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Items: 1 to 50 of 66

1.

Ontogeny and Biology of Human Small Airway Epithelial Club Cells.

Zuo WL, Shenoy SA, Li S, O'Beirne SL, Strulovici-Barel Y, Leopold PL, Wang G, Staudt MR, Walters MS, Mason C, Kaner RJ, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1375-1388. doi: 10.1164/rccm.201710-2107OC.

PMID:
29874100
2.

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration.

Zhang H, Yang J, Walters MS, Staudt MR, Strulovici-Barel Y, Salit J, Mezey JG, Leopold PL, Crystal RG.

Oncotarget. 2018 Feb 16;9(18):14324-14337. doi: 10.18632/oncotarget.24511. eCollection 2018 Mar 6.

3.

Biology of the Adrenal Gland Cortex Obviates Effective Use of Adeno-Associated Virus Vectors to Treat Hereditary Adrenal Disorders.

Markmann S, De BP, Reid J, Jose CL, Rosenberg JB, Leopold PL, Kaminsky SM, Sondhi D, Pagovich O, Crystal RG.

Hum Gene Ther. 2018 Apr;29(4):403-412. doi: 10.1089/hum.2017.203. Epub 2018 Mar 20.

PMID:
29316814
4.

Polyene-based cationic lipids as visually traceable siRNA transfer reagents.

Jubeli E, Raju L, Khalique NA, Bilchuk N, Zegel C, Chen A, Lou HH, Øpstad CL, Zeeshan M, Sliwka HR, Partali V, Leopold PL, Pungente MD.

Eur J Pharm Biopharm. 2015 Jan;89:280-9. doi: 10.1016/j.ejpb.2014.12.011. Epub 2014 Dec 20.

PMID:
25536113
5.

Patterned electrospun nanofiber matrices via localized dissolution: potential for guided tissue formation.

Jia C, Yu D, Lamarre M, Leopold PL, Teng YD, Wang H.

Adv Mater. 2014 Dec 23;26(48):8192-7. doi: 10.1002/adma.201403509. Epub 2014 Oct 28.

PMID:
25352221
6.

Novel cationic polyene glycol phospholipids as DNA transfer reagents--lack of a structure-activity relationship due to uncontrolled self-assembling processes.

Øpstad CL, Zeeshan M, Zaidi A, Sliwka HR, Partali V, Nicholson DG, Surve C, Izower MA, Bilchuk N, Lou HH, Leopold PL, Larsen H, Liberska A, Khalique NA, Raju L, Flinterman M, Jubeli E, Pungente MD.

Chem Phys Lipids. 2014 Oct;183:117-36. doi: 10.1016/j.chemphyslip.2014.04.006. Epub 2014 May 6.

PMID:
24814958
7.

A comparison of epithelial-to-mesenchymal transition and re-epithelialization.

Leopold PL, Vincent J, Wang H.

Semin Cancer Biol. 2012 Oct;22(5-6):471-83. doi: 10.1016/j.semcancer.2012.07.003. Epub 2012 Jul 31. Review.

8.

Synthesis and preliminary investigations of the siRNA delivery potential of novel, single-chain rigid cationic carotenoid lipids.

Pungente MD, Jubeli E, Øpstad CL, Al-Kawaz M, Barakat N, Ibrahim T, Abdul Khalique N, Raju L, Jones R, Leopold PL, Sliwka HR, Partali V.

Molecules. 2012 Mar 16;17(3):3484-500. doi: 10.3390/molecules17033484.

9.

Smoking is associated with shortened airway cilia.

Leopold PL, O'Mahony MJ, Lian XJ, Tilley AE, Harvey BG, Crystal RG.

PLoS One. 2009 Dec 16;4(12):e8157. doi: 10.1371/journal.pone.0008157.

10.

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.

Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J.

Nat Cell Biol. 2009 Aug;11(8):943-50. doi: 10.1038/ncb1905. Epub 2009 Jul 13.

11.

Virus-induced neuronal dysfunction and degeneration.

Berth SH, Leopold PL, Morfini GN.

Front Biosci (Landmark Ed). 2009 Jun 1;14:5239-59. Review.

PMID:
19482613
12.

Sonic hedgehog expands diaphyseal trabecular bone altering bone marrow niche and lymphocyte compartment.

Kiuru M, Hidaka C, Hubner RH, Solomon J, Krause A, Leopold PL, Crystal RG.

Mol Ther. 2009 Aug;17(8):1442-52. doi: 10.1038/mt.2009.102. Epub 2009 May 12.

13.

Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing.

Song Y, Lou HH, Boyer JL, Limberis MP, Vandenberghe LH, Hackett NR, Leopold PL, Wilson JM, Crystal RG.

Hum Gene Ther. 2009 Mar;20(3):267-81. doi: 10.1089/hum.2008.173.

14.

Emphysema mediated by lung overexpression of ADAM10.

Saitoh H, Leopold PL, Harvey BG, O'Connor TP, Worgall S, Hackett NR, Crystal RG.

Clin Transl Sci. 2009 Feb;2(1):50-6. doi: 10.1111/j.1752-8062.2008.00085.x.

15.

Dysfunctional glycogen storage in a mouse model of alpha1-antitrypsin deficiency.

Hubner RH, Leopold PL, Kiuru M, De BP, Krause A, Crystal RG.

Am J Respir Cell Mol Biol. 2009 Feb;40(2):239-47. doi: 10.1165/rcmb.2008-0029OC. Epub 2008 Aug 7.

16.

Intracellular trafficking of adenovirus: many means to many ends.

Leopold PL, Crystal RG.

Adv Drug Deliv Rev. 2007 Aug 10;59(8):810-21. Epub 2007 Jun 28. Review.

PMID:
17707546
17.

Human embryonic stem cells and gene therapy.

Strulovici Y, Leopold PL, O'Connor TP, Pergolizzi RG, Crystal RG.

Mol Ther. 2007 May;15(5):850-66. Epub 2007 Mar 20. Review.

18.

Responses of the human airway epithelium transcriptome to in vivo injury.

Heguy A, Harvey BG, Leopold PL, Dolgalev I, Raman T, Crystal RG.

Physiol Genomics. 2007 Apr 24;29(2):139-48. Epub 2006 Dec 12.

PMID:
17164391
19.

Modification of gene expression of the small airway epithelium in response to cigarette smoking.

Harvey BG, Heguy A, Leopold PL, Carolan BJ, Ferris B, Crystal RG.

J Mol Med (Berl). 2007 Jan;85(1):39-53. Epub 2006 Nov 8. Erratum in: J Mol Med. 2008 Jul;86(7):853.

PMID:
17115125
20.

Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.

Carolan BJ, Heguy A, Harvey BG, Leopold PL, Ferris B, Crystal RG.

Cancer Res. 2006 Nov 15;66(22):10729-40.

21.
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23.

Viral strategies for intracellular trafficking: motors and microtubules.

Leopold PL, Pfister KK.

Traffic. 2006 May;7(5):516-23. Review.

24.

Correction of a murine model of von Willebrand disease by gene transfer.

Pergolizzi RG, Jin G, Chan D, Pierre L, Bussel J, Ferris B, Leopold PL, Crystal RG.

Blood. 2006 Aug 1;108(3):862-9. Epub 2006 Apr 25.

25.

High levels of persistent expression of alpha1-antitrypsin mediated by the nonhuman primate serotype rh.10 adeno-associated virus despite preexisting immunity to common human adeno-associated viruses.

De BP, Heguy A, Hackett NR, Ferris B, Leopold PL, Lee J, Pierre L, Gao G, Wilson JM, Crystal RG.

Mol Ther. 2006 Jan;13(1):67-76. Epub 2005 Nov 2.

26.

AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL.

Sondhi D, Peterson DA, Giannaris EL, Sanders CT, Mendez BS, De B, Rostkowski AB, Blanchard B, Bjugstad K, Sladek JR Jr, Redmond DE Jr, Leopold PL, Kaminsky SM, Hackett NR, Crystal RG.

Gene Ther. 2005 Nov;12(22):1618-32.

PMID:
16052206
27.

Enhanced efficacy of cholesterol-minus sonic hedgehog in postnatal skin.

Lou H, Crystal RG, Leopold PL.

Mol Ther. 2005 Sep;12(3):575-8.

28.
29.

Cytoplasmic dynein mediates adenovirus binding to microtubules.

Kelkar SA, Pfister KK, Crystal RG, Leopold PL.

J Virol. 2004 Sep;78(18):10122-32.

30.

Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells.

Vincent T, Pettersson RF, Crystal RG, Leopold PL.

J Virol. 2004 Aug;78(15):8047-58.

31.

Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.

Worgall S, Busch A, Rivara M, Bonnyay D, Leopold PL, Merritt R, Hackett NR, Rovelink PW, Bruder JT, Wickham TJ, Kovesdi I, Crystal RG.

J Virol. 2004 Mar;78(5):2572-80.

33.

Association of adenovirus with the microtubule organizing center.

Bailey CJ, Crystal RG, Leopold PL.

J Virol. 2003 Dec;77(24):13275-87.

34.

Cell physiology as a variable in gene transfer to endothelium.

Leopold PL.

Curr Atheroscler Rep. 2003 May;5(3):171-7. Review.

PMID:
12667428
35.

In vivo enhanced expression of patched dampens the sonic hedgehog pathway.

Bergstein I, Leopold PL, Sato N, Panteleyev A, Christiano A, Crystal R.

Mol Ther. 2002 Aug;6(2):258-64.

36.

Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors.

Rice J, Connor R, Worgall S, Moore JP, Leopold PL, Kaner RJ, Crystal RG.

Am J Respir Cell Mol Biol. 2002 Aug;27(2):214-9.

PMID:
12151313
37.

Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions.

Crystal RG, Harvey BG, Wisnivesky JP, O'Donoghue KA, Chu KW, Maroni J, Muscat JC, Pippo AL, Wright CE, Kaner RJ, Leopold PL, Kessler PD, Rasmussen HS, Rosengart TK, Hollmann C.

Hum Gene Ther. 2002 Jan 1;13(1):65-100.

PMID:
11779413
38.

Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia.

Sato N, Leopold PL, Crystal RG.

J Natl Cancer Inst. 2001 Dec 19;93(24):1858-64.

PMID:
11752010
39.

Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle.

Seidman MA, Hogan SM, Wendland RL, Worgall S, Crystal RG, Leopold PL.

Mol Ther. 2001 Jul;4(1):13-21.

41.
42.
43.

Free cholesterol enhances adenoviral vector gene transfer and expression in CAR-deficient cells.

Worgall S, Worgall TS, Kostarelos K, Singh R, Leopold PL, Hackett NR, Crystal RG.

Mol Ther. 2000 Jan;1(1):39-48.

44.

Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis.

Leopold PL, Kreitzer G, Miyazawa N, Rempel S, Pfister KK, Rodriguez-Boulan E, Crystal RG.

Hum Gene Ther. 2000 Jan 1;11(1):151-65.

PMID:
10646647
45.

Cellular immune responses of healthy individuals to intradermal administration of an E1-E3- adenovirus gene transfer vector.

Harvey BG, Worgall S, Ely S, Leopold PL, Crystal RG.

Hum Gene Ther. 1999 Nov 20;10(17):2823-37.

PMID:
10584928
46.

Enhanced liver uptake of opsonized red blood cells after in vivo transfer of FcgammaRIIA cDNA to the liver.

Bezdicek P, Worgall S, Kovesdi I, Kim MK, Park JG, Vincent T, Leopold PL, Schreiber AD, Crystal RG.

Blood. 1999 Nov 15;94(10):3448-55.

47.

Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.

Harvey BG, Leopold PL, Hackett NR, Grasso TM, Williams PM, Tucker AL, Kaner RJ, Ferris B, Gonda I, Sweeney TD, Ramalingam R, Kovesdi I, Shak S, Crystal RG.

J Clin Invest. 1999 Nov;104(9):1245-55.

48.
49.

Specific binding of the adenovirus capsid to the nuclear envelope.

Wisnivesky JP, Leopold PL, Crystal RG.

Hum Gene Ther. 1999 Sep 1;10(13):2187-95.

PMID:
10498250
50.

Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.

Miyazawa N, Leopold PL, Hackett NR, Ferris B, Worgall S, Falck-Pedersen E, Crystal RG.

J Virol. 1999 Jul;73(7):6056-65.

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