;11(2):255-63. doi: 10.1016/j.mito.2010.10.008. Epub 2010 Oct 31.


Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.

Carregaro F, Carta A, Cordeiro JA, Lobo SM, Silva EH, Leopoldino AM.

Mem Inst Oswaldo Cruz. 2010 Aug;105(5):649-56.


Genomics and proteomics approaches to the study of cancer-stroma interactions.

Rodrigues-Lisoni FC, Peitl P Jr, Vidotto A, Polachini GM, Maniglia JV, Carmona-Raphe J, Cunha BR, Henrique T, Souza CF, Teixeira RA, Fukuyama EE, Michaluart P Jr, de Carvalho MB, Oliani SM; Head and Neck Genome Project GENCAPO, Tajara EH, Cury PM, de Carvalho MB, Dias-Neto E, Figueiredo DL, Fukuyama EE, Góis-Filho JF, Leopoldino AM, Mamede RC, Michaluart-Junior P, Moyses RA, Nóbrega FG, Nóbrega MP, Nunes FD, Ojopi EF, Serafini LN, Severino P, Silva AM, Silva WA Jr, Silveira NJ, Souza SC, Tajara EH, Wünsch-Filho V, Amar A, Bandeira CM, Braconi MA, Brandão LG, Brandão RM, Canto AL, Cerione M, Cicco R, Chagas MJ, Chedid H, Costa A, Cunha BR, Curioni OA, Fortes CS, Franzi SA, Frizzera AP, Gazito D, Guimarães PE, Kaneto CM, López RV, Macarenco R, Magalhães MR, Meneses C, Mercante AM, Pinheiro DG, Polachini GM, Rapoport A, Rodini CO, Rodrigues-Lisoni FC, Rodrigues RV, Rossi L, Santos AR, Santos M, Settani F, Silva FA, Silva IT, Souza TB, Stabenow E, Takamori JT, Valentim PJ, Vidotto A, Xavier FC, Yamagushi F, Cominato ML, Correa PM, Mendes GS, Paiva R, Ramos O, Silva C, Silva MJ, Tarlá MV.

BMC Med Genomics. 2010 May 4;3:14. doi: 10.1186/1755-8794-3-14.


Sequence and transcriptional study of HNRPK pseudogenes, and expression and molecular modeling analysis of hnRNP K isoforms.

Leopoldino AM, Carregaro F, Silva CH, Feitosa O, Mancini UM, Freitas JM, Tajara EH.

Genome. 2007 May;50(5):451-62.


Solubilization of proteins from human lymph node tissue and two-dimensional gel storage.

de Marqui AB, Vidotto A, Polachini GM, Bellato Cde M, Cabral H, Leopoldino AM, de Góis Filho JF, Fukuyama EE, Settanni FA, Cury PM, Bonilla-Rodriguez GO, Palma MS, Tajara EH.

J Biochem Mol Biol. 2006 Mar 31;39(2):216-22.


Expression, purification, and circular dichroism analysis of human CDK9.

Leopoldino AM, Canduri F, Cabral H, Junqueira M, de Marqui AB, Apponi LH, da Fonseca IO, Domont GB, Santos DS, Valentini S, Bonilla-Rodriguez GO, Fossey MA, de Azevedo WF Jr, Tajara EH.

Protein Expr Purif. 2006 Jun;47(2):614-20. Epub 2006 Mar 10.


Preliminary functional characterization, cloning and primary sequence of Fastuosain, a cysteine peptidase isolated from fruits of Bromelia fastuosa.

Cabral H, Leopoldino AM, Tajara EH, Greene LJ, Faça VM, Mateus RP, Ceron CR, de Souza Judice WA, Julianod L, Bonilla-Rodriguez GO.

Protein Pept Lett. 2006;13(1):83-9.


Colorectal cancer "methylator phenotype": fact or artifact?

Anacleto C, Leopoldino AM, Rossi B, Soares FA, Lopes A, Rocha JC, Caballero O, Camargo AA, Simpson AJ, Pena SD.

Neoplasia. 2005 Apr;7(4):331-5.


Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

Bavoux C, Leopoldino AM, Bergoglio V, O-Wang J, Ogi T, Bieth A, Judde JG, Pena SD, Poupon MF, Helleday T, Tagawa M, Machado C, Hoffmann JS, Cazaux C.

Cancer Res. 2005 Jan 1;65(1):325-30.


The mutational spectrum of human autosomal tetranucleotide microsatellites.

Leopoldino AM, Pena SD.

Hum Mutat. 2003 Jan;21(1):71-9.


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