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Items: 1 to 50 of 167

1.

On the fluxes of side-chain oxidized oxysterols across blood-brain and blood-CSF barriers and origin of these steroids in CSF (Review).

Björkhem I, Leoni V, Svenningsson P.

J Steroid Biochem Mol Biol. 2018 Dec 23. pii: S0960-0760(18)30733-7. doi: 10.1016/j.jsbmb.2018.12.009. [Epub ahead of print] Review.

PMID:
30586624
2.

Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial.

Biondi A, Gandemer V, De Lorenzo P, Cario G, Campbell M, Castor A, Pieters R, Baruchel A, Vora A, Leoni V, Stary J, Escherich G, Li CK, Cazzaniga G, Cavé H, Bradtke J, Conter V, Saha V, Schrappe M, Grazia Valsecchi M.

Lancet Haematol. 2018 Dec;5(12):e641-e652. doi: 10.1016/S2352-3026(18)30173-X.

PMID:
30501871
3.

A microglial cell model for acyl-CoA oxidase 1 deficiency.

Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct 10. pii: S1388-1981(18)30324-X. doi: 10.1016/j.bbalip.2018.10.005. [Epub ahead of print]

PMID:
30312667
4.

Long-term follow up of pediatric Philadelphia positive acute lymphoblastic leukemia treated with the EsPhALL2004 study: high white blood cell count at diagnosis is the strongest prognostic factor.

Biondi A, Cario G, De Lorenzo P, Castor A, Conter V, Leoni V, Gandemer V, Pieters R, Stary J, Escherich G, Campbell M, Attarbaschi A, Li CK, Vora A, Bradtke J, Saha V, Valsecchi MG, Schrappe M.

Haematologica. 2019 Jan;104(1):e13-e16. doi: 10.3324/haematol.2018.199422. Epub 2018 Sep 13. No abstract available.

5.

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors.

Leoni V, Vannini A, Gatta V, Rambaldi J, Sanapo M, Barboni C, Zaghini A, Nanni P, Lollini PL, Casiraghi C, Campadelli-Fiume G.

PLoS Pathog. 2018 Aug 6;14(8):e1007209. doi: 10.1371/journal.ppat.1007209. eCollection 2018 Aug.

6.

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods.

Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Geilenkeuser WJ, Lövgren-Sandblom A, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Bretillon L, Browne RW, Caccia C, Cenarro A, Crick PJ, Fauler G, García-Llatas G, Griffiths WJ, Iuliano L, Lagarda MJ, Leoni V, Lottenberg AM, Matysik S, McDonald J, Rideout TC, Schmitz G, Nunes VS, Wang Y, Zerbinati C, Diczfalusy U, Schött HF.

Biochimie. 2018 Oct;153:26-32. doi: 10.1016/j.biochi.2018.07.016. Epub 2018 Jul 29.

PMID:
30063945
7.

Evidence for sex difference in the CSF/plasma albumin ratio in ~20 000 patients and 335 healthy volunteers.

Parrado-Fernández C, Blennow K, Hansson M, Leoni V, Cedazo-Minguez A, Björkhem I.

J Cell Mol Med. 2018 Oct;22(10):5151-5154. doi: 10.1111/jcmm.13767. Epub 2018 Jul 27.

8.

Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol.

Nury T, Sghaier R, Zarrouk A, Ménétrier F, Uzun T, Leoni V, Caccia C, Meddeb W, Namsi A, Sassi K, Mihoubi W, Riedinger JM, Cherkaoui-Malki M, Moreau T, Vejux A, Lizard G.

Biochimie. 2018 Oct;153:181-202. doi: 10.1016/j.biochi.2018.07.009. Epub 2018 Jul 19.

PMID:
30031877
9.

miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling.

Migliore C, Morando E, Ghiso E, Anastasi S, Leoni VP, Apicella M, Cora' D, Sapino A, Pietrantonio F, De Braud F, Columbano A, Segatto O, Giordano S.

EMBO Mol Med. 2018 Sep;10(9). pii: e8746. doi: 10.15252/emmm.201708746.

10.

Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.

Alioui A, Dufour J, Leoni V, Loregger A, Moeton M, Iuliano L, Zerbinati C, Septier A, Val P, Fouache A, Russo V, Volle DH, Lobaccaro JA, Zelcer N, Baron S.

Nat Commun. 2018 Jul 4;9(1):2660. doi: 10.1038/s41467-018-04653-3.

11.

Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy.

Pibiri M, Leoni VP, Atzori L.

Life Sci. 2018 Jul 1;204:9-14. doi: 10.1016/j.lfs.2018.05.011. Epub 2018 May 5.

PMID:
29738777
12.

Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor.

Fadda A, Gentilini D, Moi L, Barault L, Leoni VP, Sulas P, Zorcolo L, Restivo A, Cabras F, Fortunato F, Zavattari C, Varesco L, Gismondi V, De Miglio MR, Scanu AM, Colombi F, Lombardi P, Sarotto I, Loi E, Leone F, Giordano S, Di Nicolantonio F, Columbano A, Zavattari P.

Int J Cancer. 2018 Aug 15;143(4):907-920. doi: 10.1002/ijc.31380. Epub 2018 Apr 6.

PMID:
29542109
13.

Dual Ligand Insertion in gB and gD of Oncolytic Herpes Simplex Viruses for Retargeting to a Producer Vero Cell Line and to Cancer Cells.

Petrovic B, Leoni V, Gatta V, Zaghini A, Vannini A, Campadelli-Fiume G.

J Virol. 2018 Feb 26;92(6). pii: e02122-17. doi: 10.1128/JVI.02122-17. Print 2018 Mar 15.

14.

Simultaneous Insertion of Two Ligands in gD for Cultivation of Oncolytic Herpes Simplex Viruses in Noncancer Cells and Retargeting to Cancer Receptors.

Leoni V, Petrovic B, Gianni T, Gatta V, Campadelli-Fiume G.

J Virol. 2018 Feb 26;92(6). pii: e02132-17. doi: 10.1128/JVI.02132-17. Print 2018 Mar 15.

15.

Intestinal permeability and Ménière's disease.

Di Berardino F, Zanetti D, Ciusani E, Caccia C, Leoni V, De Grazia U, Filipponi E, Elli L.

Am J Otolaryngol. 2018 Mar - Apr;39(2):153-156. doi: 10.1016/j.amjoto.2017.12.002. Epub 2017 Dec 5.

PMID:
29248204
16.

Airway inflammatory phenotypes: Making sputum cell evaluation more accessible for clinical use.

Pignatti P, Visca D, Leoni V, Zampogna E, Cherubino F, Sotgiu G, Lucini E, Spanevello A.

Clin Respir J. 2018 May;12(5):1989-1990. doi: 10.1111/crj.12747. Epub 2017 Dec 21. No abstract available.

PMID:
29193790
17.

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies.

Cazzaniga G, De Lorenzo P, Alten J, Röttgers S, Hancock J, Saha V, Castor A, Madsen HO, Gandemer V, Cavé H, Leoni V, Köhler R, Ferrari GM, Bleckmann K, Pieters R, van der Velden V, Stary J, Zuna J, Escherich G, Stadt UZ, Aricò M, Conter V, Schrappe M, Valsecchi MG, Biondi A.

Haematologica. 2018 Jan;103(1):107-115. doi: 10.3324/haematol.2017.176917. Epub 2017 Oct 27.

18.

Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.

Alioui A, Dufour J, Leoni V, Loregger A, Moeton M, Iuliano L, Zerbinati C, Septier A, Val P, Fouache A, Russo V, Volle DH, Lobaccaro JA, Zelcer N, Baron S.

Nat Commun. 2017 Sep 5;8(1):445. doi: 10.1038/s41467-017-00508-5. Retraction in: Nat Commun. 2018 Jul 04;9(1):2660.

19.

A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats.

Musman J, Paradis S, Panel M, Pons S, Barau C, Caccia C, Leoni V, Ghaleh B, Morin D.

Biochem Pharmacol. 2017 Oct 15;142:87-95. doi: 10.1016/j.bcp.2017.06.125. Epub 2017 Jun 21.

PMID:
28645478
20.

Is bronchodilator the correct treatment for COPD subjects before EBUS?

Leoni V, Pignatti P, Visca D, Spanevello A.

J Thorac Dis. 2017 May;9(Suppl 5):S410-S413. doi: 10.21037/jtd.2017.03.142. Review.

21.

The Thyromimetic KB2115 (Eprotirome) Induces Rat Hepatocyte Proliferation.

Szydlowska M, Pibiri M, Perra A, Puliga E, Mattu S, Ledda-Columbano GM, Columbano A, Leoni VP.

Gene Expr. 2017 Jul 7;17(3):207-218. doi: 10.3727/105221617X695438. Epub 2017 Apr 13.

22.

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol.

Cagno V, Civra A, Rossin D, Calfapietra S, Caccia C, Leoni V, Dorma N, Biasi F, Poli G, Lembo D.

Redox Biol. 2017 Aug;12:522-527. doi: 10.1016/j.redox.2017.03.016. Epub 2017 Mar 23.

23.

A Strategy for Cultivation of Retargeted Oncolytic Herpes Simplex Viruses in Non-cancer Cells.

Leoni V, Gatta V, Casiraghi C, Nicosia A, Petrovic B, Campadelli-Fiume G.

J Virol. 2017 Apr 28;91(10). pii: e00067-17. doi: 10.1128/JVI.00067-17. Print 2017 May 15.

24.

MIF/CD74 axis is a target for novel therapies in colon carcinomatosis.

Bozzi F, Mogavero A, Varinelli L, Belfiore A, Manenti G, Caccia C, Volpi CC, Beznoussenko GV, Milione M, Leoni V, Gloghini A, Mironov AA, Leo E, Pilotti S, Pierotti MA, Bongarzone I, Gariboldi M.

J Exp Clin Cancer Res. 2017 Jan 23;36(1):16. doi: 10.1186/s13046-016-0475-z.

25.

Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice.

Musman J, Pons S, Barau C, Caccia C, Leoni V, Berdeaux A, Ghaleh B, Morin D.

Free Radic Biol Med. 2016 Dec;101:317-324. doi: 10.1016/j.freeradbiomed.2016.10.496. Epub 2016 Oct 28.

PMID:
27989751
26.

Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice.

Shankaran M, Di Paolo E, Leoni V, Caccia C, Ferrari Bardile C, Mohammed H, Di Donato S, Kwak S, Marchionini D, Turner S, Cattaneo E, Valenza M.

Neurobiol Dis. 2017 Feb;98:66-76. doi: 10.1016/j.nbd.2016.11.013. Epub 2016 Nov 30.

PMID:
27913290
27.

Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors.

Leoni V, Nury T, Vejux A, Zarrouk A, Caccia C, Debbabi M, Fromont A, Sghaier R, Moreau T, Lizard G.

J Steroid Biochem Mol Biol. 2017 May;169:96-110. doi: 10.1016/j.jsbmb.2016.03.029. Epub 2016 Mar 25.

PMID:
27020660
28.

Retargeting Strategies for Oncolytic Herpes Simplex Viruses.

Campadelli-Fiume G, Petrovic B, Leoni V, Gianni T, Avitabile E, Casiraghi C, Gatta V.

Viruses. 2016 Feb 26;8(3):63. doi: 10.3390/v8030063. Review.

29.

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice.

Valenza M, Chen JY, Di Paolo E, Ruozi B, Belletti D, Ferrari Bardile C, Leoni V, Caccia C, Brilli E, Di Donato S, Boido MM, Vercelli A, Vandelli MA, Forni F, Cepeda C, Levine MS, Tosi G, Cattaneo E.

EMBO Mol Med. 2015 Dec;7(12):1547-64. doi: 10.15252/emmm.201505413.

30.

Comparaison appariée des flux du cholestérol cellulaire dans les tissus sains et cancéreux prostatiques : résultats de l'étude Chomecap.

Celhay O, Laurent G, Alioui A, Trousson A, Kemeny L, Pereira B, Leoni V, Lobaccaro J, Baron S.

Prog Urol. 2015 Nov;25(13):727-8. doi: 10.1016/j.purol.2015.08.025. French. No abstract available.

PMID:
26544220
31.

Systemic delivery of HER2-retargeted oncolytic-HSV by mesenchymal stromal cells protects from lung and brain metastases.

Leoni V, Gatta V, Palladini A, Nicoletti G, Ranieri D, Dall'Ora M, Grosso V, Rossi M, Alviano F, Bonsi L, Nanni P, Lollini PL, Campadelli-Fiume G.

Oncotarget. 2015 Oct 27;6(33):34774-87. doi: 10.18632/oncotarget.5793.

32.

4-IPP, a selective MIF inhibitor, causes mitotic catastrophe in thyroid carcinomas.

Varinelli L, Caccia D, Volpi CC, Caccia C, De Bortoli M, Taverna E, Gualeni AV, Leoni V, Gloghini A, Manenti G, Bongarzone I.

Endocr Relat Cancer. 2015 Oct;22(5):759-75. doi: 10.1530/ERC-15-0299. Epub 2015 Jul 23.

PMID:
26206776
33.

Global gene expression profile of normal and regenerating liver in young and old mice.

Pibiri M, Sulas P, Leoni VP, Perra A, Kowalik MA, Cordella A, Saggese P, Nassa G, Ravo M.

Age (Dordr). 2015 Jun;37(3):9796. doi: 10.1007/s11357-015-9796-7. Epub 2015 Jun 3.

34.

PEX7 Mutations Cause Congenital Cataract Retinopathy and Late-Onset Ataxia and Cognitive Impairment: Report of Two Siblings and Review of the Literature.

Nanetti L, Pensato V, Leoni V, Rizzetto M, Caccia C, Taroni F, Mariotti C, Gellera C.

J Clin Neurol. 2015 Apr;11(2):197-9. doi: 10.3988/jcn.2015.11.2.197. No abstract available.

35.

Tyrosine kinase inhibitors in BCR-ABL positive acute lymphoblastic leukemia.

Leoni V, Biondi A.

Haematologica. 2015 Mar;100(3):295-9. doi: 10.3324/haematol.2015.124016. No abstract available.

36.

The impairment of cholesterol metabolism in Huntington disease.

Leoni V, Caccia C.

Biochim Biophys Acta. 2015 Aug;1851(8):1095-105. doi: 10.1016/j.bbalip.2014.12.018. Epub 2015 Jan 14. Review.

PMID:
25596342
37.

Somatosensory conduction pathway in spastic paraplegia type 5.

Vanotti A, Nanetti L, Rossi Sebastiano D, Visani E, Duran D, Di Bella D, Sarto E, Caccia C, Leoni V, Taroni F, Mariotti C.

J Clin Neurol. 2014 Oct;10(4):373-4. doi: 10.3988/jcn.2014.10.4.373. Epub 2014 Oct 6. No abstract available.

38.

Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats.

Frau C, Loi R, Petrelli A, Perra A, Menegon S, Kowalik MA, Pinna S, Leoni VP, Fornari F, Gramantieri L, Ledda-Columbano GM, Giordano S, Columbano A.

Hepatology. 2015 Jan;61(1):249-59. doi: 10.1002/hep.27399. Epub 2014 Nov 26.

PMID:
25156012
39.

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.

Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M.

Cell Metab. 2014 Jun 3;19(6):1042-9. doi: 10.1016/j.cmet.2014.04.001. Epub 2014 May 8.

40.

Study of cholesterol metabolism in Huntington's disease.

Leoni V, Caccia C.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):697-701. doi: 10.1016/j.bbrc.2014.01.188. Epub 2014 Feb 10. Review.

PMID:
24525128
41.

Type I interferon and NF-κB activation elicited by herpes simplex virus gH/gL via αvβ3 integrin in epithelial and neuronal cell lines.

Gianni T, Leoni V, Campadelli-Fiume G.

J Virol. 2013 Dec;87(24):13911-6. doi: 10.1128/JVI.01894-13. Epub 2013 Oct 9.

42.

Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease.

Björkhem I, Lövgren-Sandblom A, Leoni V, Meaney S, Brodin L, Salveson L, Winge K, Pålhagen S, Svenningsson P.

Neurosci Lett. 2013 Oct 25;555:102-5. doi: 10.1016/j.neulet.2013.09.003. Epub 2013 Sep 10.

PMID:
24035896
43.

Susceptibility of human placenta derived mesenchymal stromal/stem cells to human herpesviruses infection.

Avanzi S, Leoni V, Rotola A, Alviano F, Solimando L, Lanzoni G, Bonsi L, Di Luca D, Marchionni C, Alvisi G, Ripalti A.

PLoS One. 2013 Aug 5;8(8):e71412. doi: 10.1371/journal.pone.0071412. Print 2013.

44.

Biomarker report from the phase II lamotrigine trial in secondary progressive MS - neurofilament as a surrogate of disease progression.

Gnanapavan S, Grant D, Morant S, Furby J, Hayton T, Teunissen CE, Leoni V, Marta M, Brenner R, Palace J, Miller DH, Kapoor R, Giovannoni G.

PLoS One. 2013 Aug 1;8(8):e70019. doi: 10.1371/journal.pone.0070019. Print 2013.

45.

Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health.

Leoni V, Solomon A, Lövgren-Sandblom A, Minthon L, Blennow K, Hansson O, Wahlund LO, Kivipelto M, Björkhem I.

J Alzheimers Dis. 2013;36(4):739-47. doi: 10.3233/JAD-130035.

PMID:
23666171
46.

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression.

Leoni V, Long JD, Mills JA, Di Donato S, Paulsen JS; PREDICT-HD study group.

Neurobiol Dis. 2013 Jul;55:37-43. doi: 10.1016/j.nbd.2013.03.013. Epub 2013 Apr 1.

47.

Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion.

Paradis S, Leoni V, Caccia C, Berdeaux A, Morin D.

Cardiovasc Res. 2013 Jun 1;98(3):420-7. doi: 10.1093/cvr/cvt079. Epub 2013 Apr 3.

48.

Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid.

Leoni V, Caccia C.

Biochem Pharmacol. 2013 Jul 1;86(1):26-36. doi: 10.1016/j.bcp.2013.03.015. Epub 2013 Mar 28. Review.

PMID:
23541982
49.

αvβ3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.

Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19792-7. doi: 10.1073/pnas.1212597109. Epub 2012 Nov 12.

50.

Pitfalls in the detection of cholesterol in Huntington's disease models.

Marullo M, Valenza M, Leoni V, Caccia C, Scarlatti C, De Mario A, Zuccato C, Di Donato S, Carafoli E, Cattaneo E.

PLoS Curr. 2012 Oct 11;4:e505886e9a1968. doi: 10.1371/505886e9a1968.

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