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Items: 1 to 50 of 138

1.

From single gene analysis to single cell profiling: a new era for precision medicine.

Di Martino MT, Meschini S, Scotlandi K, Riganti C, De Smaele E, Zazzeroni F, Donadelli M, Leonetti C, Caraglia M.

J Exp Clin Cancer Res. 2020 Mar 5;39(1):48. doi: 10.1186/s13046-020-01549-3.

2.

Correction to: Cell communication and signaling: how to turn bad language into positive one.

Chiodoni C, Di Martino MT, Zazzeroni F, Caraglia M, Donadelli M, Meschini S, Leonetti C, Scotlandi K.

J Exp Clin Cancer Res. 2019 Oct 25;38(1):425. doi: 10.1186/s13046-019-1431-5.

3.

Impact of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass on Postnatal Neurogenesis.

Maeda T, Sarkislali K, Leonetti C, Kapani N, Dhari Z, Al Haj I, Ulrey R, Hanley PJ, Jonas RA, Ishibashi N.

Ann Thorac Surg. 2020 Apr;109(4):1274-1281. doi: 10.1016/j.athoracsur.2019.08.036. Epub 2019 Sep 26.

PMID:
31563487
4.

Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease.

Romanowicz J, Leonetti C, Dhari Z, Korotcova L, Ramachandra SD, Saric N, Morton PD, Bansal S, Cheema A, Gallo V, Jonas RA, Ishibashi N.

J Am Heart Assoc. 2019 Aug 6;8(15):e012711. doi: 10.1161/JAHA.119.012711. Epub 2019 Jul 23.

5.

Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.

Tacconi EM, Badie S, De Gregoriis G, Reisländer T, Lai X, Porru M, Folio C, Moore J, Kopp A, Baguña Torres J, Sneddon D, Green M, Dedic S, Lee JW, Batra AS, Rueda OM, Bruna A, Leonetti C, Caldas C, Cornelissen B, Brino L, Ryan A, Biroccio A, Tarsounas M.

EMBO Mol Med. 2019 Jul;11(7):e9982. doi: 10.15252/emmm.201809982. Epub 2019 May 24.

6.

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.

Cherfils-Vicini J, Iltis C, Cervera L, Pisano S, Croce O, Sadouni N, Győrffy B, Collet R, Renault VM, Rey-Millet M, Leonetti C, Zizza P, Allain F, Ghiringhelli F, Soubeiran N, Shkreli M, Vivier E, Biroccio A, Gilson E.

EMBO J. 2019 Jun 3;38(11). pii: e100012. doi: 10.15252/embj.2018100012. Epub 2019 Apr 18.

PMID:
31000523
7.

Mobile Screening Units for the Early Detection of Breast Cancer and Cardiovascular Disease: A Pilot Telemedicine Study in Southern Italy.

Marino MM, Rienzo M, Serra N, Marino N, Ricciotti R, Mazzariello L, Leonetti CA, Ceraldi MP, Casamassimi A, Capocelli F, Martone G, Caracciolo AL.

Telemed J E Health. 2020 Mar;26(3):286-293. doi: 10.1089/tmj.2018.0328. Epub 2019 Apr 4.

PMID:
30945992
8.

Cell communication and signaling: how to turn bad language into positive one.

Chiodoni C, Di Martino MT, Zazzeroni F, Caraglia M, Donadelli M, Meschini S, Leonetti C, Scotlandi K.

J Exp Clin Cancer Res. 2019 Mar 13;38(1):128. doi: 10.1186/s13046-019-1122-2. Erratum in: J Exp Clin Cancer Res. 2019 Oct 25;38(1):425.

9.

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.

Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, D'Angelo C, Petti E, Amoreo CA, Mottolese M, Sperduti I, Chambery A, Russo R, Ostano P, Chiorino G, Blandino G, Sacconi A, Cherfils-Vicini J, Leonetti C, Gilson E, Biroccio A.

Nucleic Acids Res. 2019 Apr 23;47(7):3365-3382. doi: 10.1093/nar/gkz041.

10.

Cortical Dysmaturation in Congenital Heart Disease.

Leonetti C, Back SA, Gallo V, Ishibashi N.

Trends Neurosci. 2019 Mar;42(3):192-204. doi: 10.1016/j.tins.2018.12.003. Epub 2019 Jan 4. Review.

11.

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance.

Giarra S, Zappavigna S, Campani V, Abate M, Cossu AM, Leonetti C, Porru M, Mayol L, Caraglia M, De Rosa G.

Pharmaceutics. 2018 Oct 9;10(4). pii: E180. doi: 10.3390/pharmaceutics10040180.

12.

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.

Iachettini S, Trisciuoglio D, Rotili D, Lucidi A, Salvati E, Zizza P, Di Leo L, Del Bufalo D, Ciriolo MR, Leonetti C, Steegborn C, Mai A, Rizzo A, Biroccio A.

Cell Death Dis. 2018 Sep 24;9(10):996. doi: 10.1038/s41419-018-1065-0.

13.

Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth.

Scioli MG, Artuso S, D'Angelo C, Porru M, D'Amico F, Bielli A, Gentile P, Cervelli V, Leonetti C, Orlandi A.

PLoS One. 2018 Sep 7;13(9):e0203426. doi: 10.1371/journal.pone.0203426. eCollection 2018.

14.

HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma.

Lamberti D, Cristinziano G, Porru M, Leonetti C, Egan JB, Shi CX, Buglioni S, Amoreo CA, Castellani L, Borad MJ, Alemà S, Anastasi S, Segatto O.

Hepatology. 2019 Jan;69(1):131-142. doi: 10.1002/hep.30127. Epub 2018 Dec 14. Erratum in: Hepatology. 2019 Feb;69(2):925.

PMID:
30067876
15.

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities.

Porru M, Pompili L, Caruso C, Biroccio A, Leonetti C.

J Exp Clin Cancer Res. 2018 Mar 13;37(1):57. doi: 10.1186/s13046-018-0719-1. Review.

16.

Reprogramming Tumor-Immune Cell Interface in Solid and Hematological Malignancies to Enhance Response to Therapy.

Di Martino MT, Zazzeroni F, Donadelli M, Chiodoni C, Caraglia M, Scotlandi K, Meschini S, Leonetti C.

J Exp Clin Cancer Res. 2018 Mar 5;37(1):48. doi: 10.1186/s13046-018-0710-x. No abstract available.

17.

Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo.

Leonetti CP, Butt CM, Stapleton HM.

Chemosphere. 2018 Apr;197:81-88. doi: 10.1016/j.chemosphere.2017.12.172. Epub 2017 Dec 28.

18.

Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?

Pompili L, Leonetti C, Biroccio A, Salvati E.

J Exp Clin Cancer Res. 2017 Dec 22;36(1):189. doi: 10.1186/s13046-017-0657-3. Review.

19.

Xenograft as In Vivo Experimental Model.

Porru M, Pompili L, Caruso C, Leonetti C.

Methods Mol Biol. 2018;1692:97-105. doi: 10.1007/978-1-4939-7401-6_9.

PMID:
28986890
20.

ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function.

Pruvost M, Lépine M, Leonetti C, Etard O, Naveau M, Agin V, Docagne F, Maubert E, Ali C, Emery E, Vivien D.

Glia. 2017 Dec;65(12):1961-1975. doi: 10.1002/glia.23207. Epub 2017 Aug 29.

PMID:
28850711
21.

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.

Gnani D, Romito I, Artuso S, Chierici M, De Stefanis C, Panera N, Crudele A, Ceccarelli S, Carcarino E, D'Oria V, Porru M, Giorda E, Ferrari K, Miele L, Villa E, Balsano C, Pasini D, Furlanello C, Locatelli F, Nobili V, Rota R, Leonetti C, Alisi A.

Cell Death Differ. 2017 May;24(5):889-902. doi: 10.1038/cdd.2017.34. Epub 2017 Mar 24.

22.

Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination.

Leonetti C, Macrez R, Pruvost M, Hommet Y, Bronsard J, Fournier A, Perrigault M, Machin I, Vivien D, Clemente D, De Castro F, Maubert E, Docagne F.

Mol Neurodegener. 2017 Feb 23;12(1):20. doi: 10.1186/s13024-017-0160-5.

23.

Patient-derived xenografts: a relevant preclinical model for drug development.

Pompili L, Porru M, Caruso C, Biroccio A, Leonetti C.

J Exp Clin Cancer Res. 2016 Dec 5;35(1):189. Review.

24.

Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints.

Leonetti C, Butt CM, Hoffman K, Hammel SC, Miranda ML, Stapleton HM.

Environ Health. 2016 Nov 25;15(1):113.

25.

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.

Porru M, Zizza P, Franceschin M, Leonetti C, Biroccio A.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1362-1370. doi: 10.1016/j.bbagen.2016.11.010. Epub 2016 Nov 9. Review.

PMID:
27838395
26.

Breast Tuberculosis after Chest Trauma - a Case Report and Review of the Literature.

Perrone C, Altieri AM, D'Antonio S, Leonetti C, Alma MG.

Breast Care (Basel). 2016 Jun;11(3):200-3. doi: 10.1159/000446977. Epub 2016 Jun 23.

27.

Transferrin-Targeted Nanoparticles Containing Zoledronic Acid as a Potential Tool to Inhibit Glioblastoma Growth.

Salzano G, Zappavigna S, Luce A, D'Onofrio N, Balestrieri ML, Grimaldi A, Lusa S, Ingrosso D, Artuso S, Porru M, Leonetti C, Caraglia M, De Rosa G.

J Biomed Nanotechnol. 2016 Apr;12(4):811-30.

PMID:
27301207
28.

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells.

Micheli E, Altieri A, Cianni L, Cingolani C, Iachettini S, Bianco A, Leonetti C, Cacchione S, Biroccio A, Franceschin M, Rizzo A.

Biochimie. 2016 Jun;125:223-31. doi: 10.1016/j.biochi.2016.04.008. Epub 2016 Apr 13.

PMID:
27086081
29.

Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues.

Leonetti C, Butt CM, Hoffman K, Miranda ML, Stapleton HM.

Environ Int. 2016 Mar;88:23-29. doi: 10.1016/j.envint.2015.12.002. Epub 2015 Dec 14.

30.

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.

Zizza P, Cingolani C, Artuso S, Salvati E, Rizzo A, D'Angelo C, Porru M, Pagano B, Amato J, Randazzo A, Novellino E, Stoppacciaro A, Gilson E, Stassi G, Leonetti C, Biroccio A.

Nucleic Acids Res. 2016 Feb 29;44(4):1579-90. doi: 10.1093/nar/gkv1122. Epub 2015 Oct 27.

31.

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.

Nardella M, Guglielmi L, Musa C, Iannetti I, Maresca G, Amendola D, Porru M, Carico E, Sessa G, Camerlingo R, Dominici C, Megiorni F, Milan M, Bearzi C, Rizzi R, Pirozzi G, Leonetti C, Bucci B, Mercanti D, Felsani A, D'Agnano I.

Oncotarget. 2015 Oct 20;6(32):32821-40. doi: 10.18632/oncotarget.5104.

32.

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer.

Porru M, Artuso S, Salvati E, Bianco A, Franceschin M, Diodoro MG, Passeri D, Orlandi A, Savorani F, D'Incalci M, Biroccio A, Leonetti C.

Mol Cancer Ther. 2015 Nov;14(11):2541-51. doi: 10.1158/1535-7163.MCT-15-0253. Epub 2015 Aug 24.

33.

Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model.

Pessina A, Leonetti C, Artuso S, Benetti A, Dessy E, Pascucci L, Passeri D, Orlandi A, Berenzi A, Bonomi A, Coccè V, Ceserani V, Ferri A, Dossena M, Mazzuca P, Ciusani E, Ceccarelli P, Caruso A, Portolani N, Sisto F, Parati E, Alessandri G.

J Exp Clin Cancer Res. 2015 Aug 13;34:82. doi: 10.1186/s13046-015-0200-3.

34.

Critical Components of the Conjugation Machinery of the Integrative and Conjugative Element ICEBs1 of Bacillus subtilis.

Leonetti CT, Hamada MA, Laurer SJ, Broulidakis MP, Swerdlow KJ, Lee CA, Grossman AD, Berkmen MB.

J Bacteriol. 2015 Aug 1;197(15):2558-67. doi: 10.1128/JB.00142-15. Epub 2015 May 26.

35.

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Rizzo A, Iachettini S, Zizza P, Cingolani C, Porru M, Artuso S, Stevens M, Hummersone M, Biroccio A, Salvati E, Leonetti C.

J Exp Clin Cancer Res. 2015 Feb 5;34:9. doi: 10.1186/s13046-014-0101-x. No abstract available.

36.

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.

Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, Atzori MG, Ceci C, Mai A, Leonetti C, Levati L, Bonanno E, Tentori L, Caccuri AM.

Biochem Pharmacol. 2015 May 1;95(1):16-27. doi: 10.1016/j.bcp.2015.03.004. Epub 2015 Mar 17.

PMID:
25795251
37.

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.

Salvati E, Rizzo A, Iachettini S, Zizza P, Cingolani C, D'Angelo C, Porru M, Mondello C, Aiello A, Farsetti A, Gilson E, Leonetti C, Biroccio A.

Nucleic Acids Res. 2015 Feb 18;43(3):1759-69. doi: 10.1093/nar/gkv006. Epub 2015 Jan 23.

38.

Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.

Loria R, Bon G, Perotti V, Gallo E, Bersani I, Baldassari P, Porru M, Leonetti C, Di Carlo S, Visca P, Brizzi MF, Anichini A, Mortarini R, Falcioni R.

Oncotarget. 2015 Feb 20;6(5):2779-93.

39.

Long-term efficacy of adalimumab in hyperimmunoglobulin D and periodic fever syndrome.

Di Gangi M, Amato G, Converso G, Benenati A, Leonetti C, Borella E, Doria A, Foti R.

Isr Med Assoc J. 2014 Oct;16(10):605-7. No abstract available.

40.

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid.

Porru M, Zappavigna S, Salzano G, Luce A, Stoppacciaro A, Balestrieri ML, Artuso S, Lusa S, De Rosa G, Leonetti C, Caraglia M.

Oncotarget. 2014 Nov 15;5(21):10446-59.

41.

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Rizzo A, Iachettini S, Zizza P, Cingolani C, Porru M, Artuso S, Stevens M, Hummersone M, Biroccio A, Salvati E, Leonetti C.

J Exp Clin Cancer Res. 2014 Oct 6;33:81. doi: 10.1186/s13046-014-0081-x. Erratum in: J Exp Clin Cancer Res. 2015;34:9.

42.

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.

Tesauro C, Graziani G, Arnò B, Zuccaro L, Muzi A, D'Annessa I, Santori E, Tentori L, Leonetti C, Fiorani P, Desideri A.

J Exp Clin Cancer Res. 2014 Sep 17;33:71. doi: 10.1186/s13046-014-0071-z.

43.

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides.

Guerrini A, Tesei A, Ferroni C, Paganelli G, Zamagni A, Carloni S, Di Donato M, Castoria G, Leonetti C, Porru M, De Cesare M, Zaffaroni N, Beretta GL, Del Rio A, Varchi G.

J Med Chem. 2014 Sep 11;57(17):7263-79. doi: 10.1021/jm5005122. Epub 2014 Aug 28.

PMID:
25121586
44.

Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion.

Amendola D, Nardella M, Guglielmi L, Cerquetti L, Carico E, Alesi V, Porru M, Leonetti C, Bearzi C, Rizzi R, D'Agnano I, Stigliano A, Novelli G, Bucci B.

Stem Cell Res Ther. 2014 Apr 22;5(2):55. doi: 10.1186/scrt444.

45.

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.

Salvati E, Zizza P, Rizzo A, Iachettini S, Cingolani C, D'Angelo C, Porru M, Randazzo A, Pagano B, Novellino E, Pisanu ME, Stoppacciaro A, Spinella F, Bagnato A, Gilson E, Leonetti C, Biroccio A.

Nucleic Acids Res. 2014 Mar;42(5):2945-57. doi: 10.1093/nar/gkt1289. Epub 2013 Dec 11. Erratum in: Nucleic Acids Res. 2014 Dec 16;42(22):14083.

46.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E.

J Exp Clin Cancer Res. 2013 Sep 19;32:68. doi: 10.1186/1756-9966-32-68.

47.

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.

Garufi A, Trisciuoglio D, Porru M, Leonetti C, Stoppacciaro A, D'Orazi V, Avantaggiati M, Crispini A, Pucci D, D'Orazi G.

J Exp Clin Cancer Res. 2013 Oct 7;32:72. doi: 10.1186/1756-9966-32-72.

48.

Antibody-drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin.

Falvo E, Tremante E, Fraioli R, Leonetti C, Zamparelli C, Boffi A, Morea V, Ceci P, Giacomini P.

Nanoscale. 2013 Dec 21;5(24):12278-85. doi: 10.1039/c3nr04268e.

PMID:
24150593
49.

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.

Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, Simonet T, Horard B, Jamet K, Cervera L, Mendez-Bermudez A, Poncet D, Grataroli R, de Rodenbeeke CT, Salvati E, Rizzo A, Zizza P, Ricoul M, Cognet C, Kuilman T, Duret H, Lépinasse F, Marvel J, Verhoeyen E, Cosset FL, Peeper D, Smyth MJ, Londoño-Vallejo A, Sabatier L, Picco V, Pages G, Scoazec JY, Stoppacciaro A, Leonetti C, Vivier E, Gilson E.

Nat Cell Biol. 2013 Jul;15(7):818-28. doi: 10.1038/ncb2774. Epub 2013 Jun 23.

PMID:
23792691
50.

Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models.

Tesei A, Leonetti C, Di Donato M, Gabucci E, Porru M, Varchi G, Guerrini A, Amadori D, Arienti C, Pignatta S, Paganelli G, Caraglia M, Castoria G, Zoli W.

PLoS One. 2013 May 8;8(5):e62657. doi: 10.1371/journal.pone.0062657. Print 2013.

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