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Items: 1 to 50 of 112

1.

The importance of side branches in modeling 3D hemodynamics from angiograms for patients with coronary artery disease.

Vardhan M, Gounley J, Chen SJ, Kahn AM, Leopold JA, Randles A.

Sci Rep. 2019 Jun 20;9(1):8854. doi: 10.1038/s41598-019-45342-5.

2.

Precision Medicine in Pulmonary Arterial Hypertension.

Leopold JA, Maron BA.

Circ Res. 2019 Mar 15;124(6):832-833. doi: 10.1161/CIRCRESAHA.119.314757. No abstract available.

PMID:
30870130
3.

Computing the ankle-brachial index with parallel computational fluid dynamics.

Gounley J, Draeger EW, Oppelstrup T, Krauss WD, Gunnels JA, Chaudhury R, Nair P, Frakes D, Leopold JA, Randles A.

J Biomech. 2019 Jan 3;82:28-37. doi: 10.1016/j.jbiomech.2018.10.007. Epub 2018 Oct 19.

PMID:
30385003
4.

Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension.

Watanabe S, Ishikawa K, Plataki M, Bikou O, Kohlbrenner E, Aguero J, Hadri L, Zarragoikoetxea I, Fish K, Leopold JA, Hajjar RJ.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018799738. doi: 10.1177/2045894018799738. Epub 2018 Aug 21.

5.

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap7294. doi: 10.1126/scitranslmed.aap7294.

6.

Circulation: Cardiovascular Interventions: The First 10 Years.

Faxon DP, Leopold JA, Abbott JD, McElhinney DB, Williams DO.

Circ Cardiovasc Interv. 2018 Jun;11(6):e006901. doi: 10.1161/CIRCINTERVENTIONS.118.006901. No abstract available. Erratum in: Circ Cardiovasc Interv. 2018 Sep;11(9):e000037.

PMID:
29895606
7.

Emerging Role of Precision Medicine in Cardiovascular Disease.

Leopold JA, Loscalzo J.

Circ Res. 2018 Apr 27;122(9):1302-1315. doi: 10.1161/CIRCRESAHA.117.310782. Review.

8.

Pulmonary Venous Remodeling in Pulmonary Hypertension: The Veins Take Center Stage.

Leopold JA.

Circulation. 2018 Apr 24;137(17):1811-1813. doi: 10.1161/CIRCULATIONAHA.118.033013. No abstract available.

9.

Editorial commentary: Diagnosing spontaneous coronary artery dissection in women: A call for early coronary angiography.

Leopold JA.

Trends Cardiovasc Med. 2018 Jul;28(5):346-347. doi: 10.1016/j.tcm.2018.02.009. Epub 2018 Mar 14. No abstract available.

PMID:
29661711
10.

Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA.

Circ Res. 2018 Mar 16;122(6):864-876. doi: 10.1161/CIRCRESAHA.117.312482. Epub 2018 Feb 5.

11.

Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg. A Joint National Institutes of Health Clinical Center and Pulmonary Hypertension Association Symposium Report.

Elinoff JM, Agarwal R, Barnett CF, Benza RL, Cuttica MJ, Gharib AM, Gray MP, Hassoun PM, Hemnes AR, Humbert M, Kolb TM, Lahm T, Leopold JA, Mathai SC, McLaughlin VV, Preston IR, Rosenzweig EB, Shlobin OA, Steen VD, Zamanian RT, Solomon MA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):166-174. doi: 10.1164/rccm.201710-2093PP. No abstract available.

12.

A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension.

Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS.

Circ Res. 2017 Nov 10;121(11):1216-1218. doi: 10.1161/CIRCRESAHA.117.311703. Review. No abstract available.

13.

PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics.

Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA; PVDOMICS Study Group.

Circ Res. 2017 Oct 27;121(10):1136-1139. doi: 10.1161/CIRCRESAHA.117.311737. No abstract available.

14.

Systems biology: An emerging strategy for discovering novel pathogenetic mechanisms that promote cardiovascular disease.

Maron BA, Leopold JA.

Glob Cardiol Sci Pract. 2016 Sep 30;2016(3):e201627. doi: 10.21542/gcsp.2016.27. Review.

15.

Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease.

Randles A, Frakes DH, Leopold JA.

Trends Biotechnol. 2017 Nov;35(11):1049-1061. doi: 10.1016/j.tibtech.2017.08.008. Epub 2017 Sep 21. Review.

16.

Usefulness of Intracoronary Brachytherapy for Patients With Resistant Drug-Eluting Stent Restenosis.

Mangione FM, Jatene T, Badr Eslam R, Bergmark BA, Gallagher JR, Shah PB, Mauri L, Leopold JA, Sobieszczyk PS, Faxon DP, Croce KJ, Bhatt DL, Devlin PM.

Am J Cardiol. 2017 Aug 1;120(3):369-373. doi: 10.1016/j.amjcard.2017.04.036. Epub 2017 May 10.

PMID:
28583681
17.

Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.

Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1661-1670. doi: 10.1164/rccm.201701-0150WS.

18.

Persistence and proliferation of human mesenchymal stromal cells in the right ventricular myocardium after intracoronary injection in a large animal model of pulmonary hypertension.

Badr Eslam R, Croce K, Mangione FM, Musmann R, Leopold JA, Mitchell RN, Waxman AB.

Cytotherapy. 2017 Jun;19(6):668-679. doi: 10.1016/j.jcyt.2017.03.002. Epub 2017 Apr 6.

19.

Biological Phenotyping of Combined Post-Capillary and Pre-Capillary Pulmonary Hypertension: Focus on Pulmonary Vascular Remodeling.

Leopold JA.

J Am Coll Cardiol. 2016 Dec 13;68(23):2537-2539. doi: 10.1016/j.jacc.2016.10.013. No abstract available.

20.

Cangrelor Use Since FDA Approval: A Single-Center, Real-World Experience at a Tertiary Care Hospital.

Vaduganathan M, Qamar A, Singh A, Venkateswaran RV, Szumita PM, Croce KJ, Mauri L, Leopold JA, Shah PB, Sobieszczyk P, Faxon DP, Bhatt DL.

J Am Coll Cardiol. 2017 Jan 31;69(4):463-464. doi: 10.1016/j.jacc.2016.11.017. Epub 2016 Nov 30. No abstract available.

21.

Catheter-Based Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension.

Leopold JA.

Circ Cardiovasc Interv. 2016 Oct;9(10). pii: e004543. No abstract available.

22.

Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial.

Beckman JA, Goldfine AB, Leopold JA, Creager MA.

Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1431-H1436. doi: 10.1152/ajpheart.00504.2016. Epub 2016 Oct 7.

23.

Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis.

Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH.

J Am Heart Assoc. 2016 Sep 28;5(10). pii: e003845. doi: 10.1161/JAHA.116.003845.

24.

Reply: Understanding vascular calcification from an evolutionary approach.

Leopold JA.

Trends Cardiovasc Med. 2017 Jan;27(1):70-71. doi: 10.1016/j.tcm.2016.05.013. Epub 2016 Jun 8. No abstract available.

25.

The Future of Vascular Biology and Medicine.

Kinlay S, Michel T, Leopold JA.

Circulation. 2016 Jun 21;133(25):2603-9. doi: 10.1161/CIRCULATIONAHA.116.023513. Review. No abstract available.

26.

Molecular Mechanisms of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.

Leopold JA, Maron BA.

Int J Mol Sci. 2016 May 18;17(5). pii: E761. doi: 10.3390/ijms17050761. Review.

27.

Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.

Aguero J, Ishikawa K, Hadri L, Santos-Gallego CG, Fish KM, Kohlbrenner E, Hammoudi N, Kho C, Lee A, Ibáñez B, García-Alvarez A, Zsebo K, Maron BA, Plataki M, Fuster V, Leopold JA, Hajjar RJ.

J Am Coll Cardiol. 2016 May 3;67(17):2032-46. doi: 10.1016/j.jacc.2016.02.049.

28.

Whole-exome sequencing for the discovery of rare genetic variants that protect from coronary artery disease.

Leopold JA.

Coron Artery Dis. 2016 Jun;27(4):253-4. doi: 10.1097/MCA.0000000000000367. No abstract available.

29.

Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension.

Aghamohammadzadeh R, Zhang YY, Stephens TE, Arons E, Zaman P, Polach KJ, Matar M, Yung LM, Yu PB, Bowman FP, Opotowsky AR, Waxman AB, Loscalzo J, Leopold JA, Maron BA.

FASEB J. 2016 Jul;30(7):2511-27. doi: 10.1096/fj.201500042. Epub 2016 Mar 22.

30.

Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program.

Maron BA, Hess E, Maddox TM, Opotowsky AR, Tedford RJ, Lahm T, Joynt KE, Kass DJ, Stephens T, Stanislawski MA, Swenson ER, Goldstein RH, Leopold JA, Zamanian RT, Elwing JM, Plomondon ME, Grunwald GK, Barón AE, Rumsfeld JS, Choudhary G.

Circulation. 2016 Mar 29;133(13):1240-8. doi: 10.1161/CIRCULATIONAHA.115.020207. Epub 2016 Feb 12.

31.

Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice.

Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA.

Pulm Circ. 2015 Dec;5(4):610-8. doi: 10.1086/683815. Review.

32.

Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study.

Maron BA, Stephens TE, Farrell LA, Oldham WM, Loscalzo J, Leopold JA, Lewis GD.

J Heart Lung Transplant. 2016 Mar;35(3):342-351. doi: 10.1016/j.healun.2015.10.019. Epub 2015 Oct 19.

33.

Catheter-based therapies for patients with medication-refractory pulmonary arterial hypertension.

Leopold JA.

Circ Cardiovasc Interv. 2015 Nov;8(11):e003332. doi: 10.1161/CIRCINTERVENTIONS.115.003332. No abstract available.

34.
35.

The Central Role of Neutrophil Gelatinase-Associated Lipocalin in Cardiovascular Fibrosis.

Leopold JA.

Hypertension. 2015 Jul;66(1):20-2. doi: 10.1161/HYPERTENSIONAHA.115.05479. Epub 2015 May 18. No abstract available.

36.

Combination proximal pulmonary artery coiling and distal embolization induces chronic elevations in pulmonary artery pressure in Swine.

Aguero J, Ishikawa K, Fish KM, Hammoudi N, Hadri L, Garcia-Alvarez A, Ibanez B, Fuster V, Hajjar RJ, Leopold JA.

PLoS One. 2015 Apr 29;10(4):e0124526. doi: 10.1371/journal.pone.0124526. eCollection 2015.

37.

Obesity-related cardiomyopathy is an adipocyte-mediated paracrine disease.

Leopold JA.

Trends Cardiovasc Med. 2015 Feb;25(2):127-8. doi: 10.1016/j.tcm.2014.09.010. Epub 2014 Oct 2. No abstract available.

38.

Vascular calcification: Mechanisms of vascular smooth muscle cell calcification.

Leopold JA.

Trends Cardiovasc Med. 2015 May;25(4):267-74. doi: 10.1016/j.tcm.2014.10.021. Epub 2014 Oct 30. Review.

39.

Antioxidants and coronary artery disease: from pathophysiology to preventive therapy.

Leopold JA.

Coron Artery Dis. 2015 Mar;26(2):176-83. doi: 10.1097/MCA.0000000000000187. Review.

40.

Neoatherosclerosis: another consequence of endothelial dysfunction?

Leopold JA.

Circ Cardiovasc Interv. 2014 Oct;7(5):635-7. doi: 10.1161/CIRCINTERVENTIONS.114.001994. No abstract available.

41.

MicroRNAs Regulate Vascular Medial Calcification.

Leopold JA.

Cells. 2014 Oct 14;3(4):963-80. doi: 10.3390/cells3040963. Review.

42.
43.

Characterization of right ventricular remodeling and failure in a chronic pulmonary hypertension model.

Aguero J, Ishikawa K, Hadri L, Santos-Gallego C, Fish K, Hammoudi N, Chaanine A, Torquato S, Naim C, Ibanez B, Pereda D, García-Alvarez A, Fuster V, Sengupta PP, Leopold JA, Hajjar RJ.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1204-15. doi: 10.1152/ajpheart.00246.2014. Epub 2014 Aug 22.

44.
45.

Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis.

Maron BA, Oldham WM, Chan SY, Vargas SO, Arons E, Zhang YY, Loscalzo J, Leopold JA.

Circulation. 2014 Jul 8;130(2):168-79. doi: 10.1161/CIRCULATIONAHA.113.007690. Epub 2014 Apr 28.

46.

Microvascular dysfunction: genetic polymorphisms suggest sex-specific differences in disease phenotype.

Leopold JA.

Coron Artery Dis. 2014 Jun;25(4):275-6. doi: 10.1097/MCA.0000000000000122. No abstract available.

47.

Systems analysis of oxidant stress in the vasculature.

Handy DE, Loscalzo J, Leopold JA.

IUBMB Life. 2013 Nov;65(11):911-20. doi: 10.1002/iub.1221. Epub 2013 Nov 7.

48.

Prohealing endothelial progenitor cell capture stents: do the cells captured explain the clinical outcomes?

Leopold JA.

Circ Cardiovasc Interv. 2013 Oct 1;6(5):494-5. doi: 10.1161/CIRCINTERVENTIONS.113.000812. No abstract available.

49.

Cellular and molecular mechanisms of arterial stiffness associated with obesity.

Leopold JA.

Hypertension. 2013 Dec;62(6):1003-4. doi: 10.1161/HYPERTENSIONAHA.113.01872. Epub 2013 Sep 23. No abstract available.

50.

Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival.

Kao DD, Oldebeken SR, Rai A, Lubos E, Leopold JA, Loscalzo J, Handy DE.

Mol Cell Biochem. 2013 Oct;382(1-2):153-62. doi: 10.1007/s11010-013-1730-7. Epub 2013 Jun 28.

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