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Engineered Mesenchymal Stem Cell/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy.

Suryaprakash S, Lao YH, Cho HY, Li M, Ji HY, Shao D, Hu H, Quek CH, Huang D, Mintz RL, Bagó JR, Hingtgen SD, Lee KB, Leong KW.

Nano Lett. 2019 Mar 13;19(3):1701-1705. doi: 10.1021/acs.nanolett.8b04697. Epub 2019 Feb 21.


Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment.

Peng B, Liang H, Li Y, Dong C, Shen J, Mao HQ, Leong KW, Chen Y, Liu L.

Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4254-4258. doi: 10.1002/anie.201813362. Epub 2019 Feb 18.


A multifunctional mesoporous silica-gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay.

Li M, Lao YH, Mintz RL, Chen Z, Shao D, Hu H, Wang HX, Tao Y, Leong KW.

Nanoscale. 2019 Feb 7;11(6):2631-2636. doi: 10.1039/c8nr08337a.


Advanced drug delivery systems and artificial skin grafts for skin wound healing.

Kim HS, Sun X, Lee JH, Kim HW, Fu X, Leong KW.

Adv Drug Deliv Rev. 2018 Dec 31. pii: S0169-409X(18)30318-1. doi: 10.1016/j.addr.2018.12.014. [Epub ahead of print] Review.


The epidemiology and clinical characteristics of myeloproliferative neoplasms in Malaysia.

Yap YY, Law KB, Sathar J, Lau NS, Goh AS, Chew TK, Lim SM, Menon P, Guan YK, Husin AB, Wong LLL, Chew LP, Salleh S, Goh KY, Leong KW, Tan SM, Ong TC, Lim SH, Toh SG, Han XSY, Edmund SC, Tan JT, Chang KM.

Exp Hematol Oncol. 2018 Dec 17;7:31. doi: 10.1186/s40164-018-0124-7. eCollection 2018.


Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery.

Sun L, Liu Z, Tian H, Le Z, Liu L, Leong KW, Mao HQ, Chen Y.

Biomacromolecules. 2018 Dec 11. doi: 10.1021/acs.biomac.8b01530. [Epub ahead of print]


Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy.

Le Z, Chen Y, Han H, Tian H, Zhao P, Yang C, He Z, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y.

ACS Appl Mater Interfaces. 2018 Nov 29. doi: 10.1021/acsami.8b18979. [Epub ahead of print]


Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation.

Zeng Z, Dong C, Zhao P, Liu Z, Liu L, Mao HQ, Leong KW, Gao X, Chen Y.

Adv Healthc Mater. 2018 Oct 19:e1801010. doi: 10.1002/adhm.201801010. [Epub ahead of print]


Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation.

Liang H, Peng B, Dong C, Liu L, Mao J, Wei S, Wang X, Xu H, Shen J, Mao HQ, Gao X, Leong KW, Chen Y.

Nat Commun. 2018 Oct 16;9(1):4291. doi: 10.1038/s41467-018-06603-5.


Denaturation-Enhanced Droplet Digital PCR for Liquid Biopsies.

Fitarelli-Kiehl M, Yu F, Ashtaputre R, Leong KW, Ladas I, Supplee J, Paweletz C, Mitra D, Schoenfeld JD, Parangi S, Makrigiorgos GM.

Clin Chem. 2018 Dec;64(12):1762-1771. doi: 10.1373/clinchem.2018.293845. Epub 2018 Oct 1.


Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery.

He Z, Hu Y, Nie T, Tang H, Zhu J, Chen K, Liu L, Leong KW, Chen Y, Mao HQ.

Acta Biomater. 2018 Nov;81:195-207. doi: 10.1016/j.actbio.2018.09.047. Epub 2018 Sep 27.


Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy.

Lin PY, Chiu YL, Huang JH, Chuang EY, Mi FL, Lin KJ, Juang JH, Sung HW, Leong KW.

Adv Sci (Weinh). 2018 Jun 6;5(8):1701079. doi: 10.1002/advs.201701079. eCollection 2018 Aug.


Morphology, Migration, and Transcriptome Analysis of Schwann Cell Culture on Butterfly Wings with Different Surface Architectures.

He J, Sun C, Gu Z, Yang Y, Gu M, Xue C, Xie Z, Ren H, Wang Y, Liu Y, Liu M, Ding F, Leong KW, Gu X.

ACS Nano. 2018 Oct 23;12(10):9660-9668. doi: 10.1021/acsnano.8b00552. Epub 2018 Sep 11.


HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Natronobacterium gregoryi Argonaute.

Lao YH, Li M, Gao MA, Shao D, Chi CW, Huang D, Chakraborty S, Ho TC, Jiang W, Wang HX, Wang S, Leong KW.

Adv Sci (Weinh). 2018 May 18;5(7):1700540. doi: 10.1002/advs.201700540. eCollection 2018 Jul.


Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability.

Peng B, Lai X, Chen L, Lin X, Sun C, Liu L, Qi S, Chen Y, Leong KW.

ACS Omega. 2017 Sep 30;2(9):6053-6062. doi: 10.1021/acsomega.7b01221. Epub 2017 Sep 21.


Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin.

Tian H, He Z, Sun C, Yang C, Zhao P, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y.

Adv Healthc Mater. 2018 Sep;7(17):e1800285. doi: 10.1002/adhm.201800285. Epub 2018 Jul 8.


Folding artificial mucosa with cell-laden hydrogels guided by mechanics models.

Chan HF, Zhao R, Parada GA, Meng H, Leong KW, Griffith LG, Zhao X.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7503-7508. doi: 10.1073/pnas.1802361115. Epub 2018 Jul 2.


Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel.

Chen Z, Tang M, Huang D, Jiang W, Li M, Ji H, Park J, Xu B, Atchison LJ, Truskey GA, Leong KW.

Lab Chip. 2018 Jul 10;18(14):2047-2054. doi: 10.1039/c8lc00202a.


Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing.

Pinese C, Lin J, Milbreta U, Li M, Wang Y, Leong KW, Chew SY.

Acta Biomater. 2018 Aug;76:164-177. doi: 10.1016/j.actbio.2018.05.054. Epub 2018 Jun 15.


Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery.

Shao D, Li M, Wang Z, Zheng X, Lao YH, Chang Z, Zhang F, Lu M, Yue J, Hu H, Yan H, Chen L, Dong WF, Leong KW.

Adv Mater. 2018 May 28:e1801198. doi: 10.1002/adma.201801198. [Epub ahead of print]


Walking the line: The fate of nanomaterials at biological barriers.

Meng H, Leong W, Leong KW, Chen C, Zhao Y.

Biomaterials. 2018 Aug;174:41-53. doi: 10.1016/j.biomaterials.2018.04.056. Epub 2018 May 5. Review.


Anti-infective biomaterials with surface-decorated tachyplesin I.

Xue Q, Liu XB, Lao YH, Wu LP, Wang D, Zuo ZQ, Chen JY, Hou J, Bei YY, Wu XF, Leong KW, Xiang H, Han J.

Biomaterials. 2018 Sep;178:351-362. doi: 10.1016/j.biomaterials.2018.05.008. Epub 2018 May 9.


Draft Genome Sequence of New Vancomycin-Resistant Enterococcus faecium Sequence Type 1421.

Leong KWC, Cooley LA, O'Toole RF.

Genome Announc. 2018 May 17;6(20). pii: e00438-18. doi: 10.1128/genomeA.00438-18.


Potency of a Scalable Nanoparticulate Subunit Vaccine.

Qiao D, Liu L, Chen Y, Xue C, Gao Q, Mao HQ, Leong KW, Chen Y.

Nano Lett. 2018 May 9;18(5):3007-3016. doi: 10.1021/acs.nanolett.8b00478. Epub 2018 Apr 30.


Human mesenchymal stem cell basal membrane bending on gratings is dependent on both grating width and curvature.

Zeng Y, Wong ST, Teo SK, Leong KW, Chiam KH, Yim EKF.

Sci Rep. 2018 Apr 24;8(1):6444. doi: 10.1038/s41598-018-24123-6.


Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide.

Wang HX, Song Z, Lao YH, Xu X, Gong J, Cheng D, Chakraborty S, Park JS, Li M, Huang D, Yin L, Cheng J, Leong KW.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4903-4908. doi: 10.1073/pnas.1712963115. Epub 2018 Apr 23.


Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis.

Leong KWC, Cooley LA, Anderson TL, Gautam SS, McEwan B, Wells A, Wilson F, Hughson L, O'Toole RF.

Sci Rep. 2018 Apr 19;8(1):6274. doi: 10.1038/s41598-018-24614-6.


Enhanced detection of microsatellite instability using pre-PCR elimination of wild-type DNA homo-polymers in tissue and liquid biopsies.

Ladas I, Yu F, Leong KW, Fitarelli-Kiehl M, Song C, Ashtaputre R, Kulke M, Mamon H, Makrigiorgos GM.

Nucleic Acids Res. 2018 Jul 6;46(12):e74. doi: 10.1093/nar/gky251.


Scalable production of core-shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin.

He Z, Liu Z, Tian H, Hu Y, Liu L, Leong KW, Mao HQ, Chen Y.

Nanoscale. 2018 Feb 15;10(7):3307-3319. doi: 10.1039/c7nr08047f.


Atom Transfer Radical Polymerization of Multishelled Cationic Corona for the Systemic Delivery of siRNA.

Kim HS, Son YJ, Mao W, Leong KW, Yoo HS.

Nano Lett. 2018 Jan 10;18(1):314-325. doi: 10.1021/acs.nanolett.7b04183. Epub 2017 Dec 18.


Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing.

Charoensook SN, Williams DJ, Chakraborty S, Leong KW, Vunjak-Novakovic G.

Integr Biol (Camb). 2017 Dec 11;9(12):956-967. doi: 10.1039/c7ib00144d.


NLRP10 Enhances CD4+ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release.

Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A.

Front Immunol. 2017 Nov 2;8:1462. doi: 10.3389/fimmu.2017.01462. eCollection 2017.


The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27.

Cheng CW, Leong KW, Ng YM, Kwong YL, Tse E.

J Biol Chem. 2017 Dec 29;292(52):21431-21441. doi: 10.1074/jbc.M117.801373. Epub 2017 Nov 8.


Application of induced pluripotent stem cells to model smooth muscle cell function in vascular diseases.

Ji H, Kim HS, Kim HW, Leong KW.

Curr Opin Biomed Eng. 2017 Mar;1:38-44. doi: 10.1016/j.cobme.2017.02.005. Epub 2017 Mar 22.


Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography.

Yang Y, Wang K, Gu X, Leong KW.

Engineering (Beijing). 2017 Feb;3(1):36-54. doi: 10.1016/J.ENG.2017.01.014. Epub 2017 Feb 21.


Functional Recovery of Contused Spinal Cord in Rat with the Injection of Optimal-Dosed Cerium Oxide Nanoparticles.

Kim JW, Mahapatra C, Hong JY, Kim MS, Leong KW, Kim HW, Hyun JK.

Adv Sci (Weinh). 2017 Jul 8;4(10):1700034. doi: 10.1002/advs.201700034. eCollection 2017 Oct.


Cleavable Multifunctional Targeting Mixed Micelles with Sequential pH-Triggered TAT Peptide Activation for Improved Antihepatocellular Carcinoma Efficacy.

Zhang J, Zheng Y, Xie X, Wang L, Su Z, Wang Y, Leong KW, Chen M.

Mol Pharm. 2017 Nov 6;14(11):3644-3659. doi: 10.1021/acs.molpharmaceut.7b00404. Epub 2017 Oct 10.


Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.

Diamond CE, Leong KWK, Vacca M, Rivers-Auty J, Brough D, Mortellaro A.

Sci Rep. 2017 Jul 31;7(1):6861. doi: 10.1038/s41598-017-07081-3.


CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery.

Wang HX, Li M, Lee CM, Chakraborty S, Kim HW, Bao G, Leong KW.

Chem Rev. 2017 Aug 9;117(15):9874-9906. doi: 10.1021/acs.chemrev.6b00799. Epub 2017 Jun 22. Review.


pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities.

Zhang J, Li J, Shi Z, Yang Y, Xie X, Lee SM, Wang Y, Leong KW, Chen M.

Acta Biomater. 2017 Aug;58:349-364. doi: 10.1016/j.actbio.2017.04.029. Epub 2017 Apr 26.


Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin.

He Z, Santos JL, Tian H, Huang H, Hu Y, Liu L, Leong KW, Chen Y, Mao HQ.

Biomaterials. 2017 Jun;130:28-41. doi: 10.1016/j.biomaterials.2017.03.028. Epub 2017 Mar 22.


Diverse Applications of Nanomedicine.

Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, Chen X, Cheng Z, Cui D, Du J, Dullin C, Escudero A, Feliu N, Gao M, George M, Gogotsi Y, Grünweller A, Gu Z, Halas NJ, Hampp N, Hartmann RK, Hersam MC, Hunziker P, Jian J, Jiang X, Jungebluth P, Kadhiresan P, Kataoka K, Khademhosseini A, Kopeček J, Kotov NA, Krug HF, Lee DS, Lehr CM, Leong KW, Liang XJ, Ling Lim M, Liz-Marzán LM, Ma X, Macchiarini P, Meng H, Möhwald H, Mulvaney P, Nel AE, Nie S, Nordlander P, Okano T, Oliveira J, Park TH, Penner RM, Prato M, Puntes V, Rotello VM, Samarakoon A, Schaak RE, Shen Y, Sjöqvist S, Skirtach AG, Soliman MG, Stevens MM, Sung HW, Tang BZ, Tietze R, Udugama BN, VanEpps JS, Weil T, Weiss PS, Willner I, Wu Y, Yang L, Yue Z, Zhang Q, Zhang Q, Zhang XE, Zhao Y, Zhou X, Parak WJ.

ACS Nano. 2017 Mar 28;11(3):2313-2381. doi: 10.1021/acsnano.6b06040. Epub 2017 Mar 14. Review.


Progress in Nanotheranostics Based on Mesoporous Silica Nanomaterial Platforms.

Singh RK, Patel KD, Leong KW, Kim HW.

ACS Appl Mater Interfaces. 2017 Mar 29;9(12):10309-10337. doi: 10.1021/acsami.6b16505. Epub 2017 Mar 16.


High-throughput screening of microchip-synthesized genes in programmable double-emulsion droplets.

Chan HF, Ma S, Tian J, Leong KW.

Nanoscale. 2017 Mar 9;9(10):3485-3495. doi: 10.1039/c6nr08224f.


Anesthetic considerations in scoliosis patient with dopa-responsive dystonia or Segawa's syndrome.

Hasan MS, Leong KW, Chan CY, Kwan MK.

J Orthop Surg (Hong Kong). 2017 Jan;25(1):2309499016684743. doi: 10.1177/2309499016684743. Review.


A versatile platform for surface modification of microfluidic droplets.

Li M, Jiang W, Chen Z, Suryaprakash S, Lv S, Tang Z, Chen X, Leong KW.

Lab Chip. 2017 Feb 14;17(4):635-639. doi: 10.1039/c7lc00079k.


miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression.

Leong KW, Cheng CW, Wong CM, Ng IO, Kwong YL, Tse E.

Oncotarget. 2017 Feb 14;8(7):11343-11355. doi: 10.18632/oncotarget.14526.


Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage.

Christoforou N, Chakraborty S, Kirkton RD, Adler AF, Addis RC, Leong KW.

Sci Rep. 2017 Jan 10;7:40285. doi: 10.1038/srep40285.


Nucleic acid scavenging microfiber mesh inhibits trauma-induced inflammation and thrombosis.

Lee J, Jackman JG, Kwun J, Manook M, Moreno A, Elster EA, Kirk AD, Leong KW, Sullenger BA.

Biomaterials. 2017 Mar;120:94-102. doi: 10.1016/j.biomaterials.2016.12.024. Epub 2016 Dec 23.

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