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Items: 44


Fueling Cardiac Hypertrophy.

Matsuura TR, Leone TC, Kelly DP.

Circ Res. 2020 Jan 17;126(2):197-199. doi: 10.1161/CIRCRESAHA.119.316358. Epub 2020 Jan 16. No abstract available.


Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice.

Lee S, Leone TC, Rogosa L, Rumsey J, Ayala J, Coen PM, Fitts RH, Vega RB, Kelly DP.

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E394-E406. doi: 10.1152/ajpendo.00380.2016. Epub 2017 Mar 7.


MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.

Ahn B, Soundarapandian MM, Sessions H, Peddibhotla S, Roth GP, Li JL, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP.

J Clin Invest. 2016 Sep 1;126(9):3567-79. doi: 10.1172/JCI87382. Epub 2016 Aug 8.


Mitochondrial protein hyperacetylation in the failing heart.

Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC Jr, Margulies KB, Coon JJ, Kelly DP.

JCI Insight. 2016 Feb;2(1). pii: e84897. Epub 2016 Feb 25.


The Failing Heart Relies on Ketone Bodies as a Fuel.

Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27. Erratum in: Circulation. 2018 Oct 9;138(15):e422.


Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK.

J Clin Invest. 2015 Sep;125(9):3461-76. doi: 10.1172/JCI79964. Epub 2015 Aug 4.


PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein.

Ciron C, Zheng L, Bobela W, Knott GW, Leone TC, Kelly DP, Schneider BL.

Acta Neuropathol Commun. 2015 Apr 1;3:16. doi: 10.1186/s40478-015-0200-8.


Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP.

Circ Heart Fail. 2014 Nov;7(6):1022-31. doi: 10.1161/CIRCHEARTFAILURE.114.001469. Epub 2014 Sep 18.


A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP.

Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.


A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis.

Lai L, Wang M, Martin OJ, Leone TC, Vega RB, Han X, Kelly DP.

J Biol Chem. 2014 Jan 24;289(4):2250-9. doi: 10.1074/jbc.M113.523654. Epub 2013 Dec 11.


PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN.

Mol Metab. 2013 May 9;2(3):194-204. doi: 10.1016/j.molmet.2013.05.001. eCollection 2013.


Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP.

J Clin Invest. 2013 Jun;123(6):2564-75. doi: 10.1172/JCI67652. Epub 2013 May 8.


Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.

Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Calkins H, Kelly DP, Judge DP, Chen HS.

Nature. 2013 Feb 7;494(7435):105-10. doi: 10.1038/nature11799. Epub 2013 Jan 27.


PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.

Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R.

PLoS One. 2013;8(1):e54054. doi: 10.1371/journal.pone.0054054. Epub 2013 Jan 16.


Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.

Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, Finck BN.

PLoS One. 2012;7(12):e52645. doi: 10.1371/journal.pone.0052645. Epub 2012 Dec 28.


The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.

Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP.

Genes Dev. 2011 Dec 15;25(24):2619-30. doi: 10.1101/gad.178434.111. Epub 2011 Dec 1.


Transcriptional control of cardiac fuel metabolism and mitochondrial function.

Leone TC, Kelly DP.

Cold Spring Harb Symp Quant Biol. 2011;76:175-82. doi: 10.1101/sqb.2011.76.011965. Epub 2011 Nov 17. Review.


Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling.

Schilling J, Lai L, Sambandam N, Dey CE, Leone TC, Kelly DP.

Circ Heart Fail. 2011 Jul;4(4):474-82. doi: 10.1161/CIRCHEARTFAILURE.110.959833. Epub 2011 May 10.


Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response.

Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopaschuk GD, Finck BN, Kelly DP.

J Biol Chem. 2011 Apr 1;286(13):11155-62. doi: 10.1074/jbc.M110.217349. Epub 2011 Feb 14.


Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.

Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, Collia D, Chen Z, Wozniak DF, Leone TC, Kelly DP.

Cell Metab. 2010 Dec 1;12(6):633-42. doi: 10.1016/j.cmet.2010.11.008. Erratum in: Cell Metab. 2011 Jan 5;13(1):114.


Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway.

Trausch-Azar J, Leone TC, Kelly DP, Schwartz AL.

J Biol Chem. 2010 Dec 17;285(51):40192-200. doi: 10.1074/jbc.M110.131615. Epub 2010 Aug 15.


Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha.

Banke NH, Wende AR, Leone TC, O'Donnell JM, Abel ED, Kelly DP, Lewandowski ED.

Circ Res. 2010 Jul 23;107(2):233-41. doi: 10.1161/CIRCRESAHA.110.221713. Epub 2010 Jun 3.


Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes.

Beitelshees AL, Finck BN, Leone TC, Cresci S, Wu J, Province MA, Fabbrini E, Kirk E, Zineh I, Klein S, Spertus JA, Kelly DP.

Pharmacogenet Genomics. 2010 Apr;20(4):231-8. doi: 10.1097/FPC.0b013e3283377abc. Erratum in: Pharmacogenet Genomics. 2012 May;22(5):396.


Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.

Schaeffer PJ, Desantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1263-73. doi: 10.1152/ajpheart.00152.2009. Epub 2009 Aug 21.


Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, Medeiros DM, Kovacs A, Kelly DP.

Genes Dev. 2008 Jul 15;22(14):1948-61. doi: 10.1101/gad.1661708.


The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.


Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr, Kelly DP.

Cell Metab. 2006 Sep;4(3):199-210.


Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.

Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, Finck BN.

J Biol Chem. 2006 Jul 14;281(28):19000-8. Epub 2006 May 2.


Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization.

Luptak I, Balschi JA, Xing Y, Leone TC, Kelly DP, Tian R.

Circulation. 2005 Oct 11;112(15):2339-46. Epub 2005 Oct 3.


Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice.

You M, Considine RV, Leone TC, Kelly DP, Crabb DW.

Hepatology. 2005 Sep;42(3):568-77.


PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.


Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle.

Schaeffer PJ, Wende AR, Magee CJ, Neilson JR, Leone TC, Chen F, Kelly DP.

J Biol Chem. 2004 Sep 17;279(38):39593-603. Epub 2004 Jul 19.


Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice.

Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF.

Nat Med. 2003 Aug;9(8):1069-75. Epub 2003 Jul 6.


PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.

Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, Semenkovich CF.

J Lipid Res. 2002 Jun;43(6):936-43.


The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.

Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, Han X, Gross RW, Kozak R, Lopaschuk GD, Kelly DP.

J Clin Invest. 2002 Jan;109(1):121-30.


PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice.

Tordjman K, Bernal-Mizrachi C, Zemany L, Weng S, Feng C, Zhang F, Leone TC, Coleman T, Kelly DP, Semenkovich CF.

J Clin Invest. 2001 Apr;107(8):1025-34.


Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training.

Horowitz JF, Leone TC, Feng W, Kelly DP, Klein S.

Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E348-55.


Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.

Barger PM, Brandt JM, Leone TC, Weinheimer CJ, Kelly DP.

J Clin Invest. 2000 Jun;105(12):1723-30.


The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism.

Djouadi F, Brandt JM, Weinheimer CJ, Leone TC, Gonzalez FJ, Kelly DP.

Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):339-43.


The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites.

Leone TC, Cresci S, Carter ME, Zhang Z, Lala DS, Strauss AW, Kelly DP.

J Biol Chem. 1995 Oct 13;270(41):24622. No abstract available.


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