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Items: 1 to 50 of 429

1.

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.

Gasparoni G, Bultmann S, Lutsik P, Kraus TFJ, Sordon S, Vlcek J, Dietinger V, Steinmaurer M, Haider M, Mulholland CB, Arzberger T, Roeber S, Riemenschneider M, Kretzschmar HA, Giese A, Leonhardt H, Walter J.

Epigenetics Chromatin. 2018 Jul 25;11(1):41. doi: 10.1186/s13072-018-0211-3.

2.

New method of alloplastic reconstruction of the mandible after subtotal mandibulectomy for medication-related osteonecrosis of the jaw.

Bräuer C, Lauer G, Leonhardt H.

Br J Oral Maxillofac Surg. 2018 Jul;56(6):549-550. doi: 10.1016/j.bjoms.2018.04.004. Epub 2018 May 8. No abstract available.

PMID:
29751943
3.

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.

Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15.

4.

European Society of Urogenital Radiology (ESUR) Guidelines: MR Imaging of Leiomyomas.

Kubik-Huch RA, Weston M, Nougaret S, Leonhardt H, Thomassin-Naggara I, Horta M, Cunha TM, Maciel C, Rockall A, Forstner R.

Eur Radiol. 2018 Aug;28(8):3125-3137. doi: 10.1007/s00330-017-5157-5. Epub 2018 Feb 28.

5.

In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells.

Feldmann DP, Cheng Y, Kandil R, Xie Y, Mohammadi M, Harz H, Sharma A, Peeler DJ, Moszczynska A, Leonhardt H, Pun SH, Merkel OM.

J Control Release. 2018 Apr 28;276:50-58. doi: 10.1016/j.jconrel.2018.02.017. Epub 2018 Feb 20.

PMID:
29474962
6.

Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids.

Helma J, Leonhardt H, Hackenberger CPR, Schumacher D.

Methods Mol Biol. 2018;1728:67-93. doi: 10.1007/978-1-4939-7574-7_4.

PMID:
29404991
7.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.

Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V.

Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1.

8.

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.

Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V.

Immunity. 2017 Dec 19;47(6):1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. Epub 2017 Dec 12.

PMID:
29246441
9.

Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells.

Karg E, Smets M, Ryan J, Forné I, Qin W, Mulholland CB, Kalideris G, Imhof A, Bultmann S, Leonhardt H.

J Mol Biol. 2017 Dec 8;429(24):3814-3824. doi: 10.1016/j.jmb.2017.10.014. Epub 2017 Oct 18.

PMID:
29055779
10.

CDK9-dependent RNA polymerase II pausing controls transcription initiation.

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P.

Elife. 2017 Oct 10;6. pii: e29736. doi: 10.7554/eLife.29736.

11.

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.

Schumacher D, Helma J, Schneider AFL, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2314-2333. doi: 10.1002/anie.201708459. Epub 2018 Jan 26. Review.

12.

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.

Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.

Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13.

PMID:
28902841
13.

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

Reiter K, Polzer H, Krupka C, Maiser A, Vick B, Rothenberg-Thurley M, Metzeler KH, Dörfel D, Salih HR, Jung G, Nößner E, Jeremias I, Hiddemann W, Leonhardt H, Spiekermann K, Subklewe M, Greif PA.

Leukemia. 2018 Feb;32(2):313-322. doi: 10.1038/leu.2017.257. Epub 2017 Aug 14.

14.

CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.

Dahlhoff M, Gaborit N, Bultmann S, Leonhardt H, Yarden Y, Schneider MR.

FEBS J. 2017 Oct;284(19):3339-3349. doi: 10.1111/febs.14196. Epub 2017 Sep 14.

PMID:
28805349
15.

Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA.

Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10.

PMID:
28803780
16.

Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters.

Cremer M, Schmid VJ, Kraus F, Markaki Y, Hellmann I, Maiser A, Leonhardt H, John S, Stamatoyannopoulos J, Cremer T.

Epigenetics Chromatin. 2017 Aug 7;10(1):39. doi: 10.1186/s13072-017-0146-0.

17.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.

Herce HD, Schumacher D, Schneider AFL, Ludwig AK, Mann FA, Fillies M, Kasper MA, Reinke S, Krause E, Leonhardt H, Cardoso MC, Hackenberger CPR.

Nat Chem. 2017 Aug;9(8):762-771. doi: 10.1038/nchem.2811. Epub 2017 Jul 17.

PMID:
28754949
18.

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.

Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N, Waschke J.

Sci Rep. 2017 Jul 24;7(1):6329. doi: 10.1038/s41598-017-06713-y.

19.

Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

Pünzeler S, Link S, Wagner G, Keilhauer EC, Kronbeck N, Spitzer RM, Leidescher S, Markaki Y, Mentele E, Regnard C, Schneider K, Takahashi D, Kusakabe M, Vardabasso C, Zink LM, Straub T, Bernstein E, Harata M, Leonhardt H, Mann M, Rupp RA, Hake SB.

EMBO J. 2017 Aug 1;36(15):2263-2279. doi: 10.15252/embj.201695757. Epub 2017 Jun 23.

20.

Identification of the elementary structural units of the DNA damage response.

Natale F, Rapp A, Yu W, Maiser A, Harz H, Scholl A, Grulich S, Anton T, Hörl D, Chen W, Durante M, Taucher-Scholz G, Leonhardt H, Cardoso MC.

Nat Commun. 2017 Jun 12;8:15760. doi: 10.1038/ncomms15760.

21.

Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.

Schlenker R, Olguín-Contreras LF, Leisegang M, Schnappinger J, Disovic A, Rühland S, Nelson PJ, Leonhardt H, Harz H, Wilde S, Schendel DJ, Uckert W, Willimsky G, Noessner E.

Cancer Res. 2017 Jul 1;77(13):3577-3590. doi: 10.1158/0008-5472.CAN-16-1922. Epub 2017 May 22.

22.

L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins.

Zhang P, Ludwig AK, Hastert FD, Rausch C, Lehmkuhl A, Hellmann I, Smets M, Leonhardt H, Cardoso MC.

Nucleus. 2017 Sep 3;8(5):548-562. doi: 10.1080/19491034.2017.1330238. Epub 2017 May 19.

23.

Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.

Schumacher D, Lemke O, Helma J, Gerszonowicz L, Waller V, Stoschek T, Durkin PM, Budisa N, Leonhardt H, Keller BG, Hackenberger CPR.

Chem Sci. 2017 May 1;8(5):3471-3478. doi: 10.1039/c7sc00574a. Epub 2017 Mar 20.

24.

Fixation of fractures of the condylar head of the mandible with a new magnesium-alloy biodegradable cannulated headless bone screw.

Leonhardt H, Franke A, McLeod NMH, Lauer G, Nowak A.

Br J Oral Maxillofac Surg. 2017 Jul;55(6):623-625. doi: 10.1016/j.bjoms.2017.04.007. Epub 2017 Apr 29.

PMID:
28460872
25.

Quantitative 3D structured illumination microscopy of nuclear structures.

Kraus F, Miron E, Demmerle J, Chitiashvili T, Budco A, Alle Q, Matsuda A, Leonhardt H, Schermelleh L, Markaki Y.

Nat Protoc. 2017 May;12(5):1011-1028. doi: 10.1038/nprot.2017.020. Epub 2017 Apr 13. Review.

PMID:
28406495
26.

Small chromosomal regions position themselves autonomously according to their chromatin class.

van de Werken HJG, Haan JC, Feodorova Y, Bijos D, Weuts A, Theunis K, Holwerda SJB, Meuleman W, Pagie L, Thanisch K, Kumar P, Leonhardt H, Marynen P, van Steensel B, Voet T, de Laat W, Solovei I, Joffe B.

Genome Res. 2017 Jun;27(6):922-933. doi: 10.1101/gr.213751.116. Epub 2017 Mar 24.

27.

DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation.

Smets M, Link S, Wolf P, Schneider K, Solis V, Ryan J, Meilinger D, Qin W, Leonhardt H.

Hum Mol Genet. 2017 Apr 15;26(8):1522-1534. doi: 10.1093/hmg/ddx057.

28.

Universal Super-Resolution Multiplexing by DNA Exchange.

Schueder F, Strauss MT, Hoerl D, Schnitzbauer J, Schlichthaerle T, Strauss S, Yin P, Harz H, Leonhardt H, Jungmann R.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):4052-4055. doi: 10.1002/anie.201611729. Epub 2017 Mar 3.

29.

Comparative Analysis of Single-Cell RNA Sequencing Methods.

Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.

Mol Cell. 2017 Feb 16;65(4):631-643.e4. doi: 10.1016/j.molcel.2017.01.023.

30.

KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.

Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich EM, Bartke T.

Nucleic Acids Res. 2017 Feb 17;45(3):1114-1129. doi: 10.1093/nar/gkw979.

31.

Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.

Thanisch K, Song C, Engelkamp D, Koch J, Wang A, Hallberg E, Foisner R, Leonhardt H, Stewart CL, Joffe B, Solovei I.

Differentiation. 2017 Mar - Apr;94:58-70. doi: 10.1016/j.diff.2016.12.002. Epub 2017 Jan 2.

PMID:
28056360
32.

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.

Ludwig AK, Zhang P, Hastert FD, Meyer S, Rausch C, Herce HD, Müller U, Lehmkuhl A, Hellmann I, Trummer C, Storm C, Leonhardt H, Cardoso MC.

Nucleic Acids Res. 2017 Mar 17;45(5):2438-2457. doi: 10.1093/nar/gkw1197.

33.

A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies.

Stengl A, Hörl D, Leonhardt H, Helma J.

SLAS Discov. 2017 Mar;22(3):309-315. doi: 10.1177/1087057116677821. Epub 2016 Dec 13.

34.

Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells.

Röder R, Helma J, Preiß T, Rädler JO, Leonhardt H, Wagner E.

Pharm Res. 2017 Jan;34(1):161-174. doi: 10.1007/s11095-016-2052-8. Epub 2016 Oct 31.

PMID:
27800572
35.

Determination of local chromatin composition by CasID.

Schmidtmann E, Anton T, Rombaut P, Herzog F, Leonhardt H.

Nucleus. 2016 Sep 2;7(5):476-484. Epub 2016 Sep 27.

36.

Orthogonal Rings, Fiducial Markers, and Overlay Accuracy When Image Fusion is Used for EVAR Guidance.

Koutouzi G, Sandström C, Roos H, Henrikson O, Leonhardt H, Falkenberg M.

Eur J Vasc Endovasc Surg. 2016 Nov;52(5):604-611. doi: 10.1016/j.ejvs.2016.07.024. Epub 2016 Sep 7.

37.

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1.

Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, Müller MA, Deng W, Lei J, Meyer B, Kusov Y, von Brunn B, Bairad DR, Hünten S, Drosten C, Hermeking H, Leonhardt H, Mann M, Hilgenfeld R, von Brunn A.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5192-201. doi: 10.1073/pnas.1603435113. Epub 2016 Aug 12.

38.

Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time.

Chiu HY, Deng W, Engelke H, Helma J, Leonhardt H, Bein T.

Sci Rep. 2016 May 13;6:25019. doi: 10.1038/srep25019.

39.

Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.

Anton T, Leonhardt H, Markaki Y.

Methods Mol Biol. 2016;1411:407-17. doi: 10.1007/978-1-4939-3530-7_25.

PMID:
27147056
40.

Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.

Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC, von Blume J.

J Cell Biol. 2016 May 9;213(3):305-14. doi: 10.1083/jcb.201601089. Epub 2016 May 2.

41.

Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Apr 22;291(17):9382. doi: 10.1074/jbc.A115.698357. No abstract available.

42.

4D Visualization of replication foci in mammalian cells corresponding to individual replicons.

Chagin VO, Casas-Delucchi CS, Reinhart M, Schermelleh L, Markaki Y, Maiser A, Bolius JJ, Bensimon A, Fillies M, Domaing P, Rozanov YM, Leonhardt H, Cardoso MC.

Nat Commun. 2016 Apr 7;7:11231. doi: 10.1038/ncomms11231.

43.

Current Status: Site-Specific Antibody Drug Conjugates.

Schumacher D, Hackenberger CP, Leonhardt H, Helma J.

J Clin Immunol. 2016 May;36 Suppl 1:100-7. doi: 10.1007/s10875-016-0265-6. Epub 2016 Mar 22. Review.

44.

Cell-substrate impedance fluctuations of single amoeboid cells encode cell-shape and adhesion dynamics.

Leonhardt H, Gerhardt M, Höppner N, Krüger K, Tarantola M, Beta C.

Phys Rev E. 2016 Jan;93(1):012414. doi: 10.1103/PhysRevE.93.012414. Epub 2016 Jan 25.

PMID:
26871108
45.

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

Becker A, Zhang P, Allmann L, Meilinger D, Bertulat B, Eck D, Hofstaetter M, Bartolomei G, Hottiger MO, Schreiber V, Leonhardt H, Cardoso MC.

J Biol Chem. 2016 Mar 4;291(10):4873-81. doi: 10.1074/jbc.M115.698357. Epub 2016 Jan 15. Erratum in: J Biol Chem. 2016 Apr 22;291(17):9382.

46.

Generation of an alpaca-derived nanobody recognizing γ-H2AX.

Rajan M, Mortusewicz O, Rothbauer U, Hastert FD, Schmidthals K, Rapp A, Leonhardt H, Cardoso MC.

FEBS Open Bio. 2015 Sep 21;5:779-88. doi: 10.1016/j.fob.2015.09.005. eCollection 2015.

47.

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

Schumacher D, Helma J, Mann FA, Pichler G, Natale F, Krause E, Cardoso MC, Hackenberger CP, Leonhardt H.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13787-91. doi: 10.1002/anie.201505456. Epub 2015 Sep 25.

PMID:
26404067
48.

Energy profile of nanobody-GFP complex under force.

Klamecka K, Severin PM, Milles LF, Gaub HE, Leonhardt H.

Phys Biol. 2015 Sep 10;12(5):056009. doi: 10.1088/1478-3975/12/5/056009.

PMID:
26356046
49.

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination.

Qin W, Wolf P, Liu N, Link S, Smets M, La Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H, Leonhardt H.

Cell Res. 2015 Aug;25(8):911-29. doi: 10.1038/cr.2015.72. Epub 2015 Jun 12.

50.

Nanobodies and recombinant binders in cell biology.

Helma J, Cardoso MC, Muyldermans S, Leonhardt H.

J Cell Biol. 2015 Jun 8;209(5):633-44. doi: 10.1083/jcb.201409074. Review.

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