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Items: 1 to 50 of 451

1.

NHS-modified ethynylphosphonamidates enable the synthesis of configurationally defined protein conjugates.

Kasper MA, Gerlach M, Schneider AFL, Groneberg C, Ochtrop P, Boldt S, Schumacher D, Helma J, Leonhardt H, Christmann M, Hackenberger C.

Chembiochem. 2019 Oct 29. doi: 10.1002/cbic.201900587. [Epub ahead of print]

PMID:
31661184
2.

Clinical experience and results with a Rhombic Plate for transoral endoscopically-assisted osteosynthesis of fractures of the condylar neck.

Leonhardt H, Franke A, Nowak A, McLeod N, Lauer G.

Br J Oral Maxillofac Surg. 2019 Oct 5. pii: S0266-4356(19)30385-7. doi: 10.1016/j.bjoms.2019.09.016. [Epub ahead of print]

PMID:
31594713
3.

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.

Wagner A, Hofmeister O, Rolland SG, Maiser A, Aasumets K, Schmitt S, Schorpp K, Feuchtinger A, Hadian K, Schneider S, Zischka H, Leonhardt H, Conradt B, Gerhold JM, Wolf A.

J Cell Sci. 2019 Oct 1;132(19). pii: jcs223891. doi: 10.1242/jcs.223891.

PMID:
31434717
4.

BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples.

Hörl D, Rojas Rusak F, Preusser F, Tillberg P, Randel N, Chhetri RK, Cardona A, Keller PJ, Harz H, Leonhardt H, Treier M, Preibisch S.

Nat Methods. 2019 Sep;16(9):870-874. doi: 10.1038/s41592-019-0501-0. Epub 2019 Aug 5.

PMID:
31384047
5.

Publisher Correction: Heterochromatin drives compartmentalization of inverted and conventional nuclei.

Falk M, Feodorova Y, Naumova N, Imakaev M, Lajoie BR, Leonhardt H, Joffe B, Dekker J, Fudenberg G, Solovei I, Mirny LA.

Nature. 2019 Aug;572(7771):E22. doi: 10.1038/s41586-019-1454-2.

PMID:
31375785
6.

Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association.

Mahamid J, Tegunov D, Maiser A, Arnold J, Leonhardt H, Plitzko JM, Baumeister W.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16866-16871. doi: 10.1073/pnas.1903642116. Epub 2019 Aug 2.

7.

One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase.

Schumacher D, Leonhardt H, Hackenberger CPR, Helma J.

Methods Mol Biol. 2019;2033:167-189. doi: 10.1007/978-1-4939-9654-4_12.

PMID:
31332754
8.

A unified multi-kingdom Golden Gate cloning platform.

Chiasson D, Giménez-Oya V, Bircheneder M, Bachmaier S, Studtrucker T, Ryan J, Sollweck K, Leonhardt H, Boshart M, Dietrich P, Parniske M.

Sci Rep. 2019 Jul 12;9(1):10131. doi: 10.1038/s41598-019-46171-2.

9.

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.

Kasper MA, Stengl A, Ochtrop P, Gerlach M, Stoschek T, Schumacher D, Helma J, Penkert M, Krause E, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11631-11636. doi: 10.1002/anie.201904193. Epub 2019 Jul 18.

PMID:
31250955
10.

Loss of KDM6A confers drug resistance in acute myeloid leukemia.

Stief SM, Hanneforth AL, Weser S, Mattes R, Carlet M, Liu WH, Bartoschek MD, Domínguez Moreno H, Oettle M, Kempf J, Vick B, Ksienzyk B, Tizazu B, Rothenberg-Thurley M, Quentmeier H, Hiddemann W, Vosberg S, Greif PA, Metzeler KH, Schotta G, Bultmann S, Jeremias I, Leonhardt H, Spiekermann K.

Leukemia. 2019 Jun 14. doi: 10.1038/s41375-019-0497-6. [Epub ahead of print]

PMID:
31201358
11.

Heterochromatin drives compartmentalization of inverted and conventional nuclei.

Falk M, Feodorova Y, Naumova N, Imakaev M, Lajoie BR, Leonhardt H, Joffe B, Dekker J, Fudenberg G, Solovei I, Mirny LA.

Nature. 2019 Jun;570(7761):395-399. doi: 10.1038/s41586-019-1275-3. Epub 2019 Jun 5. Erratum in: Nature. 2019 Aug;572(7771):E22.

PMID:
31168090
12.

Tubulin Tyrosine Ligase-Mediated Modification of Proteins.

Gerlach M, Stoschek T, Leonhardt H, Hackenberger CPR, Schumacher D, Helma J.

Methods Mol Biol. 2019;2012:327-355. doi: 10.1007/978-1-4939-9546-2_17.

PMID:
31161516
13.

Restriction of AID activity and somatic hypermutation by PARP-1.

Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, Fischbach A, Pfeil I, Petersen-Mahrt SK, Mangerich A, Helleday T, Leonhardt H, Jungnickel B.

Nucleic Acids Res. 2019 Aug 22;47(14):7418-7429. doi: 10.1093/nar/gkz466.

14.

Biomechanical Evaluation of Mandibular Condyle Fracture Osteosynthesis Using the Rhombic Three-Dimensional Condylar Fracture Plate.

Ben Achour A, Meißner H, Teicher U, Haim D, Range U, Brosius A, Leonhardt H, Lauer G.

J Oral Maxillofac Surg. 2019 Sep;77(9):1868.e1-1868.e15. doi: 10.1016/j.joms.2019.04.020. Epub 2019 Apr 25.

PMID:
31112678
15.

Correction to: Performance of a feature-based algorithm for 3D-3D registration of CT angiography to cone-beam CT for endovascular repair of complex abdominal aortic aneurysms.

Koutouzi G, Nasihatkon B, Danielak-Nowak M, Leonhardt H, Falkenberg M, Kahl F.

BMC Med Imaging. 2019 May 2;19(1):37. doi: 10.1186/s12880-019-0335-3.

16.

TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles.

Stengl A, Gerlach M, Kasper MA, Hackenberger CPR, Leonhardt H, Schumacher D, Helma J.

Org Biomol Chem. 2019 May 28;17(20):4964-4969. doi: 10.1039/c9ob00508k. Epub 2019 Apr 1.

PMID:
30932115
17.

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.

Kasper MA, Glanz M, Stengl A, Penkert M, Klenk S, Sauer T, Schumacher D, Helma J, Krause E, Cardoso MC, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11625-11630. doi: 10.1002/anie.201814715. Epub 2019 Apr 29.

PMID:
30828930
18.

FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers.

Effenberger M, Stengl A, Schober K, Gerget M, Kampick M, Müller TR, Schumacher D, Helma J, Leonhardt H, Busch DH.

J Immunol. 2019 Apr 1;202(7):2164-2171. doi: 10.4049/jimmunol.1801435. Epub 2019 Feb 13.

PMID:
30760621
19.

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis.

Wenk C, Garz AK, Grath S, Huberle C, Witham D, Weickert M, Malinverni R, Niggemeyer J, Kyncl M, Hecker J, Pagel C, Mulholland CB, Müller-Thomas C, Leonhardt H, Bassermann F, Oostendorp RAJ, Metzeler KH, Buschbeck M, Götze KS.

Blood Adv. 2018 Dec 11;2(23):3447-3461. doi: 10.1182/bloodadvances.2018022053.

20.

Performance of a feature-based algorithm for 3D-3D registration of CT angiography to cone-beam CT for endovascular repair of complex abdominal aortic aneurysms.

Koutouzi G, Nasihatkton B, Danielak-Nowak M, Leonhardt H, Falkenberg M, Kahl F.

BMC Med Imaging. 2018 Nov 8;18(1):42. doi: 10.1186/s12880-018-0285-1. Erratum in: BMC Med Imaging. 2019 May 2;19(1):37.

21.

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.

Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC.

Genome Biol. 2018 Nov 7;19(1):189. doi: 10.1186/s13059-018-1557-3.

22.

Nanoparticle mediated delivery and small molecule triggered activation of proteins in the nucleus.

Chiu HY, Bates JA, Helma J, Engelke H, Harz H, Bein T, Leonhardt H.

Nucleus. 2018;9(1):530-542. doi: 10.1080/19491034.2018.1523665.

23.

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.

Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H, Walter J.

Epigenetics Chromatin. 2018 Jul 25;11(1):41. doi: 10.1186/s13072-018-0211-3.

24.

New method of alloplastic reconstruction of the mandible after subtotal mandibulectomy for medication-related osteonecrosis of the jaw.

Bräuer C, Lauer G, Leonhardt H.

Br J Oral Maxillofac Surg. 2018 Jul;56(6):549-550. doi: 10.1016/j.bjoms.2018.04.004. Epub 2018 May 8. No abstract available.

PMID:
29751943
25.

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.

Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15.

26.

European Society of Urogenital Radiology (ESUR) Guidelines: MR Imaging of Leiomyomas.

Kubik-Huch RA, Weston M, Nougaret S, Leonhardt H, Thomassin-Naggara I, Horta M, Cunha TM, Maciel C, Rockall A, Forstner R.

Eur Radiol. 2018 Aug;28(8):3125-3137. doi: 10.1007/s00330-017-5157-5. Epub 2018 Feb 28.

27.

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.

Feldmann DP, Cheng Y, Kandil R, Xie Y, Mohammadi M, Harz H, Sharma A, Peeler DJ, Moszczynska A, Leonhardt H, Pun SH, Merkel OM.

J Control Release. 2018 Apr 28;276:50-58. doi: 10.1016/j.jconrel.2018.02.017. Epub 2018 Feb 20.

28.

Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids.

Helma J, Leonhardt H, Hackenberger CPR, Schumacher D.

Methods Mol Biol. 2018;1728:67-93. doi: 10.1007/978-1-4939-7574-7_4.

PMID:
29404991
29.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.

Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V.

Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1.

30.

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.

Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V.

Immunity. 2017 Dec 19;47(6):1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. Epub 2017 Dec 12.

31.

Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells.

Karg E, Smets M, Ryan J, Forné I, Qin W, Mulholland CB, Kalideris G, Imhof A, Bultmann S, Leonhardt H.

J Mol Biol. 2017 Dec 8;429(24):3814-3824. doi: 10.1016/j.jmb.2017.10.014. Epub 2017 Oct 18.

PMID:
29055779
32.

CDK9-dependent RNA polymerase II pausing controls transcription initiation.

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P.

Elife. 2017 Oct 10;6. pii: e29736. doi: 10.7554/eLife.29736.

33.

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.

Schumacher D, Helma J, Schneider AFL, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2314-2333. doi: 10.1002/anie.201708459. Epub 2018 Jan 26. Review.

34.

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.

Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.

Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13.

PMID:
28902841
35.

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M, Greif PA.

Leukemia. 2018 Feb;32(2):313-322. doi: 10.1038/leu.2017.257. Epub 2017 Aug 14.

36.

CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.

Dahlhoff M, Gaborit N, Bultmann S, Leonhardt H, Yarden Y, Schneider MR.

FEBS J. 2017 Oct;284(19):3339-3349. doi: 10.1111/febs.14196. Epub 2017 Sep 14.

37.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.

38.

Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters.

Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J, Cremer T.

Epigenetics Chromatin. 2017 Aug 7;10(1):39. doi: 10.1186/s13072-017-0146-0.

39.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.

Herce HD, Schumacher D, Schneider AFL, Ludwig AK, Mann FA, Fillies M, Kasper MA, Reinke S, Krause E, Leonhardt H, Cardoso MC, Hackenberger CPR.

Nat Chem. 2017 Aug;9(8):762-771. doi: 10.1038/nchem.2811. Epub 2017 Jul 17.

PMID:
28754949
40.

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.

Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N, Waschke J.

Sci Rep. 2017 Jul 24;7(1):6329. doi: 10.1038/s41598-017-06713-y.

41.

Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB.

EMBO J. 2017 Aug 1;36(15):2263-2279. doi: 10.15252/embj.201695757. Epub 2017 Jun 23.

42.

Identification of the elementary structural units of the DNA damage response.

Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, Grulich S, Anton T, Hörl D, Chen W, Durante M, Taucher-Scholz G, Leonhardt H, Cardoso MC.

Nat Commun. 2017 Jun 12;8:15760. doi: 10.1038/ncomms15760.

43.

Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E.

Cancer Res. 2017 Jul 1;77(13):3577-3590. doi: 10.1158/0008-5472.CAN-16-1922. Epub 2017 May 22.

44.

L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins.

Zhang P, Ludwig AK, Hastert FD, Rausch C, Lehmkuhl A, Hellmann I, Smets M, Leonhardt H, Cardoso MC.

Nucleus. 2017 Sep 3;8(5):548-562. doi: 10.1080/19491034.2017.1330238. Epub 2017 May 19.

45.

Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.

Schumacher D, Lemke O, Helma J, Gerszonowicz L, Waller V, Stoschek T, Durkin PM, Budisa N, Leonhardt H, Keller BG, Hackenberger CPR.

Chem Sci. 2017 May 1;8(5):3471-3478. doi: 10.1039/c7sc00574a. Epub 2017 Mar 20.

46.

Fixation of fractures of the condylar head of the mandible with a new magnesium-alloy biodegradable cannulated headless bone screw.

Leonhardt H, Franke A, McLeod NMH, Lauer G, Nowak A.

Br J Oral Maxillofac Surg. 2017 Jul;55(6):623-625. doi: 10.1016/j.bjoms.2017.04.007. Epub 2017 Apr 29.

PMID:
28460872
47.

Quantitative 3D structured illumination microscopy of nuclear structures.

Kraus F, Miron E, Demmerle J, Chitiashvili T, Budco A, Alle Q, Matsuda A, Leonhardt H, Schermelleh L, Markaki Y.

Nat Protoc. 2017 May;12(5):1011-1028. doi: 10.1038/nprot.2017.020. Epub 2017 Apr 13. Review.

PMID:
28406495
48.

Small chromosomal regions position themselves autonomously according to their chromatin class.

van de Werken HJG, Haan JC, Feodorova Y, Bijos D, Weuts A, Theunis K, Holwerda SJB, Meuleman W, Pagie L, Thanisch K, Kumar P, Leonhardt H, Marynen P, van Steensel B, Voet T, de Laat W, Solovei I, Joffe B.

Genome Res. 2017 Jun;27(6):922-933. doi: 10.1101/gr.213751.116. Epub 2017 Mar 24.

49.

DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.

Smets M, Link S, Wolf P, Schneider K, Solis V, Ryan J, Meilinger D, Qin W, Leonhardt H.

Hum Mol Genet. 2017 Apr 15;26(8):1522-1534. doi: 10.1093/hmg/ddx057.

50.

Universal Super-Resolution Multiplexing by DNA Exchange.

Schueder F, Strauss MT, Hoerl D, Schnitzbauer J, Schlichthaerle T, Strauss S, Yin P, Harz H, Leonhardt H, Jungmann R.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):4052-4055. doi: 10.1002/anie.201611729. Epub 2017 Mar 3.

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