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Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection.

Balasubramanian S, Osburne MS, BrinJones H, Tai AK, Leong JM.

PLoS Pathog. 2019 Jan 10;15(1):e1007494. doi: 10.1371/journal.ppat.1007494. eCollection 2019 Jan.


Correction: Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells.

Bou Ghanem EN, Maung NHT, Siwapornchai N, Goodwin AE, Clark S, Muñoz-Elías EJ, Camilli A, Gerstein RM, Leong JM.

J Immunol. 2018 Dec 1;201(11):3471. doi: 10.4049/jimmunol.1801354. Epub 2018 Oct 29. No abstract available.


Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.

Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA.

mSphere. 2018 Jul 5;3(4). pii: e00303-18. doi: 10.1128/mSphere.00303-18.


Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier.

Garber JJ, Mallick EM, Scanlon KM, Turner JR, Donnenberg MS, Leong JM, Snapper SB.

Cell Mol Gastroenterol Hepatol. 2017 Dec 15;5(3):273-288. doi: 10.1016/j.jcmgh.2017.11.015. eCollection 2018 Mar.


Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells.

Bou Ghanem EN, Maung NHT, Siwapornchai N, Goodwin AE, Clark S, Muñoz-Elías EJ, Camilli A, Gerstein RM, Leong JM.

J Immunol. 2018 Jun 1;200(11):3739-3751. doi: 10.4049/jimmunol.1701065. Epub 2018 Apr 16. Erratum in: J Immunol. 2018 Dec 1;201(11):3471.


Plasticity in early immune evasion strategies of a bacterial pathogen.

Bernard Q, Smith AA, Yang X, Koci J, Foor SD, Cramer SD, Zhuang X, Dwyer JE, Lin YP, Mongodin EF, Marques A, Leong JM, Anguita J, Pal U.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3788-E3797. doi: 10.1073/pnas.1718595115. Epub 2018 Apr 2.


Pearls collections: What we can learn about infectious disease and cancer.

Knoll LJ, Hogan DA, Leong JM, Heitman J, Condit RC.

PLoS Pathog. 2018 Mar 29;14(3):e1006915. doi: 10.1371/journal.ppat.1006915. eCollection 2018 Mar. No abstract available.


Correction for Jandhyala et al., "Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation".

Jandhyala DM, Ahluwalia A, Schimmel JJ, Rogers AB, Leong JM, Thorpe CM.

Infect Immun. 2017 Dec 19;86(1). pii: e00753-17. doi: 10.1128/IAI.00753-17. Print 2018 Jan. No abstract available.


Characterization of Borrelia burgdorferi Binding to Mammalian Cells and Extracellular Matrix.

Lin YP, Leong JM.

Methods Mol Biol. 2018;1690:57-67. doi: 10.1007/978-1-4939-7383-5_5.


Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

Caine JA, Lin YP, Kessler JR, Sato H, Leong JM, Coburn J.

Cell Microbiol. 2017 Dec;19(12). doi: 10.1111/cmi.12786. Epub 2017 Sep 26.


Cytosolic Phospholipase A2α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection.

Bhowmick R, Clark S, Bonventre JV, Leong JM, McCormick BA.

Infect Immun. 2017 Oct 18;85(11). pii: e00280-17. doi: 10.1128/IAI.00280-17. Print 2017 Nov.


The Alpha-Tocopherol Form of Vitamin E Boosts Elastase Activity of Human PMNs and Their Ability to Kill Streptococcus pneumoniae.

Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A.

Front Cell Infect Microbiol. 2017 May 3;7:161. doi: 10.3389/fcimb.2017.00161. eCollection 2017.


Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic E. coli Infection Using Food-Borne Inoculation.

Flowers LJ, Bou Ghanem EN, Leong JM.

Front Cell Infect Microbiol. 2016 Nov 3;6:138. eCollection 2016.


A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.

Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM.

Toxins (Basel). 2016 Sep 2;8(9). pii: E259. doi: 10.3390/toxins8090259.


Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation.

Jandhyala DM, Ahluwalia A, Schimmel JJ, Rogers AB, Leong JM, Thorpe CM.

Infect Immun. 2015 Oct 19;84(1):138-48. doi: 10.1128/IAI.00977-15. Print 2016 Jan. Erratum in: Infect Immun. 2017 Dec 19;86(1):.


Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment.

Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM.

PLoS Pathog. 2015 Aug 27;11(8):e1005126. doi: 10.1371/journal.ppat.1005126. eCollection 2015 Aug.


Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection.

Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U.

Cell Microbiol. 2016 Jan;18(1):97-110. doi: 10.1111/cmi.12487. Epub 2015 Aug 31.


Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete.

Lin YP, Bhowmick R, Coburn J, Leong JM.

Cell Microbiol. 2015 Oct;17(10):1464-76. doi: 10.1111/cmi.12448. Epub 2015 May 13.


Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection.

Almeida MT, Mesquita FS, Cruz R, Osório H, Custódio R, Brito C, Vingadassalom D, Martins M, Leong JM, Holden DW, Cabanes D, Sousa S.

J Biol Chem. 2015 Mar 27;290(13):8383-95. doi: 10.1074/jbc.M114.591313. Epub 2015 Jan 29.


Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity.

Ristow LC, Bonde M, Lin YP, Sato H, Curtis M, Wesley E, Hahn BL, Fang J, Wilcox DA, Leong JM, Bergström S, Coburn J.

Cell Microbiol. 2015 Jul;17(7):1021-36. doi: 10.1111/cmi.12418. Epub 2015 Feb 16.


The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment.

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN.

J Immunol. 2015 Feb 1;194(3):1090-9. doi: 10.4049/jimmunol.1402401. Epub 2014 Dec 15.


Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization.

Lin YP, Chen Q, Ritchie JA, Dufour NP, Fischer JR, Coburn J, Leong JM.

Cell Microbiol. 2015 Jun;17(6):860-75. doi: 10.1111/cmi.12407. Epub 2015 Jan 24.


Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue.

DesRochers TM, Kimmerling EP, Jandhyala DM, El-Jouni W, Zhou J, Thorpe CM, Leong JM, Kaplan DL.

Infect Immun. 2015 Jan;83(1):28-38. doi: 10.1128/IAI.02143-14. Epub 2014 Oct 13.


Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete.

Lin YP, Benoit V, Yang X, Martínez-Herranz R, Pal U, Leong JM.

PLoS Pathog. 2014 Jul 31;10(7):e1004238. doi: 10.1371/journal.ppat.1004238. eCollection 2014 Jul.


Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation.

Battle SE, Brady MJ, Vanaja SK, Leong JM, Hecht GA.

Infect Immun. 2014 Sep;82(9):3713-22. doi: 10.1128/IAI.01523-13. Epub 2014 Jun 23.


Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.

Fortune DE, Lin YP, Deka RK, Groshong AM, Moore BP, Hagman KE, Leong JM, Tomchick DR, Blevins JS.

Infect Immun. 2014 Aug;82(8):3186-98. doi: 10.1128/IAI.02036-14. Epub 2014 May 19.


Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.

Kailasan Vanaja S, Rathinam VA, Atianand MK, Kalantari P, Skehan B, Fitzgerald KA, Leong JM.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7765-70. doi: 10.1073/pnas.1400075111. Epub 2014 May 14.


The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment.

Mallick EM, Garber JJ, Vanguri VK, Balasubramanian S, Blood T, Clark S, Vingadassalom D, Louissaint C, McCormick B, Snapper SB, Leong JM.

Cell Microbiol. 2014 Sep;16(9):1405-24. doi: 10.1111/cmi.12302. Epub 2014 Jun 2.


Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation.

Bhowmick R, Maung N, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM.

J Immunol. 2013 Nov 15;191(10):5115-23. doi: 10.4049/jimmunol.1300522. Epub 2013 Oct 2.


Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence.

Jandhyala DM, Vanguri V, Boll EJ, Lai Y, McCormick BA, Leong JM.

Infect Dis Clin North Am. 2013 Sep;27(3):631-49. doi: 10.1016/j.idc.2013.05.002. Epub 2013 Jul 24. Review.


Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.

Lai Y, Rosenshine I, Leong JM, Frankel G.

Cell Microbiol. 2013 Nov;15(11):1796-808. doi: 10.1111/cmi.12179. Epub 2013 Sep 3. Review.


Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution.

Hartland EL, Leong JM.

Front Cell Infect Microbiol. 2013 Apr 30;3:15. doi: 10.3389/fcimb.2013.00015. eCollection 2013. No abstract available.


A novel murine infection model for Shiga toxin-producing Escherichia coli.

Mallick EM, McBee ME, Vanguri VK, Melton-Celsa AR, Schlieper K, Karalius BJ, O'Brien AD, Butterton JR, Leong JM, Schauer DB.

J Clin Invest. 2012 Nov;122(11):4012-24. doi: 10.1172/JCI62746. Epub 2012 Oct 8.


Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB.

Infect Immun. 2012 Dec;80(12):4071-7. doi: 10.1128/IAI.06148-11. Epub 2012 Sep 10.


Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P.

Structure. 2012 Oct 10;20(10):1692-703. doi: 10.1016/j.str.2012.07.015. Epub 2012 Aug 23.


TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.

Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA.

Cell. 2012 Aug 3;150(3):606-19. doi: 10.1016/j.cell.2012.07.007. Epub 2012 Jul 19.


Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.

Campellone KG, Siripala AD, Leong JM, Welch MD.

J Biol Chem. 2012 Jun 8;287(24):20613-24. doi: 10.1074/jbc.M112.363473. Epub 2012 Apr 27.


Allele- and tir-independent functions of intimin in diverse animal infection models.

Mallick EM, Brady MJ, Luperchio SA, Vanguri VK, Magoun L, Liu H, Sheppard BJ, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM, Schauer DB.

Front Microbiol. 2012 Jan 31;3:11. doi: 10.3389/fmicb.2012.00011. eCollection 2012.


Identification of a novel prophage regulator in Escherichia coli controlling the expression of type III secretion.

Flockhart AF, Tree JJ, Xu X, Karpiyevich M, McAteer SP, Rosenblum R, Shaw DJ, Low CJ, Best A, Gannon V, Laing C, Murphy KC, Leong JM, Schneiders T, La Ragione R, Gally DL.

Mol Microbiol. 2012 Jan;83(1):208-23. doi: 10.1111/j.1365-2958.2011.07927.x. Epub 2011 Dec 9.


Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host.

Brady MJ, Radhakrishnan P, Liu H, Magoun L, Murphy KC, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM.

Front Microbiol. 2011 Nov 15;2:226. doi: 10.3389/fmicb.2011.00226. eCollection 2011.


Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli.

Lai Y, Riley K, Cai A, Leong JM, Herman IM.

Front Microbiol. 2011 Nov 8;2:222. doi: 10.3389/fmicb.2011.00222. eCollection 2011.


Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.

de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE.

Structure. 2011 Sep 7;19(9):1294-306. doi: 10.1016/j.str.2011.06.015.


Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes.

Lesser CF, Leong JM.

Sci Signal. 2011 Jul 5;4(180):pe32. doi: 10.1126/scisignal.2002252.


Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells.

Benoit VM, Fischer JR, Lin YP, Parveen N, Leong JM.

Infect Immun. 2011 Sep;79(9):3501-9. doi: 10.1128/IAI.00163-11. Epub 2011 Jun 27.


The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation.

Piscatelli H, Kotkar SA, McBee ME, Muthupalani S, Schauer DB, Mandrell RE, Leong JM, Zhou D.

PLoS One. 2011 Apr 26;6(4):e19331. doi: 10.1371/journal.pone.0019331.


Transcriptional regulators of the GAD acid stress island are carried by effector protein-encoding prophages and indirectly control type III secretion in enterohemorrhagic Escherichia coli O157:H7.

Tree JJ, Roe AJ, Flockhart A, McAteer SP, Xu X, Shaw D, Mahajan A, Beatson SA, Best A, Lotz S, Woodward MJ, La Ragione R, Murphy KC, Leong JM, Gally DL.

Mol Microbiol. 2011 Jun;80(5):1349-65. doi: 10.1111/j.1365-2958.2011.07650.x. Epub 2011 Apr 15.


Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ.

PLoS Pathog. 2011 Apr;7(4):e1001332. doi: 10.1371/journal.ppat.1001332. Epub 2011 Apr 7.


Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.

Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. doi: 10.1073/pnas.1010243107. Epub 2010 Nov 22.


Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation.

Vingadassalom D, Campellone KG, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, Leong JM.

PLoS Pathog. 2010 Aug 19;6(8):e1001056. doi: 10.1371/journal.ppat.1001056.


Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes.

Liu H, Fitzgerald D, Gran B, Leong JM, Alugupalli KR.

J Immunol. 2010 May 15;184(10):5859-64. doi: 10.4049/jimmunol.0902737. Epub 2010 Apr 9.

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